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Expression of nitric oxide synthase isoforms and N-methyl-D-aspartate receptor subunits according to transforming growth factor-β1 administration after hypoxic-ischemic brain injury in neonatal rats (신생 백서의 저산소 허혈 뇌손상에서 Transforming Growth Factor-β1 투여에 따른 Nitric Oxide Synthase 이성체와 N-methyl-D-aspartate 수용체 아단위의 발현)

  • Go, Hye Young;Seo, Eok Su;Kim, Woo Taek
    • Clinical and Experimental Pediatrics
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    • v.52 no.5
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    • pp.594-602
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    • 2009
  • Purpose : Transforming growth factor (TGF)-${\beta}1$ reportedly increases neuronal survival by inhibiting the induction of inducible nitric oxide synthase (NOS) in astrocytes and protecting neurons after excitotoxic injury. However, the neuroprotective mechanism of $TGF-{\beta}1$ on hypoxic-ischemic (HI) brain injury in neonatal rats is not clear. The aim of this study was to determine whether $TGF-{\beta}1$ has neuroprotective effects via a NO-mediated mechanism and N-methyl-D-aspartate (NMDA) receptor modulation on perinatal HI brain injury. Methods : Cortical cells were cultured using 19-day-pregnant Sprague-Dawley (SD) rats treated with $TGF-{\beta}1$ (1, 5, or 10 ng/mL) and incubated in a 1% O2 incubator for hypoxia. Seven-day-old SD rat pups were subjected to left carotid occlusion followed by 2 h of hypoxic exposure (7.5% $O_2$). $TGF-{\beta}1$ (0.5 ng/kg) was administered intracerebrally to the rats 30 min before HI brain injury. The expressions of NOS and NMDA receptors were measured. Results : In the in vitro model, the expressions of endothelial NOS (eNOS) and neuronal NOS (nNOS) increased in the hypoxic group and decreased in the 1 ng/mL $TGF-{\beta}1-treated$ group. In the in vivo model, the expression of inducible NOS (iNOS) decreased in the hypoxia group and increased in the $TGF-{\beta}1$-treated group. The expressions of eNOS and nNOS were reversed compared with the expression of iNOS. The expressions of all NMDA receptor subunits decreased in hypoxia group and increased in the $TGF-{\beta}1$-treated group except NR2C. Conclusion : The administration of $TGF-{\beta}1$ could significantly protect against perinatal HI brain injury via some parts of the NO-mediated or excitotoxic mechanism.

The Effects of the Nutrition in the Boyhood upon the Improvement of the Body in Various Regions (지역별(地域別)로 본 소년기(少年期)의 영양섭취상태(營養攝取狀態)가 체위향상(體位向上)에 미치는 영향(影響))

  • Lee, Geum-Yeong
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.5 no.1
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    • pp.39-51
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    • 1976
  • We arrive at the conclusion as follows as for the connection between dietary life, hours of exercise and growth of body, based on the survey of their height, this circumference of the breast and their body weight, and the questionnaires to the pupils of 36,547 in totals (contained the primary and middle school boys and girls) in four districts(named A, B, C and D district) of Jeonlla Bug Do from April, 1970 to March, 1973. (1) The growth in height. The boys from 6 to 7 years old are nearly same in all districts, but as age increases, those of A district grow more rapidly than those of B, C and D districts, while those of B, C and D districts grow almost samely. The girls already from 6 years old on are different between A district and B, C, D district. The average of height in Jeonlla Bug Do is not different from that of Gyungi Do and whole nation in the pupils from 6 to 11 years old, and that of Japan from 6 to 7 of age, while it falls behind them as age increases. (2) The growth in the circumference of the breast. The boys from 6 to 9 years old show nearly the same tendency in all districts, after that age the boys in A district tend to grow rapidly, those in B district most fall behind, and those in C, D districts show the same tendency. Contrasted with height the growth in the circumference of the breast does not show the difference in each district so far as 14 of age, but after 15 years old it shows a little difference by falling behind of pupils in A district, while those B, C, D districts show almost the same tendency. The average of the circumference of the breast in Jeonlla Bug Do of the pupils from 10 to 11 of age is almost same to that of Gyungi Do, whole nation and Japan, but shows difference after that age. (3) The growth of body weight. The body weight of boys over-all the investigated whole age shows the superiority in A district and a little lowness in D district which is almost same to that of B, C districts. In that of girls, A district is superior in from 6 to 9 of age, and all districts are nearly same after that age. The average in Jeonlla Bug Do is one and the same to those of Gyungi Do, whole nation and Japan as in the height, but shows the great difference as years grow. (4) The dietary life of the pupils in Jeonlla Bug Do depends chiefly upon a carbohydrate and is very low in the intake of fat and protein. Connected with a view point of districts, the intake of protein is a little more in A district than in the other districts, and is nearly same in the other districts. They tend more to eat mixed food, but about 40% of them do not yet eat it. The contents and taking of lunch is bad in the highest degree, to which their parents are entirely indifferent. As far as the hours of exercise are concerned with, about 40% of all pupils must go to the school from very far, which gives them the heavy physical suffering, and especially it is remarked that the middle school boys and girls should attend school from farther than the primary school boys and girls.

