• 한국식품영양학회지
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• 제30권2호
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• pp.371-377
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• 2017

Muscle atrophy is characterized by a decrease in the mass of the muscle. With an increase in life expectancy and chronic illnesses, the incidence of muscle atrophy is increasing and the quality of life of patients is decreasing. Thus, reducing muscle atrophy is of high clinical and socio-economic importance. Mistletoe is a semi-parasitic plant that has been used as a traditional medicine in many countries to treat various human illnesses. It has been reported that Korean mistletoe extract (KME) has diverse biological functions including anti-tumor, anti-oxidant, anti-diabetic, anti-obesity properties, and extension of lifespan. Especially, we have recently reported that KME improves exercise endurance in mice, indicating its beneficial roles in enhancing the capacity of skeletal muscle. In this study, we investigated whether KME could activate the signaling pathway related to protein synthesis in a mouse model of muscle atrophy. Interestingly, KME efficiently activated the Akt/mTOR pathway, and Akt and mTOR are important signaling hub molecules for the acceleration of protein synthesis in muscle cells. In addition, KME also increased the activity of S6 kinase which is involved in the regulation of muscle cell size. Moreover, the ERK activity, required for transcription of ribosomal RNA for protein synthesis, was also enhanced in KME-treated mouse muscle. These data support the idea that KME increases muscle mass via increased protein synthesis. Our findings also suggest that Korean mistletoe might be a promising candidate for the development of functional foods that are beneficial for preventing muscle atrophy.

• 유통과학연구
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• 제14권10호
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• pp.47-57
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• 2016

Purpose - This study's purpose is to investigate the market structure of the Korean duty free shop industry that has received recent attention from researchers and practitioners. By raising the question of whether or not the Korean duty free shop industry is unequivocally monopolistic, a wider viewpoint is provided. The study seeks to offer insights and managerial implications for marketers and policy makers who are in charge of regulating major Korean duty free shops. Research design, data, and methodology - The authors use secondary data from various sources, including Korea Customs Service and the Moodie Report, to investigate the structure of the duty free shop industry of Korea. Based on several theories, they present various criteria and statistical evidence such as K-firm concentration ratio, HHI, consumer substitutability, excess profit, and marketing costs. Results - In terms of consumer substitutability, it is difficult to confirm whether or not the Korean duty free shop industry is monopolistic. Notwithstanding monopoly characteristics in terms of market share, neither the company Lotte nor Shilla appear to have market dominating power. It is not easy for either of them to control prices or to achieve a much lower operational profit ratio due to a dominant bargaining power. Moreover, the license is not an economic rent. In this situation, it is not easy for these companies to obtain an excessive profit. Conclusions - Considering that most global duty free shops are trying to go upscale to improve bargaining power, it does not seem likely that rigid regulations are needed in the industry. Even though the Korean duty free industry ostensibly has a monopolistic structure, government and policy-makers should look beyond the surface. They should take global and other reasonable criteria into consideration when they establish or change regulation policies. Thorough understanding and appropriate support are needed for the Korean duty free shop industry. Additionally, duty free shops should position themselves as global companies struggling against unlimited international competition, rather than Korean domestic companies. At the same time, they need to give customers appropriate information about the benefits they provide.

• 통상정보연구
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• 제15권1호
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• pp.97-116
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• 2013

최근 들어 이런 환경문제와 관련된 가장 큰 특징은 선진국들을 중심으로 무역과 환경을 연계시키려는 움직임이 나타나고 있다는 것이다. 기후변화협약체제는 단순히 환경문제에만 국한되지 않는다. 경제활동에 있어 주요 동력원인 화석연료에 대한 규제는 곧 생산활동에 대한 규제로 직결되기 때문에 경제 및 무역에 미치는 영향은 지대한 것이다. 우리나라는 무역의존도가 매우 높으나 환경기준은 선진국에 비해 매우 낮기 때문에 환경문제가 무역과 연계가 강화된다면 우리나라 경제는 상당히 악영향을 받을 수밖에 없을 것이다. 따라서 본 논문에서는 기후변화협약체제가 무역에 미칠 수 있는 영향을 살펴보고, 우리나라의 대응방안을 체계적으로 수립하는데 목적이 있다. 이러한 목적을 위하여 무역과 환경문제와의 상호관계를 살펴보고, 기후변화협약과 교토의정서의 무역관련 연계에 관해 분석하여 우리나라의 대응방안을 제시하고자 한다.

