• 융합신호처리학회논문지
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• 제2권4호
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• pp.22-30
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• 2001

본 논문은 유방질환 중에서 유관(duct )에 발생하는 유방종양을 Benign, DCIS(ductal carcinoma in situ) NOS (invasive ductal carcinoma)로 분류하기 위해 3가지 분류기 (classifier) 를 생성한 후, 비교 분석하였다. 분류기 생성에서 가장 중요한 단계인 특징 추출 단계에서 세포핵의 기하학적 특징을 형태학적 특징을 추출하여 분류기를 생성하고 염색질 패턴의 내부적 변화를 나타내는 질감 특징을 추출하여 2가지 배율(100/400배)에서 2개의 분류기를 생성하였다. 400배 배율의 유방질환 영상에서 세포핵을 추출하여 핵의 형태학적 특징값인 핵의 면적, 둘레. 가로, 세로(장. 단축) 의 길이, 원형성의 비율을 구한 후 이 특징값들을 조합하여 판별분석에 의해 분류기를 생생하고, 분류 정확도를 검증하였다. 100배 배율과 400배의 배율의 유방질환 영상에서 1, 2, 3, 4 단계(level)의 wavelet 변환를 적용한 후, 분할된 서브밴드에서 GLCM(Gray Level Co-occurrence Matrix)을 이용하여 질감 특징(entropy Energy, Contrast, Homogeneity)를 추출하고, 이 특징값들을 조합하여 판변 분석에 의해 분류기를 생성한 후 분류 정확도를 검증하였다. 이 세 분류기를 비교 분석 하였을때 현민경 100배 배율의 영상을 3단계 wavelet 변환을 적용하고 질감 특징을 추출하여 생성한 분류기가 다른 두 분류기보다 유방 질환 Benign, DCIS; NOS를 분류하는데 더 나은 결과를 보였다.

• 대한치과보철학회지
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• 제43권5호
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• pp.587-598
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• 2005

Statement of problem: Ceramic restorations should be made of porcelain layers of different opacity, shade, and thickness in order to provide a natural appearance. Lithium disilicate glass-ceramic system has superior color reproducibility, because it uses the ceramic ingot which is similar to teeth shade and uses the staining technique and layering technique. However, staining technique has a fault of discoloration. Also, porcelain is divided core and dentin layer, it is not enough to study about the influence of porcelain layer thickness and shade on the shade of ceramic restorations. Purpose: The purpose of this study was to evaluate the influence of porcelain layer thickness and color on the final shade of ceramic restorations. Materials and method: The CIE $L^*a^*b^*$(CIELAB) values of 72 assembled specimens, each consisting of 3 discs (enamel porcelain 0.2 mm/dentin porcelain -1.2, 0.9, 0.7, 0.5 or 0.3 mm/ceramic core -0.3, 0.5, 0.7, 0.9 or 1.2 mm, diameter is 1.0 mm) were evaluated with a spectrophotometer (Model Chromaview 300, Spectron Tech Co, Korea) for the shade A1, A2, A3 and A4. Distilled water (refractive index: 1.7) was used to attain optical contact between the layers. White, white gray, and white brown backgrounds were used to assess the influence of the background on the final shade. And the mean color difference value$({\Delta}E)$ was calculated. Results and conclusion: The results obtained from this study were as follows. 1. There was a significant correlation between the thickness ratio of the ceramic core/dentin porcelain system and $L^*,\;a^*\;and\;b^*$ values when the total thickness of specimen combination was smaller than 1.4 mm(P<0.05). 2. The specimen which the ceramic core thickness was more than 0.7 mm had the best masking effect against background colors. 3. The mean color difference value$({\Delta}E)$ is smaller than 2 $({\Delta}E<2)$ when the ceramic core thickness was larger than 0.7 mm and the total thickness of specimen was more than 1.4 mm.

