• 한국초지조사료학회지
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• 제26권2호
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• pp.105-112
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• 2006

본 시험은 페레니얼라이그라스 위주 초지에서 목초 및 잡초의 건물중의 분포와 기능 및 목초와 잡초간 경합에 의한 상호작용을 조사하였다. 페레니얼라이그라스 위주 초지를 조파조성 및 조파 조성후 보파 관리하여 연 3회 예취와 방목이용하고 이 초지에서 발생량이 많은 잡초인 냉이, 바랭이와 피에 대하여 조파 및 보파한 채초지와 방목지에서 목초와 각 잡초간 상호작용을 측정하였다. 목초와 잡초간 상호작용의 측정을 위해 기대수량(expected yield : P), 상대지수(relative yield total : RYT), 보상지수(compensation index: CI) 및 형태지수 (morphological index: MI) 등 지수(Index)를 도입하였다. 도입된 이들 지수의 측정은 봄, 여름 및 가을의 각 예취 직전에 이루어졌는데 측정된 각 지수는 각 처리구별 예취 시기별 및 잡초 종류 따른 차이와 변화가 인정되었다. 기대수량의 경우 가을 이용시기에 보파에 의해 약간 증가하였으나 상대수량에 있어 0.17에서 0.41 범위에 있어 크게 개선되지는 않는 것으로 나타났다. 보상지수는 -0.3에서 -0.6 범위로 모두 과소보상(+, --)으로 나타나 잡초에 의한 수량감소가 크게 이루어진 것으로 나타났다. 페레니얼라이그라스 위주 초지에서 보상지수를 감소시키는 주요 잡초인 바랭이, 피의 경우 방목이용에 따른 페레니얼 위주 초지의 개선효과 보다 조파 및 조파 후 보파관리에 의한 개선효과는 크지 않았다.

• 인지과학
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• 제18권2호
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• pp.159-178
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• 2007

Lee와 Kang (2002)은 이중과제 수행동안 음운회로의 시연이 곱셈 수행을 유의하게 지연시키지만 뺄셈의 수행을 지연시키지는 못함을 보여주었다. 반면 심상을 유지하는 것은 뺄셈 수행을 지연시키지만 곱셈의 수행에는 영향을 미치지 않았다. 이 결과는 산술연산이 작업기억의 하부체계 특정적인 방식으로 관련있음을 보여준다. 본 연구의 목적은 기능자기공명영상기법을 이용하여 Lee와 Kang이 얻은 결과의 신경기반을 검토하는 것이었다. 이 목적을 위해 억제를 요구하는 이중과제 조건과 억제를 요구하지 않는 이중과제 조건에서의 뇌활성화 양상을 비교하였다. 두 조건이 모두 이중과제 조건이었음에도 불구하고 간섭조건이 비간섭조건에 비해 더 활성화되는 영역들이 관찰되었다. 더 중요한 사실은 음운억제조건에서 우측 하전회(inferior frontal gyrus), 좌측 각회(angular gyrus), 그리고 하정소엽(inferior parietal lobule) 등의 영역이 활성화 된 것에 비해, 시각억제조건에서 활성화된 영역은 우측 상측두회(superior temporal gyrus)와 전대상회 (anterior cingulate gyrus)였다 억제조건에서의 결과와 달리 음운 비억제 조건에서 활성화된 영역은 우내측 전두회 (medial frontal gyrus), 좌측 중전두회 (niddle frontal gyrus)와 양측의 내측전두회 (medial frontal gyrus)였으며, 시각 비억제 조건에서는 전대상회, 그리고 해마이랑(parahippocampal gyrus)의 영역이 활성화되었다. 이러한 결과는 처리 부호를 공유할 때 야기되는 간섭을 억제하는 것의 신경기반이 과제의 양상에 의존적임을 보여준다.

