• BMB Reports
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• 제51권2호
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• pp.79-84
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• 2018

Niemann-Pick type C disease (NP-C) is a fatal neurodegenerative disorder caused by a deficiency of NPC1 gene function, which leads to severe neuroinflammation such as astrogliosis. While reports demonstrating neuroinflammation are prevalent in NP-C, information about the onset and progression of cerebellar astrogliosis in this disorder is lacking. Using gene targeting, we generated vascular endothelial growth factor (VEGF) conditional null mutant mice. Deletion of VEGF in cerebellar Purkinje neurons (PNs) led to a significant increase of astrogliosis in the brain of NP-C mice in addition to the loss of PNs, suggesting PN-derived VEGF as an important factor in NP-C pathology. Moreover, replenishment of VEGF in neurons improved brain pathology in NP-C mice. Overall, our data provide a new pathological perspective on cerebellar astrogliosis in NP-C and suggest the importance of VEGF as a therapeutic target for this disease.

• 한국주거학회논문집
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• 제8권3호
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• pp.153-162
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• 1997

Personalities. human relations. living patterns. and so on of the aged have been moulded respectively for a long period of time and their present situation of health. family make-up. economic condition etc. are different individually. Various characteristics - physiological. psychological and social peculiarities - of the aged are analyzed and studied in preceding paper to grope planning factors of architectural spaces by referring to sundry records from many branch gerontology, medical science. psycology. sociology. etc. - of knowledge in a position of architectural planning. So. in this paper. the directions of planning residential environment for the aged are studied on the base of those planning factors of architectural spaces. there are room(X$_1$). unit home(X$_2$), public housing(X$_3$), residential district(X$_4$) as dwelling spaces for the aged in X axis and safety(Y$_1$). hygiene(Y$_2$). convenience (Y$_3$), comfortableness (Y$_4$). psychology ($Y^5$), aesthetics ($Y^6$). society ($Y^7$). economy ($Y^8$) as the terms desired to spaces in Y axis. And the directions of planning residential environment for the elderly are studied by discussing mutual matters relevant to the subject on the cells of matrix formed by X. Y axis. In planning residential environment for the elderly. their physiological. psychological. social characteristics should be considered thoroughly and many types of dwelling spaces should be built. Then they can take up their abode to suit their conditions easily.

• 한국주거학회논문집
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• 제26권5호
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• pp.37-44
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• 2015

The purpose of this study was to compare urban and rural seniors' perceptions on the eight aspects of the World Health Organization Age-Friendly Cities (AFC) initiative on Jeju Island, South Korea. Face-to-face interviews using structured questionnaires were administered to 497 persons aged 65+ living on Jeju Island. Findings suggested that urban and rural held significantly different perceptions on five aspects of AFC (outdoor space and buildings, housing, civic participation and employment, community support and health services, and respect and social inclusion). Predictors of overall AFC score for all participants included age and living in a single-family home. Among urban dwellers, monthly household income and length of residence predicted AFC score while among rural seniors, predictors of AFC included educational attainment. To make communities more age-friendly, perspectives of older residents should be sought, shared, and reflected in policy and different strategies and priorities should be developed specific to urban and rural areas.

• Architectural research
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• 제1권1호
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• pp.11-16
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• 1999

Wandering behavior is a serious problem among the elderly in nursing homes, yet it has received relatively little study by those interested in gerontology. The research that has been done has generally regarded wandering behavior as an aimless, directionless movement. Only a few studies have addressed the problem after first assuming that wanderers have a goal to their movement, and fewer still have explored the role of the physical environment on the wanderer's behavior. None have combined the two approaches. In this paper, the physical environment will be looked at for support of the theory of wandering as a goal seeking behavior. In a pilot study using behavior maps, the movements of wanderers and non-wanderers are analyzed and compared for the amount of visual access and exposure their locations contain. While the behavioral implications of these two measurements are considered, the limitations of the results are also discussed, so that their relationship to the cause of wandering behavior may be better understood. By implying that wandering is not a totally aimless but purposeful behavior at least in the subconscious level, constructive design implications can be suggested that would make wandering a more pleasant experience for the wanderer and increase the ease of the nursing home staffs management of the problem.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제19권3호
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• pp.7-19
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• 2013

Purpose: The main objective of this paper is, first, to assess a body of research evidence that articulates the impact of environmental and design factors on safety, quality of life, and health of the elderly who reside in geriatric hospitals or other elderly care facilities and, second, to draw out design implications that can be incorporated into design process and design decisions to help create healing environments for the elderly. Methods: Extensive literature review has been conducted to identify rigorous empirical studies that link the design of elderly care facilities to health-related outcomes and scrutinized peer-reviewed articles published in many different fields including architecture, psychology, nursing to gerontology. Results: The review found a growing body of rigorous studies that identified physical environmental and design factors that improve safety, quality of life, and health of the elderly in geriatric hospitals or other elderly care facilities. Implications: The findings of the review can be translated to design decisions to promote safety, quality of life, and health of the elderly in geriatric hospitals or other elderly care facilities.

