• The Korean Journal of Cytopathology
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• v.7 no.2
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• pp.144-150
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• 1996

Although bladder cancers are very common, little is known about their molecular pathogenesis. It is known that p53 alteration is found in about 60% of muscle-invasive bladder cancer, necessiating aggressive therapy and poor outcome. We examined the nuclear expression of p53 protein, using D07 monoclonal antibody in the urine samples from 31 patients with transitional cell carcinoma of the bladder to investigate the correlation of p53 overexpression with histologic grades and depth of invasion. The positive rate of p53 protein was 27% in superficial bladder tumor, but increased up to 71% in the invasive bladder carcinomas. The overexpression of p53 protein increased according to Mostofi grading system from 18% in grade I, 45% in grade II, and up to 100% in grade III. The p53 expression tended to be higher in the invasive and high grade bladder cancers than in the superficial and low grade ones(p<0.05). These results suggest that immunohistochemical analysis of the urine specimen in the bladder cancer patients could be a useful method of screening for the presence of p53 mutant protein. The mutant p53 protein expression may be an indicator of bladder cancer with more proliferative potential and/or aggressive biologic behavior.

• Journal of Food Hygiene and Safety
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• v.20 no.1
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• pp.13-17
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• 2005

The purpose of the present study was to investigate differences in the sensitizing potential of Rhus Veniciflua(Rhus-II), when tested by the guinea pig maximization test(GPMT) and Freund's complete adjuvant test(FCAT) with an identical, intradermal induction concentration. A new grading classification of the sensitization potential is proposed. The GPMT was conducted according to OECD guideline $\#406$, using a multiple-dose design and test results were analysed with logistic regression analysis. During the induction stage, we injected intradermally each three site 0.1 ml(l mg/animal) test material, 0.1 ml complete Freund's adjuvant and 0.lml the test agent emulsified in the adjuvant. 7 days later, we induced weak sensitization with $10\%$ sodium lauryl sulfate(SLS) and applide 1ml(l0mg/animal) test agent topically on the same site and made a tight occlusion. 14 days later we challenged with 1 ml(l 0mg/animal) of test material on the flank and observed ant 24 hours and 48 hours later. The results were also observed $0\%$ at 24 hours challenge. The results observed 48 hours after challenge were the identical. These data indicated that, although Rhus-II is a no contact allergen. It was reported that the skin sensitization by Rhus-II was not detected the skin sensitization in the guinea pig maximization test (GPMT). Consequently, it was confirmed that Rhus-II had no contact allergic sensitization in guinea pig maximization test.

• The Journal of Korean Academy of Prosthodontics
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• v.38 no.3
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• pp.336-347
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• 2000

Statement of problem. Luster loss in esthetic anterior ceromer restoration can occur and can be related with rough surface texture. Understanding durability of surface finishing methods like polishing and surface coating have critical importance. Purpose. This study evaluated the effect of tooth brushing and thermal cycling on surface luster of 3 ceromer systems (Artglass, Targis, Sculpture) treated with different surface finishing methods. Material and methods. Seventy-two samples were prepared: 12 for control group Z100, 12 for Artglass, 24 for Targis, and 24 for Sculpture. Half of the Targis and Sculpture were polished according to the manufacturer's recommendation. The rest of the samples were coated with staining and glazing solution for Targis and Sculpture, respectively. All specimens were subjected to 10,000 cycles between $5^{\circ}C\;and\;55^{\circ}C$ with 30 seconds dwell time. Tooth brushing abrasion tests were performed in a customized tooth brushing machine with 500g back and forth for 20,000 cycle. Luster comparisons were based on grading after direct observation, and light reflection area was measured with Image analysis software. Results. All materials showed an decrease in luster grade after thermal cycling and tooth brushing. The post-tooth brushing results revealed that the glazed Sculpture had greater mean luster grade than did any other groups. While, the stained Targis group showed greatest changes after tooth brushing (p < 0.05), polished Targis and Sculpture did not show significant changes. However, glazed Sculpture showed discretely fallen out glaze resin. Conclusion. From the results of this study, all of the ceromer specimens were much glossy than control composite group after tooth brushing. coatings used for Targis and Sculpture had not durability for long term use.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.7
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• pp.905-910
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• 2013

This study was performed to determine the influence of pig breed and gender on the ultimate pH and physicochemical properties of pork. The correlations between pH and pork quality traits directly related to carcass grade, and consumer's preference were also evaluated. The pH and meat grading scores for cold carcasses of 215 purebred pigs (Duroc, Landrace, and Yorkshire) from four different farms were obtained. Meat quality parameters of the pork loin were analyzed. Duroc and female animals were more affected compared to other breeds and male pigs. Duroc animals had the highest ultimate pH, carcass back fat thickness, marbling scores, yellowness, and fat content (p<0.05). Landrace pigs had the highest color lightness and cooking loss values (p<0.05). Among all trait parameters, marbling scores showed the highest significant differences when evaluating the impact of breed and gender on meat quality characteristics (p<0.001). Ultimate pH was positively correlated with carcass weight (0.20), back fat thickness (0.19), marbling score (0.17), and color score (0.16) while negatively correlated with cooking loss (-0.24) and shear force (-0.20). Therefore, pork samples with lower ultimate pH had lower cooking loss, higher lightness, and higher shear force values irrespective of breed.