• 문화기술의 융합
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• 제10권2호
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• pp.447-452
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• 2024

생성형 인공지능 기술의 놀라운 성과가 점차 가시화됨에 따라, 기계의 인간 지배 가능성 등 잠재적인 실존 위협이 제기되는 현시점에서 인공지능에 대한 '통제 가능성'이 첨예한 글로벌 키워드로 주목받고 있다. 이에 따라 이 연구는 인공지능 기술을 중심으로 펼쳐질 미래 사회의 혁신적 변화에 대응하기 위하여 인공지능에 대한 통제 개념과 현주소, 글로벌 현황을 면밀하게 탐색함으로써 사회적 공론장 형성의 토대를 마련하고자 하는 데 목적이 있다. 이를 통해 인공지능 기술 진화에 따라 야기될 사회문제와 예측 불가능한 변수에 대해 대응책을 마련하기 위한 시사점을 모색하고, 정부 규제 수립에 대한 가이드라인과 전략적 통찰력을 제시하는 한편, 사회적 공개 담론 형성을 위한 함의를 찾아 보고자 한다.

• KDI Journal of Economic Policy
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• 제46권1호
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• pp.21-51
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• 2024

Since the Global Financial Crisis of 2008-2009, the importance of nonbank financial institutions in macroprudential management has increased significantly. Consequently, major countries and international financial institutions have been actively discussing and implementing macroprudential supervision and regulation for non-bank financial institutions (NBFI). In this context, this paper analyzes the systemic risk of both banks and non-bank sectors (securities firms and insurance companies) in South Korea over different time periods. Using the widely recognized ΔCoVaR methodology for measuring systemic risk, the analysis reveals that systemic risk increased substantially across all three sectors (banks, securities firms, and insurance companies) during the Global Financial Crisis, the European Sovereign Debt Crisis, and the COVID-19 pandemic. Although the banking sector exhibited relatively high systemic risk compared to the securities and insurance sectors, the relative differences in systemic risk varied across the different crisis periods. Notably, during the margin call crisis in March of 2020, the gap in systemic risk between the banking and securities sectors decreased significantly compared to that during both the Global Financial Crisis and the European Sovereign Debt Crisis, indicating that securities firms had a more substantial impact on risk in the overall financial system during this period. Furthermore, I analyze the impact of the issuance of equity-linked securities (ELS) by financial institutions on systemic risk, as measured by ΔCoVaR, finding that an increase in the outstanding balance of ELS issuance by financial institutions had an impact on increasing ΔCoVaR during the three crisis periods. These findings underscore the growing importance of non-bank financial institutions in relation to South Korea's macroprudential management and supervision. To address this evolving landscape, enhanced monitoring and regulatory measures focusing on non-bank systemic risk are essential components of maintaining financial stability in the country.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3213-3222
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• 2016

