• The Korean Journal of Physiology and Pharmacology
• /
• v.18 no.1
• /
• pp.1-14
• /
• 2014

During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other diseases such as rheumatoid arthritis, osteoporosis and aging. Glycation of proteins interferes with their normal functions by disrupting molecular conformation, altering enzymatic activity, and interfering with receptor functioning. AGEs form intra- and extracellular cross linking not only with proteins, but with some other endogenous key molecules including lipids and nucleic acids to contribute in the development of diabetic complications. Recent studies suggest that AGEs interact with plasma membrane localized receptors for AGEs (RAGE) to alter intracellular signaling, gene expression, release of pro-inflammatory molecules and free radicals. The present review discusses the glycation of plasma proteins such as albumin, fibrinogen, globulins and collagen to form different types of AGEs. Furthermore, the role of AGEs in the pathogenesis of diabetic complications including retinopathy, cataract, neuropathy, nephropathy and cardiomyopathy is also discussed.

• The Korean Journal of Physiology and Pharmacology
• /
• v.6 no.2
• /
• pp.63-70
• /
• 2002

Cholinergic modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) by the activation of muscarine receptors was investigated in mechanically dissociated rat nucleus basalis of the Meynert neurons using the conventional whole-cell patch recording configuration. Muscarine $(10{\mu}M)$ reversibly and concentration-dependently decreased mIPSC frequency without affecting the current amplitude distribution. Muscarine action on GABAergic mIPSCs was completely blocked by $1{\mu}M$ methoctramine, a selective $M_2$ receptor antagonist, but not by $1{\mu}M$ pirenzepine, a selective $M_1$ receptor antagonist. NEM $(10{\mu}M),$ a G-protein uncoupler, attenuated the inhibitory action of muscarine on GABAergic mIPSC frequency. Muscarine still could decrease GABAergic mIPSC frequency even in the $Ca^{2+}-free$ external solution. However, the inhibitory action of muscarine on GABAergic mIPSCs was completely occluded in the presence of forskolin. The results suggest that muscarine acts presynaptically and reduces the probability of spontaneous GABA release, and that such muscarine-induced inhibitory action seems to be mediated by G-protein-coupled $M_2$ receptors, via the reduction of cAMP production. Accordingly, $M_2$ receptor-mediated disinhibition of nBM neurons might play one of important roles in the regulation of cholinergic outputs from nBM neurons as well as the excitability of nBM neurons themselves.

• Journal of the Korean Institute of Educational Facilities
• /
• v.7 no.3
• /
• pp.23-35
• /
• 2000

Today the supply of school sports halls for multi-functional use is absolutely insufficient in school facilities of Korea. For economical reasons and efficiency of use, a joint utilization of these halls by schools, sports clubs and other users should be strived for. This will lead, as a result, to a minimization overall in the demand for halls. Above all to satisfy this demand, the regulations of sports facilities suitable to the students' standards of play and physical conditions must be preceded in Korea. And a study on the architectural planning of this hall size for primary, middle and high school is needed. This study aims at establishing the range of optimum size of school sports hall in Korea by surveying and analyzing the regulations of sports facilities about clear height of hall, obstacle-free zone and court area in Japan, England, Germany and U.S.A. Therefore, this study will offer valuable basic data in planning the school sports hall.

• Journal of the Korean Vacuum Society
• /
• v.8 no.4A
• /
• pp.482-489
• /
• 1999

AC PDP(P1asma Display Pane1)s use the mixture of inert gases to generate a discharge inside the display pixels. Impurities such as CO, $CO_2$ and OH inside discharge region may deteriorate the characteristics of PDP operation during long life time of PDP. Electro-negative gas such as CO can cause the sustain pulse amplitude to rise by attaching electrons which will play an important role in the earlier stage of the discharge. MgO film is used to protect the dielectric layer in AC PDP, and is in contact with the free space of display pixel where it is filled with the inert gas mixture. So, MgO film can be a main source of impurities. In this experiment, we observed the change of impurity generation of various MgO films which were deposited by different methods, by using QMS. (quadropole mass spectrometer) The main impurites were $H_2$, CO and $CO_2$. And with the comparison of the TPD (temperature programmed desorption) result, it can be understood that impurity gases are generated by sputtering of MgO surface not by outgassing. Deposition method had effects on the characteristics of the impurity generation. The MgO film manufactured by e-beam evaporation generated more amount of impurity gases than the MgO films manufactured by sputtering or ion-plating. And also heat treatment of MgO film after deposition decreased the magnitude of impurity gas generation.

• Korean Journal of Childcare and Education
• /
• v.14 no.1
• /
• pp.227-248
• /
• 2018

Objective: The purpose of this study was to investigate the recognition and qualities of early childhood coding education in childcare center teachers. Methods: 158 childcare center teachers responded to 56 questions on a questionnaire extracted and revised from previous research. Frequency analysis and one-way ANOVA were applied for the data analysis. Results: Many teachers agreed that the software education policy was timely appropriate. Most of them needed the education in order to improve children's creativity and problem solving ability, and answered that it is appropriate to start the education at age 5. Most of them recognized that small group and free choice activities, play activities linked with daily life topics and coding programs by the childcare center teachers were desirable as educational methods. Provision of educational HW/SW environment was a relatively important element for effective implementation of the education. The coding educational qualities perceived by the teachers were not high, and were related to the age of the children they were in charge of and their computer literacy. Conclusion/Implications: The recognition of childcare center teachers was relatively positive, but it is necessary to educate the teachers to improve their recognition and qualities of the education in consideration of teachers' variables.

