• Journal of Korean Neurosurgical Society
• /
• v.67 no.4
• /
• pp.431-441
• /
• 2024

Objective : Gamma Knife radiosurgery (GKRS) is an effective and noninvasive treatment for high-risk arteriovenous malformations (AVMs). Since differences in GKRS outcomes by nidus type are unknown, this study evaluated GKRS feasibility and safety in patients with brain AVMs. Methods : This single-center retrospective study included patients with AVM who underwent GKRS between 2008 and 2021. Patients were divided into compact- and diffuse-type groups according to nidus characteristics. We excluded patients who performed GKRS and did not follow-up evaluation with magnetic resonance imaging or digital subtraction angiography within 36 months from the study. We used univariate and multivariate analyses to characterize associations of nidus type with obliteration rate and GKRS-related complications. Results : We enrolled 154 patients (mean age, 32.14±17.17 years; mean post-GKRS follow-up, 52.10±33.67 months) of whom 131 (85.1%) had compact- and 23 (14.9%) diffuse-type nidus AVMs. Of all AVMs, 89 (57.8%) were unruptured, and 65 (42.2%) had ruptured. The mean Spetzler-Martin AVM grades were 2.03±0.95 and 3.39±1.23 for the compact- and diffuse-type groups, respectively (p<0.001). During the follow-up period, AVM-related hemorrhages occurred in four individuals (2.6%), three of whom had compact nidi. Substantial radiation-induced changes and cyst formation were observed in 21 (13.6%) and one patient (0.6%), respectively. The AVM complete obliteration rate was 46.1% across both groups. Post-GKRS complication and complete obliteration rates were not significantly different between nidus types. For diffuse-type nidus AVMs, larger AVM size and volume (p<0.001), lower radiation dose (p<0.001), eloquent area location (p=0.015), and higher Spetzler-Martin grade (p<0.001) were observed. Conclusion : GKRS is a safe and feasible treatment for brain AVMs characterized by both diffuse- and compact-type nidi.

• Journal of Microbiology and Biotechnology
• /
• v.15 no.1
• /
• pp.59-65
• /
• 2005

Poly-${\gamma}$-glutamic acid (PGA) is an unusual anionic polypeptide and has great potential as an environmentally and industrially significant biodegradable material. A new ${\gamma}$-PGA producer, Bacillus mesentericus MJM1, with high production capacity was isolated from Korean domestic Chungkuckjang bean paste. It produced ${\gamma}$-PGA at the level of 10 g/l in suitable media. The viscosities of 5% initially extracted mucin and purified ${\gamma}$-PGA solutions were 660 cps and 600 cps, respectively. The produced ${\gamma}$-PGA polymer consisted of 2,000 glutamic acid residues with even proportion of L and D types with molecular mass of about 200- 300 kDa. Bacillus mesentericus MJM1 displayed ${\gamma}$-glutamyltranspeptidase (${\gamma}$-GTP) activity that is known to play a key role in ${\gamma}$-PGA biosynthesis. The ${\gamma}$-GTP coding region was located on the plasmid of 5.8 kb. The plasmid, named pMMH1, is a rolling-circle replication (RCR) plasmid and additionally contained a replication origin and type I signal peptidase (sipP) coding region.

• Nuclear Engineering and Technology
• /
• v.54 no.9
• /
• pp.3398-3402
• /
• 2022

We fabricated a 15 m long position-sensitive plastic scintillation optical fiber (PSOF) detector consisting of a PSOF, two photomultiplier tubes, four fast amplifiers, and a digitizer. A single PSOF was used as a sensing part to estimate the gamma-ray source position, and ¹³⁷Cs, an uncollimated solid-disk-type radioactive isotope, was used as a gamma-ray emitter. To improve the sensitivity, accuracy, and measurement time of a PSOF detector compared to those of previous studies, the performance of the amplifier was optimized, and the digital signal processing (DSP) was newly designed in this study. Moreover, we could measure very low dose rates of gamma-rays with high sensitivity and accuracy in a very short time using our proposed PSOF detector. The results of this study indicate that it is possible to accurately and quickly locate the position of a very low dose rate gamma-ray source in a wide range of contaminated areas using the proposed position-sensitive PSOF detector.

• Communications of the Korean Mathematical Society
• /
• v.31 no.1
• /
• pp.101-113
• /
• 2016

In this article, we considered the stability of the following (${\alpha}$, ${\beta}$, ${\gamma}$)-derivation $${\alpha}D[x,y]={\beta}[D(x),y]+{\gamma}[x,D(y)]$$ and homomorphisms associated to the quadratic type functional equation $$f(kx+y)+f(kx+{\sigma}(y))=2kg(x)+2g(y),\;x,y{\in}A$$, where ${\sigma}$ is an involution of the Lie $C^*$-algebra A and k is a fixed positive integer. The Hyers-Ulam stability on unbounded domains is also studied. Applications of the results for the asymptotic behavior of the generalized quadratic functional equation are provided.

• Publications of The Korean Astronomical Society
• /
• v.25 no.2
• /
• pp.31-49
• /
• 2010

Next to Paper I (Jeon 2009a), time-series BV CCD images of the open cluster M38 were taken for 4 nights on December, 2009. The observations have been carried out for total 27 nights. In addition to the 20 variable stars in the Paper I, the discovery of 44 new variable stars has been presented in this paper: $6{\delta}$ Scuti stars, $2{\gamma}$ Doradus stars, 18 eclipsing binaries and 18 semi-long periodic and/or slow irregular type variable stars. For the V photometry of the ${\delta}$ Scuti and ${\gamma}$ Doradus stars, multi-frequency analysis was performed using the Discrete Fourier Transform and linear least-square fitting. The period search for the eclipsing binaries and the semi-long periodic and/or slow irregular type variable stars was performed by phase fitting method. As a result, the periods for 23 variable stars among the 44 ones were defined.

