• Asian-Australasian Journal of Animal Sciences
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• v.19 no.8
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• pp.1090-1094
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• 2006

Histone acetylation modification is one key mechanism in the regulation of gene activation. In this study, we investigated the global levels of histone H4 acetylation of insulin like growth factor I (IGF1) and growth hormone (GH) genes in the lungs of two somatic cell cloned calves. Data showed the levels of histone H4 acetylation of IGF1 and GH genes vary widely within different gene regions, and, in almost all regions of the two genes, acetylation levels are lower in the aberrant clone than in the normal clone. Thus we suggest that inefficient epigenetic reprogramming in the clone may affect the balance between acetylation and deacetylation, which will affect normal growth and development. These findings will also have implications for improvement of cloning success rates.

• Proceedings of the KSR Conference
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• 2009.05a
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• pp.365-370
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• 2009

LCA is a tool to support for making decisions by offering information of environmental aspects of products or services. It can be used to make decisions to consumers and NGOs as well as government and enterprises. LCA evaluates the environmental aspects throughout the entire life cycle of a product. Therefore it can quantify and assess environmental impacts from raw material acquisition, manufacturing, distribution, use and disposal to end of life and recycling. The demands of the recycling rate increase and the use of suitable materials for RoHS, REACH, WEEE, ELV which are linked trade with environmental regulation have increased the worldwide. Global warming is the critical challenge of the world facing. And under post-Kyoto protocol each country has to prepare for target reduction, so it became essential to save energy and resources. In addition that, the carbon mark has been run as the way of showing example of CO2 reduction in domestic and it will be extended gradually. And also through the introduction of Eco-label, environmentally-friendly product will be promoted. When those systems are operated, global warming gases (i.e. CO2) can be calculated throughout the entire life of the products by LCA. And the environmental impacts such as harmful material emission in the process of manufacturing, energy consumption, distribution and so on, can also be assessed. Therefore, The basic concepts of LCA technique and various cases and the practical application in the future will be review in this study.

• Fashion & Textile Research Journal
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• v.11 no.1
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• pp.84-92
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• 2009

The purpose of this study was to examine the facilities, the current status, and the problems of Korean Exhibition Industry and to provide its future direction based on analysis of the characteristics and the recent trend of German Exhibition Industry. Data were obtained from previous research papers, periodicals, magazines, and newspapers. Also, statistical data provided by AUMA(Ausstellungs- und Messe- Ausschuss der Deutschen Wirtschaft e.V.), Association of Korean Exhibition Industries, and Global Exhibition Portal were used. In the result part of this study, various issues such as similarities and differences between Korean and German Exhibition Industry and problems of Korean Exhibition Industry were discussed. The strategies to improve the competitiveness of Korean Exhibition Industry were suggested. They are as follows ; development of global and specialized exhibitions, training of professional human resources for exhibition, formulating of aggressive and powerful oversee marketing, formation of oversee network, improving of laws, regulation and system in such a way to meet the realistic needs of exhibition, building of infrastructure such as roads, traffic networks and accomodations, raise of the Korea image and strengthen of quality of exhibition service.

• Molecules and Cells
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• v.27 no.4
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• pp.481-490
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• 2009

Diverse posttranslational modifications of histones, such as acetylation and methylation, play important roles in controlling gene expression. Histone methylation in particular is involved in a broad range of biological processes, including heterochromatin formation, X-chromosome inactivation, genomic imprinting, and transcriptional regulation. Recently, it has been demonstrated that proteins containing the Jumonji (Jmj) C domain can demethylate histones. In Arabidopsis, twenty-one genes encode JmjC domain-containing proteins, which can be clustered into five clades. To address the biological roles of the Arabidopsis genes encoding JmjC-domain proteins, we analyzed the temporal and spatial expression patterns of nine genes. RT-PCR analyses indicate all nine Arabidopsis thaliana Jmj (AtJmj) genes studied are actively expressed in various tissues. Furthermore, studies of transgenic plants harboring AtJmj::${\beta}$-glucuronidase fusion constructs reveal that these nine AtJmj genes are expressed in a developmentally and spatially regulated manner.

