• 한국과학교육학회지
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• 제34권4호
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• pp.407-415
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• 2014

유전자 결정론은 유전자가 인간의 생물학적인 특성 뿐 아니라 사회적인 특성까지도 결정한다고 보는 철학적 견해이다. 그럼에도 불구하고 여전히 일반대중과 생명과학자들이 유전자 결정론을 주장하곤 한다. 클레몽의 KVP모델에 의하면(Cl$\acute{e}$ment & Carvalho, 2007; Cast$\acute{e}$ra & Cl$\acute{e}$ment, 2012) 과학교육에서 교사들의 유전자 결정론은 학생들의 유전에 대한 개념 형성에 영향을 준다. 본 연구에서는 우리나라 교사들이 가지고 있는 유전자 결정론에 대한 인식을 조사하였다. 이를 위해 선행연구(Cast$\acute{e}$ra & Cl$\acute{e}$ment, 2012)의 설문지를 번역하여 생명과학, 국어 및 초등학교의 예비교사 151명, 현직교사 157명의 총 308명을 대상으로 설문 조사를 실시하였다. 응답결과에 대해 요인분석을 활용하여 주요 요인들을 추출하였으며 일원분산분석을 실시하여 교사 집단별 요인들의 차이를 분석하였다. 요인분석 결과 4개의 요인이 추출되었는데, 요인1은 남녀의 차이가 유전적으로 결정된다고 보는 관점, 요인2는 개인의 지적능력이 유전적으로 결정된다고 보는 관점, 요인3은 개인의 면역작용과 행동적 특징이 유전적으로 결정된다고 보는 관점이었으며, 요인4는 민족의 특징이 유전적으로 결정된다고 보는 관점이었다. 이 네 가지 요인에 대한 전공교과 집단별 인식 차이를 분석한 일원분산분석 결과 요인1(F=3.325, p=.006), 요인3(F=3.320, p=.006), 요인4(F=4.325, p=.001)에서 유의한 차이를 나타냈다. 사후 비교를 한 결과 생명과학 교사와 다른 교사들 사이에 유의한 차이는 없었다. 현직교사와 예비교사로 구분하여 분석한 결과, 요인1(t=-3.938, p=.000)과 요인4(t=-3.121, p=.002)에서 유의한 차이가 나타났는데 예비교사보다 현직교사가 더 유전자 결정론적 인식이 강했다. 네 요인에 대한 교사들의 종교별 차이를 분석한 결과에서는 유의한 차이가 나타나지 않았다.

• BMB Reports
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• 제49권8호
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• pp.437-442
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• 2016

We aimed to study the role of protein L-isoaspartyl methyltransferase (PIMT) in neuronal differentiation using basic fibroblast growth factor (bFGF)-induced neuronal differentiation, characterized by cell-body shrinkage, long neurite outgrowth, and expression of neuronal differentiation markers light and medium neurofilaments (NF). The bFGF-mediated neuronal differentiation of PC12 cells was induced through activation of mitogen-activated protein kinase (MAPK) signaling molecules [MAPK kinase 1/2 (MEK1/2), extracellular signal-regulated kinase 1/2 (ERK1/2), and p90RSK], and phosphatidylinositide 3-kinase (PI3K)/Akt signaling molecules PI3Kp110β, PI3Kp110γ, Akt, and mTOR. Inhibitors (adenosine dialdehyde and S-adenosylhomocysteine) of protein methylation suppressed bFGF-mediated neuronal differentiation of PC12 cells. PIMT-eficiency caused by PIMT-specific siRNA inhibited neuronal differentiation of PC12 cells by suppressing phosphorylation of MEK1/2 and ERK1/2 in the MAPK signaling pathway and Akt and mTOR in the PI3K/Akt signaling pathway. Therefore, these results suggested that PIMT was critical for bFGF-mediated neuronal differentiation of PC12 cells and regulated the MAPK and Akt signaling pathways.

