• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.221-227
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• 2014

Background: Aberrant phenotypes in acute leukemia have variable frequency and their prognostic and predictive relevance is controversial, despite several reports of clinical significance. Aims: To determine the prevalence of aberrant antigen expression in acute leukemia, assess clinical relevance and demonstrate immunophenotype-karyotype correlations. Materials and Methods: A total of 73 (40 AML and 33 ALL) newly diagnosed acute leukemia cases presenting to KAMC, Kingdom of Saudi Arabia, were included. Diagnosis was based on WHO criteria and FAB classification. Immunophenotyping by flow cytometry, conventional karyotyping and fluorescence in situ hybridization for gene rearrangements were performed. Results: Aberrant antigens were detected in 27/40 (67.5%) of AML and in 14/33 (42.4%) in ALL cases. There were statistically significant higher TLC in Ly+ AML than in Ly-AML (p=0.05) and significant higher blast count in ALL with aberrant antigens at presentation and day 14 (p=0.005, 0.046). There was no significant relation to clinical response, relapse free survival (RFS) or overall survival (p>0.05), but AML cases expressing ${\geq}2$ Ly antigens showed a lower median RFS than those expressing a single Ly antigen. In AML, CD 56 was expressed in 11/40. CD7 was expressed in 7/40, having a significant relation with an unfavorable cytogenetic pattern (p=0.046). CD4 was expressed in 5/40. CD19 was detected in 4/40 AML associated with M2 and t (8; 21). In ALL cases, CD33 was expressed in 7/33 and CD13 in 5/33. Regarding T Ag in B-ALL CD2 was expressed in 2 cases and CD56 in 3 cases. Conclusions: Aberrant antigen expression may be associated with adverse clinical data at presentation. AML cases expressing ${\geq}2$ Ly antigens may have shorter median RFS. No specific cytogenetic pattern is associated with aberrant antigen expression but individual antigens may be related to particular cytogenetic patterns. Immunophenotype-karyotype correlations need larger studies for confirmation.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.11
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• pp.5019-5023
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• 2016

Background: In Mexico, breast cancer (BCa) is in first place regarding cancer mortality and has been established as a priority health issue. The incidence of metastasis from BCa is very high and presents as the principal mortality factor among women younger than 40 years of age. OBJECTIVE. To determine any associations between clinicopathological characteristics and metastasis in Mexican women under 40 years of age. Methods: During the 2010-2015 period, a total of 180 female BCa cases seen at the Navy General High Specialty Hospital, SEMAR, in Mexico City; we collected information on 20 patients with BCa younger than 40 years of age. Statistical analyses were conducted using the Kolmogorov-Smirnov, Students t, Fisher, Chi square, and Mantel-Haenszel tests. Results: The prevalence of women with BCa younger than the age of 40 years during the 2010-2015 period was 13.3%. We found a high frequency of obesity in of these cases (>75%); 100% of obese patients with a history of smoking presented with metastasis (p <0.05). In addition, the hormone phenotype was important; HER2-positive cases were 12 times more likely tto exhibit metastasis (p <0.05), while expression of estrogen and progesterone receptors appeared to be protective. Diabetes mellitus in combination with smoking was also a risk factor for development of metastasis (p <0.05). Conclusion: In this study, we obtained essential data regarding risk of metastasis in young breast cancer cases which could be useful for predicting disease evolution and treatment response.

• Journal of the Korean Professional Engineers Association
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• v.17 no.3
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• pp.32-49
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• 1984

The East gate station area is 205M long and 24m deep which is located 13 meter in front of cultural treasure east gate. The area to be excavated by blasting is composed of granite rocks from 10M depth to 25M. Surface earth extends to up 10M depth. This job site has in involves heavy traffic congestion such as over 10,000 cars passing in rush hour where clossing No 1 lint of subway running 3 minitues head way. This east gate station construction is to be executed for the provent of the setting down of underground level and blasting vibration effects to cultural treasure east gate. Therefore, the caltural treasure committee approved this execution subject to the following condition. 1. Subway gelogical foundation and measured natural frequency 2. Execution of water tight wall 3. Sellection and test of damping material for wall and under rail 4. Measurement of monitoring system during the execution 5. Measurement of histogram system The above two projects was carried out by Dr. Kwang team in KAIST and prof, Han in Hanyang University under accadamic study contract. In the blasting work, for the pourpose of reduced vibration and low explosion velocity such as CCR, Kovex slurry. The 2nd, used electrical caps shall be delay cap and M/S caps in multi delay. The 3rd, drilling pattern is bench cut in open cut and applied control blasting in tunnelling and also shall drill anti-vibration holes as line drilling.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.1
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• pp.25-31
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• 2009

