• 제목/요약/키워드: fructus

검색결과 1,159건 처리시간 0.022초

골연화증(骨軟化症)에 대(對)한 동서의학적(東西醫學的) 문헌고찰(文獻考察) (A Literature Study of The Osteomalacia)

  • 박종혁;황영근;정지천
    • 동국한의학연구소논문집
    • /
    • 제8권1호
    • /
    • pp.159-169
    • /
    • 1999
  • 고령화와 육체적 활동의 감소로 증가 추세에 있는 골연화증(骨軟化症)의 임상치료(臨床治療)에 도움을 얻고자 역대의서(歷代醫書)와 중의서(中醫書), 중의잡지(中醫雜誌)를 중심으로 증상(症狀), 병인(病因), 병리(病理), 치법(治法), 치방(治方) 등을 동서의학적(東西醫學的)으로 고찰하였다. 골연화증(骨軟化症)은 골의 석회화 장애로 골밀도가 감소되는 대사성 골질환으로, 동양의학(東洋醫學)에서는 골위, 골고(骨枯) 등의 골질환(骨疾患)에서 유사한 증상(症狀)이 나타나며, 병인(病因)은 주로 신허(腎虛)로서 서양의학의 신장 질환으로 인한 인(燐)의 재흡수 불량, Vit-D 대사 이상과 유사하다. 증상(症狀)으로는 요통(腰痛), 골통증(骨痛症), 다발성 골절, 동요성 보행 등이 나타난다. 치법(治法)은 보신(補腎)을 위주(爲主)로 하여 건비익신(健脾益腎),자양기혈(滋養氣血), 강장근골(强壯筋骨) 등이 있고, 치방(治方)은 육미지황탕(六味地黃湯)을 위주로 하여, 호잠환(虎潛丸), 제생신기환(濟生腎氣丸), 대보음환(大補陰丸) 등이 활용되고 있으며, 약물(藥物)은 숙지황(熟地黃), 호경골(虎脛骨), 호도육(胡挑肉), 자하차(紫河車), 두충(杜沖), 녹각교(鹿角膠), 녹용(鹿茸) 등의 보신지제(補腎之劑)가 주로 사용되고 있다.

  • PDF

천연 생약 복합 추출물이 Streutozotocin 유발 당뇨성 흰쥐의 혈당 및 인슐린, 혈청 과산화지질 농도에 미치는 효과 (Effects of a Natural Medicinal Multi-plant Extract on Blood Glucose, Insulin Levels, and Serum Malondialdehyde Concentrations in Streptozotocin-induced Diabetic Rats)

  • 박형래;조정순
    • 동아시아식생활학회지
    • /
    • 제17권2호
    • /
    • pp.205-212
    • /
    • 2007
  • This study was designed to investigate a natural medicinal multi-plants extract (BG515), which consisted of multi extracts of Mori folium, Rehmannia glutinosa Liboschitz, Dioscorea japonica, Lycii fructus, and Astragalus radix, on blood glucose, insulin levels, and serum malondialdehyde (MDA) concentrations in streptozotocin-induced diabetic rats. Streptozotocin (STZ) induces a type 1 diabetes mellitus in rats. Type 1 is usually characterized by the presence of islet cell autoantibodies (ICA), autoantibodies to insulin (IAA), and autoantiboides to glutamic acid decarboxylase (GAD), which identify the autoimmune process that leads to $\beta-cell$ destruction. Thirty-five male Sprague-Dawley (SD) rats weighing $150\sim170g$ each (6 weeks old) were randomly divided into one control (Group A) and 4 STZ-induced diabetic groups, and were subjected to one of the following treatment for 12 weeks. Groups A and B were fed basal diets and Group C, D, and E received the same diets as groups A and B, but with supplements of 150 mg/kg, 300 mg/kg, and 600 mg/kg of BG515 orally for 12 weeks, respectively. Diabetes was induced in Groups B, C, D, and E by intravenous injection of 45 mg/kg of STZ per body weight in sodium citrate buffer (pH 4.5) via the tail vein. In the BG515 groups, we found increases in serum insulin levels, compared to the STZ-control group, but these data were not significant. In contrast, blood glucose and serum MDA concentrations decreased in the BG515 groups compare to the STZ-control group. At the 5th week, in all the BG515 administered groups, there were decreases in serum blood glucose levels compared to the STZ- control group, and this activity was very strong in the BG515-1 group at the 12th week. These results suggest that natural bio-complex compounds (BG515) may slightly suppress STZ-induced changes in serum MDA concentration via the maintenance of serum insulin levels, due to the prevention of $\beta-cell$ and glucagon destruction by STZ.

