• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2561-2567
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• 2015

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death worldwide. Our study aimed to reveal molecular mechanisms. Microarray data of GSE15471 (including 39 matching pairs of pancreatic tumor tissues and patient-matched normal tissues) was downloaded from Gene Expression Omnibus (GEO) database. We identified differentially expressed genes (DEGs) in PDAC tissues compared with normal tissues by limma package in R language. Then GO and KEGG pathway enrichment analyses were conducted with online DAVID. In addition, principal component analysis was performed and a protein-protein interaction network was constructed to study relationships between the DEGs through database STRING. A total of 532 DEGs were identified in the 38 PDAC tissues compared with 33 normal tissues. The results of principal component analysis of the top 20 DEGs could differentiate the PDAC tissues from normal tissues directly. In the PPI network, 8 of the 20 DEGs were all key genes of the collagen family. Additionally, FN1 (fibronectin 1) was also a hub node in the network. The genes of the collagen family as well as FN1 were significantly enriched in complement and coagulation cascades, ECM-receptor interaction and focal adhesion pathways. Our results suggest that genes of collagen family and FN1 may play an important role in PDAC progression. Meanwhile, these DEGs and enriched pathways, such as complement and coagulation cascades, ECM-receptor interaction and focal adhesion may be important molecular mechanisms involved in the development and progression of PDAC.

• The Journal of Korean Physical Therapy
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• v.29 no.4
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• pp.164-168
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• 2017

Purpose: Functional electrical stimulation (FES) is a device that activates the sensorimotor cortex through electrodes attached to the surface of the skin. However, it is difficult to expect positive changes if the recipient is not attentive to the motion. To complement the perceived cognitive limitations of FES, we attempted to investigate the changes of sensorimotor cortex activity by simultaneously providing action observation with FES. Methods: Electroencephalogram was measured in 28 healthy volunteers. Relative band power over the sensorimotor cortex was analyzed and compared in three conditions: during rest, during FES alone, during action observation with FES. Results: The results showed significant differences in each relative band power. Relative alpha power and relative beta power were the lowest by application of FES combined with action observation, while the relative gamma power was the highest. Conclusion: These results suggest that combining FES with observation could be more effective than FES alone in neurorehabilitation.

• Journal of Food Hygiene and Safety
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• v.27 no.4
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• pp.395-400
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• 2012

In this study, we analyzed the database for items reported to Korea Food and Drug Administration as for manufactured health/functional food during 2010. There were 183 health functional food products manufactured in domestic having over 2 functional ingredients (hereinafter, combinational health functional food) among total 7319 products. Among 183 products, there were 177 products having over two kinds of functional ingredient and 6 products were over 3 ingredients. The most commonly used functional ingredients in the combinational health functional food were Garcinia cambogia extracts which were used in 41 products, Octacosanol and Saw Palmetto extract. When we searched the safety information for the pair of ingredients used in combinational health functional food using several database, there were no reports for safety concern. However, as there are still safety concerns when intake various functional ingredients at once, we suggested to enforce the reporting system of adverse event in order to strength safety management of health functional food. With these complement, the safety management of health functional food might be achieved including a combinational products.

• Fashion & Textile Research Journal
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• v.10 no.6
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• pp.1006-1013
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• 2008

This study is basic material for development of a smart girdle. Through the intentionally sampling of 313 consumers from teenagers to the forties who have experienced wearing girdles, lifestyles on consumer's age, attitude to health, favor of warm functional girdle, and possibility to acceptance were surveyed and analyzed by questionnaire. The result of the study are summarized as followed. 1. Analysis about lifestyle with warmth and attitude to health showed that subjects in their thirties and forties have higher than teenagers and the twenties in frequency of distribution. This means people are tend to have more attention to warmth and health as they grow older. 2. In result about analysis of characteristic of wearing girdle, subjects were prefer girdle made of cotton which have superior permeability and hygroscopic property. The reason that wearing girdle is to complement of weak points of body somatotype in the thirties and forties and feel the stability during menstrual period in the twenties and teenagers. The time zone of putting on girdle is mainly winter while one is out wearing one-piece or skirt. 3. When surveyed about the preference to functional warmth girdle and possibility to acceptance, the results were that the subjects in their thirties were first, forty something was second, followed by subjects in their twenties, teenagers. It was shown that over 60% subjects were highly distributed. With regard to necessity of functional warmth girdle, every age groups were shown over 3.6 at average. This result was inferred that subjects had positive possibility to acceptance about functional warmth smart girdle.