The anti-vibration tables that use air suspensions as dampers have been widely used due to their high anti-vibration performance in wide frequency band. However, they face a problem of easily accelerating the vibration when triggered by external force because their air suspensions have low rigidity and dampness. In response, there has been a study on active/semi-active dampers that use only the passive components like air suspensions to complement the passive-control format. Thus, we have dynamically analyzed the active/semi-active control of such passive anti-vibration tables. To demonstrate the anti-vibration table's control system, we have also constructed a kinetic model based on the physical characteristics of an anti-vibration table with 6 degrees of freedom and verified its applicability through analysis and experiments.

• Nutrition Research and Practice
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• v.9 no.4
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• pp.420-424
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• 2015

BACKGROUND/OBJECTS: When the functions involved in the ingestion of food occurs failure, not only loss of enjoyment of eating, it will be faced with protein-energy malnutrition. Dysmasesis and difficulty of swallowing occurs in various diseases, but it may be a major cause of aging, and elderly people with authoring and dysmasesis and difficulty of swallowing in the aging society is expected to increase rapidly. SUBJECTS/METHODS: In this study, we carried out a survey targeting nutritionists who work in elderly care facilities, and examined characteristics of offering of foods for elderly and the degree of demand of development of easily chewable and swallowable foods for the elderly who can crush foods and take that by their own tongues, and sometimes have difficulty in drinking water and tea. RESULTS: In elderly care facilities, it was found to provide a finely chopped food or ground food that was ground with water in a blender for elderly with dysmasesis. Elderly satisfaction of provided foods is appeared overall low. Results of investigating the applicability of foods for elderly and the reflection will of menus, were showed the highest response rate in a gelification method in molecular gastronomic science technics, and results of investigating the frequent food of the elderly; representative menu of beef, pork, white fish, anchovies and spinach, were showed Korean barbecue beef, hot pepper paste stir fried pork, pan fried white fish, stir fried anchovy, seasoned spinach were the highest offer frequency. CONCLUSIONS: This study will provide the fundamentals of the development of easily chewable and swallowable foods, gelification, for the elderly. The study will also illustrate that, in the elderly, food undergone gelification will reduce the risk of swallowing down to the wrong pipe and improve overall food preference.

• Journal of Korea Multimedia Society
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• v.21 no.8
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• pp.837-848
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• 2018

Monitoring technology of machining has a long history since unmanned machining was introduced. Despite the long history, many researchers have presented new approaches continuously in this area. Sound based machine fault diagnosis is the process consisting of detecting automatically the damages that affect the machines by analyzing the sounds they produce during their operating time. The collected sound is corrupted by the surrounding work environment. Therefore, the most important part of the diagnosis is to find hidden elements inside the data that can represent the error pattern. This paper presents a feature extraction methodology that combines various digital signal processing and pattern recognition methods for the analysis of the sounds produced by tools. The magnitude spectrum of the sound is extracted using the Fourier analysis and the band-pass filter is applied to further characterize the data. Statistical functions are also used as input to the nonlinear classifier for the final response. The results prove that the proposed feature extraction method accurately captures the hidden patterns of the sound generated by the tool, unlike the conventional features. Therefore, it is shown that the proposed method can be applied to a sound based automatic diagnosis system.

