• 제목/요약/키워드: gastric carcinoma

검색결과 374건 처리시간 0.023초

진행 위암의 UICC와 일본식 림프절 병기의 비교 및 UICC N3M0 병기의 문제점 (Comparison of Nodal Staging, of UICC TNM and Japanese Classification, and Prognostic Nodal Grouping of UICC N3M0 in Advanced Gastric Cancer)

  • 한상준;양대현
    • Journal of Gastric Cancer
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    • 제5권3호
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    • pp.163-168
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    • 2005
  • 목적: 본 연구에서는 제5판 UICC (International Union Against Cancer) 림프절 병기와 일본 위암 학회 림프절 병기를 분석하여 병기별 분포와 예후의 차이점을 알아보고자 하였다. 그리고 UICC N3M0 위암 환자들을 여러 림프절 전이군으로 분류하여 예후 예측에서 효용성을 알아보고자 하였다. 대상 및 방법: 1990년 2월부터 2000년 5월까지 지방공사 서울 의료원 및 한림대학교 성심병원에서 진행 위암으로 근치적 절제 수술을 받은 환자 197예를 대상으로 하여 두 가지 병기의 연관성 및 예후 예측의 차이를 분석하였다. 그리고 UICC N3M0군으로 분류된 58예를 세 가지의 림프절 병기 분류 방법으로 분석하였다. 결과: UICC 림프절 병기 N1, N2, N3의 5년 생존율은 각각 62.9%, 33.0%, 21.2%였다. 일본 위암 학회 림프절 병기 n1, n2의 5년 생존율은 각각 61.2%, 25.3%였다 N3M0군에서 일본 위암 학회 병기 n1의 5년 생존율이 각각 62.5%였고, 전이 림프절 비율 0.5 미만, 전이 림프절 수 26개 미만인 군에서는 각각 33.0%, 22.9%로 통계학적으로 의미 있게 0.5이상, 26개 이상의 군보다 좋은 예후를 보였다(P=0.018, 0.021). 결론: UICC 림프절 병기 체계는 예후 예측 능력에서 일본식 림프절 병기보다 더 우수했다. N3M0 병기 위암환자에서 전이 림프절 비율, 전이 림프절 수는 의미 있는 예후 인자였다.

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악성 빈혈환자에서 발병한 위암 1예 보고 (Gastric Adenocarcinoma in Patient with Pernicious Anemia: A Case Report)

  • 김병수;김종원;이인규;김동출;김우호;이혁준;양한광
    • Journal of Gastric Cancer
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    • 제7권1호
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    • pp.38-41
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    • 2007
  • 악성빈혈을 동반한 자가면역성 만성 위축성 위염은 위암의 전구 병변으로 알려져 있다. 저자들은 악성빈혈에 동반된 위암 1예를 경험하였기에 보고한다. 40세 여자환자가 어지럼증과 공복 시 속쓰림으로 시행한 혈액검사상 혈색소 4.2 g/dl으로 측정되었다. 상부위장관 내시경상에서는 위 고위 체부의 편평 융기성 병변이 관찰되었고 조직검사상 위선암으로 보고되었다. 위전절제술을 시행하였고 병리조직 검사상 병변은 고위 체부 전벽에 점막하층(SM2)까지 침범한 조기위암이었으며, 검사된 림프절 44개 중에 전이된 림프절은 없었다. 악성빈혈 환자에서 위축성 위염이 동반된 경우 위암의 호발연령이 되면 위암의 발생 가능성이 있으므로 상부위장관 내시경의 주기적인 시행이 중요하리라 생각된다.

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위암 환자에서 Glutathione S-transferases (GSTM1, GSTT1, GSTP1) 및 N-acetyltransferase 2 유전자 다형성 분포 (Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 Polymorphisms and the Risk of Gastric Cancer)