• 대한가정학회지
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• 제25권2호
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• pp.39-54
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• 1987

One's Clothing Satisfaction, has a great influence on his role behavior in a society. Especially, as for the teacher's and the professors whose role is teaching, it can not be too emphaszed. Above all, high school girls and college women are the most likely to be influenced by their teachers' clothing behavior, to whom they pay their respect in every way. From this point of view, this study was aimed at explaining, the correlation between the teachers/professors' clothing behaviors and the learning efficiency. On clothing behaviors assessed 30 items related with the learning efficiency, selected from the instruments of preceding studies, and modified by the factors dealing with modesty, color, and design. The questionnaires were composed of two major categories: those for students and for teachers/progessors. The subjects of this study were included students and teachers/professors of high school and universities in Seoul. The data were analyzed statically by mean, standard Deviation, and F-test. The results of this study were summerized as follows; 1. The clothing behaviors of the teachers/professors influenced on the learning efficiency. Namely teachers' clothing satisfaction is in direct proportion to them teaching efficiency and students' learning efficiency. 2. Among the clothing behavior variables, modesty had a great influence on the learning efficiency, especially as for that of teachers more than professors. 3. The influence of the teachers'/professors' clothing behaviors on the learning efficiency showed no significance between high school girls and college women, but some significance between the grades of collegians. 4. As for the teachers'/professors' clothing behavior, male teachers/professors gave priority to design and female teachers/professors to modesty, color showed no significance between them irrespective of age. 5. As for the clothing behavior variabels, both the teachers/professors and the students showed some significance. In class the teachers/professors highly responded to their own clothing behaviors than the students. 6. According to priority the most favorable clothing colors for male teachers/professors are navy blue, gray, indigo blue, and black, and the most disgusting ones red, mud yellow, violet, pink, and green. The most favorable clothing colors for female teachers/professors are beign, white, pale yellow, and black, and the most disgusting ones red, mud yellow, and yellow and yellow according to priority. It is that teachers/professors should wear modestly and in color harmony to invite the desirable students' will to study. Teachers'/professors' colorful appearance and heavy toilet bring about a drop in the students' will to study.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제2권8호
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• pp.579-588
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• 2013

본 논문에서는 화재 비디오 영상의 저작권 보호를 위해 효과적인 워터마킹 기법을 제안한다. 제안하는 워터마킹 기법은 명암도 동시발생 행렬과 퍼지 클러스터링 알고리즘을 이용하여 화재의 색상과 텍스처의 특징을 효율적으로 이용한다. 명암도 동시발생 행렬은 각 후보 화재 영상의 블록에 대한 에너지와 동질성을 계산하여 텍스처 데이터 셋을 만드는데 사용하며, 퍼지 클러스터링은 화재 비디오 영상의 색상 분할과 워터마커 삽입을 위한 텍스처 블록을 결정하기 위해 사용된다. 선택된 텍스처 블록은 이산 웨이블릿 변환을 통해 네 가지 서브밴드 (LL, LH, HL, HH)를 가지는 1차 레벨 웨이블릿 구조로 분해되고, 워터마커는 사람의 시각에 영향을 주지 않는 LH 영역에 삽입된다. 모의실험결과, 제안한 워터마킹 기법은 약 48 데시벨의 높은 첨부 신호 대 잡음 비와 1.6-2.0의 낮은 M-특이치 분해 값을 보였다. 또한, 제안한 워터마킹 기법은 노이즈 첨가, 필터링, 크로핑, JPEG 압축과 같은 영상처리 공격에서도 기존 이미지 워터마킹 알고리즘보다 정규화된 상관 값에서 높은 성능을 보였다.

• Journal of Acupuncture Research
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• 제17권2호
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• pp.153-168
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• 2000

