• Genomics & Informatics
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• 제11권3호
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• pp.149-154
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• 2013

Liver enzyme elevations, as an indicator of liver function, are widely associated with metabolic diseases. Genome-wide population-based association studies have identified a genetic susceptibility to liver enzyme elevations and their related traits; however, the genetic architecture in childhood remains largely unknown. We performed a genome-wide association study to identify new genetic loci for liver enzyme levels in a Korean childhood cohort (n = 484). We observed three novel loci (rs4949718, rs80311637, and rs596406) that were multiply associated with elevated levels of alanine transaminase and aspartate transaminase. Although there are some limitations, including genetic power, additional replication and functional characterization will support the clarity on the genetic contribution that the ST6GALNAC3, ADAMTS9, and CELF2 genes have in childhood liver function.

• Molecules and Cells
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• 제39권3호
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• pp.179-185
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• 2016

Posttranscriptional regulation of RNA metabolism, including RNA processing, intron splicing, editing, RNA export, and decay, is increasingly regarded as an essential step for fine-tuning the regulation of gene expression in eukaryotes. RNA-binding proteins (RBPs) are central regulatory factors controlling posttranscriptional RNA metabolism during plant growth, development, and stress responses. Although functional roles of diverse RBPs in living organisms have been determined during the last decades, our understanding of the functional roles of RBPs in plants is lagging far behind our understanding of those in other organisms, including animals, bacteria, and viruses. However, recent functional analysis of multiple RBP family members involved in plant RNA metabolism and elucidation of the mechanistic roles of RBPs shed light on the cellular roles of diverse RBPs in growth, development, and stress responses of plants. In this review, we will discuss recent studies demonstrating the emerging roles of multiple RBP family members that play essential roles in RNA metabolism during plant growth, development, and stress responses.

• 한국농촌건축학회논문집
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• 제12권4호
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• pp.77-86
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• 2010

This study is about Tak Mok theory of feng-shui ideology which was main thought in Choson dynasty or some other thoughts and noble families' thought of garden building : planting trees and properties of the noble families garden. The result from the study of noble family's garden molding is as follows. In the noble family's garden molding, there were considerations of plant ecology known through long experience and the functional aspect of planting tree and esthetic sense of housing circumstances, in addition to feng-shui thought, Taoist thought and the doctrine of the five natural elements of the positive vs. negative. We can learn Choson's noble family's garden included playroom as well as symbolic and incantatory meaning. Also in the thought of noble family's garden molding we can found proper element for modern housing plan such as an ecological peculiarity or functional aspect of dwelling circumstance. And we can also found they didn't show a rejection symptoms against nature but enclosed with straight form which was traditional trait, and each space of it is composed organically. Also we knew they selected a diverse and refined technique with it's decorating the Choson dynasty playful and meditative space. We found that the key point of the thought of noble family's garden molding were on the basis of Confucianal mood, content amid poverty thought and free technique of it.

• 대한가정학회지
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• 제40권5호
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• pp.79-94
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• 2002

The family concepts and values are investigated in this research, using data from a sample of 999 residents aged 14 to 89 years in Seoul. The results indicate that the family concepts of the subjects imply marital and/or parent-child relationships with normative gender role. People tend to regard divorced, remarried, and adopted members as famines, while classifying gay/lesbian couples, members living together in a communal fashion, and single households into nonfamily groups. People evaluate that the current Korean family doesn't adequately meet the functional needs of families in emotional support, solidarity, recreation, leisure, social and economic security, and generational transmission of culture. More conclusions and implications are discussed.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 추계학술대회 및 한일 식물생명공학 심포지엄
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• pp.380-380
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• 2005

• 대한간호학회지
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• 제36권5호
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• pp.853-862
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• 2006

Purpose: The purpose of this study was to identify the factors that influence the functional status of patients with heart failure. Method: A descriptive, correlational study design was used. The participants in this study were 260 patients with heart failure who were admitted at Y University and U University in Seoul, Korea. Between September 2005 and December 2005 data was collected by an interview using a questionnaire and from medical records. The Functional status was measured with KASI. Physical factors (dyspnea, ankle edema, chest pain, fatigue, and sleep dysfunction), psychological factors (anxiety and depression), and situational factors (self-management compliance and family support) were examined. Result: In general, the functional status, anxiety, depression, self-management compliance, and family support was relatively not good. The level of fatigue was highest and the level of ankle edema was lowest for physical symptom experiences. In regression analysis, functional status was significantly influenced by dyspnea(23%), age(13%), monthly income(7%), fatigue(3%), ankle edema(2%), depression(1%), and length of stay in the hospital(1%). These factors explained 50% of the variables in the functional status. Conclusion: These results suggest that psycho-physiological symptoms management should be a focus to improve the functional status in patients with heart failure.

• The Journal of Korean Physical Therapy
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• 제1권1호
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• pp.83-102
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• 1989

The purpose of this study is to analyse the factors affecting rehabilitation of physically disabled persons . Data were collected from 118 physically disabled persons who were registered at facilities for disabled persons by an interview surevey Conducted from October 17 to October 26, 1988. The three facilities for the survey were selected by stratified random sampling. The results were as follows : 1. Using factor analysis, 10 variables were-grouped into 4 factors : physical need, need for social problem-solving, need for social interaction and educational need. The proportion of variance explained by these factors was $58.3\%$. 2. Age, religion and job were significantly related to the functional life scale score, but other variables were not. 3. Family APGAR score and severity of disability were significantly rotated to the functional life scale score. 4. From the multiple regression analysis on rehabilitation of the physically disabled person, the following: three variables were statistically significant : age, severity of disability and family functioning. These results suggest that age, severity of disability and family functioning variables are important factors for rehabilitation of physically disabled persons. Since the family functioning variable can be controlled by care, rehabilitation team should monitor the variable closely to improve the efficiency of rehabilitation. Because of their implication for further study, some variables, other than those considered here, are needed for studying rehabilitation of physically disabled persons.