• Journal of applied mathematics & informatics
• /
• v.28 no.5_6
• /
• pp.1285-1304
• /
• 2010

The purpose of this paper is to establish some sufficient conditions for oscillation of solutions of the second-order functional dynamic equation of Emden-Fowler type $\[a(t)x^{\Delta}(t)\]^{\Delta}+p(t)|x^{\gamma}(\tau(t))|\|x^{\Delta}(t)\|^{1-\gamma}$ $sgnx(\tau(t))=0$, $t\;{\geq}\;t_0$, on a time scale $\mathbb{T}$, where ${\gamma}\;{\in}\;(0,\;1]$, a, p and $\tau$ are positive rd-continuous functions defined on $\mathbb{T}$, and $lim_{t{\rightarrow}{\infty}}\;{\tau}(t)\;=\;\infty$. Our results include some previously obtained results for differential equations when $\mathbb{T}=\mathbb{R}$. When $\mathbb{T}=\mathbb{N}$ and $\mathbb{T}=q^{\mathbb{N}_0}=\{q^t\;:\;t\;{\in}\;\mathbb{N}_0\}$ where q > 1, the results are essentially new for difference and q-difference equations and can be applied on different types of time scales. Some examples are worked out to demonstrate the main results.

• 한국기계연구소 소보
• /
• s.20
• /
• pp.57-63
• /
• 1990

The morphologies of MC carbides (M stands for metal) and creep-rupture properties in directionally solidified Rene 80 having standard and Hf-modified chemistries were studied. It was found that Hf depressed the melting point, $\gamma$- $\gamma$’ eutectic temperature and $\gamma$’ solvus of nickel-base superalloy Rene 80, but did not depress MC carbide forming temperature. The morphologies of MC carbides depended upon solidification sequence, which led to blocky type in the early stage and script type in the late stage of solidification. Creep failure occurs through the crack initiation at the transverse components of longitudinal grain boundaries or interdendritic carbides in directionally solidified superalloys. It could be concluded MC carbide morphologies played an important role in creep properties of DS superalloys, that is, Hf additions increased the creep ductilities and lives of Rene 80.

• The korean journal of orthodontics
• /
• v.23 no.2 s.41
• /
• pp.229-248
• /
• 1993

[ $Interferon-\gamma$ ] has been suggested as a cytokine of connective tissue stabilizer. In addition, it has also been demonstrated that this cytokine inhibited bone remodeling activities of the bone derived cells. In order to illuminate the effects of this cytokine in orthodontic force induced bone remodeling, it was administered to primary cultured periodontal ligament cells which have been known to have some osteoblast like characteristics. $Interferon-\gamma$ slightly decreased $[^3H]thymidine$ incorporation rate without a significant change in the total cellular DNA content up to 1000 U/ml, which meant these doses were not cytotoxic to the cell. Total protein synthesis was not influenced by various concentration of interferon-y whether it was determined by the $[^3H]proline$ incorporation rate or by the Lowry smethod. The effect of $interferon-\gamma$ on the individual protein was, however, differential, ie, it increased $[^3H]proline$ incorporation into the noncollagenous protein marginally, while it decreased $[^3H]proline$ incorporation into the collagen, so that it caused dose-dependent suppression of the relative collagen synthesis. On the contrary, the fibronectin synthesis determined by the ELISA was increased by 1000 U/ml of $interferon-\gamma$. The differential effects of the interferon-y on the collagen and fibronectin synthesis exhibited not only their protein level but also the steady state mRNA level. $Interferon-\gamma$ decreased steady state level of ${\alpha}1(I)$ procollagen mRNA significantly, while showing no significant changes in the fibronectin mRNA level. In addition to this, it was also found that indomethacin did not affect on the $interferon-\gamma$ induced collagen decrease in this cell, which meant prostaglandins were not involed in the process of $interferon-\gamma$ induced collagen decrease. So it can be concluded that the incubation of periodontal ligament cells with 1000 U/ml of $interferon-\gamma$ for 24 hr showed differential effects on the type I collagen and fibronectin gene expression. The decrease in relative collagen synthesis in the protein level was related with decrease in the steady state level of mRNA, while the increase in the fibronectin synthesis in the protein level was not correlated with the mRNA level.

• Proceedings of the Korean Powder Metallurgy Institute Conference
• /
• 2001.11a
• /
• pp.10-10
• /
• 2001

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.21 no.1
• /
• pp.223-228
• /
• 2017

In this paper, we are proposing an optimal design of wideband pulsed type gamma-ray sensors. These sensors were manufactured based on the design results and after word electrical properties were analyzed. The sensor input parameters were derived on the basis of pulsed gamma-ray spectrum and time-dependent energy rate, and the output current which were derived on the basis of the sensor sensitivity control circuit. Pulsed gamma-ray sensors were designed using the TCAD simulators. The design results show that the optimal Epi layer thickness is 45um with the applied voltage 3.3V and the diameter is 2.0mm. The doping concentrations are as follows : N-type is an Arsenic as $1{\times}10^{19}/cm^3$, P-type is a Boron as $1{\times}10^{19}/cm^3$ and Epi layer is Phosphorus as $3.4{\times}10^{12}/cm^3$. The fabricated sensor was a leakage current, 12pA at voltage -3.3V and fully depleted mode at voltage -5V. A test result of pulsed radiation shows that the sensor gives out the optimal photocurrent.