• Journal of the Korean Society of Clothing and Textiles
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• v.31 no.5 s.164
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• pp.729-741
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• 2007

In order to examine the characteristics of brassiere products for the 1924 generation brands on the market and grasp problems, we selected three 'comparative brassieres', each one from among the 1924 underwear brands with the highest recognition and sales profit, and then designed a 'sample brassiere' pattern(75A) with a similar shape to the comparative brassieres. We set up the "New Cup Grading Rule" with a view of reflecting the wearing effect that was varied according to cup sizes, graded the sizes of 75AA and 75B with this method, and made the sample brassieres in three sizes. We conducted the wearing evaluation and body measurements of 9 subjects after analyzing the patterns and characteristics of the sample brassieres and three comparative brassieres. As a result of the wearing evaluation, the sample and comparative brassiere 2, the dimensions and shapes were appropriate for the 1924 generation consumers and expressed an overall natural silhouette, showed satisfactory results in the entire evaluation questions. On the other hand, the comparative brassiere 1 and 3 that tended toward making a big change in the physical characteristics got unsatisfactory evaluations in the dimensions of the cups, clothing pressure, and bust silhouette. As a result of observing the variation in body dimensions by body measurements when nude and when wearing each brassiere and then summing it up with the score of the wearing evaluation, it was proven that too much change in body shape can create a negative image by upsetting the balance of the whole silhouette. Therefore, it is desirable to develop brassiere products with proper dimensions and clothing pressure that can make a physical change that harmonizes the overall bust silhouette and the position and shape of the breasts.

• Journal of the Korean Society of Clothing and Textiles
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• v.33 no.8
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• pp.1306-1314
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• 2009

This study investigates the progress of obesity in men from childhood to adulthood, by analyzing the measurement references from the 5th Size Korea. It also seeks to analyze the characteristics of obese figures through the comparison of body proportions to normal-weight people, to provide a basic reference for the development of new size categories and improved pattern grading. The age range is divided into three groups: children (2-7), teenagers (13-18), and adults (19-39). The results of research into the characteristics of body proportions of obese figures and the classification of different figure groups of obese people are as follows. The ratio between width and circumference for each part of the body was investigated according to body weight that was grouped into three different categories of low, normal, and obese body weights. The result demonstrated that in all the ranges of age, the obese groups had the lowest ratio between width and circumference in having a thick body shape. According to the results that compared the ratio of the circumference of each body part divided by the waist circumference, the obese group showed a low ratio that indicates that they have a bigger waist circumference than other parts of the body. Two factors are identified as contributing to obesity in analyzing the ratio of the circumference of body parts divided by waist circumference. Using the factor loadings of the upper and lower body obesity, a cluster analysis was carried out and three different categories of obesity were defined; lower body obesity, abdominal obesity, and upper body obesity. The obese groups of children and teenagers were mostly in body shape with lower obesity and abdominal obesity, whereas the adults group showed the obesity present in the upper body obesity that have fewer cases in lower body obesity.

• Journal of Korean Neurosurgical Society
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• v.61 no.1
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• pp.66-74
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• 2018

Objective : The aim of this study was to identify the susceptibility genes responsible for lumbar spondylosis (LS) in Korean patients. Methods : Data from 1427 subjects were made available for radiographic grading and genome wide association studies (GWAS) analysis. Lateral lumbar spine radiographs were obtained and the various degrees of degenerative change were semi-quantitatively scored. A pilot GWAS was performed using the AffymetrixGenome-Wide Human single-nucleotide polymorphisms (SNPs), 500K array. A total of 352228 SNPs were analyzed and the association between the SNPs and case-control status was analyzed by stepwise logistic regression analyses. Results : The top 100 SNPs with a cutoff p-value of less than $3.7{\times}10^{-4}$ were selected for joint space narrowing, while a cutoff p-value of $6.0{\times}10^{-4}$ was applied to osteophytes and the Kellgren-Lawrence (K-L) osteoarthritis grade. The SNPs with the strongest effect on disc space narrowing, osteophytes, and K-L grade were serine incorporator 1 (rs155467, odds ratio [OR]=17.58, $p=1.6{\times}10^{-4}$), stromal interaction molecule 2 (STIM1, rs210781, OR=5.53, $p=5{\times}10^{-4}$), and transient receptor potential cation channel, subfamily C (rs11224760, OR=3.99, $p=4.8{\times}10^{-4}$), respectively. Leucine-rich repeat-containing G protein-coupled receptor 4 was significantly associated with both disc space narrowing and osteophytes (rs1979400, OR=2.01, $p=1.1{\times}10^{-4}$ for disc space narrowing, OR=1.79, $p=3{\times}10^{-4}$ for osteophytes), while zinc finger and BTB domain containing 7C was significantly and negatively associated with both osteophytes and a K-L grade >2 (rs12457004,OR=0.25, $p=5.8{\times}10^{-4}$ and OR=0.27, $p=5.3{\times}10^{-4}$, respectively). Conclusion : We identified SNPs that potentially contribute to the pathogenesis of LS. This is the first report of a GWAS in an Asian population.