  • PDF

해독사물탕(解毒四物湯)이 피부 접촉성 과민반응에 미치는 영향(影響) (Effects of Haedoksamul-tang on Trimellitic Anhydride-induced Contact Hypersensitivity in a Mouse Model)

  • 전영균;정명;복영옥;이은혜;임규상;윤용갑
    • 한방안이비인후피부과학회지
    • /
    • 제29권2호
    • /
    • pp.65-81
    • /
    • 2016
  • Objectives : Haedoksamul-tang (HSTE), a water extract from a mixture of Phellodendri Cortex, Coptidis, Scutellariae Radix, Gardeniae Fructus, Angelica acutiloba Radix, Cnidii Rhizoma, Paeoniae Radix, Rehmanniae Radix, has been traditionally used for allergic skin diseases such as atopic dermatitis and contact dermatitis in oriental countries. However, little is known about the effects of aqueous extract of HSTE on trimellitic anhydride (TMA)-induced contact hypersensitivity (CHS) in a mouse model. Methods : In this study, we investigate the pharmacological effects of HSTE on TMA-induced CHS in Balb/c mice. Contact hypersensitivity was induced in mice by topically sensitizing and challenging with TMA in flank skin and ears during oral administration (for 17 days) and topical treatment (30 min before challenge) with HSTE. We examined the effects of HSTE on IgE and IgG1 levels, inflammatory parameters in ear tissues, CD4+/CD8+ ratio, cytokine and chemokine production in sera, tissues, and immune cells from TMA-sensitized mice.Results : Oral and topical administration with HSTE reduced, in a dose dependent manner, thickness and leukocyte infiltration of ear tissues and IgE levels in serum from mice sensitized with TMA. In addition, auricula lymph node cells isolated from TMA-sensitized mice significantly elevated the expression ratio of CD4+/CD8+ as well as increased the production of IL-4, IL-5, IL-13 and IFN-γ by ex vivo stimulation with antibodies against CD3 and CD28, and these inflammatory indexes, except for IFN-γ, were significantly suppressed by orally and topically administration of HSTE. Furthermore, stimulation of auricula lymph node cells from TMA-sensitized mice with antibodies against CD3 and CD28 increased the production of MCP-1/CCL2 and MIP-1α/CCL3, and these effects were inhibited in a dose-dependent manner in cells from mice treated with HSTE. Conclusions : These results suggest that HSTE can be used for treating contact hypersensitivity by inhibiting leukocyte infiltration as well as production of serum IgE and chemokine/Th2 cytokine in an animal model.

태음인(太陰人) 이열병(裡熱病)의 병증(病證) 약리(藥理)에 대한 연구(硏究) (A Study on the medical and pharmacological theory of Interior-Overheated-Disease of Taeumin)

