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Gingival crevicular fluid CSF-1 and IL-34 levels in patients with stage III grade C periodontitis and uncontrolled type 2 diabetes mellitus

  • Ahu Dikilitas;Fatih Karaaslan;Sehrazat Evirgen;Abdullah Seckin Ertugrul
    • Journal of Periodontal and Implant Science
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    • v.52 no.6
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    • pp.455-465
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    • 2022
  • Purpose: Periodontal diseases are inflammatory conditions that alter the host's response to microbial pathogens. Type 2 diabetes mellitus (T2DM) is a complex disease that affects the incidence and severity of periodontal diseases. This study investigated the gingival crevicular fluid (GCF) levels of colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34) in patients with stage III grade C periodontitis (SIII-GC-P) and stage III grade C periodontitis with uncontrolled type 2 diabetes (SIII-GC-PD). Methods: In total, 72 individuals, including 24 periodontally healthy (PH), 24 SIII-GC-P, and 24 SIII-GC-PD patients, were recruited for this study. Periodontitis patients (stage III) had interdental attachment loss (AL) of 5 mm or more, probing depth (PD) of 6 mm or more, radiographic bone loss advancing to the middle or apical part of the root, and tooth loss (<5) due to periodontal disease. Radiographic bone loss in the teeth was also evaluated; grade C periodontitis was defined as a ratio of the percentage of root bone loss to age greater than 1.0. The plaque index (PI), gingival index (GI), presence of bleeding on probing (BOP), PD, and clinical AL were used for clinical periodontal assessments. GCF samples were obtained and analyzed using an enzyme-linked immunosorbent assay. Results: All clinical parameters-PD, AL, GI, BOP, and PI-were significantly higher in the SIII-GC-PD group than in the PH and SIII-GC-P groups for both the full mouth and each sampling site (P<0.05). The total IL-34 and CSF-1 levels were significantly higher in the SIII-GC-PD group than in the PH and SIII-GC-P groups (P<0.05), and there were significant differences between the periodontitis groups (P<0.05). Conclusions: These findings suggest that IL-34 and CSF-1 expression increases in patients with SIII-GC-PD. CSF-1 was associated with the inflammatory status of periodontal tissues and T2DM, while IL-34 was associated only with T2DM.

The Optimal Time for Initiating Probiotics for Preterm and Very-Low-Birth-Weight Infants: A 10-Year Experience in a Single Neonatal Intensive Care Unit

  • JeongHoon Park;Jae Young, Cho;Jung Sook Yeom;Jin Su Jun;Ji Sook Park;Eun Sil Park;Ji Hyun Seo;Jae Young Lim;Chan-Hoo Park;Hyang-Ok Woo
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.26 no.3
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    • pp.146-155
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    • 2023
  • Purpose: The starting time for probiotic supplementation in preterm infants after birth varies widely. This study aimed to investigate the optimal time for initiating probiotics to reduce adverse outcomes in preterm or very low birth weight (VLBW) infants. Methods: Medical records of preterm infants born at a gestational age (GA) of <32 weeks or VLBW infants in 2011-2020 were reviewed respectively. The infants who received Saccharomyces boulardii probiotics within 7 days of birth were grouped into an early introduction (EI) group, and those who received supplemented probiotics after 7 days of birth were part of the late introduction (LI) group. Clinical characteristics were compared between the two groups and analyzed statistically. Results: A total of 370 infants were included. The mean GA (29.1 weeks vs. 31.2 weeks, p<0.001) and birth weight (1,235.9 g vs. 1491.4 g, p<0.001) were lower in the LI group (n=223) than in the EI group. The multivariate analysis indicated that factors affecting the LI of probiotics were GA at birth (odds ratio [OR], 1.52; p<0.001) and the enteral nutrition start day (OR, 1.47; p<0.001). The late probiotic introduction was associated with a risk of late-onset sepsis (OR, 2.85; p=0.020), delayed full enteral nutrition (OR, 5.44; p<0.001), and extrauterine growth restriction (OR, 1.67; p=0.033) on multivariate analyses after adjusting for GA. Conclusion: Early supplementation of probiotics within a week after birth may reduce adverse outcomes among preterm or VLBW infants.