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Field Study For The Improvement of Medication System and Method for Inpatients at General Hospital (입원환자의 투약체계와 방법의 개선을 위한 현장연구)

  • Yoo, Hyung-Sook;Kuwan, Young-Mi;Song, Mi-Sook;Kim, Hyung-Ae;Park, Kyung-Sook
    • Journal of Korean Academy of Nursing Administration
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    • v.1 no.1
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    • pp.147-211
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    • 1995
  • Medication is a kind of medical service and a therapeutic nursing function which takes large portion of nursing service and requires complicated procedures. So many different medical personnel should be involved and cooporate each other in order to accomplish medication. Medication is also a vital nursing service, So nurse feels heavy responsibi lity in that she gives medication to the patient finally, so she has much responsibility if medication error is happened. Therefore it seems very important to clarify the problem of medication system and method, and find the subculture of medication situation because it may promote nursing productivity. The study was conducted to 1. Describe and interpret medication situation. 2. Find out the problem of medication system and method and on alternatives. 3. Compare the medication system and method of hospitals which are located in Seoul with object hospital Ethnographic methodology was used to study medication situation by doing participant observation and interview of health care personnel. Ten nurses and three nurse aids were interviewed. Two residents and internists, two phamacists and two accountants were also interviewed. Data was obtained and analized according to Developmental Research Sequence introduced by Spradly. On the basis of this data the results were as follows. 1. The overall flow of medication system was devided into six stage : first, checking doctor's order : second writing doctor's order, : third, transfering slip into the related departments such as account department, pharmacy : fourth, distribution of medication from pharmacy to unit : fifth, identifing medication by nurses : and finally, medicating to the patient. Behaviorors have been under a lot of stress in that they have to do much works, especially paperworks, So too much time were needed. They also have been suffered interpersonal conflicts among health care personnel and role conflicts in the process of doing medication service. 2. In the process of checking order, the problem was that too much time was required for checking order and paperwork. The more the order changes the more the paperwork is. Nurses have been suffering difficulties in calling internist in order to get bill. Even if writing down slip for medication order is doctor's job, Sometimes nurse has been expected to write slip by doctors or nurse would write slip beacuse of two much complexities and efforts for calling doctors. If the slip were incorrect, much time complicated procedures were more required for correcting it. So delay of administering drug would be resulted consequently. Drugs were delivered from pharmacy to units by delivery agent and phamacist. But because drugs were delivered without arranging room number of patient. Nurse should rearrange drugs in order of the room number So it had made waste time and effort, and Even when emergency drugs were needed, Prompt delivery of drug was not easy because of many reasons. For nurses, it took too long in the identification of the right drug. Actually nurses have heavy burden when medication error happens because nurse is the final actor who gives medication to the patient, So every three shift nurse ought to check drugs as soon as every shift begins. That's why it took too much time due to repeated confirming procedure. When nurses had to go patient room in order to give medications, there were difficulties in watching patient until the patient take medicine correctly. So it was impossible to check every patient wheather he took medicine or not especially in hectic situation. 3. There were many hospitals in Seoul which have similar medication system and method as object hospital according to the results of questionaire. This means that many hospitals have been suffering srimilar problems which were identified in object hospital. 4. Recommendations for promoting simplification of medication system and method were the following : Redesigning of slip from two pieces of paper into one : early discharge announcement system, and slip confirming through computer and controlling of period of prescreption from one day to two or three days : designing personal drug storage box for each patient and using it. If nurses follow the recommendations, they will make medication short & simple, and also have enough time of direct nursing care 5. Even though there were many difficulties in medicating patients. Medication itself has been considered as a caring among nurses because it makes rapport between nurse and patient. So nurses had better accept medication as a portion of nusing service not a original portion of phamacist. There are some limits in this research in terms of confining to only one unit of one hospital, and treating it especially in view of nurses' aspects, So further researchs should be continnued from various kmds of viewpoints of doctors, phamacists and so on. ${\cdot\cdot\cdot}$. Especially esthnographic study of computerized medication system and method seems to be followed.

