• Journal of Korean Ophthalmic Optics Society
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• v.20 no.3
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• pp.285-291
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• 2015

Purpose: The hydrogel lenses have been functionalized with HA(Hyaluronic Acid) using two different methods: construction of an IPN(Interpenetrating Polymer Networks) and formation of CCB(Chemical Covalent Bonding). The lysozyme adsorption and physical properties such as optical transmittance and water content of the hydrogel lenses have been investigated in order to determine whether method is suitable for the application potentials in contact lens industry. Methods: HA have been added to the hydrogel lenses prepared in the Lab using the two different method, e.g. IPN and CCB. The optical transmittance was measured in the wavelength range of 300~800 nm. The water content was measured by the gravimetric method using 0.9% NaCl saline solution. The amounts of adsorbed lysozyme on the contact lenses was analyzed by HPLC after incubation for 12h in artificial tears. Results: The water content of the HA added hydrogel contact lenses was increased, and the lens made by IPN method showed higher water content than the lens made by CCB method. The optical transmittance was over 90% both before and after addition of HA. Comparing the lysozyme adsorption reduction ratio, contact lens manufactured by IPN method was 60.0%, and the lens made by CCB method was 40.4%. Conclusions: CCB method is appropriate to distribute the functional material evenly throughout the lens, whereas IPN method is effective for the case of giving the functionality on the lens surface without phase separation.

• Journal of the Korean Chemical Society
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• v.61 no.6
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• pp.352-358
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• 2017

The addition of alginic acid, a natural polysaccharide, to improve the wettability and the reduction of protein adsorption of hydrogel contact lenses. Hydrogel contact lenses were manufactured with various monomers such as 2-methacryloyloxyethyl phosphorylcholine (MPC) and NVP (N-Vinyl-2-pyrrolidone). Alginic acid was added by by the initial mixing method and the interpenetrating polymer networks(IPN) method. Properties of contact lens such as contact angle, oxygen permeability, and protein adsorption amount were evaluated. The oxygen permeability and wettability of the IPN-treated alginate samples were higher than those of the samples that were not treated with IPN. The physical properties were improved as the concentration of IPN-treated alginic acid increased. Protein adsorption decreased by the addition of alginic acid and further decreased with IPN. In particular, contact lenses containing MPC and NVP significantly decreased protein adsorption. Therefore, the effect of alginate on the functional improvement of contact lens was confirmed.

• Journal of the Korean Chemical Society
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• v.54 no.1
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• pp.99-104
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• 2010

Platinum nanoparticles were added to a mixture of HEMA (2-hydroxyethyl methacrylate), NVP (N-vinyl pyrrolidone) and MMA (methyl methacrylate) in a mould at various concentrations. The resulting mixture was copolymerized by heating at $70^{\circ}C$ for 40 min, $80^{\circ}C$ for 40 min, and $100^{\circ}C$ for 40 min, respectively. The physical properties of contact lens were then measured. The oxygen transmissibility of $9{\sim}15{\times}10^{-9}$ cm/s mL $O_2$/mL ${\times}$ mmHg, water content of 34.22~35.52%, refractive index of 1.432~1.435, visible transmittance of 88.3~91.2% and tensile strength of 0.141~0.152 kgf were obtained. The addition of platinum nanoparticles to the polymer allowed the contact lens to have various colors without artificial coloring agents. The polymer materials satisfied the physical properties required to produce contact lenses, making the material suitable to be applied as a functional material for ophthalmological purposes.

• Journal of the Korean Chemical Society
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• v.54 no.2
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• pp.222-227
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• 2010

This study added Au colloid in martial of conventional contact lens in various concentrations and copolymerized by heating at $70^{\circ}C$ for 40 minutes, $80^{\circ}C$ for 40 minutes, and finally, $100^{\circ}C$ for 40 minutes. Using the polymer produced through the copolymerization process, we have produced a contact lens and measured the physical characteristics which showed oxygen transmissibility of $9{\sim}12{\times}10^{-9}$ cm/s mL $O_2$/mL ${\times}$ mmHg, water content of 27.84% ~ 32.17%, refractive index of 1.432 ~ 1.443, visible transmittance of 83.2% ~ 89.5% and tensile strength of 0.141 kgf ~ 0.152 kgf. The polymer satisfied the physical properties required to produce contact lenses. Also, we judged that the polymer is suitable to be applied as a functional material for ophthalmological purposes.

