• Journal of Nutrition and Health
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• v.32 no.4
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• pp.353-368
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• 1999

This study was performed to investigate the effects of Korean native plant diets on lipid and cadmium (Cd) metabolisms and also antioxidative enzyme activities in rats. Seventy male Sprague-Dawley rats weighing 210.3$\pm$2.7g were blocked into ten groups according to body weight. Rats were raised for four weeks with diets containing 0 or 0.04%(w/w) cadmium chloride and 5%(w/w) plant powder-Ssook(Artemisia princeps var. orientalis HARA), Chamchwi(Aster scaber THUNB), Gomchwi(Lingularia fischeri TUBCZ). or Solbeerum (Portulaca oleracea LINNE). Food intake, weight gain, food efficiency ratio, and weights of liver, kidney, spleen and epididymal fat were significantly lower in Cd-exposed groups, food efficiency ratio, and weights of liver, kidney, spleen and epididymal fat were significanlty lower in Cd-exposed groups. Plasma total lipid level, liver total lipid, cholesterol and triglycerde concentrations, and fecal total lipid, cholesterol and triglyceride excretions were decreased by Cd administration. Total lipid and triglyceride concentration in plasma and liver were lower in Chamchwi groups together with increased fecal total lipid and triglyceride excretions. Cholesterol concentration in plasma and liver were lower in Gomchwi groups with increased fecal cholesterol excretions. Activities of red-blood-cell superoxide dismutase(SOD), and liver catalase, SOD and glutathione peroxidase (GSH-px) were decreased significantly by Cd administration. Thiobarbituric acid reactive substance(TBARS) concentrations of plasma and liver were increased by Cd administration. Thiobarbituric acid reactive substance(TBARS) concentration of plasma and liver were increased by Cd administration. Administration of plant diets decreased plasma and liver catalase, SOD and GSH-px activities in Cd-free diet groups and increased them in Cd-administered groups. Plasma and liver TBARS concentrations were decreased in animals fed plant diets, with Chamchwi showing the most effective antioxidative capacity. The concentration of Cd accumulated in blood and tissue decreased in Cd-exposed groups fed plant diets. Liver Cd concentration were lower in the Chamchwi and Gomchwi groups, and kidney Cd levels were lower in the Ssook and Chamchwi groups. Among them, Chamchwi was the most effective in Cd detoxification. In conclusion, Chamchwi and Gomchwi were effective in lowering tissue lipid levels, with Chamchwi having the greatest antioxidative and detoxifying effects.

• Journal of the Korean Society of Food Science and Nutrition
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• v.17 no.4
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• pp.336-340
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• 1988

This study was performed to investigate the influence of mixtures of 0(control), 1, 2 and 3% ethanol and water respectively on growth and various blood parameters of growing broiler chicks. At the end of the 7 weeks' experiment, body weight gain in 1% ethanol group and liver weight in 3% ethanol group were significantly higher than those of control group. It was found that the levels of red blood cell, hemoglobin, hematocrit, and serum protein were within normal ranges. Serum GOT and r-GTP activities were significantly increased in 2 and 3% ethanol groups compared with those in control group. But serum CPT activity was slightily decreased in all ethanol groups. Serum LDH activity was increased in all ethanol groups compared with that In control group. Serum alkaline phosphatase was not affected by the ethanol. Serum glucose concentration in 3% ethanol group was significantly lower than that in control group.

• Journal of Conservation Science
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• v.29 no.3
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• pp.243-247
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• 2013

This study was conducted to investigate the penetration of PEG for conservation treatment conditions of archaeological waterlogged wood. The weight percent gain was examined, depending on the solvent of PEG, concentration and treatment period and temperature of treatment solutions. The penetration of PEG in the cell lumina of treatment woods was observed by scanning electron microscope. The results showed that the type of solvents had no influence on PEG penetration. In the concentration of the PEG treatment solutions, the weight percent gains (WPGs) were increased with increase in concentration of PEG. In terms of the period of the soaking treatment, a maximum WPGs were obtained for only 20 days. There was no distinctive difference in the WPGs by difference the temperature of the treatment. In conclusion, in the conservation of small size of archaeological waterlogged wood, it is confirmed that optimal solvent type and treatment period of PEG are water and 20 days, respectively.

