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Changes in the thyroid hormone profiles in children with nephrotic syndrome

  • Jung, Sun Hee;Lee, Jeong Eun;Chung, Woo Yeong
    • Clinical and Experimental Pediatrics
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    • v.62 no.3
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    • pp.85-89
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    • 2019
  • Purpose: We compared thyroid hormone profiles in children with nephrotic syndrome (NS) during the nephrotic phase and after remission. Methods: This study included 31 pediatric NS patients. The thyroid hormone profiles included serum levels of triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), and free T4. Results: Of the 31 patients, 16 (51.6%) showed abnormal thyroid hormone profiles: 6 had overt hypothyroidism, 8 had subclinical hypothyroidism, and 2 had low T3 syndrome. The mean serum T3, T4, and free T4 levels in the nephrotic phase and after remission were $82.37{\pm}23.64$ and $117.88{\pm}29.49ng/dL$, $5.47{\pm}1.14$ and $7.91{\pm}1.56{\mu}g/dL$, and $1.02{\pm}0.26$ and $1.38{\pm}0.23ng/dL$, respectively; the levels were significantly lower in the NS nephrotic phase (P=0.0007, P<0.0001, and P=0.0002). The mean serum TSH levels during the nephrotic phase and after remission were $8.05{\pm}3.53$ and $4.08{\pm}2.05{\mu}IU/mL$, respectively; they were significantly higher in the nephrotic phase (P=0.0005). The urinary protein/creatinine ratio during the nephrotic phase was significantly correlated with serum T3, T4, and free T4 levels (r=-0.5995, P=0.0032; r=-0.5797, P=0.0047; r=-0.5513, P=0.0078) as well as with TSH levels (r=0.5022, P=0.0172). A significant correlation was found between serum albumin and serum T3 levels during the nephrotic phase (r=0.5385, P=0.0018) but not between serum albumin and T4, TSH, or free T4 levels. These significant correlations all disappeared after remission. Conclusion: Abnormal thyroid hormone profile findings were observed in 51.6% of pediatric patients with NS. Thyroid hormone levels normalized after remission, regardless of levothyroxine therapy.

Serum Thyroxine to Thyroxine-Binding Globulin Ratio in Pregnancy and Newborn (신부(娠婦)와 신생아(新生兒)에서 혈청(血淸)Thyroxine/Thyroxine-Binding Globulin 비(比))

  • Kim, Ji-Yeul
    • The Korean Journal of Nuclear Medicine
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    • v.16 no.2
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    • pp.59-61
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    • 1982
  • To evaluate the diagnostic value of the ratio of serum tyroxine$(T_4)$/thyroxine-binding globulin (TBG) for the thyroid status in pregnancy and newborn serum thyroxine, TBG, triiodothyronine, and free thyroxine levels were radioimmunoassayed in normal pregnant women at each of the trimesters, and the calculated serum $T_4/TBG$ ratios were compared with other parameters such as $T_3/TBG$ ratio and free $T_4/TBG$ ratio and free $T_4/TBG$ ratio. Serum $T_4$ levels were elevated with the propotionate increase in TBG levels during pregnancy, leading to the nearly constant value of serum $T_4/TBG$ ratios as in normal non-pregnant controls. In contrast, serum $T_3/TBG$ and free $T_4/TBG$ ratios varied considerably during pregnancy. In newborn, $T_4$ levels were nearly not changed with compared non-pregnant control value and TBG levels were elevated. The results indicate that serum $T_4/TBG$ ratio is a better parameter than others in evaluating the thyroid status during pregnancy and but newborn is a no better.

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Magnetoresistance of IrMn-Based Spin Filter Specular Spin Valves (IrMn 스핀필터 스페큘라 스핀밸브의 자기저항 특성)

  • Hwang, J.Y.;Rhee, J.R.
    • Journal of the Korean Magnetics Society
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    • v.14 no.6
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    • pp.236-239
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    • 2004
  • We studied the specular spin valve (SSV) having the spin filter layer (SFL) in contact with the ultrathin free layer composed of Ta3/NiFe2/IrMn7/CoFel/(NOLl)/CoFe2/Cu1.8/CoFe( $t_{F}$)/Cu( $t_{SF}$ )/(NOL2)/Ta3.5 (in nm) by the magnetron sputtering system. For this antiferromagnetic I $r_{22}$M $n_{78}$-pinned spin filter specular spin valve (SFSSV) films, an optimal magnetoresistance (MR) ratio of 11.9% was obtained when both the free layer thickness ( $t_{F}$) and the SFL thickness ( $t_{SF}$ ) were 1.5 nm, and the MR ratio higher than 11% was maintained even when the $t_{F}$ was reduced to 1.0 nm. It was due to increase of specular electron by the nano-oxide layer (NOL) and of current shunting through the SFL. Moreover, the interlayer coupling field ( $H_{int}$) between free layer and pinned layer could be explained by considering the RKKY and magnetostatic coupling. The coercivity of the free layer ( $H_{cf}$ ) was significantly reduced as compared to the traditional spin valve (TSV), and was remained as low as 4 Oe when the $t_{F}$ varied from 1 nm to 4 urn. It was found that the SFL made it possible to reduce the free layer thickness and enhance the MR ratio without degrading the soft magnetic property of the free layer.

