• The Journal of Internal Korean Medicine
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• v.22 no.2
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• pp.207-213
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• 2001

Objectives : In order to study the clinical efficiency of Dohwatang, based on Oriental Medical References, using experimental animals, we studied ulcers, gastric juice secretion, free acidity, total acidity, and the action of transport rates in the intestine. Methods : We used rats administered with the above herbs. Results : Dohwa-tang showed remarkable inhibitory effects on peptic ulcers, gastric juice secretion, free acidity, and total acidity in pyloricligated rat. It also showed remarkable inhibitory effects on the transportability in the large intestine of rats. But Dohwa-tang didn't show any remarkable difference on stressed rats. Conclusions : Dohwatang works better for chronic pyloristenosis-peptic ulcer and for diarrhea than acute stress ulcer.

• Natural Product Sciences
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• v.7 no.3
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• pp.90-93
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• 2001

The effects of the dried fruit powder of Opuntia ficus-indica var. saboten (OF-f) were investigated on gastric lesion and ulcer models in rats. It showed significant inhibition in HCl ethanol and HCl aspirin induced gastric lesion at a dose of 600 mg/kg, p.o. OF-f also showed significant inhibition in indomethacin induced gastric lesion at the doses of 200 and 600 mg/kg, p.o. However, it did not affect aspirin and Shay ulcer in rats. It also did not affect the gastric juice secretion, acid output and pH. These data suggest that OF-f possesses pronounced inhibitory action on gastric lesion of rats.

• The Journal of Internal Korean Medicine
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• v.15 no.2
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• pp.197-208
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• 1994

In order to investigate the efficacy of Siljangsan by using the experimental animals, the action of gastric juice secretion, antiulcer. transport rates in the intestine and anti-cathartic action were studied. The following results were obtained. 1. Preventive effects on ulcer induced by pylorus-ligated and Ethanol-HCI were recognized 2. Suppression effects on gastric juice secretinon, free of acidity and total acidity were recognized, but pepsin output was not recognized. 3. For the transport ability of intestine of mice, the ability of small intestine was activated and large intestine was suppressed in the group administrated 4. Anti-cathatic action of mice induced by castor oil was recognized. According to above results, effect based on oriental medical reference was consistent with the actual experimental effect.

• Biomolecules & Therapeutics
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• v.23 no.5
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• pp.458-464
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• 2015

Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer. To elucidate their gastroprotective effects, the inhibitions of $HCl{\cdot}tOH$-induced gastritis and indomethacin-induced gastric ulcers were assessed in rats. It was observed that both sennoside A and sennoside B increased prostaglandin $E_2$ ($PGE_2$) levels and inhibited $H^+/K^+$-ATPase (proton pump). In a rat model, both compounds reduced gastric juice, total acidity and increased pH, indicating that proton pump inhibition reduces gastric acid secretion. Furthermore, sennoside A and B increased $PGE_2$ in a concentration-dependent manner. In a gastric emptying and intestinal transporting rate experiment, both sennoside A and sennoside B accelerated motility. Our results thus suggest that sennoside A and sennoside B possess significant gastroprotective activities and they might be useful for the treatment of gastric disease.

• The Journal of Dong Guk Oriental Medicine
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• v.8 no.1
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• pp.145-158
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• 1999

Objective : To observe Sagunjatanghapchangchuljiyutang in rectifying the digestive dysfunctional spleen deficiency syndrome caused by chronic diarrhea. Methods : Sagunjatanghapchangchuljiyutang was chosen to treat the digestive dysfunctional spleen deficiency syndrome caused by chronic diarrhea. The model was induced by Rhei Radix and castor oil. The effects on the gastric secretion ability(gastrin, secretin, volume of gastric juice, free acidity, total acidity, pepsin activity) and nutritional condition(protein, albumin, total cholesterol, triglyceride, total lipid, BUN, creatinine, RBC, WBC, hemoglobin, hematocrit) were observed in vivo. Results : The group induced chronic diarrhea by Rhei Radix and castor oil had lower gastric secretion ability and nutritional condition was lower than that of the normal group. The figures for group given Sagunjatanghapchangchuljiyutang showed improvement, especially gastrin, total lipid and hematocrit. Conclusion : Sagunjatanghapchangchuljiyutang have an effect on the digestive dysfunctional spleen deficiency syndrome caused by chronic diarrhea. And experimental study syndrome could be proceed.

• Korean Journal of Pharmacognosy
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• v.17 no.3
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• pp.215-222
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• 1986

Although the 'Insamyangwee-tang' has been widely used in clinical purposes in the oriental medicine, its clinical efficacy is only documentated for the cases of gastritis, gastric ulcer and enteritis, but the experimental study on these has not been undertaken. So, to investigate the clinical efficacy of 'Insamyangwee-tang' comparing with animal experiments, This study was carried out. The results showed that relaxing action was shown on the isolated ileum in mice and that strong antagonistic actions were seen on $BaCl_2$, acetylcholine and histamine induced contraction of the ileum in mice, rats, rabbits and guinea-pigs that the relaxing effect of the intestinal smooth muscle was recognized. Inhibitory effects on transport rate in the small intestine of mice. Strong antagonistic actions were seen on acetylcholine induced contraction of duodenum in rats and remarkably inhibiting actions were seen of duodenum in rats. Inhibitory action on the secretion of gastric juice and pepsin, anti-ulceration effect was recognized.