• Biomolecules & Therapeutics
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• v.10 no.1
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• pp.59-69
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• 2002

Recently, recombinant human erythropoietin (rHu-EPO) has been used to treat various types of anemia. YHB216 is a new rHu-EPO developed by Yuhan Research Institute. In this study, we investigated the single dose and 4-week repeated dose toxicity of YHB216 in Beagle dogs. In the single dose toxicity study, YHB216 was administered intravenously at single dose levels of 0 and 25,000 IU/kg to dogs (2 dogs/sex/group). There were no treament-related changes in survivals, clinical signs, body weight gain, hematological values, blood chemical values, and necropsy finding during experimental period. In the repeated dose toxicity study, YHB216 was administered intravenously to dogs for 4 weeks at the dose levels of 0, 100, 500, and 2,500IU／kg (3 dogs/sex／group). There were no toxicologically significant changes in clinical signs, body weights, food and water consumptions, ophthalmoscopy, urinalysis and blood chemistry. There were increased values of red blood cell, hemoglobin, and hematocrit at all treated groups. Spleen revealed increased weight and extramedullary hematopoiesis at 500 IU/kg or more. These changes are all considered to be Pharmacology-related effects and were recovered after 4-week recovery period. From these results, it is concluded that LD50 value was above 25,000 IU/kg in the single dose toxicity study of YHB216 in dogs and the no observed adverse effect level (NOAEL) was 100 IU/kg day in the repeated dose toxicity study of YHB216 in dogs.

• Korean Journal of Veterinary Research
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• v.34 no.2
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• pp.275-286
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• 1994

Plasma protein which has been known as one of nonspecific immunostimulators was added to feedstuff to examine its effect on the enhancement of cellular immune response in porcine immune system. A total of 40 piglets, 20 male and 20 female each, were fed for 30 days with or without plasma protein. The peripheral blood were collected and analyzed for the investigation of leukocyte subpopulations and their activities by using a panel of monoclonal antibodies specific to porcine leukocyte differentiation antigens and flow cytometry. The results obtained as follows. 1. Total weight gain, daily feed intake and feed conversion rate for 10 days were significantly improved to 56%, 20% and 22% in the piglets fed plasma protein, respectively. 2. A significant increase in N (null or non T/non B) cells was also noticed. Leukocyte proportion from piglets fed plasma protein was 20.2-24.7%, otherwise that from piglets fed without plasma protein was 12.3-13.4%, respectively. 3. A significant increase in the proportion of B cells and cells expressing poCD1 was not found in piglets fed plasma protein. 4. Reaction with monoclonal antibodies specific to adhesion molecules, poCD11a, poCD11b, poCD44 and poCD45A and poCD45B, has shown that leukocyte subpopulation from piglets fed plasma protein did not significantly higher than that from piglets fed without plasma protein. 5. Total proportion of granulocytes and monocytes was about 50% in both group and the proportion after treated with Hypaque/Ficoll was 2.7% and 5.8% in each group, respectively.

• Genomics & Informatics
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• v.5 no.3
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• pp.102-106
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• 2007

Radiofrequency (RF) radiation at the frequency of mobile phones has been not reported to induce cellular responses in in vitro and in vivo models. We exposed HEI-OC1, conditionally-immortalized mouse auditory cells, to RF radiation to characterize cellular responses to 1763 MHz RF radiation. While we could not detect any differences upon RF exposure, whole-genome expression profiling might provide the most sensitive method to find the molecular responses to RF radiation. HEI-OC1 cells were exposed to 1763 MHz RF radiation at an average specific absorption rate (SAR) of 20 W/kg for 24 hr and harvested after 5 hr of recovery (R5), alongside sham-exposed samples (S5). From the whole-genome profiles of mouse neurons, we selected 9 differentially-expressed genes between the S5 and R5 groups using information gain-based recursive feature elimination procedure. Based on support vector machine (SVM), we designed a prediction model using the 9 genes to discriminate the two groups. Our prediction model could predict the target class without any error. From these results, we developed a prediction model using biomarkers to determine the RF radiation exposure in mouse auditory cells with perfect accuracy, which may need validation in in vivo RF-exposure models.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.6
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• pp.1514-1525
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• 1998