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Study on true nature of the Fung(風) and that of application to the medicine (풍(風)의 본질(本質)과 의학(醫學)에서의 운용(運用)에 관(關)한 고찰(考察))

  • Back, Sang Ryong;Park, Chan Kug
    • Journal of Korean Medical classics
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    • v.7
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    • pp.198-231
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    • 1994
  • Up to now, after I had examined the relation between the origin of Fung(風) and Gi(氣) and the mean of Fung in medical science, I obtained the conclusion being as follows. The first, Fung(風) means a flux of Gi(氣) and Gi shows the process by virtue of the form of Fung, namely, Fung means motion of Gi. In other words, it is flow of power. Accordingly, the process of all power can give a name Fung. The second, Samul(事物) ceaselessly interchange with the external world to sustain the existence and life of themselves. And they make a adequate confrontation against the pressure of the outside. This the motive power of life action(生命活動) is Gi and shows its the process on the strength of Fung. The third, Samul(事物) incessantly releases power which it has to the outside. Power released to the outside forms the territory of the established power in the environment of them and keep up their substance(實體) in the space time(時空). It can be name Fung because the field(場) of this power incessantly flows. The fourth, man operates life on the ground of the creation of his own vigor(生氣) for himself as the life body(生命體) of the independence and self-support. The occurence of this vigor and the adjustment process(調節作用) is supervised by Gan(肝). That is to say, Gan plays a role to regulate and manage the process of Fung or the action of vigor with Fung-Zang(風臟). The fifth, because the Gi-Gi adjustment process(氣機調節作用) of Gan is the same as the process of Fung, Fung that operates the cause of a disease is attributed to the disharmony of the process of the human body Gi-Gi. Therefore, the generating pathological change is attributed to the extraordinary of the function by the incongruity of Gi-Gi(氣機) or the disorder of the direct motion of Gi-Hyul(氣血). Because the incongruity of this Gi-Gi of the human body gives rise to the abnormal of Zung-Gi(正氣) in the human body properly cannot cope with the invasion of 'Oi-Sa(外邪). Furthermore, Fung serves as the mediation body of the invasion of other Sa-Gi(邪氣) because of its dynamics, By virtue of this reason, Fung is named the head of all disease. And because the incongruity of the Gi-Gi has each other form according to Zang-Bu(臟腑), Kyung-Lak(經絡), and a region, the symptoms of a disease appear differently in line with them as well. The sixth, Fung-byung(風病) is approximately separated Zung-Fung(中風) and Fung-byung(猍義의 風病). Zung-fung and Fung-byung is to be attributed to the major invasion of each Jung-gi and Fung-sa(正氣와 風邪). But these two kinds stir up the problem to the direct motion of Gi-hyul(氣血) and the harmony of Gi-Gi in the human body. When one cures it, therefore, Zung-fung has to rectify Gi-Gi and the circulation of Gi-hyul on the basis of the supplement of Jung-gi(正氣) and Fung-byung must make the harmony of Gi-Gi with the Gu-fung(驅風). -Go-gi(調氣), Sun-Gi(順氣). Hang-Gi(行氣) - All existing living things as well as man maintain life on the ground of the pertinent harmony between the soul(精神) and the body(肉體). As soon as the harmony falls down, simultaneously life disappears as well. And Fung which means the outside process between Gi(氣) and Gi(氣) makes the action of their life cooperative and unified, Accordingy, the understanding of Fung, first, has to start wi th the whole thought that not only all Samul(事物) but also the soul and the body are one.

