• 한국실내디자인학회논문집
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• 제36호
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• pp.14-21
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• 2003

The Propose of this research was to consider how the New Media Architecture was applied to contemporary architecture according to the analysis of the design method process of Toyo Ito. Sendai Mediatheque by Toyo Ito stands as one of the most symbolic statement In New Media architecture. The four principal architectural elements of the Mediatheque are the digital image, the continuous space, the tube, and the skin facade. The digital image express forms of communication, person-to-person and person-to-thing, and they vary according to the media utilized on each level. The three skin elements of the Mediatheque are a double skin of MPG, skin of louvers, skin of fine-floor decking. The tubes act as columns while enveloping light, air, water, electricity the passage of people, as well as the means of transferring material. The thirteen tubes of different sizes prevent the erection of wall and suggest places instead of rooms. Instead of being limited to certain specified actions in clearly defined rooms, people are free to choose places for their actions in the continuous space.

• 한국산업보건학회지
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• 제11권2호
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• pp.169-178
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• 2001

Numerous regulations have been introduced and a various kinds of institutional intervention have been made by government against the occupational safety and health problems. However, it was serious issue to the workers that what can be claimed by those who meet with apparently harmful and risky working conditions in their social systems. In the view point of employees, their right to be free from unacceptable risk and hazards has not been clearly defined. Therefore, workers have very limited rights to take any actions unless employer or government do their actions. It is believed that this undesirable conditions resulted from Jack of legal definition of workers' right to work in the safe and healthy environment. It has been found increased social pressure to make intervention to the industry to protect workers' health. Also, increased pressure has been kept for deregulation. This conflict lay the current situation in dilemma. The concept of the working environmental right has been developed and discussed in this study to overcome this trade-off confliction. It should be clearly separated between legal aspects and administrative and Policy area to make the regulations effective. Strong enforcement to the industry based on the law should be minimum, however, it should be practically effective in the aspect of workers' right. Administration and policy should be focused on supportive and leading activities to achieve the ultimate goal, safe and healthy working environment. It is concluded that establishment of working environmental right would satisfy workers and industry and it would result in improvement workers' environment and conditions.

• 생약학회지
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• 제15권3호
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• pp.121-127
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• 1984

Attempts were to investigate the effects of 'Bojungikgi-tang' on the digestive system, blood pressure and diuresis. The results showed that relaxing action was shown on the isolated ileum in mice and that strong antagonistic actions were seen on $BaCl_2$, acetylcholine and histamine-induced contraction of the ileum in mice and guinea-pigs that the relaxing effect of the intestinal smooth muscle was recognized. Inhibitory effects on transport rate in the small intestine of mice and castor oil-induced catharsis in mice were noted. Inhibitory action on the secretion of gastric juice, pH ascending effect and decreasing effect of the free acidity and total acidity were recognized. Continuous hypotensive action was seen, but when the vagus nerve was cut, hypotensive action was remarkably decreased. The diuretic effect was also recognized.

• 정보처리학회논문지B
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• 제19B권1호
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• pp.27-30
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• 2012

지능형 에이전트에게 요구되는 가장 기초적인 기능 중의 하나가 불확실한 센서 데이터에 의존하여 자신의 현재 위치가 어디인지를 파악하는 일이다. 본 논문에서는 가장 효과적인 확률 기반의 측위 기법인 파티클 필터를 실제 로봇 측위에 적용한 로봇 측위 시스템의 구현에 대해 설명하고, 성능 평가를 위한 실험의 결과를 소개한다. 특히 비-잡음 상태 전이 모델과 로봇 동작의 오차를 고려한 잡음 모델간의 비교 실험을 통해, 실제 로봇 동작의 불확실성에 근사한 상태 전이 모델이 파티클 필터 측위의 성능 개선에 도움이 될 수 있음을 보인다.

• 대한불안의학회지
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• 제11권2호
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• pp.114-119
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• 2015

A conflict of interest is usually defined as a set of circumstances that creates a risk that professional judgments or actions regarding a primary interest will be unduly influenced by a secondary interest. In general, a conflict of interest can be classified as either a financial or a non-financial one. A financial conflict of interest reportedly occurs frequently in medical (and psychiatric) research and practice and is associated with a greater likelihood of reporting results favorable to the intervention being studied. A non-financial conflict of interest may occur in psychiatric research and practice as a result of the so-called "allegiance effect." It is very important that clinicians and researchers in the field of psychiatry be aware that their field is vulnerable to both financial and non-financial conflicts of interest. Considering that it is impossible in modern psychiatry to be completely free from possible conflicts of interest, the best way to manage a conflict of interest is disclosure based on the principles of transparency. Actions that might lead to conflicts of interest should be avoided as much as possible.

