• Journal of Information Technology Services
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• v.9 no.1
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• pp.1-25
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• 2010

Many organizations are facing larger and more frequent changes in the current economic and managerial environment. And what is more, change is supposed to be a business as usual. Considering the importance of change management process and the organizational competency to rapidly and successfully change, in this study the components of change management maturity(CMM) was selected such as the leadership, communication, resistance, people culture factor, methodology, functional group, and change review. And information system performance affected by CMM is confined to the efficiency and effectiveness of information systems. Some results from the verification of research hypotheses and the analysis of the most appropriate model was drawn out. The result of this study can be applied to all organizations which plan to manage more successful change and implement more effective information systems.

• Journal of Dairy Science and Biotechnology
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• v.28 no.2
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• pp.19-24
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• 2010

Milk components and their derivatives are a rich source of bioactive substances and play a central role in the development of functional foods. Many scientific evidences have shown that milk proteins have a biological health-promoting functionality. However, in recent times, dairy calcium and growth factors derived from milk have been misunderstood to cause diseases such as osteoporosis or cancer. This review focuses on the importance of milk-derived growth factors and some minor active components and briefly considers the emerging trends of personalized nutrition in future dairy research and development.

• Molecules and Cells
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• v.37 no.8
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• pp.569-574
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• 2014

As a scaffold, SLX4/FANCP interacts with multiple proteins involved in genome integrity. Although not having recognizable catalytic domains, SLX4 participates in diverse genome maintenance pathways by delivering nucleases where they are needed, and promoting their cooperative execution to prevent genomic instabilities. Physiological importance of SLX4 is emphasized by the identification of causative mutations of SLX4 genes in patients diagnosed with Fanconi anemia (FA), a rare recessive genetic disorder characterized by genomic instability and predisposition to cancers. Recent progress in understanding functional roles of SLX4 has greatly expanded our knowledge in the repair of DNA interstrand crosslinks (ICLs), Holliday junction (HJ) resolution, telomere homeostasis and regulation of DNA damage response induced by replication stress. Here, these diverse functions of SLX4 are reviewed in detail.

• Journal of Biosystems Engineering
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• v.30 no.6 s.113
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• pp.360-365
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• 2005

Precision agriculture attempts to improve cropping efficiency by variable application of crop treatments such as fertilizers and pesticides, within field on a point-by-point basis. Therefore, a more complete understanding of the relationships between yield and soil properties is of critical importance in precision agriculture. In this study, the functional relationships between measured soil properties and rice yield were investigated. A supervised back-propagation neural network model was employed to relate soil chemical properties and rice yields on a point-by point basis, within individual site-years. As a results, a positive correlation was found between practical yields and predicted yields in 1999, 2000, 2001, and 2002 are 0.916, 0.879, 0.800 and 0.789, respectively. The results showed that significant overfitting for yields with only the soil chemical properties occurred so that more of environmental factors, such as climatological data, variety, cultivation method etc., would be required to predict the yield more accurately.

• YAKHAK HOEJI
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• v.49 no.3
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• pp.205-211
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• 2005

The 3' UTR (3' untranslated region) plays important roles in controlling gene expression through regulating 3' polyadenylation, mRNA export, subcellular localization, translational efficiency, and mRNA stability. Changes in the 3' UTR sequence in an expressed transcript can result in functional changes of the genes that are expressed in pathological conditions compared with those genes expressed in normal physiologic conditions. A genome-wide survey of 3' UTR variation was performed for the genes expressed during hematopoietic differentiation from CD34+ stem/progenitor cells to CD 15 + myeloid progenitor cells. Wide-spread differential usage of the 3' UTR was observed from the genes expressed during this cellular transition. This study implies that the 3' UTR can be a highly coordinated region for post-transcriptional regulation of the function of expressed genes.

• YAKHAK HOEJI
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• v.47 no.3
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• pp.180-183
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• 2003

Crystal structure of TRAF6 in complex with TRAF6-binding sites from CD40 was previously determined. The structure revealed a distinct TRAF6-binding groove of CD40, the key structural determinant of interaction. The structural information leads to a proposed TRAF6-binding motif. This allows the identification of TRAF6-binding sequences in the hIRAK protein, whose functional requirement in IL-1/Toll-like receptor superfamilies-mediated signal transduction is further demonstrated using site-directed mutagenesis. The mutational effects of hIRAK on the down-stream NF-kB signaling shows the importance of the TRAF6 interface for signaling by IL-1/Toll-like receptor superfamilies.

• Molecules and Cells
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• v.25 no.3
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• pp.428-437
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• 2008

To identify transcriptional markers for beef traits related to meat tenderness and moisture, we measured the transcriptome of the Longissimus dorsi skeletal muscle in 10 Korean native cattle (KNC). We analyzed the correlation between the beef transcriptome and measurements of four different beef traits, shear force (SF), water holding capacity (WHC), cooking loss (CL), and loin eye area (LEA). We obtained non-overlapping and unique panels of genes showing strong correlations (${\mid}r{\mid}$ > 0.8) with SF, WHC, CL, and LEA, respectively. Functional studies of these genes indicated that SF was mainly related to energy metabolism, and LEA to rRNA processing. Interestingly, our data suggested that WHC is influenced by protein metabolism. Overall, the skeletal muscle transcriptome pointed to the importance of energy and protein metabolism in determining meat quality after the aging process. The panels of transcripts for beef traits may be useful for predicting meat tenderness and moisture.

• Journal of architectural history
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• v.4 no.1
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• pp.141-151
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• 1995

For many social scientists, the comparative method has been a part of the common enterprise of describing, explaining, and developing theories about socio-cultural phenomena. However, it is rare that comparison has been methodologically considered in architectural history in spite of the usefulness for understanding the similarities and differences among architectural styles. This research emphasizes the importance of comparative methodology in architectural history and proposes an example which can be introduced from the comparative method for social studies. The application in this study is based on the assumption that an architectural phenomenon is a kind of social phenomenon and comparative method in social study can be applied to architectural history. The method is to generate and test hypotheses through establishing functional correlation between variables treated as the objective facts that differentiate one type of building from another.

• Korean Journal of Computational Design and Engineering
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• v.14 no.3
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• pp.150-158
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• 2009

In these days, the importance of design becomes increasing and the design aspect that customers decide to purchase products such as television, mobile phone is more important than functional one. And the progress of virtual reality technology enables us to feel the reality from the virtual prototype as the real one. In this paper, we introduce the collaboration design review system consist of MEMPHIS, CORE. We can create a realistic virtual prototype more fastly, conveniently and efficiently using MEMPHIS and carry out the design review through collaboration using CORE. As a result of this study, it would be possible that decision making can be done effectively at early stage of the design process.

• Biomedical Science Letters
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• v.26 no.1
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• pp.1-7
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• 2020

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is expected to become more and more widespread as life expectancy increases. New therapeutic target, as well as the identification of mechanisms responsible for pathology, is urgently needed. Recently, microglial actin cytoskeleton has been proposed as a beneficial role in axon regeneration of brain injury. This review highlights in understanding of the characteristics of microglial actin cytoskeleton and discuss the role of specific actin-interacting proteins and receptors in AD. The precise mechanisms and functional aspects of motility by microglia require further study, and the regulation of microglial actin cytoskeleton might be a potential therapeutic strategy for neurological diseases.