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The Effect of Informal Learning of University Students on Employment Competency and Entrepreneurial Intention: Focusing on the Satisfaction Level of Team-based Learning (대학생의 무형식학습이 구직능력 및 창업의도에 미치는 영향: 팀 학습 만족도의 조절효과를 중심으로)

  • Ka, Hye Young;Jeon, Hye Jin
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.15 no.3
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    • pp.121-132
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    • 2020
  • University Students go through the development process of expertise in a single field based on theoretical knowledge they have learned in the university. Their plans to develop their careers could lead to a shift in business as they choose to find jobs and start businesses throughout their lives. The attitude of career decision making process has been changed from learning in the form of receiving and memorizing existing knowledge to learning in a more proactive and autonomous manner, and there is a growing need for informal learning. In this study, the informal learning is investigated to clarify the impact on the employment competency and entrepreneurial intention. New implications are deduced by the introduction of start-up business to the traditional approach based on the employment ability. In addition, the importance of team-work has been increased in the field of eduction and business. The impact on the employment competency and entrepreneurial intention is studied based on the satisfaction level of team-based learning. Survey was conducted on 163 university students in North Chungcheong Province from March to June 2019 and the results of the study were summarized as follows. First, it has been confirmed that the informal learning of university students has a significant impact on their employment competency, but not on their entrepreneurial intention. Second, the employment competencies have perfect mediating effect on the informal learning and the entrepreneurial intention. Third, the satisfaction on the team-based learning did not have a significant impact on the employment competency of university students by informal learning, but it had a positive effect on the dependency between employment competency and entrepreneurial intention. In these days, start-up education at universities has been strengthened. Throughout this research, the need for informal learning is confirmed to enhance the employment competency and entrepreneurial intention of the university education program. In addition, team-based learning is introduced actively to utilize a variety of information from the university students.

Ecological Study of Narrow-mouthed Toad (Kaloula borealis) Population at Myeongji District in Busan Metropolitan City (부산시 명지지구에 서식하는 맹꽁이 개체군 생태연구)

  • Hong, Sung-Gu;An, Chi-Kyung;Kim, Hyun-jung;Oh, Ki Cheol;Park, Sun Young;Na, Sumi;Yi, Hoonbok
    • Journal of Wetlands Research
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    • v.19 no.1
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    • pp.172-179
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    • 2017
  • The purpose of this study is to analyze the current original habitat and to conserve the narrow-mouthed toad populations. For this study, we used 240 pitfall traps (30 cm height ${\times}$ 20 cm width) to catch the narrow-mouthed toads that inhabit in Myeongji-dong, Gangseo-gu, in Busan metropolitan city from August 2, 2013 to November 7, 2013. We measured the environmental characteristics (soil composition factors, soil moisture, Humidity, soil temperature) for the seven habitat patterns of narrow-mouthed toads based on vegetation types. Main habitats of narrow mouthed toads were flat grassland where grass and false acacia grew and there was wetland all over the place. When analyzing habitats that main habitats of narrow-mouthed toads prefer after selecting representative seven vegetation, it was found that the most narrow-mouthed toads were caught in amur silver grass colony while the least narrow-mouthed toads were caught in bare land. Totally, we caught 846 narrow-mouthed toads over 68 times, and released them into the newly constructed habitat after injection VIE-tag. It seems that the reason for which the least narrow mouthed toads were caught in bare land is that bare land is not suitable for narrow mouthed toads to protect themselves from strong sunlight and to hide themselves from natural enemy. We found that temperature had the greatest influence on activities of narrow mouthed toads and at temperature of less than $15.6^{\circ}C$. We also found that the activities of narrow mouthed toads were remarkably low and then temperature was below $15.6^{\circ}C$. It meant that narrow mouthed toads seemed to go into hibernation. From this research, we could find the prefer habitat after analyzing habitats for the narrow-mouthed toads and could suggest for construction for the better habitat of narrow-mouthed toads.