  • 홍수형;김정완;김호각;박인규;류준욱;이창형;손윤경;이종영
    • Journal of Preventive Medicine and Public Health
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    • 제39권2호
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    • pp.135-140
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    • 2006
  • Objectives : Polymorphisms of genes from glutathione Stransferases (GSTs) and N-acetyltransferase 2 (NAT2) have been associated with increased susceptibility to various cancers. Previous results showed that East Asians such as Koreans, Japanese and Chinese have a much higher frequency of the GSTM1 and GSTT1 null genotypes and NAT2 rapid acetylator type. Therefore, we investigated the association between the polymorphic types of GSTs (GSTM1, GSTT1, GSTP1) and NAT2 and the incidence of gastric cancer which is one of the most prevalent cancers among the East Asians. Methods : It was performed in a case-control study consisting of 238 healthy subjects and 108 cancer patients (54 distal and 54 proximal carcinomas). We also evaluated the association between GSTs and NAT2 and the risk factors for gastric cancer such as alcohol consumption, smoking, H. pylori infection, family history of gastric cancer, and tumor location. Results : In our study, the percentage of cases whose hometown was rural was higher than those of controls (odds ratio (OR) =2.88; 95% CI=1.72-4.76), and the frequency of the lower socio-economic status increased significantly in patients (OR=2.53; 95% CI=1.59-4.02). There was no significant difference in the GST polymorphic types between the cases and controls. However, NAT2 rapid or intermediate acetylator types were frequently detected in the cases with family history of gastric cancer (OR=1.92; 95% CI=1.79-26.0). Conclusions : These results suggest that the hometown and socio-economic status are important environmental factors for gastric carcinogenesis, and NAT2 polymorphic types could be associated with familial gastric carcinoma.

참취뿌리 에탄올추출물의 항돌연변이성 및 암세포 성장억제효과 (Antimutagenic and Cytotoxic Effects of Aster scaber Root Ethanol Extract)

  • 황보현주;함승시
    • 한국식품과학회지
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    • 제31권4호
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    • pp.1065-1070
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    • 1999
  • 참취뿌리의 에탄올 추출물과 용매 분획물에 대한 생리활성 효과를 밝히기 위해 항돌연변이성 및 암세포 성장억제효과를 실시한 결과 에탄올 추출물 자체의 돌연변이성은 없었다. 직접변이원인 N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)에 대해서는 Salmonella typhimurium TA100의 경우 에탄올 추출물이 79%, 에틸아세테이트 분획물은 82%의 억제효과를 나타내었다. 4-Nitroquinoline-1-oxide(4NQO)에 대해서는 Salmonella typhimurium TA98에서 에탄올 추출물이 48%, 에틸 아세테이트 분획물은 60%의 억제효과를 보였다. 한편 간접 변이원인 benzo(${\alpha}$)pyrene[B(${\alpha}$)P]에 대해서는 에틸아세테이트 분획물의 경우 TA98에서는 78%, TA100에서는 85%의 높은 억제활성을 나타내었다. 그리고 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole(Trp-P-1)에 대해서는 TA98에서 89%의 높은 억제효과를 보였다. 한편 참취 에탄올 추출물에 대한 암세포 성장억제 실험에서도 chronic myelogenous leukemia (K562), human gastric carcinoma (KATOIII), human hepatocellular carcinoma (Hep3B) 및 human breast adenocarcioma (MCF-7)에 대하여 높은 세포독성을 나타내었으며 용매 분획물의 경우 KATOIII 세포에서는 모든 분획물이 높은 세포독성을 나타내었으나 그외세포에 대해서는 물분획물을 제외한 에틸아세테이트, 부탄올 및 클로로포름 분획물이 높은 세포독성을 나타내었다.

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Inhibition of Cellular Proliferation by p53 dependent Apoptosis and G2M Cell Cycle Arrest of Saussurea lappa CLARKE in AGS Gastric Cancer Cell Lines

  • Jeong Han Su;Kim Dong Jo;Heo Geum Jeong;Nam Chang Gyu;Go Seong Gyu
    • 동의생리병리학회지
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    • 제18권4호
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    • pp.1186-1191
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    • 2004
  • The root of Saussurea lappa includes sesquiterpene lactones such as costunolide and dehydrocostus lactone, and has been shown to be anti-tumorigenic with being used in traditional medicinal therapy in the Eastern Asia. However, the molecular basis of the effects of Saussurea lappa on fate of gastric carcinoma, which incur very frequently in the area, has not been well identified. In this study, the cytostatic effects of Saussurea lappa were examined using gastric AGS cancer cells. Cell viability was dramatically reduced by Saussurea lappa, in a dose-dependent manner. As time passed after its treatment, apoptotic population was increased and clearly showed G2-arrest. Being consistent, its treatment resulted in maintaining of G1 and S-phase cyclins D1, E, and A even until a significant apoptotic population was observed, for example, at 24h after treatment. However, G2/M phase cyclin B1 was reduced even at 12 h after treatment. In addition, its treatment increased expression of p53, p21/sup Wafl / cyclin dependent kinase inhibitor (CKI), and Bax, resulted in cleavages of procaspase 3 and poly ADP-ribose polymerase(PARP), indicating that such G2 arrest- and apoptosis-related molecules are involved. Therefore, these suggest that extracts of Saussurea lappa root may be a safer and effective reagent to deal with gastric cancers either by traditional herbal therapy or combinational therapy with conventional chemotherapy.

