• Title/Summary/Keyword: global regulation

Search Result 462, Processing Time 0.029 seconds

Detecting DNA hydroxymethylation: exploring its role in genome regulation

  • Sun-Min Lee
    • BMB Reports
    • /
    • v.57 no.3
    • /
    • pp.135-142
    • /
    • 2024
  • DNA methylation is one of the most extensively studied epigenetic regulatory mechanisms, known to play crucial roles in various organisms. It has been implicated in the regulation of gene expression and chromatin changes, ranging from global alterations during cell state transitions to locus-specific modifications. 5-hydroxymethylcytosine (5hmC) is produced by a major oxidation, from 5-methylcytosine (5mC), catalyzed by the ten-eleven translocation (TET) enzymes, and is gradually being recognized for its significant role in genome regulation. With the development of state-of-the-art experimental techniques, it has become possible to detect and distinguish 5mC and 5hmC at base resolution. Various techniques have evolved, encompassing chemical and enzymatic approaches, as well as third-generation sequencing techniques. These advancements have paved the way for a thorough exploration of the role of 5hmC across a diverse array of cell types, from embryonic stem cells (ESCs) to various differentiated cells. This review aims to comprehensively report on recent techniques and discuss the emerging roles of 5hmC.

Exploratory Analysis on the Global Sourcing and Implications for Competitiveness of the Korean Apparel Firms (국내의류업체의 글로벌 소신 현황과 경쟁력 강화방안)

  • 이윤숙;육심현;최원경;이수경;진병호
    • Journal of the Korean Society of Clothing and Textiles
    • /
    • v.26 no.6
    • /
    • pp.751-762
    • /
    • 2002
  • Korean apparel industry is facing critical moment due to shortage of labor, wage increases and intensive competition among domestic manufactures. In addition, international production has been shifting to China and the other low-wage countries from established locations such as Korea, Hong Kong and Taiwan. Global sourcing has been received considerable attention since firms can enhance their competitive advantage as well as comparative advantage by coordinating their sourcing activities global]y. This studs regarded global sourcing as one of the strategic tools to achieve competitive advantage of Korean apparel firms, and explored the current status by literature reviews and series of in-depth interviews with managers of korean apparel firms. The findings of this study were as follows: 1) Due to geographical advantage, China was the most favored nation for outsourcing for domestic markers. However, exporting firms preferred Latin America (including Mexico) to take advantage of duties, quotas and geographical proximity to the US market. 2) In selecting the global sourcing country, productivity, technical ability, local government regulation, and culture were considered important. 3) Most Korean apparel firms sources production globally, and followed by raw materials and trims. 4) Cost and quality were the most important factors in deciding subcontractors, and experience, productivity, equipment and finances were the next concerns. Academic implications and future directions were suggested based on findings.

IMPROVING GLOBAL SUPPLY CHAIN RISK IDENTIFICATION USING RCF

  • MYUNGHYUN, JUNG;SEYEON, LEE;MINJUNG, GIM;HYUNGJO, KIM;JAEHO, LEE
    • Journal of the Korean Society for Industrial and Applied Mathematics
    • /
    • v.26 no.4
    • /
    • pp.280-295
    • /
    • 2022
  • This paper contains an introduction to industrial problems, solutions, and results conducted with the Korea Association of Machinery Industry. The client company commissioned the problem of upgrading the method of identifying global supply risky items. Accordingly, the factors affecting the supply and demand of imported items in the global supply chain were identified and the method of selecting risky items was studied and delivered. Through research and discussions with the client companies, it is confirmed that the most suitable factors for identifying global supply risky items are 'import size', 'import dependence', and 'trend abnormality'. The meaning of each indicator is introduced, and risky items are selected using export/import data until October 2022. Through this paper, it is expected that countries and companies will be able to identify global supply risky items in advance and prepare for risks in the new normal situation: the economic situation caused by infectious diseases such as the COVID-19 pandemic; and the export/import regulation due to geopolitical problems. The client company will include in his report, the method presented in this paper and the risky items selected by the method.

Study on the Strategy of CO2 Reduction Technology in Vehicle according to CO2 Emissions Regulation in EU - Focusing on Auxiliary Energy Improvement - (유럽 CO2 감축법에 따른 차량 CO2 감축 기술 전략에 관한 연구 - 보기류 개선을 중심으로 -)

  • Seok, Kyu-Up;Yoon, Hyoung Jin
    • Transactions of the Korean Society of Automotive Engineers
    • /
    • v.23 no.2
    • /
    • pp.230-238
    • /
    • 2015
  • The main purpose of this paper is to suggest opportunities for reducing $CO_2$ emission in energy conversion of a vehicle, focused on auxiliary energy improvement in the automotive field. As part of worldwide efforts to curb global warming and to protect the domestic industry as trade barriers, many countries have set goals to regulate greenhouse gas emissions. As an example, new $CO_2$ emission regulation in EU was expected to go into effect strictly in 2020. Therefore, global car-makers need to establish strategic responsiveness of the regulations. This paper shows $CO_2$ economic value by using the correct interpretation of the relevant laws and regulations. The $CO_2$ value analyzed using quantitative figures leads to the possibility of auxiliary(accessories, HVAC, electric apparatus etc.) technology for improving fuel economy. As a result, this study generalizes the meaning of electric power saving for each driving mode by auxiliary energy improvement.