Long-term simultaneous monitoring observations of SiO and H2O masers toward Mira variable WX Serpentis

  • Lim, Jang Ho;Kim, Jaeheon;Son, Seong Min;Suh, Kyung-Won;Cho, Se-Hyung;Yang, Haneul;Yoon, Dong-Hwan
    • The Bulletin of The Korean Astronomical Society
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    • v.46 no.2
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    • pp.49.1-49.1
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    • 2021
  • We carried out simultaneous monitoring observations of five maser lines, H2O (22 GHz), SiO 𝝊 =1, 2, J =1-0 (43.1, 42.8 GHz), and SiO 𝝊 =1, J=2-1, J =3-2 (86.2, 129.3 GHz), toward the Mira variable star WX Serpentis with the 21-m antennas of the Korean VLBI Network (KVN) in 2009-2021 (~12 years). Most spectra of the H2O maser are well separated into two parts of two blue- and one redshifted features within ± 10 km s-1 of the stellar velocity. All detected SiO masers are generally concentrated within ± 5 km s-1 of the stellar velocity, and sometimes appear split into two components. Overall, the profiles of SiO and H2O masers detected in WX Serpentis illustrate typical characteristics of the Mira variable. In addition, flux variations of both SiO and H2O masers are well correlated with the optical light curve of the central star, showing a phase lag of ~ 0.1 for SiO masers and ~ 0.2 for H2O maser. This phenomenon is considered to be the direct effect of propagating shock waves generated by the stellar pulsation, because SiO and H2O masers are sequentially distributed at different positions with respect to the central star. In addition, we analyzed long-term trends and characteristics of maser velocities, maser ratio, and the velocity extents (the full width at zero power; FWZP). We also investigated a spectral energy distribution (SED) ranging from 1.2 to 240 ㎛ obtained using several infrared data: 2MASS, WISE, IRAS, ISO, COBE DIBRE, RAFGL, and AKARI (IRC and FIS). From the IRAS LRS and ISO SWS spectra of this star, we identified 9.7 and 12 ㎛ silicate emission features consistent with the SE6 spectrum model, corresponding to the typical AGB phase.

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Science electives in high school will improve nutrition knowledge but not enough to make accurate decisions

  • Takahiro Mitsui;Susumu Yamamoto;Morito Endo
    • Nutrition Research and Practice
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    • v.17 no.4
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    • pp.803-811
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    • 2023
  • BACKGROUND/OBJECTIVES: Nutrition knowledge has been reported to have a weak positive effect on healthy eating behavior. This study aimed to determine if there was a difference in nutrition knowledge depending on the choice of science subject in high school and whether that affected the actual eating habits of college students in Japan. SUBJECTS/METHODS: The subjects were 514 college students, the majority first-year students, in 3 cities in Japan. A questionnaire survey was conducted on elective subjects in science in high school, diet (11 items), lifestyle (5 items), and nutrition knowledge (34 questions). The preliminary survey was conducted on 47 students in the fall of 2019, and the full-scale survey was conducted in May-June and October-November 2021 at the end of lectures for the first-year students. RESULTS: The students in the high-score group (24-31 points, n = 180) had a higher intake of vegetables (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.12-2.82; P = 0.015) and breakfast (OR, 1.64; 95% CI, 1.03-2.60; P = 0.035), and a reduced intake of fast food (OR, 0.27; 95% CI, 0.14-0.51; P < 0.001) than those in the low-score group (6-19 points, n = 150). Only the biology and chemistry students had significantly higher nutrition scores than the other groups (all: P < 0.001), but no significant difference was found between the other groups. Understanding nutrition learned in elementary and junior high school is appropriate, while molecular structure, recommended amount, and food poisoning were insufficient. CONCLUSIONS: Knowledge of nutrition appears to have a positive effect on the actual eating habits of college students. Although biology and chemistry in high school may help students understand the foundations of good nutrition, specialized food education may be required to make informed dietary choices.