Introduction : In spite of the use of Bee Venom aqua-acupuncture in the clinics, the scientific evaluation on effects is not enough. Bee Venom aqua-acupuncture is used according to the stimulation of acupuncture point and the chemical effects of Bee Venom. The aims of this study is to investigate the analgegic effects of the Bee Venom aqua-acupuncture, through the change of writhing reflex and the change of c-fos in secondary neurons in the spinal cord. Materials and Methods : Pain animal model was used acetic acid method. The changes of writhing reflex of the mice which were derived pain by injecting acetic acid into the abdomen, after stimulating Bee Venom aqua-acupuncture on Chungwan(CV12) were measured. We used Fos immunohistochemical technique to study the neuronal activity in the spinal cord. Results : 1. Expression of c-fos in superficial dorsal horn(SDH), nucleus proprius(NP) and neck of dorsal hom(N) on 6~9th thoracic spine decreased significantly at $2.5{\times}10-4$g/kg Bee Venom aqua-acupuncture, compared with saline-acetic acid group. 2. The numeral change of Fos-LI neurons on the NP, N, and ventral gray(V) on 6-9th thoracic spine, SDH on 9-11th thoracic spine, and SDH and V on 11~13th thoracic spine decreased significantly at Chungwan(CV12) Bee Venom aqua-acupuncture, compared with saline-acetic acid group. 3. The correlation between the numbers of writhing refleax and Fos-LI neurons in T6-13 segment was statistically statistically significant at Chungwan(CV12) Bee Venom aqua-acupuncture. Conclusion : This study shows that the Bee Venom aqua-acupuncture on Chungwan(CV12) decreases the numbers of Fos-LI neurons. As the analgegic effects of Bee Venom aqua-acupuncture is recognized. Bee Venom aqua-acupuncture treatment is expected for pain modulation. In order to use it in many ways, more researches are needed for the dose and stability of Bee Venom aqua-acupuncture.

• 한국작물학회지
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• 제38권1호
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• pp.15-22
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• 1993

들깨 국내 수집 유전자원 80종에 대한 종실의 단백질 함량과 아미노산 조성을 분석 조사하여 고단백 양질 아미노산 품종육성에 오필요한 기초자료를 얻고자 시험을 실시하였던 바 그 결과를 요약하면 다음과 같다. 1. 들깨 종실의 단백질 함량은 최고 28.5%, 최저 17,9%, 평균 24.6%였다. 2. 단백질 함량은 숙기와 천입중에 따라서는 큰 차이가 없었으나 종피색에서는 암갈색에서 백색에 가까울수록 높았는데 암갈색에 비해 은회색은 1.4% 더 높았다. 3. 들깨 수집 유전자원 80종의 총 필수아미노산은 품종에 따라 최고 44.85%, 최저 36.41%, 평균 40.55% 였으며 일반 아미노산 함량은 최고 60.01%, 최저 47.23%, 평균 55.29%였다. 4. 필수 아미노산 함량과 종피색간에는 고도의 정상관(r=0.3389＊＊) 관계로서 종피색이 암갈색에서 백색에 가까울수록 높은 경향이었다. 5. 들깨에서 필수 아미노산중 함량이 많은 것은 arginine과 leucine, 가장 적었던 것은 methionine 이었고, 일반 아미노산중 함량이 많은 것은 glutamic acide와 asparagine이었다. 6. 필수아미노산 중에서 lysine, methionine, valine 등의 평균함량은 FAO 권장량 보다 높았다.

• Korean Journal of Radiology
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• 제22권7호
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• pp.1152-1162
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• 2021

Objective: This study aimed to determine whether there are regional differences in the blood-brain barrier (BBB) permeability of cognitively normal elderly participants and to identify factors influencing BBB permeability with a clinically feasible, 10-minute dynamic contrast-enhanced (DCE) MRI protocol. Materials and Methods: This IRB-approved prospective study recruited 35 cognitively normal adults (26 women; mean age, 64.5 ± 5.6 years) who underwent DCE T1-weighted imaging. Permeability maps (K_trans) were coregistered with masks to calculate the mean regional values. The paired t test and Friedman test were used to compare Ktrans between different regions. The relationships between K_trans and the factors of age, sex, education, cognition score, vascular risk burden, vascular factors on imaging, and medial temporal lobar atrophy were assessed using Pearson correlation and the Spearman rank test. Results: The mean permeability rates of the right and left hippocampi, as assessed with automatic segmentation, were 0.529 ± 0.472 and 0.585 ± 0.515 (K_trans, x 10^-3 min^-1), respectively. Concerning the deep gray matter, the K_trans of the thalamus was significantly greater than those of the putamen and hippocampus (p = 0.007, p = 0.041). Regarding the white matter, the K_trans value of the occipital white matter was significantly greater than those of the frontal, cingulate, and temporal white matter (p < 0.0001, p = 0.0007, p = 0.0002). The variations in K_trans across brain regions were not related to age, cognitive score, vascular risk burden, vascular risk factors on imaging, or medial temporal lobar atrophy in the study group. Conclusion: Our study demonstrated regional differences in BBB permeability (K_trans) in cognitively normal elderly adults using a clinically acceptable 10-minutes DCE imaging protocol. The regional differences suggest that the integrity of the BBB varies across the brains of cognitively normal elderly adults. We recommend considering regional differences in K_trans values when evaluating BBB permeability in patients with neurodegenerative diseases.