• Journal of Korean Ophthalmic Optics Society
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• v.21 no.2
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• pp.91-98
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• 2016

Purpose: This study investigated the masking effect of the hydrogel lens and silicone hydrogel lens on the cornea with refractive surgery and without surgery. Methods: 24 university students (means age: $23.48{\pm}2.89years$) without refractive surgery (12, control group) and with refractive surgery (LASIK: 8, LASEK: 4, experimental group) participated in the study. Mean refractive errors of right eyes were -2.73 D for control group and -0.24 D for experimental group. The differences in the refractive power and corneal topography map between pre- and post-wearing the -3.00 D lenses were compared, and 2 kinds of hydrogel contact lenses (0.89 Mpa, 0.49 Mpa) and 2 kinds of silicone hydrogel lenses (1.5 Mpa, 0.8 Mpa) were used for -3.00 D lenses. NVision-K5001 (Shin nippon, Japan) was used to measure the refractive power and Keratograph 5M (Oculus, Germany) to measure the corneal topography map change. Results: Variations in the refractive power increased to the plus direction in the experimental group after wearing soft contact lenses. The corneal topography map showed significant changes on the both groups after wearing soft contact lenses (p<0.05). However there were no significant differences in the refractive power and corneal topography map variations by lens materials. Conclusions: Wearing soft contact lenses showed corneal topography map changes. Especially wearing soft contact lenses on the flat cornea after corneal refractive surgery showed greater corneal power changes. Therefore, it should pay attention to refractive change in case of prescribing soft contact lenses to patients with corneal refractive surgery.

• Journal of Integrative Natural Science
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• v.11 no.1
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• pp.1-8
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• 2018

HEMA, AA, MMA, and EGDMA as crosslinking agent and AIBN as an initiator, and 2,4-dihydroxybenzophenone, 2-ethylhexyl-trans-4-methoxy-cinnamate, 2-hydroxy-4-(methacryloyloxy)benzophenone as additives at 0.1-1.0% ratios were used to manufacture hydrophilic ophthalmic lenses through thermal polymerization before their physical properties were measured. The results showed that the samples containing of 2,4-dihydroxybenzophenone and 2-ethylhexyl-trans-4-methoxy-cinnamate resulted in a decrease of the UV blocking performance after high-pressure sterilization whereas the sample containing 2-hydroxy-4-(methacryloyloxy)benzophenone showed no change in the UV blocking performance. It is judged that this is induced by presence or absence of an acyl functional group in benzophenone.

• Journal of Korean Ophthalmic Optics Society
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• v.14 no.1
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• pp.39-45
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• 2009

Purpose: The purpose of this study is to compare the visual performance by contrast sensitivity (CS) and disability glare (DG) in low astigmatic eyes corrected with toric soft lenses and other optical corrections. Methods: Twenty university students with myopia (-1.00 to -6.50D Sph. with astigmatism up to 1.50 cyl) were enrolled and corrected by five different methods: 1) soft toric lenses; 2) spherical soft contact lenses; 3) RGP lenses; 4) best spectacle corrected visual acuity; 5) spherical equivalent spectacles. All subjects had corrected vision acuity of 20/20 or better. Contrast sensitivity and disability glare were measured using the OPTEC 6500 contrast sensitivity view-in tester included the EyeView Functional Vision Analysis software at photopic or mesopic conditions with glare. Results: At photopic condition, best corrected spectacle wearers had the highest monocular contrast sensitivity at all spatial frequency followed by soft toric lenses, RGP lenses, spherical equivalent spectacles, and spherical soft contact lenses. However, all of them were in normal contrast sensitivity value at photopic condition. At mesopic condition with glare, toric soft lenses were the highest and followed by RGP lenses, spherical equivalent spectacles, best spectacle corrected visual acuity and spherical soft contact lenses. It was observed that spherical soft contact lens wearers demonstrated lower range than normal contrast sensitivity value at mesopic condition with glare. Conclusion: Toric soft lenses gave better visual performance than spherical soft lenses in low astigmatic eyes. Subjects requiring the use of contact lenses under mesophic conditions could benefit from toric soft lenses.

