• Journal of IKEEE
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• v.11 no.1 s.20
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• pp.69-76
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• 2007

This paper presents the design of LVDS (Low-Voltage-Differential-Signaling) transmitter for Gb/s-per-pin operation. The proposed LVDS transmitter is designed using BiCMOS technology, which can be compatible with CMOS technology. To reduce chip area and enhance the robustness of LVDS transmitter, the MOS switches of transmitter are replaced with lateral bipolar transistor. The common emitter current gain($\beta$) of designed bipolar transistor is 20 and the cell size of LVDS transmitter is $0.01mm^2$. Also the proposed LVDS driver is operated at 1.8V and the maximum data rate is 2.8Gb/s approximately In addition, a novel ESD protection circuit is designed to protect the ESD phenomenon. This structure has low latch-up phenomenon by using turn on/off character of P-channel MOSFET and low triggering voltage by N-channel MOSFET in the SCR structure. The triggering voltage and holding voltage are simulated to 2.2V, 1.1V respectively.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.1
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• pp.59-66
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• 2011

In this paper, a co-planar waveguide(CPW)-fed zeroth-order resonant(ZOR) antenna with an improved radiation efficiency was built and tested. The unit cell of the proposed antenna consists of a series metal-insulator-metal(MIM) capacitor and a shorted shunt stub inductor. In order to reduce the antenna size and to achieve the high radiation efficiency two shorted shunt stub arms bent by 90 degree were connected to the ground plane through the via. The proposed antenna consisting of two unit cells has an open ended composite right/left-handed(CRLH) transmission line structure. As a result the dominantly radiating parts of the antenna comes from shunt stub arms and vertical vias. The total size of the fabricated zeroth-order resonant antenna is $0.22\;{\lambda}_0{\times}0.22\;{\lambda}_0$. The measured gain and efficiency of the fabricated antenna have been enhanced by 3.07 dBi and 75 %, respectively, at the zeroth-order resonant frequency of 2.97 GHz.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.4
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• pp.718-723
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• 2017

We propose a pilot hopping scheme that improves the limited system capacity due to pilot contamination in multi-cell environment with large-scale antenna arrays at a base station, assuming the infinite number of antennas. In the conventional fixed pilot scheme, each user obtains the same signal-to-interference ratio (SIR) over a long period of time. Therefore, a user with strong interference has continuously low SIR which degrades its service quality. In the proposed pilot hopping scheme, different pilot signals are used for each time slot, and different amounts of interference are received every time. When such a pilot hopping technique is applied, the SIR fluctuates at every time slot. When the Hybrid Automatic Repeat & reQuest (HARQ) technique is applied in such a channel, the outage probability and transmission rate are improved. We show that there is the performance gain of the proposed scheme over the conventional scheme through computer simulations.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.42 no.1
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• pp.111-118
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• 2005

The shape of vertical pattern of base station antenna affects greatly quality of the communication of not only a service zone but also adjacent cells and then it is an important point to be considered in designing cell coverage. Currently type of vertical patterns to be applied to base station antenna are divided into five classes. In designing antenna, these five classes are applied solely or compositely according to the environment to be used antenna. In this paper, the dual polarized antenna for base station that is with a continuous electrical down tilting and with a shaped beam pattern, that an upper side lobe is suppressed and a lower null is filled, is designed and fabricated for synthesizing of the shape beant the pattern synthesis methods proposed by R. S. Elliott is used sequentially and for the electrical don tilting, the phased array theory is applied. Measured results show the down tilting range from 0° to 14°, the gain of Min. 13.3dBi and the upper side lobe of Max. -23dB. And we verified that upper side lobe is not to vary greatly and null filling performance is favorable overall.

• Journal of the Korean Institute of Telematics and Electronics
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• v.18 no.1
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• pp.51-56
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• 1981

A new I2L process for a high performance I2L structure is proposed. The modifiedstructure consists of a heavily doped extrinsic base and lowly doped intrinsic base where the collector regions are self-alignment with the intrinsic base regions. The proposed process untilizes spin-on sources as the diffusion sources and the self-alignment of collectors is achieved by using the hardened spin-on source as a diffusion mask. Test devices including a 13-stage ring oscillator have been fabricated by the proposed process on n/n+ silicon wafers with 6.5$\mu$m epitaxial layer. The maximum upward current gain of npn transistors is 8 for a three collector I2L cell. The speed-power product and minimum propagation delay for a one collector structure are 3.5 pJ and 50 ns, respectively.