• Journal of Pharmaceutical Investigation
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• 제33권2호
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• pp.113-120
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• 2003

Drug interactions with food, on occasion, lead to serious nutritional and functional changes in the body as well as alternations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increased risk of micovascular, macrovascular, and neuropathic complications. However, the precise mechanism of diabetes mellitus remains unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo- or hyperglycemia and preventing complications. The purpose of this study was to investigate thε effect of Laminaria japonica diet on the absorption, distribution, metabolism and excretion of glipizide which are frequently used in the treatment of diabetes. Diabetic rats induced by streptozotocin were employed in this study. Blood concentrations of oral hypoglycemic agents were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as $k_{a},\;t_{1/2},\;C_{max},\;t_{max}$ and AUC. Administration of glipizide in normal rats treated with Laminaria japonica diet showed significant increase in AUC, $k_{a},\;t_{1/2},\;t_{max}$ and decrease in $C_{max}$, compared to those without Laminaria japonica diet. This might result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption. Administration of glipizide in diabetic rats treated with Laminaria japonica diet showed significant increase in $t_{1/2}\;and\;t_{max}$, and decrease in $C_{max}$, compared to those without Laminaria japonica diet. This might also result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption and flattened blood concentration of glipizide. The oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of glipizide caused by long-term Laminaria japonica diet.

• 만화애니메이션 연구
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• 통권40호
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• pp.337-365
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• 2015

본 연구의 목적은 소셜네트웍게임에서 사용자 중독에 대한 새로운 모델을 제안하고자 한다. 본 모델은 논리적 특성과 정서적 특성에서 유래한다. 논리적 특성은 기능(F), 키스트록(K), 목표(G)로 구성된다. 정서적 특성은 감정(E), 사교(S), 감성(A)으로 구성된다. 30명의 참가자를 통해서 예비조사를 실시하여 설문문항의 적합성, 대략적인 모형의 타당성 및 연구의 방향성 등을 점검하였다. 이후 본 연구에서 300명의 피험자를 대상으로 조사를 실시하였다. 그중 261명만 채택하였다. 왜냐하면 39명은 SNG 게임을 전혀 해보지 않았으며 설문 응답에 불성실하게 이행하여 본 연구에서 제외하였다. 본 연구는 부분최소자승-구조방정식모델링 기법을 활용하여 가설검증을 하였다. 그 결과 모형적합도가 높게 나타났으며 12가지 가설 가운데 11가지가 유의미한 효과가 발생하였다(H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H12). 그러나 유일한 가설 H11인 소셜네트워크중독과 키스트록 간에는 유의미한 효과가 발생하지 않았다. 본 연구는 소셜네트워크게임 개발을 위한 사용자 행동을 이해하며 중독의 기저를 밝히는데 기초가 되는 탐색적 연구가 될 것으로 기대된다.

• 유통과학연구
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• 제11권12호
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• pp.51-62
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• 2013

Purpose - A pre-study on service quality-based customer value is conducted with the path structure (perceived value of service quality→customer satisfaction→behavior intention) based on the hierarchical model of service quality including interaction and outcome quality, physical environment quality and the SERVQUAL model of process quality, namely, reliability, responsiveness, assurance, empathy, and tangibles. In addition, customer value in the service industry is studied by dividing into the two-way structure of utilitarian and emotional values. This study classifies customer values of family restaurants through the customer value model based on the 4×4 matrix needs system of Jeon and Kim (2009). It illustrates the path structure of customer value→customer satisfaction→behavior intention targeting college students in order to generalize the customer value system of family restaurants. Research design, data, and methodology - This study established seven hypotheses based on the relationship between each type of customer value (food quality, convenience, social, emotional, interior quality, service encounter, and purchasing) and customer satisfaction, and the relationship between customer satisfaction and behavior intention. The study data were collected from students in the Department of Business and Tourism at Kimpo University. In all, 294 survey papers were returned of the 300 distributed: 253 pieces were used in the final analysis excluding 41 with insufficient and less effective answers. For statistical analysis, the statistics software package SPSS 15.0 was used. Results - The results of the analysis are as follows: first, the customer values of family restaurants are classified by seven customer values: goods quality value, emotional value, convenience value, social value, purchasing value, service encounter value, and inner quality value. Second, emotional value, purchasing value, service encounter value, and inner quality value had positive impact on customer satisfaction. In particular, purchasing value through being included in functional value was not classified in the previous study; however, this study could classify and generalize this value in a new way. Finally, customer satisfaction had a positive impact on behavior intention. This showed that college students had behavior intention - repurchase intention and word-of-mouth - because they could be content with the food items on the menu and the service provided by employees. Conclusions - The main points based on the above-mentioned results are as follows. This study with college students as study subjects could be classified into four dimensions, namely, generic value, usage value, purchasing value, and physical value and seven sub-dimensions on customer values of family restaurants based on a 4×4 matrix needs system. Then, to confirm its generalization, the path structure of customer value→customer satisfaction→behavior intention was verified. While existing pre-studies used simplified values by classifying restaurant values largely as utilitarian value and hedonic value, this study classified various forms of customer value, and that customer value especially could be expanded by adding purchasing value. As a result, it is shown that marketers need to diversify their customer services because this study proved that customer values can be classified in various ways based on customer needs.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권4호
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• pp.355-362
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• 2000