• Journal of Plant Biotechnology
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• v.48 no.3
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• pp.148-155
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• 2021

Gibberellins (GAs) are essential phytohormones for plant growth that influence developmental processes and crop yields. Recent functional genomic analyses of model plants have yielded good characterizations of the canonical GA signaling pathways and related genes. Although Panax ginseng has long been considered to have economic and medicinal importance, functional genomic studies of the GA signaling pathways in this crucial perennial herb plant have been rarely conducted. Here, we identified and performed functional analysis of the GA signaling-related genes, including PgGID1s, PgSLY1s, and PgRGAs. We confirmed that the physiological role of GA signaling components in P. ginseng was evolutionarily conserved. In addition, the important functional domains and amino acid residues for protein interactions among active GA, GID1, SCF^SLY1, and RGA were also functionally conserved. Prediction and comparison of crystallographic structural similarities between PgGID1s and AtGID1a supported their function as GA receptors. Moreover, the subcellular localization and GA-dependent promotion of DELLA degradation in P. ginseng was similar to the canonical GA signaling pathways in other plants. Finally, we found that overexpression of PgRGA2 and PgSLY1-1 was sufficient to complement the GA-related phenotypes of atgid1a/c double- and rga quintuple-mutants, respectively. This critical information for these GA signaling genes has the potential to facilitate future genetic engineering and breeding of P. ginseng for increased crop yield and production of useful substances.

• Korean Journal of Human Ecology
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• v.16 no.3
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• pp.577-585
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• 2007

This research aimed for 20 latter man whose body shape of torso alters remarkably to develop nipper pattern of running type considered characteristic of body shape of 20 latter man to keep rather balanced body shape against middle age when body shape changes extremely. 1. running type nipper pattern design. Pattern of running, lining and nipper were designed by flattening surface shell. A basis line of running pattern is completed by applying reduction ratio after 3 times of modification & complement based on surface shell. Nipper pattern is designed with design line set by a plaster cast based on running pattern line. Lining pattern is designed with lining design line set by a plaster cast based on running type outside material and nipper pattern. 2. Functional evaluation of research and commercial nipper. Functional inspection through dress test was applied 5point evaluation method and the result of functional inspection on the sight of a wearer is that research nipper(running reduction ratio 15%, nipper reduction ratio 18%) averaged more 4.8point but commercial nipper averaged less 1.8point in the aspect of 20 items such as wear sensibility, motional function and external appearance aesthetic. Research running type nipper scored high in order of motional function, looks of side, back, front and whole and wear sensibility. Functional inspection in the point of view of an observer is that research nipper(running reduction ratio 15%, nipper reduction ratio 18%) averaged over 4.8point and commercial nipper averaged under 1.9point in 17 items of external appearance beauty. Research running type nipper marked high in order of looks of back, whole, front and side.