Feasibility Study of Early Oral Intake after Gastrectomy for Gastric Carcinoma

  • Jo, Dong-Hoon;Jeong, Oh;Sun, Jang-Won;Jeong, Mi-Ran;Ryu, Seong-Yeop;Park, Young-Kyu
    • Journal of Gastric Cancer
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    • 제11권2호
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    • pp.101-108
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    • 2011
  • Purpose: Despite the compelling scientific and clinical data supporting the use of early oral nutrition after major gastrointestinal surgery, traditional bowel rest and intravenous nutrition for several postoperative days is still being used widely after gastric cancer surgery. Materials and Methods: A phase II study was carried out to evaluate the feasibility and safety of postoperative early oral intake (water intake on postoperative days (POD) 1-2, and soft diet on POD 3) after a gastrectomy. The primary outcome was morbidity within 30 postoperative days, which was targeted at <25% based on pilot study data. Results: The study subjects were 90 males and 42 females with a mean age 61.5 years. One hundred and four (79%) and 28 (21%) patients underwent a distal and total gastrectomy, respectively. The postoperative morbidity rate was within the targeted range (15.2%, 95% CI, 10.0~22.3%), and there was no hospital mortality. Of the 132 patients, 117 (89%) successfully completed a postoperative early oral intake regimen without deviation; deviation in 10 (8%) due to gastrointestinal symptoms and in five (4%) due to the management of postoperative complications. The mean times to water intake and a soft diet were $1.0{\pm}0.2$ and $3.2{\pm}0.7$ days, respectively, and the mean hospital stay was $10.0{\pm}6.1$ days. Conclusions: Postoperative early oral intake after a gastrectomy is feasible and safe, and can be adopted as a standard perioperative care after a gastrectomy. Nevertheless, further clinical trials will be needed to evaluate the benefits of early oral nutrition after upper gastrointestinal surgery.

Identification of Biomarkers for Diagnosis of Gastric Cancer by Bioinformatics

  • Wang, Da-Guang;Chen, Guang;Wen, Xiao-Yu;Wang, Dan;Cheng, Zhi-Hua;Sun, Si-Qiao
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권4호
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    • pp.1361-1365
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    • 2015
  • Background: We aimed to discover potential gene biomarkers for gastric cancer (GC) diagnosis. Materials and Methods: Genechips of 10 GC tissues and 10 gastric mucosa (GM, para-carcinoma tissue, normal control) tissues were generated using an exon array of Affymetrix containing 30,000 genes. The differentially expressed genes (DEGs) between GC tissues and normal control were identified by the Limma package and analyzed by hierarchical clustering analysis. Gene ontology (GO) and pathway enrichment analyses were performed for investigating the functions of DEGs. Receiver operating characteristics (ROC) analysis was performed to measure the effects of biomarker candidates for diagnosis of GC. Results: Totals of 896 up-regulated and 60 down-regulated DEGs were identified to be differentially expressed between GC samples and normal control. Hierarchical clustering analysis showed that DEGs were highly differentially expressed and most DEGs were up-regulated. The most significantly enriched GO-BP term was revealed to be mitotic cell cycle and the most significantly enriched pathway was cell cycle. The intersection analysis showed that most significant DEGs were cyclin B1 (CCNB1) and cyclin B2 (CCNB2). The sensitivities and specificities of CCNB1 and CCNB2 were both high (p<0.0001). Areas under the ROC curve for CCNB1 and CCNB2 were both greater than 0.9 (p<0.0001). Conclusions: CCNB1 and CCNB2, which were involved in cell cycle, played significant roles in the progression and development of GC and these genes may be potential biomarkers for diagnosis and prognosis of GC.