Background: Methyl donor status influences DNA stability and DNA methylation although little is known about effects on DNA methyltransferases. The aim of this study was to determine whether methyl-donor status influences DNA methyltransferase (Dnmt) gene expression in cervical cancer cells, and if so, whether there are associated effects on global DNA methylation. Materials and Methods: The human cervical cancer cell line, C4-II, was grown in complete medium and medium depleted of folate (F-M+) and folate and methionine (F-M-). Growth rate, intracellular folate, intracellular methionine and homocysteine in the extracellular medium were measured to validate the cancer cell model of methyl donor depletion. Dnmt expression was measured by qRT-PCR using relative quantification and global DNA methylation was measured using a flow cytometric method. Results: Intracellular folate and methionine concentrations were significantly reduced after growth in depleted media. Growth rate was also reduced in response to methyl donor depletion. Extracellular homocysteine was raised compared with controls, indicating disturbance to the methyl cycle. Combined folate and methionine depletion led to a significant down-regulation of Dnmt3a and Dnmt3b; this was associated with an 18% reduction in global DNA methylation compared with controls. Effects of folate and methionine depletion on Dnmt3a and 3b expression were reversed by transferring depleted cells to complete medium. Conclusions: Methyl donor status can evidently influence expression of Dnmts in cervical cancer cells, which is associated with DNA global hypomethylation. Effects on Dnmt expression are reversible, suggesting reversible modulating effects of dietary methyl donor intake on gene expression, which may be relevant for cancer progression.

• 한국CDE학회논문집
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• 제17권6호
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• pp.387-397
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• 2012

The world has faced with various environmental problems such as climatic change, global pollution, and depletion of natural resources. Conventional economic development continues not only to intensify the magnitude of the problems but also to damage growth potential of future generations. Therefore, recent manufacturers are highly required to accommodate themselves to sustainable development that aims at preventing the loss to the future generations. Moreover, the manufacturers are under heavy pressure from various environmental regulations. This paper proposes green bill of material (Green-BOM) which conforms to the environmental regulations to restructure eco-friendly manufacturing system. Green-BOM is useful for managing green product and process information to satisfy several environmental regulations by recording energy consumption, recycle rate, volatile organic compounds (VOCs), substance information, and so on.

• Industrial Engineering and Management Systems
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• 제10권2호
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• pp.123-127
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• 2011

Nowadays, green purchasing, stop global warming, love the mother earth, and others that related to environment become hot issues. Manufactures industries tend to more active and responsive to those issues by adopting green strategies or program like Environmentally Conscious Manufacturing (ECM). In this article, an electronic company had applied 12 ECM Program and tries to choose one of those programs using 6 criteria, such as total cost involved, quality, recyclable material, process waste reduction, packaging waste reduction, and regulation compliance. By using multi-criteria decision making model, i.e. Analytical Hierarchy Process (AHP), Technique for Order Preference by Similarity to Ideal Solution (TOPSIS), and Modified TOPSIS methods, the ECM Program 9 (Open pit) is the best option.

• 한국게임학회 논문지
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• 제11권4호
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• pp.93-104
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• 2011

세계적인 게임심의제도의 추세를 찾아보기 위해 전 세계의 16개 게임심의제도를 찾아 검토하였으며, 주로 표현의 자유라는 관점에서 이들 제도들의 추이 및 함의점을 찾고자 하였다. 게임의 위상이 높아지면서 게임전문심의기관의 증가, 민간자율심의기관의 증가, 게임에서의 표현의 자유의 확대라는 추세를 찾을 수 있었다. 이러한 추세는 게임자체의 발전 양상과 맞물려 필연적으로 나타나는 현상으로 보이며, 우리도 이러한 추세에 맞추어 신속한 변화와 혁신이 필요함을 알 수 있었다.

• 한국유기농업학회:학술대회논문집
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• 한국유기농업학회 2001년도 심포지엄
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• pp.163-178
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• 2001

The last few nears have seen significantly increased interest in organic food. Organic food is still a small but growing part of the food industry with an identity defined and protected by law. Its existence provides an element of consumer choice. To obtain consumer confidence and, product credibility and transparency in the organic market, organic legislation and certification is needed, To facilitate export of organic products, harmonization of the organic legislation is favoured. The IFOAM accreditation programme has already achieved very much in this respect. Several national regulation, such as the NOP(USA) and EC2092/91(European Union) have already complied with the IFOAM basic standards. But in many countries there is still a lack of national legislation on organic agriculture. Because of the fast globalisation, organic agriculture is facing major challenges for international trade, so it is very important to consider the future development and certification of organic produce in all countries.