• Journal of Food Hygiene and Safety
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• v.28 no.4
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• pp.367-375
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• 2013

Kalopanax pictus has pharmacologically anti-inflammatory and analgesic effect and is known to respond to treatment of backache, knee pain and etc. In this study, we investigated the effects on gastric lesions of Kalopanax pictus both from Korea (KPK) and China (KPC) compared with their related origin, Znthoxylum ailanthoide both from Korea (ZAK) and China (ZAC), and Korean Bombax malabaricum (BMK). In preliminary screening, KPK and KPC shown effective inhibition of HCI EtOH-induced gastritis in rats. To elucidate their protective effects on gastric lesions, we assessed inhibition of H. pylori colonization, 2,2-diphenyl-1-picrylhydrazyl(DPPH) radical scavenging activities, reducing power test, and inhibition of lipid peroxidation. KPK was the most effective from antioxidant assays. KPK also shown the inhibition of indomethacin-induced gastric ulcer in rats. Gastric secretion in rats, KPK reduced the secretion of gastric juice and total acidity and raised pH. Therefore, it is possible that KPK can be developed as health functional food and natural medicine. In addition, it can contribute to the standardization with objectivity and reliability for KPK through the criteria establishment of the precise origin of medicine, the prevention of indiscriminate distribution of imitation, and the rising rate of dependence on imports of medicinal herbs, and mixing prevention of low-quality goods.

• The Journal of Internal Korean Medicine
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• v.15 no.2
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• pp.37-47
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• 1994

To investigate the effect of ILGUAN-JEON on liver and gastrointestinal track. this experiment were performed and obtained results wewe as follows. 1. ILGUAN-JEON depressed the isolated intestine movement and showed anti- acethylcholine and barium chloride effect in mice. 2. ILGUAN-JEON showed anti- acethylcholine and barium chloride effect on isolated stomach in rats. 3. ILGUAN-JEON showed anti-ulcer effect in rats induced by indomethacin and pyrous cracking. 4. ILGUAN-JEON depressed the gastric lesion in rats induced by HCI-ethanol. 5. ILGUAN-JEON depressed the gastric juice and pepsin secretion, free acid and total acid level in Shay rats. 6. ILGUAN-JEON depressed the GOT and GPT level in rats induced by $CCl_4$ and d-galactosamine. From above results, think that ILGUAN-JEON can be applied to recover the liver and gastrointestinal function.

• The Journal of Pediatrics of Korean Medicine
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• v.1 no.1
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• pp.23-37
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• 1986

Although the Insamyangwee-Tang has been widely used in clinical purposes in the oriental medicine and its clinical efficiency is documented for the cases of gastritis, gastric ulcer and enteritis but the experimental study on these has not been undertaken. So,To investigate the clinical efficiency, of Insamyangwee-Tang and validate its oriental medical theory, these experiments were undertaken, by being compared with animal experiment. ?The following results were obtained. ?1. By effect of Insamyangwee-Tang on isolated ileum from mice, rats, rabbits and Guinea pigs, the motility of ileums was inhibited remarkably. ?2. By effect of Insamyangwee-Tang on motility of the small intestine in rabbits, the motility was inhibited remarkably too. ?3. Insamyangwee-Tang inhibited charcoal transport functions in the small intestine of mice. ?4. By effect of Insamyangwee-Tang on isolated duodenum from rats, the motility of duodenum was inhibited remarkably.?5. Gastric juice and pepsin secretion was decreased, anti-ulceration effect was recognized.

• Journal of Sasang Constitutional Medicine
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• v.9 no.2
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• pp.187-201
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• 1997

An experimental study was done to examine the effects of Dokwhaljiwhang-tang on gastro-intestinal track and central nervous system and were undertaken by being carried out with rat. The following results have been obtained ; 1. Dokwhaljiwhang-tang showed to have an inhibitory effect on the smooth muscle contraction of the isolated ileum by acetylcholene chloride and barium chloride. 2. Dokwhaljiwhang-tang showed to have an inhibitory effect on the contraction of the gastric fundus-strip by acetylcholine chloride and barium chloride. 3. The preventive effect was recognized on the pylorus-ligated ulcer, by administration of Dokwhaljiwhang-tang. 4. The preventive effect was not recognized on the indomethacine -induced ulcer, by administration of Dokwhaljiwhang-tang. 5. The inhibitory effects on the secretion gastric juice, free acidity were recognized, by administration of Dokwhaljiwhang-tang 6. The transport ability in the small intestine was increased, by administration of Dokwhaljiwhang-tang. 7. The transport ability in the large intestine was increased, by administration of Dokwhaljiwhang-tang. 8. The analgesic effect was recognized, by administration of Dokwhaljiwhang-tang. 9. The effect of sleeping time was not recognized, by administration of Dokwhaljiwhang-tang. according to the results, it is considered that Dokwhaljiwhang-tang has effects of gastric ulcer, chronic gastritis,hyper-acidity, gastroptosis such as abdominal discomfort, gastric acid, indigestion and anorexia.