• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 1995년도 추계학술발표회논문집(1)
• /
• pp.185-190
• /
• 1995

Conventional alarm system has many difficulties in the operator's identifying the plant status during special situations such as design basis accidents. To solve the shortcomings, an on-line alarm annunciator system, called dynamic alarm console (DAC), was developed. In the DAC, a signal is generated as alarm by the use of an adaptive setpoint check strategy based on operating mode, and time delay technique is used not to generate nuisance alarms. After alarm generation, if activated alarm is a level precursor alarm or a consequencial alarm, it would be suppressed, and the residual alarms go through dynamic prioritization which provide the alarms with pertinent priorities to the current operating mode. Dynamic prioritization is achieved by going through the system- and mode-oriented prioritization. The DAC has the alarm hierarchical structure based on the physical and functional importance of alarms. Therefore the operator can perceive alarm impacts on the safety or performance of the plant with the alarm propagation from equipment level to plant functional level. In order to provide the operator with the most possible cause of the event and quick cognition of the plant status even without recognizing the individual alarms, reactor trip status tree (RTST) was developed. The DAC and the RTST have been simulated with on-line data obtained from the full-scope simulator for several abnormal cases. The results indicated that the system can provide the operator with useful and compact information fur the earlier termination and mitigation of an abnormal state.

• Clinical and Experimental Pediatrics
• /
• 제57권11호
• /
• pp.472-478
• /
• 2014

Kawasaki disease (KD), an acute vasculitis that primarily affects young children, is the most common acquired paediatric cardiovascular disease in developed countries. While sequelae of arterial inflammation in the acute phase of KD are well documented, its late effects on vascular health are increasingly unveiled. Late vascular dysfunction is characterized by structural alterations and functional impairment in term of arterial stiffening and endothelial dysfunction and shown to involve both coronary and systemic arteries. Further evidence suggests that continuous low grade inflammation and ongoing active remodeling of coronary arterial lesions occur late after acute illness and may play a role in structural and functional alterations of the arteries. Potential importance of genetic modulation on vascular health late after KD is implicated by associations between mannose binding lectin and inflammatory gene polymorphisms with severity of peripheral arterial stiffening and carotid intima-media thickening. The changes in cholesterol and lipoproteins levels late after KD further appear similar to those proposed to be atherogenic. While data on adverse vascular health are less controversial in patients with persistent or regressed coronary arterial aneurysms, data appear conflicting in individuals with no coronary arterial involvements or only transient coronary ectasia. Notwithstanding, concerns have been raised with regard to predisposition of KD in childhood to accelerated atherosclerosis in adulthood. Until further evidence-based data are available, however, it remains important to assess and monitor cardiovascular risk factors and to promote cardiovascular health in children with a history of KD in the long term.

• 대한지역사회영양학회지
• /
• 제25권2호
• /
• pp.112-125
• /
• 2020

Objectives: Diet and incidence of chronic diseases are highly related. This study examined the characteristics of dietary safety awareness and competency for chronic disease prevention among adults. Methods: Data were collected from 247 adults in Daegu and Gyeongbuk areas using a self-administered questionnaire in May and June of 2018. Data were analyzed by frequency analysis, χ²-test, factor analysis, reliability analysis, t-test, one-way analysis of variances, and correlation. Results: The results of the factor analysis indicate that dietary safety awareness of health management was classified into chronic disease anxiety and obsession. Awareness of dietary safety management was sub-grouped into difficulty in acquiring knowledge, lack of awareness of over and malnutrition, food safety anxiety, importance of weight management, education requirement for cancer prevention, and knowledge. Dietary safety behavior composed of a balanced diet, unhealthy diet, and health-functional pursuit. Dietary safety management competency was comprised of health management, food management, and cooking. The competency scores of dietary safety management factors were significantly different according to sex, age, and education level (P < 0.05). Balanced diet factor was significantly correlated with knowledge, health-functional pursuit, health management, food management, and cooking capacity factors (P < 0.01). Conclusions: Active education for dietary safety management competency according to age, gender, and education level should provide dietary safety education to reduce anxiety and obsession regarding chronic diseases and sustainable health management.

