• Journal of Microbiology
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• v.42 no.2
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• pp.117-125
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• 2004

Propionibacterium acnes (P. acnes) plays an important role in the disease pathogenesis of acne vulgaris, a disorder of pilosebaceous follicles, seen primarily in the adolescent age group. In the present study, the presence of antibodies against P. acnes (MTCC1951) were detected in acne patient (n=50) and disease free controls (n=25) using dot-ELISA and Western blot assay. The ability of P. acnes to induce pro-inflammatory cytokines by human peripheral blood mononuclear cells (PBMCs), obtained from acne patients and healthy subjects, were also analysed. The patients (n=26) who were culture positive for skin swab culture, were found to have a more advanced disease and higher antibody titres (1:4000 to >1:16000) compared to the P. acnes negative patients (n=24) and normal controls (n=25). An analysis of patients' sera by western blot assay recognized a number of antigenic components of P. acnes, rang-ing from 29 to 205 kDa. The major reactive component was an approximately 96 kDa polypeptide, which was recognised in 92％ (24 of 26) of the patients sera. Further, the P. acnes culture supernatant, crude cell lysate and heat killed P. acnes whole cells, obtained from 72-h incubation culture, were observed to be able to induce significant amounts of IL-8 and tumor necrosis factor alpha (TNF-${\alpha}$) by the PBMCs in both the healthy subjects and patients, as analysed by cytokine-ELISA. The levels of cytokines were significantly higher in the patients than the healthy subjects. A major 96 kDa polypep-tide reactant was eluted from the gel and was found to cause dose dependent stimulation of the pro-ductions of IL-8 and TNF-${\alpha}$. Thus, the above results suggest that both humoral and pro-inflammatory responses play major roles in the pathogenesis of acne.

• Korean Journal of Health Education and Promotion
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• v.22 no.3
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• pp.135-155
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• 2005

'Healthy Japan 21' is a new health policy that has been proposed for the 21st century: it embodies a totally new concept for its viewpoints and methods. To start with, for its goal, the focus is placed on the 'quality of life' or a life that is free of diseases, rather than mere prolongation of life. For its doctrine, the emphasis has shifted dramatically from improving the health of the entire population(the traditional approach for health improvement) to 'achieving an ideal health status for each individual. The ultimate aged society that arrives first in Japan is a society in its ultimate form for human being. Why did Japan become westernized, giving up her traditional culture? Why did she go through industrialization, sacrificing her nature? And why does she try so hard to industrialize the developing countries? These efforts are all preparation for the arrival of a ultimate aged society. During the 20th century, we believed in unlimited possibilities and expanded our social frontier. In the 21st century, on the other hand, a super-aged society(the ultimate society), a glimpse of which we have witnessed from time to time, will descend on us sooner or later. It is expected to arrive first in Japan. 'Healthy Japan 21' is intended to prepare for the arrival of the hitherto unheard of super-aged society by building the physiological basis of people. This policy is social experimentation on an immense social scale, in which questions are posed on the understanding of health, the relationship between individuals and society, the relationship between administration and citizens, the manner by which central and local governments operate, and the new relationship between prevention and therapy, 'Healthy Japan 21' may be summarized as an experiment on a huge scale directed to the ultimate form of human society, in which Japan and each of her citizens play a role and set an example for the rest of the world. Even just by considering various approaches newly suggested for this venture, one may be convinced that it is a policy with features suitable for a country that has already achieved the world's highest longevity.

• Journal of Korea Game Society
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• v.14 no.2
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• pp.19-28
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• 2014

This paper studies current market of smart phone game and suggests the new earning model. In paper, it is not just for spending free time but seeking profits to play game. Making profits is operated in mutual beneficial way. First, a partnership company cooperates with a game company. And then the partnership company issues coupons about its product which game players can get in game and can use in real. by this way, the partnership company can expect the advertising effect. Besides, game company can spare some burden about earning by cooperation. Eventually It is respected that users spend their money and purchase products with coupon they get in game on offline shop. In this paper, the earning model is integrated in real platform and explain the process.