  • 김종열;김경요
    • 사상체질의학회지
    • /
    • 제10권2호
    • /
    • pp.111-150
    • /
    • 1998
  • 1. 연구배경 및 목적 이제마가 태음인(太陰人) 이열병(裡熱病)을 인식하고 태음인(太陰人) 처방(處方)을 계발한 과정을 파악함으로써 태음인의 병증(病證) 약리(藥理)에 대한 이해를 높이고자 한다. 2. 방 법 동의수세보원(東醫壽世保元) 병증론(病證論)에 나타난 인용문과 처방의 출전을 시대별로 고찰함으로써 병증(病證)과 약리(藥理)에 대한 인식의 변화를 관찰하고 분석하였다. 3. 결 과 이제마(李濟馬) 이전에는 태음인(太陰人) 간열증(肝熱證)이 소양인(少陽人) 위열증(胃熱證)과 다르다는 것은 알았으나, 병리에 있어서는 둘을 구분하지 못하고 똑같이 열결(熱結)로만 이해하였고, 그러면서도 처방은 어느 정도 서로 다르게 쓰여지는 경향이 있었다. 문헌 고찰 결과 위열이 상하로 치성(熾盛)하여 번조(煩燥), 두통(頭痛) 소편불이(小便不利), 편비(便秘)를 거의 대부분 동반하는 소양인 위열증과 '호산지기(呼散之氣) 부족흡취지기(不足吸聚之氣) 태과(太過)로 인해 내부에 조와 열(熱)이 발생함으로써 목동(目疼), 비건(鼻乾), 인통(咽痛), 음일수이 등의 특징적 증상을 보이는 태음인 간열증을 구분할 수 있었다. 한편 약재에 있어서도 갈근, 승마(升麻), 고본(藁本), 백지(白芷), 대황(大黃)은 태음인 간열증의 치방에 군약으로 쓰이는 점에서, 황금(黃芩)과 길경(桔梗)은 폐에 작용하는 약임이 분명하므로, 그리고 라복자(蘿卜子)와 급각은 각각 치담약(治痰藥)과 개열락(開悅樂)이면서 천식(喘息), 해수(咳嗽) 등 폐병증을 함께 치료하는 점에서 각각 태음인 약으로 알 수 있었다.

  • PDF

국내 유통 한약재에서 이산화황 잔류량에 대한 연구 (Studies on the Residual Contents of Sulfur Dioxide in Herbal Medicines Distributed at Domestic)

  • 김재이;김우성;박건상;김종명;채갑용;조대현;김대병;김옥희;신영민
    • 동의생리병리학회지
    • /
    • 제21권4호
    • /
    • pp.1039-1044
    • /
    • 2007
  • We investigated the residual contents of sulfur dioxide ($SO_2$) on the 280 kinds of herbal medicines distributed at 8 cities including in Seoul, Busan, Daegu, Gwangju, Jecheon, Yeongju, Geumsan and Jeonju in Korea. The residual contents of $SO_2$ were determinated by modified Monier-Williams method. The residual contents of $SO_2$ were not detected at 206 products in total 280 products. However, it was detected below 100 ppm in 39 products, between 101 and 1000 ppm in 30 products and exceeded 1000 ppm in 5 products. $SO_2$ contents ranged 11 ${\sim}$ 2339 mg/kg (mean 293 mg/kg) at domestic samples distributed. Regardless of region, $SO_2$ contents were not found at Notopterygii Rhizoma, Ligustici Scinensis Rhizoma et Radix, Bombyx Batryticatus, Coicis Semen, Cnidii Rhizoma, Anemarrhenae Rhizoma, Gardeniae Fructus, Alismatis Rhizoma. But it's found at Batatatis Rhizoma, Paeoniae Radix and Codonopsitis Radix of every region collected the samples. $SO_2$ contents were not detected at 58 products which collected cultural fields of dometic. After treated with water wash and hot water extraction, the reduction rates of sulfur dioxide were appeared with 14.3% ${\sim}$ 40.4% and 55.2% ${\sim}$ 100.0%, respectively. These data will be used to establish a criteron of residual sulfur dioxide in herbal medicines.

金元四大家의 外科疾患에 對한 硏究;(癰疽瘍瘡을 中心으로) (A Literature Study on Surgical Disease of the Four Famous Physicians in JinYuan Period)