• 에너지공학
• /
• 제26권2호
• /
• pp.12-22
• /
• 2017

국내 가동원전은 안전성 및 설비 신뢰도 제고를 위해 엔지니어링 프로그램들을 이행하고 있다. 엔지니어링 프로그램에는 설비의 정비효과를 감시하는 정비규정(MR), 예방정비 프로그램 개발 및 설비관리 우선순위 결정을 위한 기능적중요도결정(FID), 발전설비 불시정지 최소화를 위한 발전정지유발기기(SPV) 및 효율적 작업관리를 위한 기능적설비그룹(FEG) 등이 있다. 최근에 건설 중인 APR1400형 원전도 운영초기 단계부터 엔지니어링 체계 정착을 위해 고유 설계특성을 반영하여 급수공급계통의 엔지니어링 프로그램들을 개발하였으며, 향후 운영단계에서 프로그램 이행을 통해 각 프로그램의 적합성을 검증할 예정이다. 결과적으로 신규원전 고유 설계특성을 반영하여 개발한 엔지니어링 프로그램 이행을 통해 APR1400 급수공급계통의 신뢰성이 향상될 것으로 기대된다.

• Molecules and Cells
• /
• 제41권1호
• /
• pp.35-44
• /
• 2018

Mitochondria are responsible for supplying of most of the cell's energy via oxidative phosphorylation. However, mitochondria also can be deleterious for a cell because they are the primary source of reactive oxygen species, which are generated as a byproduct of respiration. Accumulation of mitochondrial and cellular oxidative damage leads to diverse pathologies. Thus, it is important to maintain a population of healthy and functional mitochondria for normal cellular metabolism. Eukaryotes have developed defense mechanisms to cope with aberrant mitochondria. Mitochondria autophagy (known as mitophagy) is thought to be one such process that selectively sequesters dysfunctional or excess mitochondria within double-membrane autophagosomes and carries them into lysosomes/vacuoles for degradation. The power of genetics and conservation of fundamental cellular processes among eukaryotes make yeast an excellent model for understanding the general mechanisms, regulation, and function of mitophagy. In budding yeast, a mitochondrial surface protein, Atg32, serves as a mitochondrial receptor for selective autophagy that interacts with Atg11, an adaptor protein for selective types of autophagy, and Atg8, a ubiquitin-like protein localized to the isolation membrane. Atg32 is regulated transcriptionally and post-translationally to control mitophagy. Moreover, because Atg32 is a mitophagy-specific protein, analysis of its deficient mutant enables investigation of the physiological roles of mitophagy. Here, we review recent progress in the understanding of the molecular mechanisms and functional importance of mitophagy in yeast at multiple levels.

• Fisheries and Aquatic Sciences
• /
• 제11권3호
• /
• pp.159-165
• /
• 2008

Intertidal benthic algal communities on the shores of Gujido and Daeyeonpyeongdo islets, Korea, were examined in October 2007. At both sites, 45 seaweeds including 7 green, 6 brown and 32 red algae were identified. The number of species at Gujido(38 species) was 1.5 times higher than at Daeyeonpyeongdo(25 species), but seaweed coverage was very similar with about 20%. Dominant seaweeds in terms of coverage and importance value were Hildenbrandtia sp., Caulacanthus okamurae, Ulva pertusa, and Gelidium amansii at Gujido and U. pertusa, Hildenbrandtia sp., Gelidium divaricatum at Daeyeonpyeongdo. The vertical distribution pattern of the seaweeds was G. divaricatum-U. pertusa, Hildenbrandtia sp.-U. pertusa, Hildenbrandtia sp., Ishige okamurae from upper to lower intertidal zone but seaweed zonations were not observed on the Gujido rocky shore. At both sites, coarsely-branched forms were the dominant functional group in species number and percent cover(among benthic algal species). The rocky shores of the two sites were dominated by crustose coralline and green algae, whose presence generally results in decreased seaweed biodiversity and community stability. Therefore, the shores of the Yeonpyeongdo islets are of considerable environmental concern and should be monitored for seaweed species composition and community structure.

• Archives of Plastic Surgery
• /
• 제47권3호
• /
• pp.277-280
• /
• 2020

Functionally, the lip serves to prevent food and drink from spilling out of the beginning of the gastrointestinal tract, and it is also used for vocalization. In addition, the lip has cosmetic importance as part of the face involved in making expressions, and in many cultures, it is considered to be sexually appealing. The results of lip reconstruction procedures must therefore be both functionally and cosmetically satisfactory. When the orbicularis oris muscle and oral mucosa are excised, functional reconstruction is prioritized. In contrast, if there are no functional problems, cosmetic reconstruction is the main focus. This case involved the reconstruction of a right upper lip defect caused by a dog bite. When the skin defect was covered with a local flap, the right angulus oris shifted medially, so we incorporated a YV flap at the right angulus oris to modify its position and allow for a cosmetically satisfactory result. We believe that this method can be used not only for cases in which asymmetry of the angulus oris is expected to occur at the time of lip reconstruction, but also for cases in which it has already occurred in the initial operation.