• 한국가구학회지
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• 제23권4호
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• pp.342-354
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• 2012

This study aimed at acknowledging characteristics of space usage and suggesting orientation of space planning and furniture designing that meet various residents' demands correlating with residential area, furniture and family members by doing fact finding of volume of the furniture in medium/small sized apartment. The contents of the study are "experience of functional remodeling," "a number of bedrooms correlating with a number of family" and "furniture arrangement of each space and characteristics of space utilization" based on forty six cases. Followings are results of the study. 1) It was acknowledged that the function of space relating to family members largely depends on furniture arrangement correlating with age of children. It is needed that flexible planning of residential area to meets growing children and various family demands. 2) Functional remodeling requires furniture rearrangement attended with the remodeling. Thus, it is required that ideas in more simple and efficient furniture designing and consideration of construction environment embracing that ideas. 3) It can be acknowledged that the most demanding matter to enjoy satisfied and comfortable life in residential area is the matter of storage area. It is also understandable that the matter can be worse by time going by and the change of living pattern. Therefore, it is required that the consideration of enough storage area compatible with its function of the room and the planning of built-in furniture for storage.

• 가정과삶의질연구
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• 제5권2호
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• pp.127-144
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• 1987

The purpose of this study is to explore the family communication and power. Communication is a symbolic, transactional process in functional view . To say tat communication is a process implies a continuous interaction of an indefinite large number of variables with a concomitant, continuous change in the values taken by these variables. Finally the process implies change. Family functions include the primary functions of cohesion and adaptability and supporting functions of family images, themes, boundaries, and biosocial issues, The primary functions reveal concepts integrated family interaction and supporting functions, along with those of cohesion and adaptability, give shape of family life. The message system is the major element of communication process and influences both the form and the content of thier relationship and create and share meanings. The family-of-origin issues influence all aspects of family communication and account for many of the communication patterns, rules and networks. Power does not belong to an individual. rather it is a property of a relationship between two or more persons, Power, a system property is the ability of an individual to change the behavior of other members in a social system. Power operate transactionally in a family and any power maneuvers within it have a system wide effect. In order to study power in families , it is necessary to examine 1) family power operations 2) development of family power and 3) the communication of power strutegies. The research presented indicated that a rigid power structure, characterized by dominance and little sharing, restricts family flexibility reduce cohesion, and adversely affects satisfaction in families. power constantly changes as a family grows and develops within its system. Although power changes may be more obvious in children as they mature and more from a independent stated to an independent one, each of the parents experience egual or greater. Communication and activities take place that either enhance positively or negatively the images, themes, and degree of unity of cohesion the family desires. Power operated within a dynamic, growing, changing, interdependent transactional family system. Power struggle may develop when as issue becomes important to one or more family member. When this happens, and the rational exploration of alternatives ceases, various one-up power maneuvers usally follows, This affect family intimacy. a vital element in meaningful relationships . To resolve differences and not become the victim of another's power , one need to engage in constructive conflict since the ability to clearly and comfortably repudiate another is part of the achievement of intimacy.

• 근관절건강학회지
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• 제4권2호
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• pp.221-237
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• 1997

In an attempt to measure effects of the Programmed Resistance Exercise on the daily performance of patients with rheumatoid arthritis, a quasi-experiment ; non-synchronised control group pre-post-test, was carried out for 8 weeks : from June 3 to November 29, 1996. 25 for the experimental group and 26 for the control group were conveniently sampled among registered out-patients on rheumatoid arthritis clinic of Anam Hospital, Korea University Medical Center. The programmed experimental resistance exercises were carried out by the experimental group five times a week for eight weeks. Before and after experiments, level of functional task performance, functional disability, joint mobility, ESR, CRP, self-efficacy and family support were measured and statistically analysed. The results of the analysis of the effects on the Programmed Resistance Exercise are as follows : 1. A statistically significant post-test effects on functional task performance were revealed : 1) the experimental group climbed up and down the 10 steps of the stairs significantly faster than the control group(P=0.0001). 2) the experimental group walked 100 m significantly faster than the control group (P=0.0000). 3) After the experiment, the experimental group could sit down and get up from chairs with no armrest as low as 30cm, 40cm, 50cm on their on, with no assistance as opposed to the control group who could not sit down and get up from such low chairs (P=0.0084). 4) the experimental group lifted 0-15 kg object up to their own heights with no specific strain than the control group (P=0.0000). 2. A significant reduction in the functional disabilities was revealed in the experimental group(P=0.0017). 3. A notable incresement of the joint mobility was revealed in the experimental group. 4. A decrease in the ESR in both the experimental and the control groups was noticed, however, the difference was not statistically significant (P=0.9546). 5. The CRP of both the experimental and control groups decreased with no significant difference (P=0.6022). 6. The self-efficacy increased significantly in the experimental group(P=0.0042), however, no significant effect of self-efficacy on the actual practice of the program was noticed. 7. The family support revealed to be significantly higher in the experimental group (P=0.0013), however, the effect of the family support on actual practice of the program revealed not significant. Judging from the results of these experiments, the resistance exercise program not only improves the functional capacity of rheumatoid arthritis, but also diminishes their functional disabilities and has a great influence on increasing their joint mobility, self-efficacy, and family support. Concluding, in promoting the daily performance of rheumatoid arthritis, the resistance exercise program would be an appropriate nursing intervention.