• Korean Journal of Radiology
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• 제22권5호
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• pp.770-781
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• 2021

Objective: Chemical exchange-dependent saturation transfer (CEST) MRI is sensitive for detecting solid-like proteins and may detect changes in the levels of mobile proteins and peptides in tissues. The objective of this study was to evaluate the characteristics of chemical exchange proton pools using the CEST MRI technique in patients with dementia. Materials and Methods: Our institutional review board approved this cross-sectional prospective study and informed consent was obtained from all participants. This study included 41 subjects (19 with dementia and 22 without dementia). Complete CEST data of the brain were obtained using a three-dimensional gradient and spin-echo sequence to map CEST indices, such as amide, amine, hydroxyl, and magnetization transfer ratio asymmetry (MTR_asym) values, using six-pool Lorentzian fitting. Statistical analyses of CEST indices were performed to evaluate group comparisons, their correlations with gray matter volume (GMV) and Mini-Mental State Examination (MMSE) scores, and receiver operating characteristic (ROC) curves. Results: Amine signals (0.029 for non-dementia, 0.046 for dementia, p = 0.011 at hippocampus) and MTR_asym values at 3 ppm (0.748 for non-dementia, 1.138 for dementia, p = 0.022 at hippocampus), and 3.5 ppm (0.463 for non-dementia, 0.875 for dementia, p = 0.029 at hippocampus) were significantly higher in the dementia group than in the non-dementia group. Most CEST indices were not significantly correlated with GMV; however, except amide, most indices were significantly correlated with the MMSE scores. The classification power of most CEST indices was lower than that of GMV but adding one of the CEST indices in GMV improved the classification between the subject groups. The largest improvement was seen in the MTR_asym values at 2 ppm in the anterior cingulate (area under the ROC curve = 0.981), with a sensitivity of 100 and a specificity of 90.91. Conclusion: CEST MRI potentially allows noninvasive image alterations in the Alzheimer's disease brain without injecting isotopes for monitoring different disease states and may provide a new imaging biomarker in the future.

• 감성과학
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• 제5권4호
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• pp.59-66
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• 2002

