• Korean Journal of Psychosomatic Medicine
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• v.15 no.2
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• pp.73-80
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• 2007

Anumber of prior studies have reported eye movement dysfunction in patients with dementia. The eye movement test which is non-invasive can evaluate the local brain function quantitatively. Therefore, it can be a useful method for characterizing regional brain abnormalities of patients with dementia. The aim of this paper is to review the literatures on eye movement abnormalities in dementia patients. Saccade system dysfunctions in Alzheimer disease include increased latency, reduced accuracy, and increased antisaccade error rates. Patients with frontotemporal dementia showed impaired reflexive saccade inhibition and increased latency and errors of antisaccade task. And delayed initiation of voluntary saccades, slow saccades, and increased errors and latency on antisaccade task were found in Huntington's disease. Patients with Parkinson’s disease dementia and dementia with Lewy bodies have characteristics of impaired in both reflexive saccade execution and complex saccade performance. However, there were few reports of abnormal eye movements in Creutzfeldt-Jakob disease; they could be found at the later stages after symptoms of dementia came to be evident, and secondary to cerebellar and vestibular involvement. Slowing of saccades and hypometric saccades might precede the supranuclear limitation of vertical gaze in PSP. Dysfunction of voluntary eyelid movements was a characteristic finding of PSP as well. In conclusion, patients with dementia can show various abnormal eye movements and they are related with cortial and subcortical brain dysfunctions. The research on localization of brain relevant to each symptom can promise more clinical implications of eye movement of dementia.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.1
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• pp.45-51
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• 2013

Purpose: This study was performed to provide indicator of expected aniseikonia by correcting refractive error and to investigate influential factors on aniseikonia. Methods: 20 college students (14 males, 6 females, a mean age of $22.50{\pm}2.72$ years) were selected as subjects whose refractive error with spherical equivalent were within ${\pm}0.50$ D, corrected visual acuity were more than 1.0, and aniseikonia values by AWAYA were less than 1%. After correcting refractive error with spectacles in anisometropia induced by wearing contact lens on their dominant eye or non-dominant eye, practical measured values of aniseikonia were compared with theoretical expected values of it by the formula of spectacle magnification. Results: Practical measured values were higher than theoretical expected values in induced aniseikonia over the whole range of diopter of wearing contact lens. And there was higher measured value of aniseikonia in case of higher diopter of wearing contact lens to induce anisometropia and correcting refractive error with spectacles of (+) diopter after wearing contact lens of (-) diopter to induced anisometropia in dominant eye of women. Conclusions: It is considered that dominant eye plays more important role for visual function in induced aniseikonia and factors such as the induced eye of aniseikonia, the diopter of wearing contact lens, and gender have influenced on aniseikonia.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.1 no.1
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• pp.161-171
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• 1990

The study was to examine the effectiveness of the educational program for the parents of autistic children in promoting the development and amelioration of psychopathology. Behavioral pathology and developmental function of autistic children of two parent groups, parents who participated in educational program and parents who did not participate in that program, were compared before and after partent education program. For these purpose, the data were collected from 30 subjects(15 for participant group and 15 for non-participant group) who were diagnosed as Autism according to DSM-III at Child-Psychiatry of Seoul National University Hospital during May 16, 1987 through April 30, 1988. Pre and post tests by Schopler's Psycho-Educational Profile scale were performed for all of the subjects and the data were analyzed by Wilcoxon Rank Sum test, Wilcoxon Sign Rank test and $X^2-test.$ The results obtained were as follows ; 1) The autistic children of participant group were significantly higher than those of non-participant group after education on Imitation, Gross motor and Eye-hand Integration scale of developmental function area (p<0.05) 2) After education, the autistic children of participant group were significantly improved in Affect and Language scale of behavioral pathology area (p<0.05). 3) After education, the autistic children of participant group were significantly improved in developmental function, such as perception, Fine motor, Gross motor, Eye-hand Integration, Cognitive Performance, Cognitive Language (p<0.05). 4) The autistic children of non-participant group were significantly improved in Relating behavior and developmental functions such as Perception, Fine motor and Eye-hand Integration at post test in comparison to pre test (p<0.05). From these results, it might be concluded that the autistic children of participant group were improved much more, and obtained higher score in developmental function area than those of non-participant group. It is suggested that this kind of education program helped and supported the parents to do some more appropriate approach for the development of their children.

• Journal of Biomedical Engineering Research
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• v.10 no.3
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• pp.289-292
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• 1989

In this study we propose an approach based on statistical method which use the whole of saccades instead of using a few points of saccades in the quantitative analyse saccades. We computed statistical parameters such as mean velocity, quadratic mean velocity, standard duration, skewness of saccades velocity, flattness factor of saccades velocity, and mean delay by considering eye velocity as a probability density function. The results abtained are the following as ; This parameters showed the same trend like that of the main sequence. They were not biased by the systematic errors due to the arbitrary threshold. They were also less sensitive to noise, which was tested through the model simulation. So they are expected to provide a more comprehensive quantitative description of the dynamic properties of saccade in the diagnostic field.