• Journal of the Korean Ceramic Society
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• v.56 no.3
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• pp.211-232
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• 2019

Porous ceramics are promising materials for a number of functional and structural applications that include thermal insulation, filters, bio-scaffolds for tissue engineering, and preforms for composite fabrication. These applications take advantage of the special characteristics of porous ceramics, such as low thermal mass, low thermal conductivity, high surface area, controlled permeability, and low density. In this review, we emphasize the direct foaming method, a simple and versatile approach that allows the fabrication of porous ceramics with tailored microstructure, along with distinctive properties. The wet foam stability is achieved under the controlled addition of amphiphiles to the colloidal suspension, which induce in situ hydrophobization, allowing the wet foam to resist coarsening and Ostwald ripening upon drying and sintering. Different components, like contact angle, adsorption free energy, air content, bubble size, and Laplace pressure, play vital roles in the stabilization of the particle stabilized wet foam to the porous ceramics. The mechanical behavior of the load-displacements curves of sintered samples was investigated using Herzian indentations testes. From the collected results, we found that microporous structures with pore sizes from 30 ㎛ to 570 ㎛ and the porosity within the range from 70% to 85%.

• Journal of Bio-Environment Control
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• v.2 no.1
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• pp.16-26
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• 1993

A sundry system is one of popular systems for composting livestock manure, of which main honest is to utilize unlimited, clean, and free solar radiation. A sundry system with a composter of two horizontal screw-type concrete ducts at different height, was constructed and operated for three days for each test in May, 1993, to evaluate its composting performance. Four treatments of the mixture ratio of swine manure and saw dust (manure : sawdust= 1 : 1.25, 1 : 1, 1 : 0.7, 1 : 0.5) were implemented to evaluate the effect of the mixture ratio on degradation of the composting materials of a sundry system with a screw-type composter. Maximum temperature of the composting materials was over 5$0^{\circ}C$ at D1 or D2 (one or two days after operation starts) for each test. Mean C/N ratio and water contents of the materials were reduced by more than 15 and 20％, respectively. Microbial density of each test showed a typical variation with the lapse of the composting time. Mesophilic microorganism seemed to play more important role on degradation of the materials than thermophilic. A sundry system with a screw-type composter can be considered as a feasible system on basis of maturity data. The conclusion was completely reverse from that of Choi et at., although both adopted a sundry system. A further study is recommended to pursue the cause of better performance of the screw-type composter, whether it was due to affirmative weather or more efficient composter.

• Journal of Fashion Business
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• v.17 no.2
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• pp.46-62
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• 2013

This thesis aims to provide basic resources for the development of various uniform designs of cheerleaders by investigating the currently favoured uniform designs. The 13 professional cheerleader teams were existed among the 25 professional sports teams-9 baseball, 10 basketball and 6 volleyball teams. In each sports teams, four cheerleader's uniform were chosen and evaluated in terms of the cheerleader uniform design by analyzing the forms, colors, decorations and accessories. The result shows that the common kinds of design representing the symbolic color and the emblem were generally prevalent, instead of particular types of uniform design and subject in accordance with different kinds of the professional baseball, basketball and volleyball respectively. Throughout all the kinds of the sports, the combination of the sleeveless top and hot-pants were most frequently observed. In case of the skirts, the mini flare, wrap, and pleats skirts were the most prevalent, because it gave free to motion for cheerleading. The one-piece style were rather infrequent, comparing with the two-pieces, with the hourglass and fitted silhouette the most frequent type, and all those were mini in length. The sleeve in top were generally absent or short, however the bare top style was never found that the top would have a risk of being taken off downwardly during cheerleading. The accessories and the cheering tools were not so much used. The cap and headdresses were not many in kinds. The pompom, megaphone, tube stick, towel, umbrella and musical instruments would not be sufficient to play a role of tools for cheering, which suggests that the rather advanced tools or instruments for cheering in the sports need to be developed, not alone the uniform design.

• Journal of the Korean Institute of Intelligent Systems
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• v.17 no.5
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• pp.575-581
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• 2007

Though the Hough transform is a well-known method for detecting analytical shape represented by a number of free parameters, the basic property of the Hough transform, the one-to-many mapping from an image space to a Hough space, causes the innate problem, the sensitivity to noise. To remedy this problem, Edge Strength Hough Transform (ESHT) was proposed and proved to reduce the noise sensitivity. However the performance of ESHT depends on the size of a Hough space and image and some other parameters which should be decided experimentally. In this paper, we derived formulae to decide 2 parameter values; decreasing parameter and broadening parameter, which play an important role in ESHT. Using the derived formulae, 2 parameter values can be decided only with the pre-determined values, the size of a Hough space and an image, which make it possible to decide them automatically. The experiments with different parameter values also support the result.