Neoplastic growth is characterized by alterations of oncogenes and antioncogenes. The interaction between activated oncogenes and functional deletion of antioncogene appears to be the driving force directing normal cells to uncontrolled growth resulting in tumor. In addition to those genes mentioned, other genes controlling the entry of cells into the cell cycle have recently been implicated in cancer development. The overexpression of the cyclin D1 gene, which has been mapped to 11q13, either by gene rearrangement or amplification has been noted in various malignant tumors. The product of the cyclin D1 gene forms a complex with cyclin-dependent protein kinases(CDK4) that governs a key transition in the cell cycle. The relationships between the overexpression of cyclin D1 assessed by immunihistochemistry and the amplification of the cyclin D1 gene by differential polymerase chain reaction(DPCR) using primers for dopamin D2 receptor gene in 13 cases of squamous cell carcinomas of the oral cavity have been studied. The semiquantitative assay of cyclin D1 amplification has been made by cyclin D1/dopamin D2 receptor(CD/DR) ratio. The results were as follows; 1. In the normal tissue and the tumor, the CD/DR ratios were 0.82 and 1.36 respectively. This implicates 1.65-fold amplification of cyclin D1 gene in tumor compared to that in normal tissue. 2. The tumor tissue which showed overexpression of cyclin D1 by immunohistochemistry revealed 2-fold amplification of cyclin D1 compared to the normal tissue. 3. The tumor tissue which showed mild expression of cyclin D1 by immunihistochemistry revealed 1.7-fold amplification of cyclin D compared to the normal tissue. 4. The cyclin D1 was overexpressed in the tumor tissue at the rate of 38%. Above results suggest that cyclin D1 has close correlation with the development of carcinoma in the oral cavity. But further studies were needed to elucidate the carcinogeneic mechanisms by comparative studies among cyclin D1, pRb and p53.

• 대한가정학회지
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• 제17권4호
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• pp.117-127
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• 1979

This study attempts to shed additional light on the national diffusion process and interaction of welfare services for children and mothers. The central hypothesis examined is the following : In general, the implant of social welfare system is first considered on the characteristics of their own socio-economics , and diffusion prodess of welfare services tends to occur faster in countries with open sicieties than in countries where entry barriers are high and society ranking rigid. The scope of the study is limited in several ways. Attention is concentrated on the agency of woman in the belief that an in-depth case study of one field can yield more insight than a less detailed investigation embracing a number of social welfare systems. The angency of woman is selected for several reasons. a) It is important the agency of woman alone produce more effective than services affecting both the child welfare and women's libertion bradually. Moreover, these services will form the heart of mother's welfare. b) The services of women's agency is gradually wide spread, since a role of government is still negligible before a full realization of economic income. c) The services of women agency is a prime example of a social welfare. d) statistical data and other information are more readily available. One of major findings of our study is the existence of the barriers inhibiting child welfare form " motherhood cult". Despite all the distinct advantages for mother and child , social attitudes appear to be some resistant on child welfare system among men and women even the agenices of women. What is surprised is the extent of the awareness that strategies of women's agency to liberate woman and to increate activities of women involve the strategies to liberate child. The conviction that solving application problems for child welfare in line with the activities of agency by women offer greater freedom and more advantage to mother are not apparent on the data collected from 18 of multi-functional agencies in our country. there are little sign that such agencies cooperate toward attainment of common goals. The intensive early focus of the movement on consciousness raising is a necessary beginning and such efforts by women's organizations would help both in the continuous evolution of women and child. Some of the agencies offer a variety of services to women and children, others are specialized in that they offer fewer services or even only one. Social welfare agenices giving service to children and their families are identified by various names usually women service and child welfare from govern , mental agency and voluntary public agency to foreign aided. What is totally missing , however, is an integrated synthesis of child welfare program Through women's agency. Social changes to occur, but delineation of appropriate and comprehensive social policy is also necessary at this point at this point since efforts, social changes and polices must be well coordianted and focused, as well as mutually supprotive and reinforcing.