• 가정과삶의질연구
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• 제20권6호
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• pp.37-48
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• 2002

Mid of 1980s witnessed the beginning of a new trend regarding the elderly as the Third Age Group, which is capable of positive selection for their later life. These changes are caused not only by the rising cost of caring them as the dependent to the society, but also by paradigm shift from the clinical and biomedical model to political economy and critical gerontology. The paradigm shift is based on the social constructionism as a perspective on the later life. In this communication the development of social constructionism is reviewed as an approach on the living environment for later life through literature survey. Emphases were made on the anti-ageism instead of ageism in the analysis of the social constructionism perspective for living environment in later life. Individual practice, influencing the practice of others, influencing agency policy, and developing theory were addressed and emphasized for the practice of anti-ageism. This study found the importance of the development of the social constructionism perspective on the study and practice regarding living environment for ‘the Third Age’ in Korean situation.

• Journal of Preventive Medicine and Public Health
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• 제46권sup1호
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• pp.50-54
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• 2013

Out-of-home mobility is necessary for accessing commodities, making use of neighborhood facilities, and participation in meaningful social, cultural, and physical activities. Mobility also promotes healthy aging as it relates to the basic human need of physical movement. Mobility is typically assessed either with standardized performance-based tests or with self-reports of perceived difficulty in carrying out specific mobility tasks. Mobility declines with increasing age, and the most complex and demanding tasks are affected first. Sometimes people cope with declining functional capacity by making changes in their way or frequency of doing these tasks, thus avoiding facing manifest difficulties. From the physiological point of view, walking is an integrated result of the functioning of the musculoskeletal, cardio-respiratory, sensory and neural systems. Studies have shown that interventions aiming to increase muscle strength will also improve mobility. Physical activity counseling, an educational intervention aiming to increase physical activity, may also prevent mobility decline among older people. Sensory deficits, such as poor vision and hearing may increase the risk of mobility decline. Consequently, rehabilitation of sensory functions may prevent falls and decline in mobility. To promote mobility, it is not enough to target only individuals because environmental barriers to mobility may also accelerate mobility decline among older people. Communities need to promote the accessibility of physical environments while also trying to minimize negative or stereotypic attitudes toward the physical activity of older people.

• 보건행정학회지
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• 제32권1호
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• pp.45-52
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• 2022

Background: There are regional variations in the incidence of coronavirus disease 2019 (COVID-19), which means that some regions are more exposed to the risk of COVID-19 than others. Therefore, this study aims to investigate regional variations in the incidence of COVID-19 in Korea and identify risk factors associated with the incidence of COVID-19 using community-level data. Methods: This study was conducted at the districts (si·gun·gu) level in Korea. Data of COVID-19 incidence by districts were collected from the official website of each province. Data was also obtained from the Korean Statistical Information Service and the Community Health Survey; socio-demographic factor, transmission pathway, healthcare resource, and factor in response to COVID-19. Community risk factors that drive the incidence of COVID-19 were selected using a least absolute shrinkage and selection operator regression. Results: As of June 2021, the incidence of COVID-19 differed by more than 80 times between districts. Among the candidate factors, sex ratio, population aged 20-29, local financial independence, population density, diabetes prevalence, and failure to comply with the quarantine rules were significantly associated with COVID-19 incidence. Conclusion: This study suggests setting COVID-19 quarantine policy and allocating resources, considering the community risk factors. Protecting vulnerable groups should be a high priority for these policies.

• 한국심리학회지 : 문화 및 사회문제
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• 제12권5호_spc
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• pp.29-43
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• 2006

With longevity (75 years plus and still increasing) now commonly achievable, the new challenge for individuals and society is less concerned with adding more years to life, though that remains important, and more with adding life to years. To explore the quality of long life more fully, a concept broader than healthy ageing or active ageing is needed. For this purpose, the present article describes a framework of Positive Ageing, also known as Successful Ageing, which views the quality of long life as comprising good health, physical and cognitive functional independence, and meaningful engagement with life. Narrowly defined, it refers to old people ageing well in all these aspects. More broadly defined, it refers to ageing well from midlife on. The framework also identifiesvariables that may affect the process of ageing positively. These variables include the social-cognitive styles of control, humour and future-time perspective on the one hand, and on the other hand, resources based on finance, social network and lifestyle.

• Imaging Science in Dentistry
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• 제46권3호
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• pp.173-178
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• 2016

Purpose: Optical coherence tomography (OCT) has been investigated as a novel diagnostic imaging tool. The utilisation of this equipment has been evaluated through several studies in the field of dentistry. The aim of this preliminary study was to determine through basic experiments the effectiveness of OCT in implant dentistry. Materials and Methods: To assess detection ability, we captured OCT images of implants in each of the following situations: (1) implants covered with mucosae of various thicknesses that were harvested from the mandibles of pigs; (2) implants installed in the mandibles of pigs; and (3) implants with abutments and crowns fixed with temporary cement. The OCT images were captured before cementation, after cementation, and after removing the excess submucosal cement. Results: If the thickness of the mucosa covering the implant body was less than 1 mm, the images of the implants were clearly detected by OCT. In the implants were installed in pigs' mandibles, it was difficult to capture clear images of the implant and alveolar bone in most of the samples. Remnants of excess cement around the implants were visible in most samples that had a mucosa thickness of less than 3 mm. Conclusion: Currently, OCT imaging of implants is limited. Cement remnants at the submucosal area can be detected in some cases, which can be helpful in preventing peri-implant diseases. Still, though there are some restrictions to its application, OCT could have potential as an effective diagnostic instrument in the field of implant dentistry as well.