  • 김희택;노석선
    • 한방안이비인후피부과학회지
    • /
    • 제12권1호
    • /
    • pp.179-214
    • /
    • 1999
  • The result were as follows: 1. Yu Wan So(劉完素) regarded the cause of surgical disease as the heat(熱). He used the three method to drain(疏通), promoting pus drainage(托裏) and the balance between ying-energy(營氣) and wei-energy(衛氣). 2. Jang Jong Jeung(張從正) only refered to medicines without entire theory. 3. Lee Dong Won(李東垣) regarded the cause of surgical disease as the greasy diet(膏梁厚味), damp air(濕氣), wetness heat(濕熱). For each treatment he used the method of Yu Wan So's treatment and emphasized the balance between ying-energy(營氣) and wei-energy(衛氣), stomach energy(胃氣). 4. Ju Jin Heung(朱震亨) distinguished the cause of surgical disease from enternal(內), external(外) and channel(經). For each treatment he used the method to drain(疏通), promoting pus drainage(托裏) and the balance between ying-energy(營氣) and wei-energy(衛氣). The first stage used the clearing away heat and toxic materials(淸熱解毒) and the last stage used the invigoration and dispersion(補托). 5. Yu Wan So(劉完素) used to be very busy of Moschus(麝香), Alumen(白礬), Olibanum(乳香), Coptidis Rhizoma(黃連), Minium(黃丹) and Scutel1ariae Radix(黃芩) In classification of the medical action, great part of the medicine are activating blood circulation to dissipate blood stasis(活血祛瘀), clearing away heat and toxic materials( 淸熱解毒) and external application(外用). 6. Jang Jong Jeung(張從正) used to be very busy of Olibanum(乳香), Angelicae Gigantis Radix(當歸), Minium(黃丹), Myrrha(沒藥), Calomelas(輕粉), Rhei Radix Et Rhizoma(大黃) and Phellodendri Cortex(黃柏). In classification of the medical action, great part of the medicine arc activating blood circulation to dissipate blood stasis(活血祛瘀), clearing away heat and toxic materials(淸熱解毒) and diverged wind-cold evil(發散風寒). 7. Lee Dong Won(李東垣) used to be very busy of Forsythiae Fructus(連翹), Scuteliariae Radix(黃芩), Angelicae Gigantis Radix(當歸). Astragali Radix(황기), Glycyrrhizae Radix(炙甘草), Bupleuri Radix(紫胡), Phellodendri Cortcx(黃柏), and Coptidis Rhizoma(黃連). In classification of the medical action, great part of the medicine are activating blood circulation to dissipate blood stasis(活血祛瘀), regulating vital energy(理氣) and clearing away heat and toxic materials(淸熱解毒). 8. Ju Jin Heung(朱震亨) used to be very busy of Glycyrrhizae Radix(甘草), Astragali Radix(황기), Angelicae Gigantis Radix(當歸), Phellodendri Cortex(黃柏), Scutellariae Radix(黃芩), Ginseng Radix(人蔘), Qlibanum(乳香). In classification of the medical action, great part of the medicine are clearing away heat and toxic materiaIs(淸熱解毒), activating blood circulation to dissipate blood stasis(活血祛瘀) and diverged wind-cold evil(發散風寒).

  • PDF

乾癬에 對한 東.西醫 文獻的 硏究 (The Oriental and Occidental bibliographic Study of Psoriasis)