• Journal of the Ergonomics Society of Korea
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• v.26 no.4
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• pp.17-24
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• 2007

Analyses of eye tracking and think-aloud protocol data were performed to examine novice-expert differences in perceptual and cognitive aspects of air traffic controllers' situation awareness. In Experiment 1, three groups of field air traffic controllers (experts, intermediates, novices) were asked to perceive situations that were manipulated by situation complexity. In Experiment 2, protocol analysis for previous situation awareness tasks was performed to extract different task models and strategy models as a function of expertise. Then delayed-recall task and interviews about air control plans for the recalled situations were also executed. Results showed that expert controllers concentrate only on several critical features and have their own strategies to reduce mental workloads.

• Journal of the Optical Society of Korea
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• v.16 no.2
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• pp.95-100
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• 2012

We show that the minimum EOP (eye-opening penalty) obtained by tunable dispersion compensation is a function of a figure of merit for a nonlinear process, $I_0L_{eff}$, where $I_0$ is the optical intensity and $L_{eff}$ is the effective length of the interaction region. Using this rule, we do not need to conduct nonlinear simulations in all the cases of signal power and transmission length to obtain the signal distortion in dispersion-managed optical transmission. Instead, we need to conduct a simulation in only one case of a signal power and find the functional relation, and then we can obtain the values of the signal distortion in other cases using the discovered functional relation. This technique can reduce the number of nonlinear simulations to less than 10%.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1999.11a
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• pp.111-114
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• 1999

Off-vertical axis rotator was developed to differentiate each function of the canal and otolith in the vestibular system and evaluate subjective symptoms during postural change. Eye movement induced by various types of rotation was measured in normal subjects. Nystagmus with fast component corresponding to direction of rotation was occurred by sinusoidal earth vertical axis rotation, and the gain of eye movement in vestibuloocular reflex (VOR) was lower than in visual vestibuloocular reflex (VVOR) and higher than in visual fixed vestibuloocular reflex (VFX). Degree of dizziness was proportioned to degree of gain. off-vertical axis rotation was produced severe dizziness than earth vertical axis rotation. These results suggest stimulation of the otolith should be minimized to make a stable and pleasant condition in work and travel.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.28.1-28
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• 2001

An automatic face recognition(AFR) of individuals is a significant problem in the development of computer vision. An AFR consists of two major parts which are detection of face region and recognition process, and the overall performance of AFR is determined by each. In this paper, the face region is acquired using chromaticity space, but this face region is a simple rectangle which doesn´t consider the shape information. By applying deformable templates to the face region, we can locate the position of the eyes in images. With the face region and the eye location information, more precise face region can be extract from the image. Because processing time is critical in real-time system, we use simplified eye templates and the modified energy function for the efficiency. We can get a good detection performance in experiments.

• BMB Reports
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• v.46 no.2
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• pp.124-129
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• 2013

FK506 binding protein 12 (FK506BP) belongs to a family of immunophilins, and is involved in multiple biological processes. However, the function of FK506BP in corneal disease remains unclear. In this study, we examined the protective effects on dry eye disease in a Botulinum toxin A (BTX-A) induced mouse model, using a cell-permeable PEP-1-FK506BP protein. PEP-1-FK506BP efficiently transduced into human corneal epithelial cells in a time- and dose-dependent manner, and remained stable in the cells for 48 h. In addition, we demonstrated that topical application of PEP-1-FK506BP was transduced into mouse cornea and conjunctiva by immunohistochemistry. Furthermore, topical application of PEP-1-FK506BP to BTX-A-induced mouse model markedly inhibited expression levels of pro-inflammatory cytokines such as interleukin-$1{\beta}$ (IL-$1{\beta}$), tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and macrophage inhibitory factor (MIF) in corneal and conjunctival epithelium. These results suggest PEP-1-FK506BP as a potential therapeutic agent for dry eye diseases.

• Journal of the Korean Institute of Intelligent Systems
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• v.26 no.6
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• pp.464-470
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• 2016

In this paper, we propose an improved face detection algorithm and determination method for drowsiness status of driver from the opening and closing frequency of the detected eye. For this purpose, face, eyes, nose, and mouth are detected based on conventional Viola-Jones face detection algorithm and spatial correlation of face. Here the spatial correlation of face is performed by DFP(Detect Face Part) based on seven characteristics. The experimental results on Caltect face image database revealed that the detection rates of noise particularly showed the improved performance of 13.78% in comparison to that of the previous Viola-Jones algorithm. Furthermore, we analyze the driver's drowsiness determination cumulative value of the eye closed state as a function of time based on SVM (Support Vector Machine) and PERCLOS(Percentage Closure of Eyes). The experimental results confirmed the usefulness of the proposed method by obtaining a driver's drowsiness determination rate of 93.28%.