Long-term Elevated Temperature Affects the Growth and Quality of 'Shiranuhi' Mandarin Grown in a Green House (장기간 온도상승이 시설재배 '부지화'의 수체 생장 및 과실 품질에 미치는 영향)

  • Misun Kim;Young-Eel Moon;Sang Suk Kim;Jaeho Joa;Seok Kyu Yun;YoSup Park
    • Korean Journal of Environmental Agriculture
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    • v.41 no.4
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    • pp.318-327
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    • 2022
  • BACKGROUND: The mean annual temperature of the Korean Peninsula will continue to rise due to global warming. 'Shiranuhi' mandarin-a late-harvest cultivar-is primarily cultivated in plastic greenhouses where high temperatures cannot be directly avoided. Therefore, growth and fruit quality changes under elevated temperatures must be investigated. METHODS AND RESULTS: Elevated temperatures were divided into three groups [2℃ (T-I), 4℃ (T-II), and 6℃ (T-III) above the ambient temperature] during the 2019-2020 season. Mean temperatures were 17.1℃, 18.6℃, and 20.2℃ in T-I, T-II, and T-III, respectively. The bud bursts in T-II and T-III were earlier than that in T-I at 7 days and 11 days, respectibely. And the full blooms in T-II and T-III were earlier than that in T-I at 11 days and 23 days, respectively. Fruit size significantly increased with increased temperature. The citrus color index in the coloring phase markedly differed across treatments. Further, total soluble solid and acid contents markedly changed with temperature rise but the sugar-to-acid ratio did not. Sucrose content tended to decrease with increase in temperature, but citric acid content remained unaffected. CONCLUSION(S): Elevated temperature accelerated plant growth and development but delayed rind color development in 'Shiranuhi' mandarin. Therefore, rise in ambient temperature by >4.6℃ may negatively affect yield and fruit quality.

Evaluation of Characteristics of Ground Anchor Using Large Scale Laboratory Test (실규모 실험을 이용한 그라운드 앵커의 거동 특성 평가)

  • Sangrae Lee;Seunghwan Seol
    • Journal of the Korean GEO-environmental Society
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    • v.24 no.11
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    • pp.19-24
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    • 2023
  • Ground anchor has been widely used specially for maintaining stability on reinforced cut slope in expressway. While the durability of the ground anchors should be ensured over the service life. However, the long-term loss of tensile force has occurred in most of field-installed anchors. Main causes are not clearly identified and very few studies have been made for analyzing long-term behavior of ground anchor in slopes. In this study, full-scale model tests and long-term measurements were made to obtain the load-displacement data and identified the causes of the long-term behaviors of ground anchor. As a result, the bond strength decreases exponentially with increasing water-binder ratio. Especially, groundwater is the most influencing factor to the bond strength. In the long-term behavior, the load decreases sharply until the initial settlement stabilized, and thereafter the tension force decreases constantly.

Vaccination Status and In-hospital Mortality Among Adults With COVID-19 in Jakarta, Indonesia: A Retrospective Hospital-based Cohort Study

  • Hotma Martogi Lorensi Hutapea;Pandji Wibawa Dhewantara;Anton Suryatma;Raras Anasi;Harimat Hendarwan;Mondastri Korib Sudaryo;Dwi Gayatri
    • Journal of Preventive Medicine and Public Health
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    • v.56 no.6
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    • pp.542-551
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    • 2023
  • Objectives: Prospective studies on vaccination status and mortality related to coronavirus disease 2019 (COVID-19) in low-resource settings are still limited. We assessed the association between vaccination status (full, partial, or none) and in-hospital mortality among COVID-19 patients at most hospitals in Jakarta, Indonesia during the Delta predomination wave. Methods: We conducted a retrospective cohort study among hospitalized COVID-19 patients who met the study criteria (>18 years old and admitted for inpatient treatment because of laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection). We linked individual-level data in the hospital admission database with vaccination records. Several socio-demographic and clinical characteristics were also analyzed. A Cox proportional hazards regression model was used to explore the association between vaccination status and in-hospital mortality in this patient group. Results: In total, 40 827 patients were included in this study. Of these, 70% were unvaccinated (n=28 543) and 19.3% (n=7882) died during hospitalization. The mean age of the patients was 49 years (range, 35-59), 53.2% were female, 22.0% had hypertension, and 14.2% were treated in the intensive care unit, and the median hospital length of stay across the group was 9 days. Our study showed that the risk of in-hospital mortality among fully and partially vaccinated patients was lower than among unvaccinated adults (adjusted hazard ratio [aHR], 0.43; 95% confidence interval [CI], 0.40 to 0.47 and aHR, 0.70; 95% CI, 0.64 to 0.77, respectively). Conclusions: Vaccinated patients had fewer severe outcomes among hospitalized adults during the Delta wave in Jakarta. These features should be carefully considered by healthcare professionals in treating adults within this patient group.