• Journal of the Korean Society of Industry Convergence
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• v.22 no.5
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• pp.467-473
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• 2019

In this study, approached to improve durability of the multi-functional nano-pattern fabricated on the curved lens surface using nanoimprint lithography (NIL) was proposed, and the effects of the proposed methods on functionality after wear test were examined. To improve the mechanical property of ultraviolet(UV)-curable resin, UV-NIL was conducted at the elevated temperature around $60^{\circ}C$. In addition, micro/nano hierarchical structures was fabricated on the lens surface with a durable film mold. Analysis on the worn surfaces of nano-hole pattern and hierarchical structures and measurements on the static water contact angle and critical water volume for roll-off indicated that the UV curing process with elevated temperature is effective to maintain wettability by increasing hardness of resin. Also, it was found that the micro-scale pattern is effective to protect nano-pattern from damage during wear test.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.1
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• pp.69-77
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• 2014

Purpose: The functional ophthalmic lenses containing fluorine-substituted aniline group (2,4-difluoroaniline, 2,6-difluoroaniline, 3,4-difluoroaniline) were manufactured and the physical and optical characteristics of copolymerized ophthalmic lens were investigated. Methods: HEMA (2-hydroxyethylmethacrylate), NVP (N-vinyl pyrrolidone), MA (methacrylic acid), the cross-linker EGDMA (ethylene glycol dimethacrylate) and the initiator AIBN (azobisisobutyronitrile) were used as a basic combination and fluorine-substituted aniline group (2,4-difluoroaniline, 2,6-difluoroaniline, 3,4-difluoroaniline) were used as additives for preparing the hydrogel soft contact lenses. The hydrogel ophthalmic lens was manufactured by cast mould method and the ophthalmic lenses were stored in a 0.9% NaCl normal saline for 24 hrs. Results: The optical transmittance of the sample with addition 2,4-difluoroaniline showed that the UV-B(9.8~51.4%), UV-A(58.8~79.2%) and visible transmittance(87.0~90.4%). In the case of 2,6-difluoroaniline were measured the UV-B(80.2~83.2%), UV-A(85.8~86.4%), and visible transmittance(90.8~91.4%). Also, the optical transmittance of ophthalmic lens containing 3,4-difluoroaniline were measured the UV-B transmittance of 3.8~30.4%, UV-A transmittance of 47.8%~74.4% and the visible transmittance of 86.2~91.0% respectively. Conclusions: Based on the results of this study, 2,4-difluoroaniline and 3,4-difluoroaniline can be used effectively as additive for UV-blocking ophthalmic contact lenses.

• Journal of the Korean Chemical Society
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• v.53 no.6
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• pp.755-760
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• 2009

Styrene is broadly used as a polymer and a copolymer and is useful in manufacturing contact lenses due to its high refractive index. This study used styrene with the cross-linker EGDMA (ethylene glycol dimethacrylate), HEMA (2-hydroxyethyl methacrylate) and the initiator AIBN (azobisisobutyronitrile) for copolymerization. Measurement of the physical characteristics of the copolymerized material showed that the refractive index is 1.4412 - 1.4628, water content 20 - 35%, visible transmittance 82.6 - 87% and the tensile strength 0.143 - 0.344 Kgf. Also, measurements showed that the refractive index and tensile strength increased while the water content decreased as the ratio of styrene increased. Based on the results of this study, the produced copolymer can be estimated to be suitable for use as a material for high performance functional contact lenses.