• International Journal of Highway Engineering
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• v.7 no.2 s.24
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• pp.57-67
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• 2005

Almost most of literatures treat behaviors of asphalt binders as a homogeneous single-phase fluid, but this generalization turns out to be a serious mistake. This study introduces all the characteristic equations for asphalt binders, which are modified or unmodified. Especially, characteristic equations for a unhomogeneous multi-phase fluid for modified asphalts is first time proposed. Characteristics of each equations introduced are explained by employing dynamic shear testing data actually measured for specific asphalt binders. Differences of moving behaviors and characteristic equations between a homogeneous single-phase and a unhomogeneous multi-phase fluid are emphasized. These differences help us understand which characteristic equations must be used for a given asphalt fluid and what kinds of properties must be investigated for analysis of a specific asphalt binder. Results of this study provide how to analyse modified and unmodified asphalts, and informations necessary for binder grading.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.10a
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• pp.131-134
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• 1996

본 연구의 목적은 수업의 효과를 측정할 때 수업평가 설문을 통하여 각 질문의 단순한 결과를 나열하여 비교하기보다, 수업평가 설문의 모든 질문에 대한 요인분석 (Factor Analysis)과 AHP (Analytic Hierarchy Process) 방법을 이용하여 수업효과의 측정을 보다 효과적으로 할수 있는 방법을 제시하고자 한다. 따라서 본 연구는 미국 경영학부 학생들의 수업평가 설문에 대한 요인분석 결과와 동일한 수업평가 설문을 이용하여 숭실대학교 경영학부 학생들의 요인분석 결과를 분석, 비교하였다. 또한 AHP를 이용하여 한국학생들의 수업효과에 대한 이들 요인들의 상대적 가중치를 조사함으로써, 수업효과 향상을 위한 주요한 요인들을 찾고자 하였다. 본 연구의 수업평가 측정에 사용된 설문지는 조지아 주립대학에서 사용하고 있는 UC-Berkely Instrument로 1(전혀 그렇지 않다)부터 5(매우 그러하다)의 5점 척도를 이용한 33개의 질문항목으로 이루어져 있다. 미국 조지아 주립대학 경영학부 학생들의 요인분석 결과는 다음과 같은 6개의 요인으로 나누어져 있다. (Appendix A): (1) Organization and Clarity, (2) Communication Ability, (3) Grading and Assignment, (4) Interaction with Student, (5) Intellectual/Scholarly, and (6) Student Motivation. 숭실대학 경영학부 학생들의 요인분석 결과는 미국의 경우와는 달리, (1) 수업준비 및 강의방법, (2) 시험 및 성적평가, (3) 비주입식 교육방법, (4) 교수-학생간의 인간적인 관계, (5) 숙제 및 과제물과 같은 5가지의 요인으로 구성되어진 것으로 분석되었다. 특히 한국학생을 대상으로 하여 AHP를 이용하여 각 요인들의 수업효과에 대한 상대적 가중치를 조사하였다. 특이한 결과는, 미국학생의 경우 수업준비 및 강의 방법이 상대적으로 중시된 반면, 한국학생들은 미국학생들이 비교적 덜 중시하는 교수-학생간의 인간적인 관계가 수업효과를 높이는데 가장 큰 기여를 하는 것으로 나타났다. 본 연구는 한국 문화의 특징이라 할 수 있는 교수-학생간의 인간적인 관계가 중시되는 교육환경하에서, 정보화 사회의 한 수업형태인 재택수업을 외국(특히 미국)의 방법을 그대로 따라 실시할 경우, 많은 부작용이 있을 수 있다는 것을 암시하며, 따라서 우리 교육문화에 맞는 재택수업 형태의 개발이 시급함을 제시한다고 하겠다.

• Structural Monitoring and Maintenance
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• v.5 no.1
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• pp.67-78
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• 2018

The stability of cutting slope influences the safety of railway operation, and how to identify the stability of the slope quickly and determine the rational monitoring plan is a pressing problem at present. In this study, the attribute recognition model of risk assessment for high cutting slope stability in the heavy haul railway is established based on attribute mathematics theory, followed by the consequent monitoring scheme design. Firstly, based on comprehensive analysis on the risk factors of heavy haul railway loess slope, collapsibility, tectonic feature, slope shape, rainfall, vegetation conditions, train speed are selected as the indexes of the risk assessment, and the grading criteria of each index is established. Meanwhile, the weights of the assessment indexes are determined by AHP judgment matrix. Secondly, The attribute measurement functions are given to compute attribute measurement of single index and synthetic attribute, and the attribute recognition model was used to assess the risk of a typical heavy haul railway loess slope, Finally, according to the risk assessment results, the monitoring content and method of this loess slope were determined to avoid geological disasters and ensure the security of the railway infrastructure. This attribute identification- risk assessment- monitoring design mode could provide an effective way for the risk assessment and control of heavy haul railway in the loess plateau.