Landscape Gardening Culture in Late Joseon Dynasty Depicted in 'Ahoi-do' Paintings (아회도(雅會圖)에 나타난 조선후기 원림문화)

  • Lim, Eui-Je;So, Hyun-Su
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.32 no.3
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    • pp.46-57
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    • 2014
  • This study contemplated the gardening culture from the pictures, which the scholars of late Joseon Dynasty, the aspects of garden landscapes and garden use behaviors are drawn as follows. 1. The yard by the detached house for men and guest in front of the premises(Sarang Madang) and backyard were the major places for Ahoi(social gatherings of the scholars). The mansions had interests in the management of the outer garden beyond the house wall with building structures like the pavilions on the high walls and side gates. This management and the selection of location anticipating in advance of the management are noteworthy. 2. Only house gardens had plant pots with flowers and the small flower bed(Hwa-O) at Sarang Madang occasionally had plant pots without flowers and oddly shaped stone pots and equipped pine branch eaves and traditional awnings made of plant material like a trellis. 3. The oddly shaped stones were significant landscape elements in the gardens of houses and villas. Some of them were depicted as the Taihu stone and this draws attention to the question of whether the Taihu stone was actually used in the garden of late Joseon Dynasty. 4. The gardens in villas accommodated the borrowed scenery with various materials like wooden fences, bamboo or reed fences, mud walls. They also had the artificial gardens with some odd shaped stones, old pines, bamboos, Japanese apricots, willows, paulownia trees, lotuses and plantains in the secured Madangs. 5. Gyeong Hwa Sa Jog(The scholars of the ruling class adapted to the 18th century's new historical aspect) of late Joseon Dynasty built the villas at the beautiful scenery closed to the their houses. 6. The Gardens around pavilions were located high closed to the mountain streams with nature like beautiful forests, oddly formed rocks, precipitous cliffs and viewing stones. The back side of the pavilion was enclosed by bamboo forests and the front had pines, ginkgoes and willows as shade trees. 7. The beautiful scenery which was preferred as the place for Ahoi was basically with fantastic peaks and precipitous cliffs which forms the distant view harmonized with a waterfall. Broad and flat rocks at the summit of a mountain which commands a bird's-eye view or on a mountain streamside with pine forest, willows and plum trees were chosen as the optimal places for Ahoi. 8. Pine trees were presumed to be more preferable than other species in the garden, especially an single planted old pine tree accented symbolism. 9. Portable tea braziers for boiling tea were adopted in all four types of the gardens. 10. The gardens mixed with auspicious landscape elements were the places of the arts for an unworldliness Ahoi through GeumGiSeoHwa(enjoying strings, go, writing and painting) and boiling tea.

Analysis of Energy Savings and CO2 Emission Reductions via Application of Smart Grid System (지능형 전력망(스마트 그리드) 적용을 통한 에너지 절감 및 CO2 감축 효과 분석)

  • Park, Soo-Hwan;Han, Sang-Jun;Wee, Jung-Ho
    • Journal of Korean Society of Environmental Engineers
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    • v.39 no.6
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    • pp.356-370
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    • 2017
  • The energy savings and $CO_2$ emission reductions obtainable from the situation that the Smart Grid system (SGs) is assumed to be applied in Korea up to 2030 is quantitatively analyzed with many reported data. For calculation, SGs is divided into five sectors such as Smart Transmission and Distribution (ST&D), Smart Consumer (SC), Smart Electricity Service (SES), Smart Renewable Energy (SRE) and Smart Transportation (ST). Total annual energy savings in 2030 is estimated to be approximately 103,121 GWh and this is 13.1% of total electricity consumption outlook. Based on this value, total amount of reducible $CO_2$ emissions is calculated to 55.38 million $tCO_2$, which is 17.6% of total nation's GHG reduction target. Although the contribution of energy saving due to SGs to total electricity consumption increases as years go by, that of $CO_2$ emission reduction gradually decreases. This might be because that coal fired based power generation is planned to be sharply increased and the rate of $CO_2$ emission reduction scheduled by nation is very fast. The contributable portion of five each sector to total $CO_2$ emission reductions in 2030 is estimated to be 44.37% for SC, 29.16% for SRE, 20.12% for SES, 5.11% for ST&D, and 1.24% for ST.