Olivine Synthesis Using Stainless Steel Tube (스테인리스강관을 이용한 감람석 합성)

  • Gi Young Jeong
    • Korean Journal of Mineralogy and Petrology
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    • v.36 no.4
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    • pp.337-343
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    • 2023
  • Olivine is a complete solid solution of fayalite and forsterite that is abundant in Earth and extraterrestrial materials such as rocky planets, meteorites, asteroids, and interplanetary dust. Due to the wide range of olivine compositions, diverse olivine standards are required for quantitative mineralogical analysis of olivine-bearing materials. Olivine standards were synthesized using an electric furnace and stainless steel tubes at temperatures ranging from 1000~1100 ℃. Overall, olivine was synthesized covering the full range of composition, with some synthetic impurities and unreacted material. The synthesized olivine showed a linear increase in the unit cell dimension in proportion to the molar ratio of fayalite in the starting materials, and the diffraction intensity was consistent with that of natural olivine. However, iron-rich synthetic olivine samples tend to have a higher content of impurity, suggesting that not all synthetic olivine can be used as a standard material yet, and improvements in the synthesis process, such as using high purity starting materials and control of reaction time and temperature, are required.

Calibration of ShadowCam

  • David Carl Humm;Mallory Janet Kinczyk;Scott Michael Brylow;Robert Vernon Wagner;Emerson Jacob Speyerer;Nicholas Michael Estes;Prasun Mahanti;Aaron Kyle Boyd;Mark Southwick Robinson
    • Journal of Astronomy and Space Sciences
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    • v.40 no.4
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    • pp.173-197
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    • 2023
  • ShadowCam is a high-sensitivity, high-resolution imager provided by NASA for the Danuri (KPLO) lunar mission. ShadowCam calibration shows that it is well suited for its purpose, to image permanently shadowed regions (PSRs) that occur near the lunar poles. It is 205 times as sensitive as the Lunar Reconnaissance Orbiter Camera (LROC) Narrow Angle Camera (NAC). The signal to noise ratio (SNR) is greater than 100 over a large part of the dynamic range, and the top of the dynamic range is high enough to accommodate most brighter PSR pixels. The optical performance is good enough to take full advantage of the 1.7 meter/pixel image scale, and calibrated images have uniform response. We describe some instrument artifacts that are amenable to future corrections, making it possible to improve performance further. Stray light control is very challenging for this mission. In many cases, ShadowCam can image shadowed areas with directly illuminated terrain in or near the field of view (FOV). We include thorough qualitative descriptions of circumstances under which lunar brightness levels far higher than the top of the dynamic range cause detector or stray light artifacts and the size and extent of the artifact signal under those circumstances.

Adaptive Enhancement of Low-light Video Images Algorithm Based on Visual Perception (시각 감지 기반의 저조도 영상 이미지 적응 보상 증진 알고리즘)

  • Li Yuan;Byung-Won Min
    • Journal of Internet of Things and Convergence
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    • v.10 no.2
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    • pp.51-60
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    • 2024
  • Aiming at the problem of low contrast and difficult to recognize video images in low-light environment, we propose an adaptive contrast compensation enhancement algorithm based on human visual perception. First of all, the video image characteristic factors in low-light environment are extracted: AL (average luminance), ABWF (average bandwidth factor), and the mathematical model of human visual CRC(contrast resolution compensation) is established according to the difference of the original image's grayscale/chromaticity level, and the proportion of the three primary colors of the true color is compensated by the integral, respectively. Then, when the degree of compensation is lower than the bright vision precisely distinguishable difference, the compensation threshold is set to linearly compensate the bright vision to the full bandwidth. Finally, the automatic optimization model of the compensation ratio coefficient is established by combining the subjective image quality evaluation and the image characteristic factor. The experimental test results show that the video image adaptive enhancement algorithm has good enhancement effect, good real-time performance, can effectively mine the dark vision information, and can be widely used in different scenes.