• 한국항공우주학회지
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• 제48권2호
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• pp.135-146
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• 2020

경계면을 정의하는 기존의 레벨-셋 기법은 대개 수학적인 수식을 이용한다. 그러나 3차원 데카르트 좌표계에서 복잡한 경계면을 수식으로 설정하는 방식은 거의 불가능하다. 이러한 이유로 우리는 보편적으로 사용되는 스테레오리쏘그래피(STL) 형식을 매개 변수화하여 3D 캐드 형상의 내부와 외부를 구분하는 레벨-셋 경계면 설정 알고리즘을 개발하였다. 본 논문은 반응막대 실험 모사를 통해 기존의 경계면 설정 방식과 새로운 경계면 설정 방식 결과와 비교하여 이 알고리즘이 적용된 하이드로 다이내믹 솔버의 타당성을 확보하였다. 이를 통해 가연성 기체로 채워진 다양한 형상 안에서 충격파와 상호작용이 연소 폭발 천이 현상에 미치는 영향을 수치적으로 해석하였다. 또한, 실제 크기의 공장 설비에서 화염이 퍼져나가는 과정과 데토네이션 발생이 설비에 미치는 피해를 수치적으로 예측하는 시뮬레이션을 진행하였다.

• 대한한의학회지
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• 제35권1호
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• pp.50-57
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• 2014

Objectives: The purpose of this study was to examine whether Temporomandibular Joint Balance Appliance-Golf (TBA-G) can improve postural control ability of healthy adults. Methods: Twenty participants (10 male, 10 female) aged 20 to 39 years were involved. Postural control ability of all participants was assessed before and after applying TBA-G with Balance $Master^{(R)}$ system. Modified clinical test sensory interaction on balance (mCTSIB), unilateral stance, weight bearing and rhythmic weight shift were used to evaluate postural control ability. Results: After applying TBA-G, mCTSIB on a firm plate with eyes open increased from 0.2 to 0.23 (p<0.05) but directional control was improved in slow and moderate velocity of front/back rhythmic weight shift test (P<0.05). In two cases with postural imbalance, most of the postural control measures improved after applying TBA-G. Conclusions: The results suggest that TBA-G could improve balance control ability. A larger controlled trial is needed to determine more accurately the effect of TBA-G on balance control ability.

• 생명과학회지
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• 제20권2호
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• pp.298-303
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• 2010

본 연구에서는 발아 후 2일된 옥수수 유식물의 뿌리 생장에 미치는 영향을 조사하였다. 5 mM에서 30 mM에 이르는 CsCl을 처리하였을 때 옥수수 뿌리와 자엽초 마디 위쪽 shoot의 생중량이 감소하였다. 뿌리의 길이 생장도 역시 동일한 농도 범위의 CsCl에 의하여 감소하였는데 CsCl을 처리할 때 60 mM의 KCl을 함께 처리하면 CsCl에 의하여 감소되었던 신장 생장이 일부 회복되었다. CsCl과 KCl의 관계를 Lineweaver-Burk plot으로 분석한 결과 10 mM - 30 mM CsCl은 KCl과 경쟁 관계에 있는 것으로 나타났지만 5 mM CsCl은 경쟁관계에서 벗어나는 것으로 나타나 주변의 CsCl 농도에 따라 KCl의 작용 모드가 다른 또 하나의 메커니즘이 존재하는 것으로 사료되었다. CsCl의 농도에 따라서 KCl과의 상호작용 모드가 달라지는 현상은 CsCl에 의하여 유도되는 옥수수뿌리 정단 하부의 횡축 팽창에서도 관찰되었다. 또한, CsCl은 10 mM 이상에서 농도 증가에 비례하여 $K^+$ transporter인 ZmKUP1의 발현을 유도하였지만 5 mM CsCl의 ZmKUP1 발현 효과는 뚜렷하게 관찰되지 않았다. 한편, CsCl 존재 하에서도 근단 분열 조직의 수축은 관찰되지 않았다. 종합하면, 외부에서 처리된 CsCl은 2일된 옥수수 유식물의 뿌리의 생중량과 신장을 감소시켰으며 정단 하부의 횡축 팽창을 유도하고 ZmKUP1의 발현을 촉진하였다. 그러나 근단 분열조직의 수축은 없었으므로 CsCl의 효과는 주로 세포 팽창과 관련되는 것으로 판단되며 $Cs^+$와 $K^+$의 경쟁 및 비경쟁적 상호작용을 모두 포함하는 복합적인 메커니즘이 존재하는 것으로 사료된다.