Two main characteristics of VBR MPEG video traffic are different statistics according to different picture types and the periodic traffic pattern due to GOP structure. Especially, the I-pictures at the beginning of each GOP generate $$\mu$h more traffic than other pictures. When several VBR Mpeg video sources are superposed, the I-picture starting times of these sources may significantly affect the cell loss characteristics of ATM $$\mu$tiplexers. In this paper, we propse a performance model for ATM $$\mu$tiplexers with VBR MPEG video sources whose starting times are arbitrary given. For analysis, both single and superposed source traffic are modeled as NDPPs (non-deterministic periodic processes), and the ATM $$\mu$tiplexer is modeled as a U-state NDPPD/D/1/B queueing system. It is hown that the numerical results are very close to the si$$\mu$ation results. From the relationships between the starting tiem distributions and the corresponding $$\mu$tiplexer performances, some considerations for designing a scheduling policy in order to obtain the maxi$$\mu$ $$\mu$tiplexing gain are presented.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.8A
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• pp.785-793
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• 2007

This paper presents the digital signal processing submodule of a 100Base-TX Ethernet receiver to support 100Mbps at TP cable channel. The proposed submodule consists of programmable gain controller, timing recovery, adaptive equalizer and baseline wander compensator. The measured Bit Error Rate is less than $10^{-12}BER$ when continuously receiving data up to 150m. The proposed signal processing submodule is implemented in digital circuits except for PLL and amplifier. The performance improvement of the proposed equalizer and BLW compensator is measured about 1dB compared with the existing architecture that removes BLW using errors of an adaptive equalizer. The architecture has been modeled using Verilog-HDL and synthesized using samsung $0.18{\mu}m$ cell library. The implemented digital signal processing submodule operates at 142.7 MHz and the total number of gates are about 128,528.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.6
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• pp.648-653
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• 2011

In this paper, coordinated space division multiple access(SDMA) technology is proposed to mitigate inter-cell interference by using partial channel state information in cooperative wireless communications system with limited feedback. Each AT selects an optimal cluster transmission mode and sends it back to a cluster scheduler, and at the cluster scheduler, ATs are scheduled within a AT group with the identical cluster transmission mode, and the optimal transmission mode and the corresponding scheduled ATs are determined to maximize scheduling priority. Also, in order to enhance multiuser diversity gain, an extended transmission feedback method is proposed to feed back multiple preferred cluster transmission modes at each AT. It is shown that the proposed coordinated SDMA scheme outperforms existing non-coordinated SDMA schemes in terms of the average system throughput.

• Korean Journal of Acupuncture
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• v.24 no.1
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• pp.113-129
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• 2007

Objectives : This research was performed to investigate the effect of acupuncture using invasive low level laser therapy (LLLT) at Yolgyol (LU7) + Yogu (LR5) on weight gain, food intake, food efficiency, lipid metabolism, atherogenic index, HTR (HDL-cholesterol to total cholesterol ratio) and morphological change of hepatic tissue in hyperlipdemia rats. Methods : Experimental groups were divided into high fat diet group (Control group), high fat diet and acupuncture therapy group at LU7 + LR5 (AT group), high fat diet and acupuncture group using 10 mW LLLT at LU7 +LR5 (LA10 group), high fat diet and acupuncture group using 20 mW LLLT at LU7+LR5(LA20 group), high fat diet and acupuncture group using 60 mW LLLT at LU7 + LR5 (LA60 group), once per 3 days during 9 weeks. Results : Body weight was decreased significantly in AT and LA20 groups compared with Control group. Food intake was increased significantly in LA60 group compared with Control group. Food efficiency was decreased significantly in LA10, LA20 and LA60 groups compared with control group. In the lipid metabolism, total cholesterol was decreased significantly in AT, LA10, LA20 and LA60 groups, triglyceride was decreased significantly in LA10, LA20 and LA60 groups, TG/HDL-cholesterol ratio was decreased significantly in LA 60 group compared with control group. In the morphological change, hepatic tissue were not showed balloning degeneration and irregular arrangement of hepatic cell in LA10 and LA20 groups with control group. Conclusions : Acupuncture using LLLT at LU7+LR5 can manage hyperlipemia by controlling body weight, food intake, food efficiency ratio and lipid metabolism.