An Evaluation of Thyroid Hormones$(T_4,\;T_3\;&\;Free\;T_4)$ Concentrations During Pregnancy (임신중(姙娠中) 유리(遊離)Thyroxine $(T_4)$의 동태(動態))

  • Lee, Kyu-Bo;Kim, Ji-Yeul
    • The Korean Journal of Nuclear Medicine
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    • v.15 no.1
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    • pp.21-25
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    • 1981
  • Serum concentrations of $T_4,\;T_3$, and free $T_4$ were measured by radioimmunoassay in normal pregnant women at each trimesters, in postpartum women, and cord blood of neonates. Total $T_4$ were increased during pregnancy, remarkably high in the first trimester, and also somewhat increased in postpartum, and normal in neonate. Total $T_3$ were in normal range during pregnancy, but increased in postpartum, whereas decreased in neonate. Free $T_4$ were decreased in 2nd and 3rd trimesters of pregnancy, however normal in post partum and neonate.

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Study of quality characteristics in gluten-free rice batter according to ultra-high speed conditions

  • Ku, Su-Kyung;Park, Jong-Dae;Sung, Jung-Min;Choi, Yun-Sang
    • Korean Journal of Agricultural Science
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    • v.48 no.3
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    • pp.535-544
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    • 2021
  • When baking, the proper blending or mixing of materials will affect the quality of the product. The mixing strength is important when establishing the optimal conditions for batter, and control of the mixing condition is accordingly an important factor. This study investigated the effects of the mixing speed and time on the quality characteristics of a gluten-free type of rice batter. The batter samples manufactured for this purpose are as follows: control (+) (wheat flour), control (-) (rice flour), T1 (1,800 rpm, 1 min), T2 (1,800 rpm, 2 min), T3 (1,800 rpm, 3 min), T4 (3,600 rpm, 1 min), T5 (3,600 rpm, 2 min), T6 (3,600 rpm, 3 min). In this study, rice flour was used in the T1 to T6 samples. The pH of the batter tended to be higher when the mixing speed was slower and the time was shorter depending on the ultra-high mixing conditions. The moisture content of T3 was highest, and there was no difference according to the ultra-high speed conditions. The specific volumes of the ultra-high mixing treatments were higher than those of the control samples. The relationship between the specific volume, hardness and springiness of rice bread according to the mixing speed and time was weak. Therefore, it is considered that the application of ultra-high speeds when manufacturing gluten-free batter can have a positive effect on improving the production efficiency by reducing the processing time.

An existence of solutions for an infinte diffusion constant

  • Ham, Yoon-Mee
    • Bulletin of the Korean Mathematical Society
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    • v.33 no.4
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    • pp.631-638
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    • 1996
  • The parabolic free boundary problem with Puschino dynamics is given by (see in [3]) $$ (1) { \upsilon_t = D\upsilon_{xx} - (c_1 + b)\upsilon + c_1 H(x - s(t)) for (x,t) \in \Omega^- \cup \Omega^+, { \upsilon_x(0,t) = 0 = \upsilon_x(1,t) for t > 0, { \upsilon(x,0) = \upsilon_0(x) for 0 \leq x \leq 1, { \tau\frac{dt}{ds} = C)\upsilon(s(t),t)) for t > 0, { s(0) = s_0, 0 < s_0 < 1, $$ where $\upsilon(x,t)$ and $\upsilon_x(x,t)$ are assumed continuous in $\Omega = (0,1) \times (0, \infty)$.

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Effects of Mixed Application of Chemical Fertilizer and Liquid Swine Manure on Agronomic Characteristics, Yield and Feed Value of Sorghum × Sudangrass Hybrid for Silage in Paddy Field Cultivation

  • Hwang, Joo Hwan;Lee, Sang Moo
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.34 no.3
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    • pp.155-162
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    • 2014
  • This study was conducted to investigate the influence of the mixed application of chemical fertilizer (CF) and liquid swine manure (LSM) on the agronomic characteristics, dry matter yield, amino acids, minerals, and free sugars in cultivating Sorghum ${\times}$ Sudangrass hybrid (SSH) on paddy soil. The field experiment was designed in a randomized block design with three replications and consisted of CF 100% (C), CF 70% + LSM 30% (T1), CF 50% + LSM 50% (T2), CF 30% + LSM 70% (T3), and LSM 100% treatment (T4). The application of LSM was based solely on the nitrogen. Plant length, leaf length, leaf width and number of leaf were significantly higher in T4 (p<0.05), but stem diameter did not show significant differences among treatments. Stem hardness increased significantly (p<0.05) as the LSM application rate decreased, but sugar degree decreased significantly (p<0.05) as the LSM application rate decreased. Fresh yield, dry matter yield and TDN yield were the highest in T4, whereas the lowest in T2 (p<0.05). Crude protein, crude fat and crude ash were the highest in C, T4 and T2, respectively (p<0.05). However, NDF and ADF did not show significant difference among treatments. Crude fiber decreased significantly (p<0.05) as the LSM application rate increased. The total mineral content was decreased significantly (p<0.05) as the LSM application rate increased. Total amino acid content was higher in the order of T1> C> T3> T4> T2 (p<0.05). Free sugar content increased significantly (p<0.05) as the LSM application rate increased. The analysis of all the above results suggests that the application of liquid swine manure is very effective, considering the yield performance and the content of sugar degree and free sugar. In addition, liquid swine manure may be possible to grow Sorghum ${\times}$ Sudangrass hybrid without chemical fertilizer.