• Journal of Genetic Medicine
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• 제7권1호
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• pp.1-8
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• 2010

Hemophilia A is a sex-linked recessive coagulation disorder associated with diverse mutations of the factor VIII gene and a variety of phenotypes. The type of mutation involved dictates the activity of factor VIII, and in turn the severity of bleeding episodes and development of alloantibodies against factor VIII (inhibitors). Missense mutations are the most common genetic risk factors for hemophilia A, especially mild to moderate cases, but carry the lowest risk for inhibitor development. On the other hand, intron 22 inversion is the most common mutation associated with severe hemophilia A and is associated with high risk of inhibitor formation. Large deletions and nonsense mutations are also associated with high risk of inhibitor development. Additional mutations associated with hemophilia A include frameshift and splice site mutations. It is therefore valuable to assess the mutational backgrounds of hemophilia A patients in order to to interpret their symptoms and manage their health problems.

• 농업과학연구
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• 제50권4호
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• pp.869-881
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• 2023

A genetic improvement program in Korea was implemented to improve the performance of Hanwoo cattle by generating livestock with genetically desirable economic characteristics. In particular, in response to external changes, such as the expansion of Free Trade Agreement (FTA), the livestock genetic improvement program has increased farm income by improving the productivity and quality of Hanwoo cattle. Using production cost data from Statistics Korea, the total input and output indices of Hanwoo feeding cattle from 2008 - 2021 were estimated and the growth and productivity changes were analyzed. The productivity change measures results were used to estimate the cumulative effects of the Hanwoo genetic improvement program on quality improvement, another purpose of the program, using a finite distributed lag model. The average annual increase in output (market weight) of Hanwoo was 0.9%. However, total input increased by 1.6%, resulting in a 0.6% decline in total factor productivity. In contrast, the Hanwoo genetic improvement program contributed significantly to the production of high quality beef, rather than contributing to improved productivity of the cattle. Hanwoo carcass weight, which is used as a performance indicator for the livestock genetic improvement program, has significantly improved and is projected to increase at a slower rate. The collective findings indicate the need for new performance indicators that can comprehensively indicate the performance of the genetic improvement of Hanwoo.

• 대한한방소아과학회지
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• 제24권3호
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• pp.138-149
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• 2010

Objectives: The purpose of this study is to estimate genetic and environmental factors which can effect growth, and predict final height using this factors. Methods: Correlation analysis and regression analysis were conducted between measurements of height and Genetic & environmental factors through survey from 1352 child & adolescent patients. Results: Factors which have correlation with height percentile are MPH(Mid-Parental Height), NBW(Neonatal body weight), anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time. MPH has moderate relation, NBW and anorexia have fair relation, and other factors have linear but poor relation. Regression equation from factors which have correlation and height percentile has 26.9% of predictive power. Regression equation considering only genetic factor has 20.4%. MPH has the most effect on height percentile. Anorexia has more effect than NBW. Other factors also have small and similar effect. Conclusions: Height of parents has the most effect on growth, anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time also has effect.

• Molecules and Cells
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• 제26권2호
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• pp.193-199
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• 2008

The pro-apoptotic Bcl-2 family member Bim acts as a sensor for apoptotic stimuli and initiates apoptosis through the mitochondrial pathway. To identify novel regulators of Bim, we employed the yeast two-hybrid system and isolated the human gene encoding macrophage migration inhibitory factor (MIF), a ubiquitously expressed proinflammatory mediator that has also been implicated in cell proliferation, the cell cycle and carcinogenesis. The interaction between MIF and Bim was confirmed by both in vitro and in vivo protein interaction assays. Intriguingly, protein complexes between MIF and the three major Bim isoforms (BimEL/BimL/BimS) could be detected in HEK293 and K562 cells, especially in cells undergoing apoptosis. Moreover, exogenous expression of MIF partially inhibited Bim-induced apoptosis in HEK293 cells. SiRNA-mediated knockdown of MIF increased apoptosis in K562 cells exposed to the chemical oxidant diamide. Endogenous MIF may regulate the pro-apoptotic activity of Bim and inhibit the release of cytochrome c from mitochondria.