• Journal of Advanced Navigation Technology
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• v.22 no.1
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• pp.27-30
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• 2018

In this study, a 40 GHz band pass filter(BPF) employing a hair-pin structure has been designed, fabricated, and characterized for millimeter-wave wireless communication applications. Using the 3 dimensional(3-D) electromagnetic(EM) tool and design equations of the hairpin BPF, the BPF was desgned on the 5 mil-thick Duroid substrate(RT5880) with a relative dielectric constant (${\varepsilon}_r$) of 2.2. The tapping point (t) of the U-shape resonator in the input and output port has been determined using extracted an external Q-factor ($Q_e$). The coupling coefficients between the other resonators are calculated by adjusting the physical dimensions for the desired response of the BPF. The fabricated BPF was characterized using probing method on a probe station. Its measured center frequency(fc) and fractional BW are 41.6 GHz and 7.43 %, respectively. The measured return loss is below -10 dB at the pass band and the insertion loss is 3.87 dB. The fabricated BPF is as small as $9.1{\times}2.8mm^2$.

• Journal of Biomedical Engineering Research
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• v.27 no.6
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• pp.376-383
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• 2006

Noise induced hearing loss (NIHS), the well-known occupational disease, is caused by continuous excessive noise. The prevention of NIHS is very important, because it is unrecoverable. There are some kinds of hearing protection device (HPD), and those are effective in preventing NIHS. But workers in noisy environment often resist to wearing them. Because they are ready - made products, so workers feel uncomfortable to wear. Also, they didn't maintain the conversation frequency range, so workers are hard to communicate in wearing them. To prevent hearing loss effectively, it is important that workers keep wearing HPD. Therefore, a HPD is needed to be comfortable to wear and be effective not only in hearing protection but also in preserving communication ability. So we proposed a custom - made hearing protection device in which a small acoustic filter is inserted. We designed several kinds of small acoustic filters and carried out some acoustic experiments for measuring characteristics of filters. We confirmed that acoustic transmission characteristic can be adjusted from experimental results using designed small acoustic filters. And we researched for the actual efficiency of a new developed custom - made hearing protection device using a small size acoustic filter. Also, we found out that workers are more satisfied with the new development than a former protection device from a workers' response.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.12
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• pp.2232-2240
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• 2017

IMO has made AIS and VHF mandatory for international sailing vessels through SOLAS, and korea if mandating specific vessels through the law for safety of vessels and the ship installation technology standards. However, due to various communication equipments and complicated usage method, malfunction occurs, and the response delay to the actual structure signal often causes human accidents. So recently, as a part of GMDSS modernization, maritime communication devices are attempting to interwork and integrate different types of marine communication system in order to construct a next generation maritime communication system. In this paper, we describe a technique to implement the DSC function by interlocking and integrating the AIS device and VHF. We will present the basis for achieving domestic technical standards and standardization through the linking algorithm of the data that can extract the ship information from AIS and utilize it the DSC function of VHF.

• Journal of Power Electronics
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• v.15 no.6
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• pp.1673-1681
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• 2015

A low dropout (LDO) regulator with a wide-bandwidth is proposed in this paper. The regulator features a Human Body Model (HBM) 8kV-class high robustness ElectroStatic Discharge (ESD) protection circuit, and two error amplifiers (one with low gain and wide bandwidth, and the other with high gain and narrow bandwidth). The dual error amplifiers are located within the feedback loop of the LDO regulator, and they selectively amplify the signal according to its ripples. The proposed LDO regulator is more efficient in its regulation process because of its selective amplification according to frequency and bandwidth. Furthermore, the proposed regulator has the same gain as a conventional LDO at 62 dB with a 130 kHz-wide bandwidth, which is approximately 3.5 times that of a conventional LDO. The proposed device presents a fast response with improved load and line regulation characteristics. In addition, to prevent an increase in the area of the circuit, a body-driven fabrication technique was used for the error amplifier and the pass transistor. The proposed LDO regulator has an input voltage range of 2.5 V to 4.5 V, and it provides a load current of 100 mA in an output voltage range of 1.2 V to 4.1 V. In addition, to prevent damage in the Integrated Circuit (IC) as a result of static electricity, the reliability of IC was improved by embedding a self-produced 8 kV-class (Chip level) ESD protection circuit of a P-substrate-Triggered Silicon Controlled Rectifier (PTSCR) type with high robustness characteristics.