• Journal of Pathology and Translational Medicine
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• v.52 no.6
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• pp.357-362
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• 2018

Background: The up-regulation of the lipogenic pathway has been reported in many types of malignant tumors. However, its pathogenic role or clinical significance is not fully understood. The objective of this study was to examine the expression levels of adipophilin and related hypoxic signaling proteins and to determine their prognostic impacts and associations with the pathologic characteristics of lung adenocarcinoma. Methods: Expression levels of adipophilin, heat shock protein 27 (HSP27), carbonic anhydrase IX, and hypoxia-inducible factor $1{\alpha}$ were examined by immunohistochemical staining using tissue microarray blocks. Correlations between protein expression levels and various clinicopathologic features were analyzed. Results: A total of 230 cases of primary adenocarcinoma of the lung were enrolled in this study. Adipophilin expression was more frequent in males and with the solid histologic type. It was correlated with HSP27 expression. Patients with adipophilin-positive adenocarcinoma showed a shorter progression-free survival (PFS) (median PFS, 17.2 months vs 18.4 months) in a univariable survival analysis, whereas HSP27 positivity correlated with favorable overall survival (OS) and PFS. In a multivariable analysis, adipophilin and HSP27 were independent prognostic markers of both OS and PFS. Conclusions: Activated lipid metabolism and the hypoxic signaling pathway might play a major role in the progression of lung adenocarcinoma, especially in the solid histologic type.

• Structural Engineering and Mechanics
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• v.72 no.1
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• pp.113-129
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• 2019

A four-variable shear deformation refined plate theory has been proposed for dynamic characteristics of smart plates made of porous magneto-electro-elastic functionally graded (MEE-FG) materials with various boundary conditions by using an analytical method. Magneto-electro-elastic properties of FGM plate are supposed to vary through the thickness direction and are estimated through the modified power-law rule in which the porosities with even and uneven type are approximated. Pores possibly occur inside functionally graded materials (FGMs) due the result of technical problems that lead to creation of micro-voids in these materials. The variation of pores along the thickness direction influences the mechanical properties. The governing differential equations and boundary conditions of embedded porous FGM plate under magneto-electrical field are derived through Hamilton's principle based on a four-variable tangential-exponential refined theory which avoids the use of shear correction factors. An analytical solution procedure is used to achieve the natural frequencies of embedded porous FG plate supposed to magneto-electrical field with various boundary condition. A parametric study is led to carry out the effects of material graduation exponent, coefficient of porosity, magnetic potential, electric voltage, elastic foundation parameters, various boundary conditions and plate side-to-thickness ratio on natural frequencies of the porous MEE-FG plate. It is concluded that these parameters play significant roles on the dynamic behavior of porous MEE-FG plates. Presented numerical results can serve as benchmarks for future analyses of MEE-FG plates with porosity phases.

• Food Science and Preservation
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• v.12 no.4
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• pp.411-416
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• 2005

Vitamin U(S-methylmethionin) levels were affected by cultivars, portion and storage times in Kimchi made from Korean Chinese cabbages. From this study, the outward parts contained high levels of vitamin U in two cultivars of Winter Pride and 55 days. Vitamin U levels in Kimchi during storage were increased during fermentation at $4^{\circ}C$. Leaf parts were 1.1-5.2 times higher in vitamin U levels than midribs in both cultivars. The levels of vitamin U were shown highest in outward leaf parts of 55 days cultivars. Like vitamin U, free amino acid also showed much higher levels in leaves. Levels of amino acids showed similarly changing patterns at different parts and cultivars of Korean Chinese cabbages in Kimchi. Threonine, alanine and proline appeared relatively abundant amino acids in most parts of sample. Moreover, methionine as a precursor of vitamin U has been reported that leaf parts contained the higher levels than midrib parts. But methionine was shown most core leaf parts. Methionine as a precursor of vitamin U, may not play a role in an increase of vitamin U of Korean Chinese cabbages in Kimchi.