• International journal of advanced smart convergence
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• v.8 no.1
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• pp.153-158
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• 2019

Language and letter are represented by a combination of its signifier and signified. All symblos are commonly calling direct attention to people who are living in the physical world. However, in cyberspace, the image takes control once inhabited by the language. Cyberspace with anonymity and deoent physical nature has something with physical laws. In this space the statue transcends the imaginary realm. Ideology gives a greater connotation by giving a series of regulation to images floating in cyberspace. Even if various media have the same image, the meaning of the image changes depending on which ideology is used. The impact of this on the public is great. In this study, I discuss the ideology in cyberspace where is supposedly wide open to who visits and spreads all the thoughts without suppression and the human body. The main ideas would be who owns the ideology and what does it want to control and how the people would react to the ideology. This paper would eventually head the prototype that visualizes above ideas. Though the interactive media it will also show the subject in the real world is accept the images floating in the cyberspace without any doubts.

• The Journal of Korean Medicine
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• v.39 no.4
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• pp.1-15
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• 2018

Objectives: Cerebral ischemia results from a variety of causes that cerebral blood flow is reduced due to a transient or permanent occlusion of cerebral arteries. Reactive astrocytes and microglial activation plays an important role in the neuronal cell death during ischemic insult. Acupunctural treatment is effective for symptom improvement in cerebrovascular accident, including cerebral ischemia. Methods: In the present study, the effects of acupuncture at the ST40 acupoint on short-term memory and apoptosis in the hippocampal CA1 region following transient global cerebral ischemia were investigated using gerbils. Transient global ischemia was induced by occlusion of both common carotid arteries with aneurysm clips for 5 min. Acupuncture stimulation was conducted once daily for 7 consecutive days, starting one day after surgery. Results: In the present results, ischemia induction deteriorated short term memory, increased apoptosis, and induced reactive astrocyte and microglial activation. Acupuncture at ST40 acupoint ameliorated ischemia-induced short-term memory impairment by suppressing apoptosis in the hippocampus through down-regulation of reactive astrocytes and microglial activation. Conclusion: The present study suggests that acupuncture at the ST40 acupoint can be used for treatment of patients with cerebral stroke.

• International Journal of Advanced Culture Technology
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• v.10 no.3
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• pp.127-145
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• 2022

Vaccine diplomacy is a manifestation of competition for political influence among great powers amidst the Covid-19 pandemic's blatant illustration of ineluctable interdependency across the global community. The reinforcement of trends bolstering global polity construction intensify concomitantly with nationalist populist value and attitude expressions increasing political polarization. The interdependency graphically illustrated in the Cold War-era's mutual assured destruction incentivized competition into indirect competitive intervention in the internal politics of third actors. Indirect international influence contestations included extended, de facto challenge competitions to generate soft power on behalf of the victor, e.g., the space race. The Covid-19 pandemic has intensified this competition to offer alternative development models while intense domestic political polarization undermines the mobilizational capacities for achieving sustainable development. In contrast to multinational and multiethnic states, nation states have an inherent mobilizational advantage because of the enhanced control capabilities available to the authorities without emphasizing coercion. Control through Gramscian hegemonic mechanisms is more readily feasible in nation states through the greater feasibility of commodification of social relations by states authorities regulating and channeling social competition to encourage social mobility and creativity. The regulation of the so-called private sector serves to manage and contain social competition while channeling it to develop the institutional capacities for control and allocation of developing societal human resources. It enhances developed state control mechanisms and international influence capacities. The appeal of offers of aid and assistance to the so-called developing world becomes ever more urgent amidst Anthropocene crises including its most recent, current Covid-19 pandemic disaster.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.536-547
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• 2020