  • 김남권;황충연;임규상
    • 한방안이비인후피부과학회지
    • /
    • 제12권1호
    • /
    • pp.154-178
    • /
    • 1999
  • Psoriasis is the recurrent disease of skin and till now its mechanism, pathogenesis and treatment are not clearly discovered. So, like these papers, we must investigate more safety and effective treatment of psoriasis. And I obtained the following condusions from the Oriental and Occidental bibliographic investigation. 1. In Oriental medicine. Baikbi, Pungsun, Eunselbyong, Songpisun, Baikselpung were the other names of Psoriasis. 2. In Occidental medicine, genetic factors, aggravation and inducible factors, biochemical factors, immunologic factors, disorder of epidermal kinetics, vascular malformation of dermis were cosidered to the pathogenic factors of psoriasis. 3. In Oriental medicine, the pathogenic factors of psoriasis were divided two parts. One is exogenous pathogenic factors which including the blood-heat, blood dryness, blood stasis, deficiency of liver and kidney, inharmony of impulsive and appointed pulsation, deficiency of blood. The other is exogenous pathogenic factors which including the wind-evil, wind-wetness, wind-heat, wind-cold, wetness-heat, cold-wetness, heat-evil. 4. In Occidental medicine, external applicative medicine, internal medicine, ultraviolet therapy, ultraviolet - external applicative medicine compound therapy and etc. were used the therapy of psoriasis. 5. In Oriental medicine, clean away heat and cooling blood, aliment the blood and moisturize, activating blood and expelling blood stasis, harmonize and invigorate the liver and kidney, invigorate the kidney, aliment the blood and moisturize the skin, aliment the blood and expelling the wind, expelling the wind and wetness, clean away heat and expelling wind, expelling the wind and scatter the cold, clean away heat and expelling the wetness, heat up the meridian and scatter the cold, clean away heat and remove the toxin and etc. were used the method of internal therapy of psoriasis. 6. Until Qing dynasty, wind expelling effective prescriptions like Bangpungtongsungsan, Sopungsan. Supungsunkisan and etc. were used and recently Yanghyelgeupungtang, Hwalhyelgeupungtang, Samultanggagam and etc. were used the internal therapy of psoriasis. 7. In the external therapy of psoriasis, Yuhonggo, Pungyugo, Sekryupiyeongo were used the plaster therapy and Folium Rerillae, Camphora, Fructus, Xanthii, Herba Spirodelae compound prescription were used the cleansing therapy, Okgisan, Chiunsan, Galmyogo, Hobunsan, Muisan, Madugo, Jeyugohengin were used the rubbing skin therapy. Rangdok Radix Aconiti, Bijeonilchoalkwang were used the attaching therapy, the extract of Rhizoma Et Radix Veratri was used the spreading pouder therapy. 8. In the acupuncture therapy of psoriasis, the Jelgol, chok Samni(S36), Kansa(P5), Haegye(S41), Wijung(B40) and etc. were used the acupuncture point, and the angle of helix incision threapy that disinfect and cut the angle of helix and plaster the Semen Glycine and Squama Manitis were used.

  • PDF

마우스 흑색종 B16F10세포에서 loganin의 티로시나아제 발현 억제를 통한 멜라닌 생성 억제에 대한 기전연구 (Loganin Inhibits α-MSH and IBMX-induced Melanogenesis by Suppressing the Expression of Tyrosinase in B16F10 Melanoma Cells)

  • 정희진;방은진;김병무;정성호;이길한;정해영
    • 생명과학회지
    • /
    • 제29권11호
    • /
    • pp.1200-1207
    • /
    • 2019
  • Loganin은 Corni fructus의 주요 iridoid glycoside이며 항염증, 항당뇨 그리고 뇌신경보호 효과 등이 보고되었다. 본 연구에서는 ${\alpha}-MSH$와 IBMX처리된 B16F10세포에서 loganin의 melanogenesis억제효과의 신호전달 경로를 조사하였다. Loganin의 미백 활성을 확인하기 위해 B16F10세포에서 $1{\mu}m$에서 $20{\mu}m$사이의 농도를 처리하여 세포독성 실험을 수행한 결과 최대 $20{\mu}m$농도에서 독성을 나타내지 않았다. 또한 loganin은 ${\alpha}-MSH$와 IBMX처리된 B16F10세포에서 농도-의존적으로 멜라닌 생성을 감소시키는 것을 확인하였다. 또한 loganin의 멜라닌 생성을 억제하는 신호전달 경로를 Western blotting을 실시하여 조사하였다. Western blot결과에 따르면 loganin은 ${\alpha}-MSH$와 IBMX 처리된 B16F10세포에서 증가된 CREB인산화(Ser133)와 MITF 발현 및 tyrosinase의 유전자 발현을 감소시켰고 ERK의 인산화를 증가시켜 melanin 생성을 억제하였다. 결론적으로 loganin은 ${\alpha}-MSH$와 IBMX에 의해 유도된 과도한 멜라닌 합성을 CREB인산화와 MITF 및 tyrosinase의 유전자 발현을 억제하고 ERK의 활성화를 통해 멜라닌 합성을 감소됨을 확인하였다. 따라서 loganin은 과색소 침착과 관련된 피부질환의 보호제로서 활용될 가능성을 가지는 것으로 사료된다.

연교를 함유한 처방단 추출물의 항노화 효과 (Anti-aging Effects of Prescription Extracts Containing Forsythia viridissima L.)