The new explore of the animated content using OculusVR - Focusing on the VR platform and killer content - (오큘러스 VR (Oculus VR)를 이용한 애니메이션 콘텐츠의 새로운 모색 - VR 플랫폼과 킬러콘텐츠를 중심으로 -)

  • Lee, Jong-Han
    • Cartoon and Animation Studies
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    • s.45
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    • pp.197-214
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    • 2016
  • Augmented Reality, virtual reality in recently attracted attention throughout the world. and Mix them mixed reality etc., it has had a significant impact on the overall pop culture beyond the scope of science and technology. The world's leading IT company : Google, Apple, Samsung, Microsoft, Sony, LG is focusing on development of AR, VR technology for the public. The many large and small companies developed VR hardware, VR software, VR content. It does not look that makes a human a human operation in the cognitive experience of certain places or situations or invisible through Specific platforms or program is Encompass a common technique that a realization of the virtual space. In particular, out of the three-dimensional image reveals the limitations of the conventional two-dimensional structure - 180, 360 degree images provided by the subjective and objective symptoms such as vision and sense of time and got participants to select it. VR technology that can significantly induce the commitment and participation is Industry as well as to the general public which leads to the attention of colostrum. It was introduced more than 10 related VR works Year 2015 Sundance Film Festival New Frontier program. The appearance VR content : medical, architecture, shopping, movies, animations. Also, 360 individuals can be produced by the camera / video sharing VR is becoming an interactive tunnel between two possible users. Nevertheless, This confusion of values, moral degeneration and the realization of a virtual space that has been pointed out that the inherent. 4K or HUD, location tracking, motion sensors, processing power, and superior 3D graphics, touch, smell, 4D technology, 3D audio technology - It developed more than ever and possible approaches to reality. Thereafter, This is because the moral degeneration, identity, generational conflict, and escapism concerns. Animation is also seeking costs in this category Reality. Despite the similarities rather it has that image, and may be the reason that the animation is pushed back to the VR content creation. However, it is focused on the game and VR technology and the platform that is entertaining, but also seek new points within the animation staying in the flat Given that eventually consist of visual images is clear that VR sought. Finally, What is the reality created in the virtual space using VR technology could be applied to the animation? So it can be seen that the common interest is research on what methods and means applied.

A Study on Xu Bing's artworks Contributed to expansion of printmaking in Contemporary Chinese Art (중국 현대미술에서의 판화 매체 확장을 일으킨 쉬빙(徐冰) 작품 연구)

  • Song, Dae-Sup;Cho, Ye-In
    • Cartoon and Animation Studies
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    • s.45
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    • pp.321-343
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    • 2016
  • The purpose of this thesis is to look through the political and social background of China preparing for a new era after getting out of the Communist Party of Mao Zedong, rapid inflow of the Western modernism and the avant-garde art arising in China with the focus of art works of Xu Bing, which contributed to the expansion of printmaking of China. Particularly, 85 New Wave Movement arose by young artists since 1985 and the China/Avant-Garde Exhibition held in Beijing in 1989 are the two important issues which reflect a new change from the traditional Chinese art. The artists of 85 New Wave Movement, who pursued a historical revolution and novelty, worked very actively by leading private exhibitions. Since the Cultural Revolution, the government owned the National Museum of Fine Art Beijing had exhibitions on a large scale displaying various visual arts such as performing art, installation, painting, sculpture but the Chinese government interrupted exhibitions two time due to bold performing art and unconcealed installation. Some artists were even taken to the police when performing art. Under these circumstances, Xu Bing, who majored printmaking, produced one of his major works, Books from the sky(1988), while he was working on various experiments focusing on the production process of printmaking and its repetitiveness. Xu Bing devised letters, carved them in trees and finally created approximately 2000 characters. Going further he displayed it as installation work, which means the developed characters go beyond a printed form, for audiences. This made him earn favorable reviews since it was a form of western art coupled with Chinese contents 'Chinese character'. After he received unfavorable reviews, however, he went to America leaving his last work in China, Ghost Pounding the Wall, in 1990, which was not able to exhibited. In those days, China society was going through a chaotic era thanks to the extinction of the Cultural Revolution and Deng Xiaoping's(1904-1997) reformation after the debacle of Tiananmen Massacre. This study looks into Xu Bing's artworks from his initial print works until he went to the US in 1991 and examines how he performed experiments utilizing reproductivity and plurality of prints tinged with Chinese traditional elements, and ultimately became one of the avant-garde artists representing the period.