This study analyzed the correlation between adolescents' smartphone addiction as well as depression, self-esteem, and self-regulation based on QEEG (Quantitative Electroencephalogram) analysis. The study period was from March 19 to July 12, 2019, and the subjects were 76 students at P Middle School in Gyeonggi-do (normal group 47, risk group 29) who filled out a questionnaire and were subjected to quantitative EEG. The data analysis was performed via frequency analysis, independent t-test, correlation analysis, and path analysis of the IBM SPSS Statics 21.0 program. First, smartphone addiction had a positive correlation with depression. Second, smartphone addiction showed a negative correlation with self-esteem and α wave. Third, depression showed a negative correlation with self-esteem, which did not show a significant correlation with self-regulation. Fourth, depression was higher in the risk group than the normal group. For self-esteem, the normal group scored higher than the risk group. Self-regulation showed higher significant differences with the normal group than the risk group. Fifth, for α wave and SMR, the normal group scored higher than the risk group. Sixth, α waves had a negative effect on smartphone addiction. This study is meaningful in that it applied a brain science approach using quantitative analysis for objective evaluation of smartphone addiction.

• Bulletin of the Korean Chemical Society
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• v.32 no.11
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• pp.3893-3898
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• 2011

Cellular uptake of double-stranded DNA (dsDNA) triggers strong innate immune responses via activation of NF-${\kappa}B$ transcription factor. However, the detailed mechanism of dsDNA-mediated innate immune response remains yet to be elucidated. Here, we show that the expression of tazarotene-induced gene 3 (TIG3) is dramatically induced by dsDNA stimulation, and the siRNA-mediated down-regulation of TIG3 mRNA results in significant suppression of dsDNA-triggered cytokine expression. Because TIG3 has been previously shown to physically interact with transglutaminase (TG) 1 to activate TG activity, and TG2 has been shown to induce NF-${\kappa}B$ activity by inducing $I{\kappa}B{\alpha}$ polymerization, we tested whether TG also plays a role in dsDNA-mediated innate immune response. Pre-treatment of TG inhibitors dramatically reduces dsDNA-triggered cytokine induction. We also show that, in HeLa cells, TG2 is the major TG, and TIG3 physically interacts with TG2. Combined together, our results suggest a novel mechanism of dsDNA-triggered innate immune response which is critically dependent on TIG3 and TG2.

• Korean Journal of Clinical Pharmacy
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• v.23 no.2
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• pp.106-113
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• 2013

Background: For Korean pharmaceutical industry to continue to grow, it is requisite to enter the global markets of developed countries. However, the export volume has fallen short of 10% of the gross sales and the industry has only recently warming up to prepare the globalization along with suchlike the Columbus Project. Purpose: This research was conducted to identify the difficulties Korean pharmaceutical companies perceived and to discover the gap in the needs for the government aid the companies have been seeking in the purpose of entering the developed pharmaceutical markets. Method: A survey method was used for this research. Six experts were surveyed and provided comments for the pre-questionnaire. Then, a final questionnaire was developed consisting of 10 items on regulatory-related and another 10 items on non-regulatory-related factors in drug exportation using the Likert scale (1 to 5). The survey sample was 30 Korean companies which have participated in the Columbus Project since 2010. Results: Nineteen (63%) companies responded to the survey. Most companies perceived difficulty (mean = 4.19) over the entire pathway of the regulatory process of global markets. Clinical trials and post-marketing surveillance were remarked as the most difficult barrier to follow the regulatory globalization. Among non-regulatory related factors, marketing, arranging a distribution network, obtaining experts, and projecting a timeline in exportation were brought up as the most difficulty. Conclusion: Especially, cost and language barrier were considered as the main cause producing these difficulties across regulatory and non-regulatory processes and accordingly, securing both long term budget and experts at governmental level was suggested by the domestic pharmaceutical companies.