• Biomedical Science Letters
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• v.23 no.3
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• pp.261-271
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• 2017

It has been suggested that ginseng is beneficial for ameliorating the aging males' symptoms, such as weight gain, fatigue, erectile dysfunction, and depression, in elderly men with testosterone deficiency. We thus investigated the effects of Korean red ginseng (Panax ginseng C.A. Meyer; Araliaceae) on obesity in a mouse model of testosterone deficiency (castrated C57BL/6J mice). The effects of ginseng extract (GE) and/or testosterone on obesity and adipogenesis in high-fat diet (HFD)-fed castrated C57BL/6J mice and 3T3-L1 adipocytes were examined using in vivo and in vitro approaches. After feeding mice a HFD for 8 weeks, we found that mice also receiving GE and/or testosterone showed decreased body weight, adipose tissue mass, adipocyte size, and hepatic lipid accumulation compared with untreated HFD-fed mice. Expression of adipogenic genes ($PPAR{\gamma}$, $C/EBP{\alpha}$, and aP2) was decreased by GE and/or testosterone in adipose tissues. Consistent with the in vivo data, lipid accumulation and the mRNA expression of adipogenesis genes in 3T3-L1 adipocytes were decreased by GE, ginsenosides, and testosterone. The inhibitory effects of GE (or ginsenosides) were comparable to those of testosterone, and the effects of co-treatment with GE (or ginsenosides) and testosterone were greater than those of testosterone alone in vivo and in vitro. Our results indicate that ginseng may be able to potentiate the inhibitory effects of testosterone on obesity and adipogenesis in HFD-fed castrated mice, providing possible therapeutic implications in men with testosterone deficiency.

• BMB Reports
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• v.39 no.5
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• pp.560-570
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• 2006

Mistletoe (Viscum album) lectins, which are classified as a type II ribosome-inactivating protein (RIP) due to their unique biological function and the potential medical and therapeutic application in cancer cells, receive a rising attention. The heterodimeric glycoproteins contain the A-chain with catalytic activity and the B-chain with sugar binding properties. In recent years, studies involving the lectins from the white berry European mistletoe (Viscum album) and the yellow berry Korean mistletoe (Viscum album coloratum) have been described. However, the detailed mechanism in exerting unique cytotoxic effect on cancer cells still remains unclear. Here, we aim to understand and define the molecular basis and biological effects of the type II RIPs, through the studies of the recombinant Korean mistletoe lectin. To this end, we expressed, purified the recombinant Korean mistletoe lectin (rKML), and investigated its molecular characteristics in vitro, its cytotoxicity and ability to induce apoptotic cell death in cancer cells. To gain structural basis for its catalytic activity and sugar binding properties, we performed homology modeling studies based on the high degree of sequence identity and conserved secondary structure prediction between Korean and European, Himalayan mistletoe lectins, and Ricin.

• Parasites, Hosts and Diseases
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• v.54 no.4
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• pp.447-453
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• 2016

Acanthamoeba, a free-living amoeba, is widely distributed in the environment, water sources, soil, dust, and air. It can cause keratitis in contact lens wearers with poor hygiene and also fatal granulomatous amebic encephalitis (GAE) in immunocompromised hosts. The aim of this study was to gain some insights into the distribution and genotypes of the potentially pathogenic species of Acanthamoeba present in water sources in north of Iran. Total 43 Acanthamoeba species were isolated from 77 water samples taken from different water sources within the Mazandaran province in Northern Iran (Sari city and suburbs). Isolates were identified based on cyst and trophozoite morphological characteristics as well genetics. PCR fragments corresponding to the small-subunit 18S rRNA gene were sequenced for 20 of 43 positive isolates. The results revealed that 83.3% of sequenced isolates belonged to the T4 genotype and the rest belonged to the T2 genotype. Our results indicated that Acanthamoeba is widely distributed in Sari city. As the incidence in Iran of amoebic keratitis has increased in recent years, the exact estimation of the prevalence of this amoeba and its predominant genotype may play a crucial role in prevention of the disease. Sari city has several rivers, seashores, and natural recreational amenities, which attract visitors during the year. This is the first report of Acanthamoeba genotypes from water sources in Sari city, Mazandaran province of Iran, and the results suggest that more attention is needed to protect the visiting population and immunocompromised individuals.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3741-3745
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• 2012

Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the most common form of liver cancer. However, while it is associated frequently with hepatitis C virus (HCV) there is only an elementary understanding of its molecular pathogenesis. Methods: To gain insight into the molecular mechanisms of HCV-induced hepatocarcinogenesis, we performed microarray analysis on 75 surgical liver samples from 48 HCV-infected patients. Results: There were 395 differentially expressed geness between cirrhotic samples and HCC samples. Of these, 125 genes were up-regulated and 270 genes were down-regulated. We performed pathway enrichment analysis and screened as described previously. Conclusions: The differentially expressed genes might be involved in hepatocarcinogenesis through upregulating the pathways of ECM-receptor interaction, focal adhesion, cell adhesion molecules and other cancer-related pathways, and downregulating the pathways of "complement and coagulation cascades". We hope our results could aid in seeking of therapeutic targets for HCV-induced hepatocellular carcinoma.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.12
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• pp.36-42
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• 2009

This paper proposes the high-performance pipeline architecture for modified Booth multipliers. The proposed multiplier circuits are based on modified Booth algorithm and pipeline architecture which are the most widely used techniques to accelerate the multiplication speed. In order to implement the optimally pipelined multipliers, many kinds of experiments have been conducted. The experimental results show that the speed improvement gain exceeds the area penalty and this trend is manifested as the number of pipeline stages increases. It is also important to insert the pipeline registers at the proper positions. We described the proposed modified Booth multiplier circuits in Verilog HDL and synthesized the gate-level circuits using 0.13um standard cell library. The resultant multiplier circuits show better performance than others. Since they operate at GHz ranges, they can be used in the application systems requiring extremely high performance such as optical communication systems.