• Biomolecules & Therapeutics
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• 제7권2호
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• pp.112-120
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• 1999

The protective actions of ambroxol, rutin, glutathione and harmaline on oxidative damages of various tissue components were compared. The mechanisms by which they prevent oxidative tissue damages were explored. Lipid peroxidation of liver microsomes induced by combinations of $Fe^{2+}$ and ascorbate or $Fe^{+3}$, ADP and NADPH was inhibited by $50\; \muM$ of rutin, ambroxol, harmaline and glutathione. Ambroxol ($100\; \muM$) inhibited the degradation of hyaluronic acid by $Fe^{2+}$, $H_2O$_2$ and ascorbate, and it was greater than that of harmaline, whereas hyaluronic acid degradation was not prevented by rutin and glutathione. The compounds used ($100\; \muM$) did not protect the degradation of cartilage collagen by xanthine and xanthine oxidase. Rutin, glutathione and harmaline decreased the degradation of IgG by xanthine and xanthine oxidate, while ambroxol did not attenuate degradation of IgG. Glutathione showed a scavenging action on $H_2O_2$. The compounds all showed scavenging actions on hydroxyl radical. Ambroxol and harmaline exhibited quenching effects en singlet oxygen. In conclusion, ambroxol, rutin, glutathione and harmaline may exert protective effects differently on tissue components against oxidative attack depend on kind of tissue component and free radical.

• Biomolecules & Therapeutics
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• 제18권1호
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• pp.24-31
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• 2010

Taurine, 2-aminoethanesulfonic acid, is an abundant free amino acid present in brain cells and exerts many important biological functions such as anti-convulsant, modulation of neuronal excitability, regulation of learning and memory, anti-aggressiveness and anti-alcoholic effects. In the present study, we investigated to explore whether taurine has any protective actions against oxidative stress-induced damages in neuronal cells. ERK I/II regulates signaling pathways involved in nitric oxide (NO) and reactive oxygen species (ROS) production and plays a role in the regulation of cell growth, and apoptosis. We have found that taurine significantly inhibited AMPA induced cortical depolarization in the Grease Gap assays using rat cortical slices. Taurine also inhibited AMPA-induced neuronal cell damage in MTT assays in the differentiated SH-SY5Y cells. When the neuronal cells were treated with $H_2O_2$, levels of NO were increased; however, taurine pretreatment decreased the NO production induced by $H_2O_2$ to approximately normal levels. Interestingly, taurine treatment stimulated ERK I/II activity in the presence of AMPA or $H_2O_2$, suggesting the potential role of ERK I/II in the neuroprotection of taurine. Taken together, taurine has significant neuroprotective actions against AMPA or $H_2O_2$ induced damages in neuronal cells, possibly via activation of ERK I/II.

• 대한약리학회지
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• 제17권2호
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• pp.17-22
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• 1981

Guinea-pig ileum을 naloxone을 가(加)하거나 가(加)하지 않은 전해질(電解質) 농도(濃度)가 다른 modified Krebs-Henseleit bicarbonate buffer solution에 $4^{\circ}C$에서 24시간 incubation한 다음, morphine의 수축(收縮) 억제작용(抑制作用)으 관찰(觀察)하여 다음과 같은 성적(成績)을 얻었다. 1) Incubation 자체(自體)로써 morphine의 작용(作用) 강화(强化)되었다. 2) Incubation media 내(內) 전해질(電解質) 변동(變動)은 $Na^+\;75mM$ 군(群)과 $K^+2.9mM$ 군(群)에서는 morphine의 작용(作用)이 강화(强化)되었고, $Ca^{++}\;3.6mM$ 군(群), $Mg^{++}$ free 군(群)과 $Mn^{++}\;0.2mM$ 군(群)에서는 약화(弱化)되었다. 3) Incubation media내(內) naloxone은 morphine의 작용(作用)을 강화(强化)하였다. Incubation media 내(內) naloxone을 가(加)하고 전해질(電解質)을 변동(變動)시킨 실험(實驗)에서 $Na^+\;75mM$ 군(群), $K^+2.9mM$ 군(群)과 $Ca^{++}3.6mmM$ 군(群)에서는 naloxone에 의(依)하여 morphine 작용(作用)이 약화(弱化)되었고, $Mg^{++}$ free 군(群)과 $Mn^{++}\;0.2mM$ 군(群)에서는 강화(强化)되었다. 4) Naloxone에 대(對)한 $pA_2$치(値)는 전군(全群)에서 변동(變動)이 없었다. 5) 이상(以上) 실험성적(實驗成績)은 naloxone opiate receptor에 대(對)한 작용외(作用外)에 세포막 또는 근세포수축기구(筋細胞收縮機構)에 영향(影響)을 미처 morphine의 작용(作用)에 영향(影響)을 줄 수 있음을 시사(示唆)한다.

