Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
권호 표지

Issues of Conflict of Interest in Psychiatric Research and Practice

정신건강의학과 임상 및 연구에서 이해 상충 관련 문제

  • Shin, Eun-Hee (Department of Nursing, College of Health Sciences, Sangji University) ;
  • Lim, Se-Won (Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
  • 신은희 (상지대학교 보건과학대학 간호학과) ;
  • 임세원 (성균관대학교 의과대학 강북삼성병원 정신건강의학과)
  • Received : 2015.10.01
  • Accepted : 2015.10.15
  • Published : 2015.10.30
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Abstract

A conflict of interest is usually defined as a set of circumstances that creates a risk that professional judgments or actions regarding a primary interest will be unduly influenced by a secondary interest. In general, a conflict of interest can be classified as either a financial or a non-financial one. A financial conflict of interest reportedly occurs frequently in medical (and psychiatric) research and practice and is associated with a greater likelihood of reporting results favorable to the intervention being studied. A non-financial conflict of interest may occur in psychiatric research and practice as a result of the so-called "allegiance effect." It is very important that clinicians and researchers in the field of psychiatry be aware that their field is vulnerable to both financial and non-financial conflicts of interest. Considering that it is impossible in modern psychiatry to be completely free from possible conflicts of interest, the best way to manage a conflict of interest is disclosure based on the principles of transparency. Actions that might lead to conflicts of interest should be avoided as much as possible.

Keywords

References

  1. Macrina FD. Scientific Integrity. Washington DC: ASM Press 2005:165.
  2. Thompson DF. Understanding financial conflicts of interest. N Engl J Med 1993;329:573-576. https://doi.org/10.1056/NEJM199308193290812
  3. Maj M. Conflicts of interests in psychiatric practice and research. Psychiatric 2005;3 138-140.
  4. Perlis RG, Perlis CS, Wu Y, Hwang C, Joseph M, Nierenberg AA. Industry sponsorship and financial conflict of interest in the reporting of clinical trials in psychiatry. Am J Psychiatry 2005;162:1957-1960. https://doi.org/10.1176/appi.ajp.162.10.1957
  5. Fava GA. Financial conflicts of interest in psychiatry. World Psychiatry 2007;6: 19-24.
  6. Heres S, Davis J, Maino K, Jetzinger E, Kissling W, Leucht S. Why olanzapine beats risperidone, risperidone beats quetiapine. and quetiapine beats olanzapine: an exploratory analysis of head -to-head comparison studies of second-generation anti psychotics. Am J Psychiatry 2006;163:185-194. https://doi.org/10.1176/appi.ajp.163.2.185
  7. Baker CB, Johnsrud MT, Crismon ML, Rosenheck RA, Woods SW. Quantitativeanalysis of sponsorship bias in economic studies of antidepressants. Br J Psychiatry 2003:183:498-506. https://doi.org/10.1192/bjp.183.6.498
  8. Steinbrook R. Controlling conflict of interest: proposals from the Institute of Medicine. N Engl J Med 2009;360:2160-2163. https://doi.org/10.1056/NEJMp0810200
  9. Lee IK, Koo YM. Ethical principles in physician-pharmaceutical industry interactions. Korean J Med Ethics 2011;14:193-201
  10. Phillips ML, Kupfer DJ. Bipolar disorder diagnosis: challenges and future directions. Lancet 2013:381:1663-1671 https://doi.org/10.1016/S0140-6736(13)60989-7
  11. Kuehn BM. APA targets unnecessary antipsychotic use. JAMA 2013; 310:1909-1910 https://doi.org/10.1001/jama.2013.281140
  12. Lopez OL, Becker JT, Olang YF, Sweet RA, Aizenstein H, Snitz B, et al. The long-term effects of conventional and atypical antipsychotics in patients with probable Alzheimer's disease, Am J Psychiatry 2013;170:1051-1058, https://doi.org/10.1176/appi.ajp.2013.12081046
  13. Carpenter WT Jr, Gold JM, Lahti AC, Queern CA, Conley RR, Bartko JJ, et al. Decisional capacity for informed consent in schizophrenia research. Arch Gen Psychiatry 2000;57:533-538. https://doi.org/10.1001/archpsyc.57.6.533
  14. Kim SY, Caine ED, Currer GW, Leibovici A, Ryan JM. Assessing the competence of persons with Alzheimer's disease in providing informed consent for participation in research, Am J Psychiatry 2001;158:712-717. https://doi.org/10.1176/appi.ajp.158.5.712
  15. Norris SL, Holmer HK, Ogden LA, Burda BU, Fu R. Characteristics of physicians receiving large payments from pharmaceutical companies and the accuracy of their disclosures in publications: An observational study. BMC Med Ethics 2012;13:24. https://doi.org/10.1186/1472-6939-13-24
  16. Tanne JH. US university psychiatrist loses chairmanship over drug company payments. BMJ 2009;338:3188. https://doi.org/10.1136/bmj.a3188
  17. Safer DJ Design and reporting modifications in industry sponsored comparative psychopharmacology trials. J Nerv Ment Dis 2002;190:583-592, https://doi.org/10.1097/00005053-200209000-00002
  18. Otto MW, Nirenberg AA. Assay sensitivity, failed clinical trials and the conduct of science. Psychother Psychosom 2002;71:241-243 https://doi.org/10.1159/000064813
  19. Meier B. Major medical journals will require registration oftrials. New York Times, Sep 9;2004. p. C11
  20. Who.int [homepage Oil the internet]. Geneva: World Health Organization. international clinical trials registry platform. [cited 2015 Oct 1]. Available from:http://www.who.int/ictrp/en/
  21. Helmchen H. Ethics of clinical research with mentally ill persons. Eur. Arch Psychiatry Clin Neurosci 2012;262:441-452. https://doi.org/10.1007/s00406-011-0287-2
  22. 이하영, 이민창. 의약품 리베이트 자율규제의 한계: 제도론적 접근. 행정논총 2011;49:149-150
  23. Kang MS, Koh YS. Management of conflicts of interest in physicianpharmaceutical industry Interaction. Korean J Med Ethics 2011;14:361-371.
  24. Maj M. Financial and non-financial conflicts of interests in psychiatry. Eur. Arch. Psychiatry Clin. Neurosci 2010;260:S147-S151. https://doi.org/10.1007/s00406-010-0131-0
  25. Maj M. Non-financial conflicts of interests in psychiatric research and practice. Br J Psychiatry 2008;193:91-92. https://doi.org/10.1192/bjp.bp.108.049361
  26. Luborsky L, Diguer L, Seligman DA, Rosenthal R, Krause ED, Johnson S, et al. The researcher's own therapy allegiance: a "wild card" in comparisons of treatment efficacy, ClinPsychol Sci Pract 1999;6:95-106.
  27. Hussain A, Smith R. Declaring financial competing interests: survey of five medical journals, BMJ 2001;323:263-264 https://doi.org/10.1136/bmj.323.7307.263
  28. International Committee of Medical Journals Editors. Uniform requirements for manuscripts submitted to biomedical journals: writing and editing for biomedical publications. Ann Intern Med 1997;126:36-47 https://doi.org/10.7326/0003-4819-126-1-199701010-00006
  29. Facs.org[homepage on the internet] Chicago: American College of Surgeon& Statements on Principles [updated 2008 Sep 1; cited 2015 Oct 1]. Available from:https://www.facs.org/about-acs/statements/stonprin