• Smart Structures and Systems
• /
• 제1권4호
• /
• pp.355-368
• /
• 2005

Large and complex structures are being built now-a-days and, they are required to be functional even under extreme loading and environmental conditions. In order to meet the safety and maintenance demands, there is a need to build sensors integrated structural system, which can sense and provide necessary information about the structural response to complex loading and environment. Sophisticated tools have been developed for the design and construction of civil engineering structures. However, very little has been accomplished in the area of monitoring and rehabilitation. The employment of appropriate sensor is therefore crucial, and efforts must be directed towards non-destructive testing techniques that remain functional throughout the life of the structure. Fiber optic sensors are emerging as a superior non-destructive tool for evaluating the health of civil engineering structures. Flexibility, small in size and corrosion resistance of optical fibers allow them to be directly embedded in concrete structures. The inherent advantages of fiber optic sensors over conventional sensors include high resolution, ability to work in difficult environment, immunity from electromagnetic interference, large band width of signal, low noise and high sensitivity. This paper brings out the potential and current status of technology of fiber optic sensors for civil engineering applications. The importance of employing fiber optic sensors for health monitoring of civil engineering structures has been highlighted. Details of laboratory studies carried out on fiber optic strain sensors to assess their suitability for civil engineering applications are also covered.

• PNF and Movement
• /
• 제7권1호
• /
• pp.33-46
• /
• 2009

Purpose : N.A.P.(Neuromuscular Skeletal Plasticity) an integrative neuro-orthopedic concept to facilitate motor strategies in daily life. The primary thesis is, that treatment of body functions and structural impairments should be integrated within goal-oriented activities. The purpose of this article is to demonstrate that the functional activity itself, determines the structure. Material and Methods : A case report of a dentist with brachial plexus lesion after a motor vehicle accident is presented. The necessity for training body functions within relevant tasks is undermined by references which emphasize the importance of training realistic activities to enhance long-term changes in neural representation. Results : The treatment methods presented in this case show significant effects for the patient's ability to participate in his profession within less than a year's time after his motor vehicle accident. Conclusions : Current evidence supports the treatment methods of this concept. The inability to flex his elbow and supinate his forearm placed a considerable doubt to his ability to ever be able to participate in his profession again. Structural reorganization is possible and depends on functional demands, which need to be trained task-specifically. Single case reports may serve as the basis for further randomized controlled studies to support the efficacy of the treatment methods within the N.A.P. concept.

• 한국환경성돌연변이발암원학회:학술대회논문집
• /
• 한국환경성돌연변이발암원학회 2004년도 춘계학술대회
• /
• pp.27-29
• /
• 2004

Drug transporters play an essential role in the absorption, distribution and elimination of clinical drugs, nutrients and toxicants. The importance of the transporters is exampled by therapeutic failure in cancer chemotherapy that is mainly caused by the overexpression of multidrug resistance (MDR)-related transporters. In addition, the transporters may involve in drug-drug interactions that lead to serious adverse drug responses and some transporters also contribute to inter-individual variation in drug responses. As an effort to understand the mechanism underlying the inter-individual variation of transporters activity, genetic and environmental factors influencing the expression or function of the transporters have extensively explored through last decade. Among them, genetic polymorphism of drug transporter encoding genes has generated much interest since the discovery of functional single nucleotide polymorphisms (SNP) of MDR1 gene. Besides drug transporters, xenobiotic receptors also modulate drug disposition by regulating the transcription of drug metabolizing enzymes and drug transporters. Among many xenobiotic receptors, pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two most well characterized since these receptors show wide substrate specificities and regulate the expression of various enzymes involved in drug disposition. Recently, several functional genetic polymorphisms were reported in PXR coding gene. In the present study, genetic polymorphisms of two drug transporters, MDR1 and BCRP, and two xenobiotic receptors, PXR and CAR, were investigated in Korean population.