• The Journal of Sustainable Design and Educational Environment Research
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• v.6 no.2
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• pp.1-24
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• 2007

The knowledge-based 21st century requires lifelong education for the development of qualification of man's life and self-development. Schools are considered a place of lifelong education due to easy access to human resources as well as facilities. Furthermore, schools need a more multi-functional openness in order to lead lifelong education of the local society. Jeju schools are in the early stages of creating multi-functional facilities to meet to the needs of the knowledge-based 21st century. In order to bring change into the local school s, this needs to be solved. therefore, the purpose of this research is to complement the elements to needed to open schools, project, management, and operation of multi-functional facilities, so that schools can play a role In lifelong education. To achieve this purpose, this research examined programs and the area of lifelong education at schools through investigating documents on the definition of local society and lifelong education, and analyzed the relationship of schools and local society, and public access of schools' facilities. The results of this study are summarized as follows; 1) Comparing to traditional middle and high school facilities, it occurs various types of plane and the area is somewhat expanded in the school with same class size, however, it needs to improve facility standards in its reality to deal with the change of future educational environment actively. 2) Spatial composition of educational facilities should functionally designed considering that the characteristics of design process mood. In facilities arrangement of middle and high schools, it shows diverse forms of arrangement from existing uniform straight type, however, most of schools do not being against the simple in their external space. Therefore, it requires an expansion of space size and facilities for the change of school life outside class.

• Clean Technology
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• v.14 no.3
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• pp.193-203
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• 2008

A surfactant is used to assist the effect of cleaning, dispersibility and adhesion during leather manufacturing process. Existing surfactant for that process includes many hydrophilic groups that may cause problem such as stain, bad water resistance and poor durability, etc. It is potential problem to make high-performance property for future leather market. In this study, we have synthesized the fluorinated surfactant of which property decreases surface tension, increases dispersion, cleaning effect and the better chrome absorption by the high bond energy of C-F to complement weakness that the present alkyl derivative surfactants have. Using fluorinated surfactant, we can confirm that dispersion is increased, chrome absorption ratio is augmented with high osmosis and coherence, chrome content in the tanning waste water is reduced, BOD and COD contents are diminished and physical characteristics are improved.

• Journal of Genetic Medicine
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• v.20 no.2
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• pp.39-45
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• 2023

As advanced sequencing technologies continue to uncover an increasing number of variants in genes associated with human genetic diseases, there is a growing demand for systematic approaches to assess the impact of these variants on human development, health, and disease. While in silico analyses have provided valuable insights, it is essential to complement these findings with model organism studies to determine the functional consequences of genetic variants in vivo. Drosophila melanogaster is an excellent genetic model for such functional studies due to its efficient genetic technologies, high gene conservation with humans, accessibility to mutant fly resources, short life cycles, and cost-effectiveness. The traditional GAL4-UAS system, allowing precise control of gene expression through binary regulation, is frequently employed to assess the effects of monoallelic variants. Recombinase medicated cassette exchange or CRISPR-Cas9-mediated GAL4 insertion within coding introns or substitution of gene body with Kozak-Gal4 result in the loss-of-function of the target gene. This GAL4 insertion strategy also enables the expression of reference complementary DNA (cDNA) or cDNA carrying genetic variants under the control of endogenous regulatory cis elements. Furthermore, the CRISPR-Cas9-directed tissue-specific knockout and cDNA rescue system provides the flexibility to investigate candidate variants in a tissue-specific and/or developmental-timing dependent manner. In this review, we will delve into the diverse genetic techniques available in Drosophila and their applications in diagnosing and studying numerous undiagnosed diseases over the past decade.

• Journal of information and communication convergence engineering
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• v.3 no.3
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• pp.152-156
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• 2005

Korea-China with the fastest speed Internet Broad Band, has achieved many progresses on Internet shopping. Especially, Korea has made a great effort on comparison website construction. A research prototype design and exploratory analysis are presented to assess success factors and impacts of Korea and China price comparison websites. For different user groups, the relationships between the characteristics of technology and tasks, usage, and organizational impacts were analysed. It shows us how to improve the applicability of fit-viability of the price comparison web sites in China after analysis. These results indicate a need for simple but highly functional price comparison applications. And we designed a sample model to include an interactive web service system for price comparison sites that complement existing information systems. This paper provides a basis for further research aiming to improve the design and management of business applications based on emerging technologies of web service and browser for information management.