• Korean Journal of Child Studies
• /
• v.32 no.5
• /
• pp.135-150
• /
• 2011

The purpose of this study was to examine the interaction strategies used by typically developing boys and girls in their dealings with young children with ADHD in free play situations in inclusive classes. This was done in order to gain an in-depth understanding of the meaning of their interaction strategies. The subjects were 52 typically developing children (comprising 27 boys, 25 girls) and 3 young children with ADHD. The findings were as follows : First, the overall frequency of interaction strategies with the young children with ADHD was greater among the young female children (n = 372) than the young male children (n = 298). Second, when the utterance strategies of the male and female children were sub-categorized, both the male children (79.5%) and the female children (57.0%) mostly made use of avoidance strategies, one of the typical withdrawal strategies. Third, the interaction strategy of control represented 42.0 percent and as such was identified as the most prevalent interaction strategy utilized by the young male children studied. In the case of the young female children, obliging strategies were the most common interaction strategies representing 33.1 percent of the total used. In the light of the findings yielded from this study, some educational recommendations are provided.

• Journal of the East Asian Society of Dietary Life
• /
• v.19 no.2
• /
• pp.143-156
• /
• 2009

This study was performed in order to investigate the difference of general environment, life style, dietary behavior and food habit between the obese children and normal children. The number of subject was 98 obese children, 347 normal children. General characteristic was not significantly different, however father's BMI of obese children was significantly (p<0.05) higher than that of normal children. There was significant difference between obese children and normal children in mother's office-closing hour (p<0.05). Normal children spent more time to play outdoor than obese children in their free time. Normal children slept over 8 hours, but obese children slept below 8 hours. Most of obese children (70.4%) ate too many times and most of obese children (72.4%) recognized their overweight. Parents of obese children considered that their children need to control their weight and correct their eating habits such as overeating. Obese children could not bear hunger and kept eating a meal until they feel full. Obese children preferred fried or broiled food. Therefore nutritional education is necessary to improve the food habits of obese children and to reduce the obesity rate of children.

• Nuclear Engineering and Technology
• /
• v.52 no.7
• /
• pp.1557-1564
• /
• 2020

In this paper, 3D model-based interactive gamma ray shielding package (MIGSHIELD) is developed in virtual reality platform for windows operating system. In MIGSHIELD, the computational methodology is based on point kernel algorithm (PK), several key parameters of PK are obtained using new technique and new methods. MIGSHIELD has interactive capability with virtual world. The main features made in the MIGSHIELD are (i) handling of physical information from virtual world, (ii) handling of arbitrary shapes radioactive source, (iii) calculating the mean free path of gamma ray, (iv) providing interactive function between PK and virtual world, (v) making better use of PK for virtual simulation, (vi) plug and play. The developed package will be of immense use for calculations involving radiation dose assessment in nuclear safety and contributing to fast radiation simulation for virtual nuclear facilities.

• Journal of Environmental Science International
• /
• v.11 no.11
• /
• pp.1173-1181
• /
• 2002

The present study was undertaken to investigate the effect of low temperature and salicylic acid(SA) on the chilling tolerance of acclimated and nonacclimated cucumber(Cucurmis sativus L.) seedlings. The acclimation phenomenon was characterized in chilling-sensitive cucumber seedlings and found to have a significant effect on the survival and shoot dry weights. The injuries experienced by the acclimated seedlings in the third leaf stage were on average smaller by half than those experienced by the nonacclimated seedlings. Chilling also caused a large increase in the free proline levels, regardless of the acclimation status. Exogenous treatment with SA(0.5mM) resulted in improved growth and survival of the nonacclimated chilled seedlings, indicating that SA induced chilling tolerance and SA and acclimation had common effects. The application of cycloheximide in the presence of SA restored the acclimation-induced chilling tolerance. The elevated proline level observed in the cold-treated and SA-treated plants was more pronounced in the light than in the dark at a chilled temperature, indicating that endogenous proline may play a role in chilling tolerance by stabilizing the water status in response to chilling. From these results it is suggested that SA provided protection against low-temperature stress by increasing the proline accumulation, and pre-treatment with SA may induce antioxidant enzymes leading to increased chilling tolerance.

• Journal of the Korean Home Economics Association
• /
• v.46 no.4
• /
• pp.25-35
• /
• 2008

The purpose of this study was to investigate the relationship pattern among the children's negative and aimless behaviors, and the variables related to teachers (characteristics, stress, efficacy, and quality of teachers' behaviors). Subjects were 190, 5 year-old children and 48 teachers at 45 child care centers. The children's negative and aimless behaviors were observed with time sampling method. The quality of teachers' interaction behaviors was rated by the Assessment Scales for Day Care Programs during the free play activities. Teachers responded to the Scale for the Teachers' Job Stress and Teachers' Efficacy. The data were analyzed with descriptive statistics, Pearson's correlations, multiple regressions, and partial correlations. The results were as follows. The teachers' experience and the quality of teachers' behaviors significantly explained the children's negative behaviors. The quality of teachers' behaviors significantly explained the children's aimless behaviors. Lastly, the quality of teachers' behaviors mediated the relationship between the teachers' job stress and the children's aimless behaviors.