• 한방안이비인후피부과학회지
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• 제20권3호
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• pp.82-97
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• 2007

Objective : Cortex of Ulmi pumilae(CUP) has been used to treat several diseases including boil, swelling, and scabies etc. Recently, CUP was known to have wrinkle care and whitening actions. But, It's exact mechanisms are unclear. Methods : The present study was designed to investigate effects of CUP on Human HaCaT keratinocyte and malignant melanoma cells such as SK-MEL-2 and B16F10 in terms of cell viabilities, proliferations, DPPH free radical scavenging activities, oxygen free radical productions and inhibitory action on elastase activities. Results : CUP accelerated proliferation of HaCaT keratinocytes in the lower concentration. CUP also prevented cell death of HaCaT induced by Hydrogen peroxide, which products oxygen free radicals. On the contrary, CUP did not affect proliferations of SK-MEL-2 or B16F10. Futhermore, CUP showed inhibitory action against SK-MEL-2 proliferation at the concentration of $500{\mu}g/m{\ell}$ In addition, CUP was shown to have DPPH free radical scavenging activities and also have inhibitory effects on elastase activities too. On the fluorescent examinations, the present author knows that CUP elevated production levels of oxygen free radicals in malignant melanoma cell, SK-MEL-2. Conclusions : These results suggest that CUP has possibilities of usage for functional cosmetics which have wrinkle care and whitening activities and related mechanisms are involved in inhibition of elastase action and acceleration of oxidative stress in melanoma cell.

• 철학연구
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• 제116권
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• pp.181-206
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• 2010

우리는 흔히 인간은 자신의 행위를 선택하고 통제할 수 있는 자유의지를 지닌 존재이기 때문에 행위에 대해 그 책임을 물을 수 있다고 말한다. 인간의 행위는 자연현상처럼 단순한 움직임으로 파악될 수 없다. 행위에는 마음이 작용하여 매우 복잡한 내면의 과정을 거쳐 나타나기 때문이다. 인간의 행위는 인간의 내부와 외부로부터 다양한 영향을 받는다. 행위에 영향을 주는 다양한 내적 외적 요인들은 '자신의 자유의지로 선택하고 통제할 수 있는 영역', '통제가능한 영역으로 변환 될 수 있는 영역', '부분적으로 결정된 영역', 그리고 '선택이나 통제가 불가능한 완전히 결정된 영역'으로 나뉘어진다. 인간의 행위에 영향을 주는 내적 외적 요인들에는 자신의 자유의지로 선택되고 통제가능한 요인들이 있는 반면, 자신이 선택하거나 통제 할 수 없는 상당히 많은 요인들도 있다는 것에 우리는 주목해야 한다. 인간에게 자유의지가 있다는 사회통념에 의해, 자신이 선택하거나 통제할 수 없는 요인들로부터 영향을 받아 발생된 인간의 행위에 대한 책임까지도 행위자에게 지우게 하는 것은 매우 불합리하다. 스스로 선택할 수없는 유전요인이나 환경요인으로 인한 책임문제가 이에 해당한다. 이런 문제를 해결하기위해서는 정치력과 교육력이 요청된다. 좋지 못한 외적인 환경요인들로 인해 발생한 책임은 정치에 있다. 인간의 내면에 올바른 가치관을 형성시킴으로 좋지 않은 내적 유전요인을 극복할 수 있는 힘은 교육에 있다. 이런 점에서 정치와 교육은 인간행위에 대한 책임문제에서 자유로울 수 없다.