조기위암과 우연히 동반된 위의 샘근종(Adenomyoma) 1예 (Incidental Adenomyoma of Stomach Associated with Early Gastric Cancer)

  • 여민석;양현준;서동엽;김기홍;변창규;고영택;이효진;최석호
    • Journal of Gastric Cancer
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    • 제6권1호
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    • pp.43-46
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    • 2006
  • 위의 샘근종과 이소성 췌장의 구별은 어려우며, 샘근종을 이소성 췌장의 한 종류라고 생각하기도 한다. 위의 샘근종과 이소성 췌장의 구별은 이소성 체장에서는 샘창자샘 (Brunner's gland)이 발견되지 않는다는 점이다. 위의 샘근종이 악성화하는 경우는 매우 드물다. 본 증례의 경우, 위체부 하방과 유문부에 종괴가 있었으며, 조직겅검 결과에서 위체부 하방의 종괴는 샘암종으로 진단되었고, 유문부의 종괴는 샘근종으로 진단되었다. 본 증례의 경우, 위의 샘근종이 위암과 우연히 동반된 것이라고 생각된다.

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한약처방제의 인체 위암 세포주에 대한 세포독성 효과에 관한 연구 (Cytotoxic Effect of Korean Traditional Prescriptions on the Human Gastric Cancer Cell Lines)

  • 김은해;은영아;강봉주;성현제;박갑주
    • 생약학회지
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    • 제28권4호
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    • pp.233-238
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    • 1997
  • ln order to search for antigastric cancer agents from Korean traditional prescriptions. We selected 41 traditional prescriptions, based on a review of the Korean traditional medicine books. Both boiling water and methanol extracts were tested, by means of the Sulforhodamine B (SRB) protein assay. Six of the 41 water extracts; #3, #34, #35, #38, #40, #41 showed efficacy against gastric cancer cell (AGS: Human gastric carcinoma, ATCC HTB 103). #3 inhibited 50% cancer cell growth1 at the concentration of $152\;{\mu}g/ml$, #34, #35, #38, #40 and #41 inhibited 50% cancer cell growth at the concentration of $145\;{\mu}g/ml$, $129\;{\mu}g/ml$, $173\;{\mu}g/ml$, $10\;{\mu}g/ml$ and $19\;{\mu}g/ml$ respectively. Ten of the 41 methanol extracts; #1, #3, #32, #33, #35, #36, #37, #38, #41 were active. #1 inhibited 50% cancer cell growth at the concentration of $206\;{\mu}g/ml$, #3, #32, #33, #35, #36, #37, 738, #40, #41 inhibited 50% cancer cell growth at the concentration of $133\;{\mu}g/ml$, $159\;{\mu}g/ml$, $199\;{\mu}g/ml$, $147\;{\mu}g/ml$, $113\;{\mu}g/ml$, $187\;{\mu}g/ml$, $130\;{\mu}g/ml$, $9\;{\mu}g/ml$, $15\;{\mu}g/ml$ respectively. Prescription #3, #35, #38, #40, #41 were also interesting because both methanol and water extracts were active.

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진행성 위암의 추적 관찰 도중 다발성 수막내 전이가 발견된 환자 1례 (A Case of Advanced Gastric Cancer with Multiple Leptomeningeal Metastasis)

  • 신해진;정현용;문희석;성재규;강선형
    • Journal of Digestive Cancer Research
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    • 제4권2호
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    • pp.122-126
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    • 2016
  • Leptomeningeal carcinomatosis occurs in approximately 5% of patients with cancer. The most common cancers involving the leptomeninges are breast, lung cancer and melanoma. However, gastric adenocarcinoma has been rarely reported with leptomeningeal carcinomatosis. The presenting manifestations are usually headache, visual disturbances and seizures. We report a case of leptomeningeal metastasis that presented as a gastric cancer. A 75-year old man was transferred to our hospital for further evaluation and treatment after being diagnosed with adenocarcinoma through endoscopic biopsy during a regular health examination. An abdominal computed tomography (CT) showed AGC, stage IA (cT1N0M0), while an endoscopic examination showed AGC, Borrmann type 2. The patient is currently under observation after undergoing radical subtotal gastrectomy with gastroduodenostomy and subsequent administration of oral chemotherapeutic agents. As an abdominal CT response assessment performed after surgery revealed new metastasis to the liver, the patient received palliative chemotherapy as recurrence was suspected. After receiving chemotherapy in the order of DP (Cisplatin + Docetaxel), FOLFIRI (5-FU + Leucovorin + Irinotecan), an abdominal CT response assessment showed complete response. Since decreased mentality maintained throughout the follow up period based on outpatient clinic, brain MRI was performed and revealed multiple leptomeningeal metastasis. The Patient died 2 days after the diagnosis.

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