본 실험은 청각 사상관련전위(ERP)를 이용하여 다양한 성격 특질 모형들의 생물학적 근거와, 구조의 공통점과 차이점을 명확히 하기 위해서 설계되었다. 48명의 대학생 피험자들에게 4가지 성격 측정 검사(NEO-Pl-R, EPQ-R, BIS/BAS 척도, IVE)를 시행하고, 이어 두 종류의 청각 자극 세트(50㎳와 300㎳)를 이용한 오드볼 과제를 통해 ERP를 측정하였다. 설문지 간의 상관과, 설문지와 ERP 내외생적 구성 요소 간의 상관, 그리고 그 상관의 두피 분포 양상을 통합적으로 고려하여 해석하였다. 각 성격 검사의 외향성 척도에 해당한다 할 수 있는 E, E, BAS-FUN은 양성 모두에서 높은 수준의 설문지 척도 간 정적 상관을 보였으나, 50㎳ 자극으로 유발된 P3 진폭은 E와 BAS-FUN에 대해서만 유의하게 높은 상관을 나타내었다 이 결과는 Eysenck의 모델과 일견 일치하는 결과이지만, 그가 개발한 EPQ-R의 외향성 척도(E)보다는 오히려 다른 척도들이 뇌파에 반영된 성격의 생물학적 기제를 측정하기 위한 적절한 도구일 수도 있음을 시사한다. 신경증적 경향성을 반영하는 N과 N 척도는 50㎳ 자극에 대한 여성 피험자의 N1, P2 진폭과 유의한 상관을 보였다. 그러나 이론적으로 두 척도에 등가적인 것으로 예상되었던 BIS 척도는 설문지 간 상관이나 ERP요소와의 상관에서 모두 유의한 결과를 보이지 않았다. Eysenck가 성격의 세 번째 축(차원)으로 제시했던 P(정신병적 경향성) 역시 여성 피험자들에게서 두드러지는 설문지간 상관을 보였으나, 300㎳자극에 대한 P2 진폭과의 정적인 상관은 양성을 합한 자료에서만 발견되었다. 여성의 상관 분포는 비록 통계적으로 유의한 수준에는 이르지 못하였으나, 양성 자료의 분포와 유사함이 확인되었다 이 실험의 결과는 P3 진폭과 외향성 간의 부적인 상관 관계를 보고하였던 기존 연구들을 지지한다. 또한 본 실험에서 확인된 Eysenck 모델의 신경증적 경향성이나 정신병적 경향성이 ERP의 비교적 초기에 나타나는 외생적 구성 요소들(Nl, P2)과의 상관 양상은, P3 요소에 집중하였던 기존 연구들이 외향성 이외의 차원으로 일관된 결과를 얻어내지 못했던 이유를 설명해줄 수 있을 것이다. 또한 성격 차원과 그것을 지표 하는 ERP구성 요소 간의 관계를 해석할 때에 성별이나 유발 자극의 속성을 고려해야 함을 보여준다.

• Korean Journal of Radiology
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• 제23권2호
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• pp.226-236
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• 2022

Objective: This study aimed to explore the myelin volume change in patients with mild traumatic brain injury (mTBI) with post-concussion syndrome (PCS) using a multidynamic multiecho (MDME) sequence and automatic whole-brain segmentation. Materials and Methods: Forty-one consecutive mTBI patients with PCS and 29 controls, who had undergone MRI including the MDME sequence between October 2016 and April 2018, were included. Myelin volume fraction (MVF) maps were derived from the MDME sequence. After three dimensional T1-based brain segmentation, the average MVF was analyzed at the bilateral cerebral white matter (WM), bilateral cerebral gray matter (GM), corpus callosum, and brainstem. The Mann-Whitney U-test was performed to compare MVF and myelin volume between patients with mTBI and controls. Myelin volume was correlated with neuropsychological test scores using the Spearman rank correlation test. Results: The average MVF at the bilateral cerebral WM was lower in mTBI patients with PCS (median [interquartile range], 25.2% [22.6%-26.4%]) than that in controls (26.8% [25.6%-27.8%]) (p = 0.004). The region-of-interest myelin volume was lower in mTBI patients with PCS than that in controls at the corpus callosum (1.87 cm³ [1.70-2.05 cm³] vs. 2.21 cm³ [1.86-3.46 cm³]; p = 0.003) and brainstem (9.98 cm³ [9.45-11.00 cm³] vs. 11.05 cm³ [10.10-11.53 cm³]; p = 0.015). The total myelin volume was lower in mTBI patients with PCS than that in controls at the corpus callosum (0.45 cm³ [0.39-0.48 cm³] vs. 0.48 cm³ [0.45-0.54 cm³]; p = 0.004) and brainstem (1.45 cm³ [1.28-1.59 cm³] vs. 1.54 cm³ [1.42-1.67 cm³]; p = 0.042). No significant correlation was observed between myelin volume parameters and neuropsychological test scores, except for the total myelin volume at the bilateral cerebral WM and verbal learning test (delayed recall) (r = 0.425; p = 0.048). Conclusion: MVF quantified from the MDME sequence was decreased at the bilateral cerebral WM in mTBI patients with PCS. The total myelin volumes at the corpus callosum and brainstem were decreased in mTBI patients with PCS due to atrophic changes.