A study on the existing state of things and hereafter subject for the Strategy of Korea according as the Climate Change Convention (기후변화협약에 따른 우리나라의 대응 동향 및 향후 과제에 관한 연구)

  • Jung, Kyung-Hee;Cho, Jai-Rip
    • Proceedings of the Korean Society for Quality Management Conference
    • /
    • 2006.04a
    • /
    • pp.392-399
    • /
    • 2006
  • Since the global warming problem emerged in the international community, the problem has been sought to be not at the national but at the global level. As a result, the United Nations Framework Convention on Climate Change was agreed by international delegates in 1992, and the Kyoto Protocol which imposes industrialized nations to decrease their greenhouse gas emission was agreed by the international community in 1997. Kyoto protocol came into effect for reduction duty of greenhouse gas.(16-Feb-2005) High developed countries press environmental regulation. It will strengthen an environment regulation from advanced nation with this protocol. This study is intended to examine unfolding transition on negotiations of Conference of Parties(COP), the Kyoto Mechanism referred as a cost-effective tool to meet a targeted level of greenhouse gas decrease, and trends in responses of developed countries to the Kyoto Protocol, and finally suggests legal and politic counterplans responding to the United Nations Framework Convention on Climate Change (hereafter, UNFCCC).

  • PDF

Regulation of International Economic-Legal Cooperation in the Field of Agricultural Production through the Prism of Information Technology Development

  • Matvieiev, Petro;Baadzhy, Nataliia;Gurenko, Maria;Myroshnychenko, Volodymyr;Feofanova, Iryna
    • International Journal of Computer Science & Network Security
    • /
    • v.21 no.11
    • /
    • pp.143-150
    • /
    • 2021
  • International economic and legal cooperation can ensure the transition of agriculture to the trajectory of sustainable development. The paper considers in detail the set of common goals and problems of an international nature, the solution of which is aimed at global legal regulation of cooperation between states. It is also noted about the impact of information technology on agricultural development. The following methods of scientific cognition are used: a historical, systematic approach to research, method of analysis, and synthesis. Research results: a scientific idea of the importance of international cooperation in general and global collaboration in the field of agricultural production in particular. It is stated that states are obliged to cooperate, regardless of differences in their political, economic, and social systems, in various areas of international relations to maintain international peace, security and promote worldwide economic stability and progress, the common good of peoples. It is emphasized the need to build such relations in the agricultural sector, which take into account the interests of all states.

Current Status of Countermeasure for Overcoming the International Environmental Regulations in Korea (국제환경규제에 대한 국내의 대응 현황)

  • Jung, Bong-Jin;Lee, Kwi-Ho
    • Clean Technology
    • /
    • v.16 no.3
    • /
    • pp.155-161
    • /
    • 2010
  • Product-based environmental regulations, such as RoHS, REACH, EuP, etc., on electrical and electronic equipments, chemicals, and so on, initiated by the European Union, are becoming a global trend. These regulations can create barriers to trade among nations worldwide and may thereby have a direct impact on the function of internal market. If domestic companies utilize well the international environmental regulations in advance, they will get good opportunity for expanding overseas market. In this paper the current status of countermeasure for overcoming the international environmental regulations in domestic industries was investigated and the future plans were discussed.

Global warming effect Comparison of each material for railway vehicle (철도차량 차체재료별 온실가스발생량 비교)

  • Lee, Cheul-Kyu;Kim, Yong-Ki;Phirada, Pruitichaiwiboon
    • Proceedings of the KSR Conference
    • /
    • 2009.05a
    • /
    • pp.219-222
    • /
    • 2009
  • Green ocean is one of the main issues internationally. Most governments are leading the role in boosting the economy through creating new green market and establishing system of coping with increasing international environmental regulation. Green ocean, which is a solution for the environmental issue of global warming, is applied throughout the industry. Domestic transportation industry including railway is also developing technology for creating green ocean. Transportation must decrease energy consumption at running stages because it shows high environmental loads expecially on using stages during its life cycle. Therefore, There are some tries for developing technologies; new engine through alternative energies, hybrid and lightweight. Railway transportation can not be exception. it is intended for this paper to suggest the direction of manufacturing environmentally friendly railway vehicle through the global warming effect evaluation of several materials being applied to vehicle and comparison of the results.

  • PDF