• 영재교육연구
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• 제17권2호
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• pp.280-306
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• 2007

본 논문은 영재성의 중요한 요소 가운데 하나인 지력(知力)에 초점을 두어, 이에 대한 생득설과 경험설의 입장과 그에 대한 영향력에 대한 다양한 연구들을 종합 분석하고, 이와 관련된 몇 가지 논의를 함으로써 영재성을 이해하는 데에 목적을 두고 있다. 다양한 연구 내용들을 검토한 결과, 인간의 지력은 절반 정도는 타고난다는 것이 보편적인 입장이었다. 하지만 중요한 것은 그것이 평생 고정되는 것이 아니라 후천적 경험에 의해 변하고 발달한다는 점이다. 결국 지력이 중요한 요소인 영재성 자체는 잠재력으로 타고나는 것이지만, 그것은 여러 가지 환경 요인에 따라 그 발현의 여부나 정도가 결정된다는 것이다. 따라서 영재교육에 관한 오늘날의 주요 관심은 생득 요인과 후천 요인의 정도에 대한 논쟁보다는, 그 영재성을 후천적으로 어떻게 최대로 발현시킬 것인가에 있다. 영재성은 뛰어난 유전 요인과 특별한 환경 요인이 역동적으로 상호작용하여 쌍방향의 절묘한 증폭 현상이 일어날 때 비로소 촉발되고 발달한다는 점에서, 그것을 도식적으로 설명하는 데에 깊은 난관이 있음을 이해할 수 있다.

• Genomics & Informatics
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• 제11권2호
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• pp.83-92
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• 2013

Genetic studies on facial morphology targeting healthy populations are fundamental in understanding the specific genetic influences involved; yet, most studies to date, if not all, have been focused on congenital diseases accompanied by facial anomalies. To study the specific genetic cues determining facial morphology, we estimated familial correlations and heritabilities of 14 facial measurements and 3 latent factors inferred from a factor analysis in a subset of the Korean population. The study included a total of 229 individuals from 38 families. We evaluated a total of 14 facial measurements using 2D digital photographs. We performed factor analysis to infer common latent variables. The heritabilities of 13 facial measurements were statistically significant (p < 0.05) and ranged from 0.25 to 0.61. Of these, the heritability of intercanthal width in the orbital region was found to be the highest ($h^2$ = 0.61, SE = 0.14). Three factors (lower face portion, orbital region, and vertical length) were obtained through factor analysis, where the heritability values ranged from 0.45 to 0.55. The heritability values for each factor were higher than the mean heritability value of individual original measurements. We have confirmed the genetic influence on facial anthropometric traits and suggest a potential way to categorize and analyze the facial portions into different groups.

• KIEAE Journal
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• 제15권3호
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• pp.29-36
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• 2015

Purpose: This study is as only basic research for the model Development of the New-Hanok Type Service Facilities in Apartment Housing, which is as a decisive factor used as a planning element for developing the model inherited tradition, There aimed at extracting the genetic factor of Korea's traditional architecture. Method: For this purpose, Consider the concept and regulations of the New-Hanok Type Service Facilities in Apartment Housing and examined the Domestic Application Status of the New-Hanok Type Service Facilities in Apartment Housing. It sets direction of the New-Hanok Type models development based on Expert advice and the literature, and was reviewed a primal reason system of Korea as an extraction base of genetic factors. Result: Then Through the framework of the vertical axis (the form), the horizontal axis (space), It extracted the genetic factors of the Korea Traditional Architecture, classified the genetic factors extracted as the structure(layout, construction, space), features, traditional beauty, investigated the content of the form representation and spatial meaning, and were characterized. Based on the result, It were comprehensive the genetic factors extracted as plan Elements for inheriting of the traditions.

• Asian-Australasian Journal of Animal Sciences
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• 제21권3호
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• pp.309-313
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• 2008

The insulin-like growth factor binding protein 3 (IGFBP3) has been investigated as a candidate gene for growth promoting effects in beef cattle and a modulator of IGF bioactivity. Previously, we have reported twenty two sequence variants discovered in Korean native cattle (Hanwoo). In this study, we examined the association between gene-specific polymorphisms of IGFBP3 and cold carcass weight (CW) and marbling score (MS) among Korean native cattle. Among twenty two polymorphisms, four common polymorphic sites (-854G>C, -100G>A, +421G>T and +3863C>A) were genotyped in our beef cattle (n = 437). Statistical analysis revealed that one common polymorphism in the promoter region (-854G>C) showed putative associations with MS (p = 0.03). IGFBP3 variation/haplotype information analyzed in this study will provide valuable information into strategies for the production of a commercial line of beef cattle.