  • 김미진;정택규;윤경섭
    • 대한화장품학회지
    • /
    • 제41권1호
    • /
    • pp.85-96
    • /
    • 2015
  • 항산화 활성, 항염증 효과, 항균작용, 주름개선 및 미백 효과 등이 알려져 있는 연교를 함유하며, 항염증 효과를 갖는 연교승마탕(連翹升麻湯), 가미연교승마탕(加味連翹升麻湯) 및 회춘양격산(回春凉膈散) 각각의 처방단을 추출하여 항노화 관련 효능을 알아보았다. 연교처방단 추출물의 자유라디칼 및 활성산소 소거 활성, 타이로시네이즈 활성 저해효과, 최종당화산물 생성 저해효과를 알아보았으며, 콜라겐 생성 및 자외선에 의해 유도된 MMP-1 생성 저해, ${\alpha}$-MSH에 의해 유도된 멜라닌의 생성 저해효과를 확인하였다. 그 결과 항산화 및 항당화 효과를 보였으며, 효소처리 한 연교승마탕 추출물과 가미연교승마탕 75% 에탄올수용액 추출물은 콜라겐 생성 및 MMP-1 생성 저해효과를 나타내었다. 효소처리 한 회춘양격산 추출물들은 멜라닌 생성 저해효과를 나타내었다. 이로써, 연교처방단 추출물을 이용한 항노화 소재로서의 개발 가능성을 확인하였다.

연교김패전(連翹金貝煎)의 Escherichia coli에 대한시험관내 항균력 평가 (In Vitro Antibacterial Effects of Yeonkyokeumpae-jeon against Escherichia coli)

  • 한상겸;김동철
    • 대한한방부인과학회지
    • /
    • 제28권1호
    • /
    • pp.29-45
    • /
    • 2015
  • Objectives: The object of this study was to observe the in vitro antibacterial effects of Yeonkyokeumpae-jeon (YKKPJ) have been used for treating various gynecological diseases including mastitis in Korea, and individual six kinds of herbal composition aqueous extracts - Forsythiae Fructus (FF), Millettiae Caulis (MC), Lonicerae Flos (LF), Fritillaria Thunbergii Bulb (FT), Taraxci Herba (TH) and Prunellae Spica (PS) against E. coli. Methods: Antibacterial activities against E. coli of YKKPJ, FF, MC, LF, FT, TH and PS aqueous extracts were detected using standard agar microdilution methods. In addition, the effects on the bacterial growth curve were also monitored at MIC and $MIC{\times}2$ levels. The effects on the intracellular killing and bacterial invasion of individual test materials were also observed using Raw 264.7 and MCF-7. The results were compared with ciprofloxacin, a second generation of quinolone antibiotics in the present study. Results: MIC of YKKPJ, FF, MC, LF, FT, TH, PS aqueous extracts against E. coli were detected as $0.039{\pm}0.013mg/ml$, $0.064{\pm}0.033mg/ml$, $0.108{\pm}0.053mg/ml$, $0.078{\pm}0.027mg/ml$, $16.250{\pm}8.385mg/ml$, $15.625{\pm}9.375mg/ml$, $0.254{\pm}0.131mg/ml$, repectively. YKKPJ, FF, MC, LF, FT, TH, PS aqueous extracts showed antibacterial effects against to E. coli, except for FT and TH, which were showed negligible antibacterial effects, respectively. In addition, ciprofloxacin with YKKPJ, FF, MC, LF and PS aqueous extracts also showed marked dosage-dependent inhibition of bacterial growth, and favorable inhibitory effects on the both bacterial invasion and intracellular killing assays using MCF-7 and Raw 264.7 cells were detected in this experiment. Conclusions: The results obtained in this study suggest that traditional polyherbal formula YKKPJ aqueous extracts showed more favorable antibacterial activities as compared to individual six kinds of herbal composition aqueous extracts. The antibacterial effects of YKKPJ against E. coli considered as results of complicated synergic effects of their six kinds of herbal components rather than simple antibacterial effects of single herbal components. It means, YKKPJ aqueous extracts may show potent anti-infectious effects against E. coil for mastitis.