Effects of Changes in Exercise Intensity on Resting Metabolic Rate (RMR) and Energy Expenditure in Young Men (운동강도의 차이가 안정시대사량 및 에너지 소비량에 미치는 영향)

  • Kawk Yi-Sub;Jin Young-Wan;Park Chan-Ho
    • Journal of Life Science
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    • v.15 no.3 s.70
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    • pp.352-358
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    • 2005
  • The purpose of this study was to examine the effect of various exercise intensity on Resting Metabolic Rate (RMR), excess post exercise energy expenditure (EPEE), and thyroid hormonal changes in trained (TR) and untrained (UT) people. The subject of the present study were divided into two groups and four periods: trained (TR; n=6) and untrained (UT; n=6) group. And the periods were divided as follows; Resting (R), Maximal (M), High intensity (H), and Low intensity (L). The percent body fat and RMR of all subjects were measured at every periods. The RMR was measured early in the morning following a 12-hour fast using MMX3B gas analyzer and blood sample were collected from the anticubital vein to investigate thyroid hormonal (T3, T4, Free T3, Free T4, & TSH) changes. All the RMR values were expressed as absolute value/BSA $(kcal/d/m^2)$. And We also analyzed mean energy expenditure for 30 minutes during and after different intensity exercise. There was significant difference in RMR among different intensity of exercise. in TR (p < .05) not in the UT group. however, there was no significant different percent body fat in TR and in UT group. In the energy expenditure, there was significant different between TR and UT in HEE (high intensity exercise energy expenditure), LEE (low intensity exercise energy expenditure), HEEPE (high intensity exercise energy expenditure post exercise) & LEEPE (low intensity exercise expenditure post exercise). In the hormonal level, there was significant different in T4 level in the TR group at H period and in T4, Free T3, & Free T4 levels in TR group at L period, however there was no significant different in the UT group. The present cross-sectional study was design to investigate the relationship between exercise intensity and RMR. The focus of this investigation was to compare RMR in aerobically trained (TR) and untrained (VI). The relationship among RMR, exercise intensity and percent body fat would best be investigated using MMX3B and body composition analyzer. Each subject completed measurement of percent body fat, RMR, hormone in the period of maximal oxygen uptake exercise (M), high intensity exercise (H), and low intensity exercise (L). From the results, Low intensity of exercise (L), there was a trend for an increased RMR (kcal/day) in the TR not for the UT. This is best explained not by the reduced percent body fat but by the highly induced energy expenditure (during exercise and post exercise energy expenditure) and increased T4, Free T3, and Free T4 hormonal levels in the low intensity exercise for the TR group.

Effect of Ultramarathon on the Anterior Pituitary and Thyroid Hormones (울트라마라톤이 뇌하수체 전엽 및 갑상선 호르몬에 미치는 영향)

  • Shin, Kyung-A;Kim, Young-Joo
    • The Korean journal of sports medicine
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    • v.36 no.4
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    • pp.214-220
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    • 2018
  • Purpose: The purpose of this research is to study changes in pituitary hormone in anterior lobe and thyroid hormone before, after, and during recovery time in severe 100 km ultramarathon. Methods: Healthy middle-aged runners (age, $52.0{\pm}4.8$ years) participated in the test. Grade exercise test is done, and then blood is taken from those participants before and after completing 100 km ultramarathon at the intervals of 24 hours (1 day), 72 hours (3 days), and 120 hours (5 days) to analyze their luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), and free thyroxine (Free T4). Results: For LH, it decreased more significantly at 100 km than pre-race. However, after 1 day result increased more than that of 100 km. At 3 days, it was significantly higher than pre-race and 100 km, recovering at 5 days. In terms of FSH, it decreased at 100 km, 1 day, and 3 days more than pre-race but recovered at 5 days. TSH was higher at 1 day and 5 days compared to pre-race. T3 was only higher at 100 km than pre-race. T4 was higher till 5 days at 100 km than pre-race. Free T4 increased more significantly at 100 km than pre-race. Conclusion: In terms of severe long distance running, LH and FSH which belong to hormone from anterior lobe as well as T3, T4, and Free T4 which belong to thyroid hormone showed their variation within the standard range. However, TSH showed abnormal increase from enhanced concentration of blood after marathon becoming hyper-activation even during the recovery period.