• Asian Pacific Journal of Cancer Prevention
• /
• 제14권5호
• /
• pp.3029-3035
• /
• 2013

Background: Most developing countries have been unable to implement well-organized health care systems, especially comprehensive Pap smear screening-based programs. One of the reasons for this is regional differences in medical services, and a low-cost portable cervical screening system is necessary. To improve regional discrepancies in cervical screening systems, we investigated the usefulness and acceptability of cervical selfsampling by liquid-based cytology (LBC) for 290 volunteers in the Lao PDR. Materials and Methods: Following health education with comprehensive documents, cervical self-sampling kits by LBC were distributed in three provincial, district, and village areas to a total of 290 volunteers, who were asked to take cytology samples by themselves. Subsequently, the acceptability of self-sampling was evaluated using a questionnaire. Results: The documents were well understood in all three regions. Regarding the acceptability of self-sampling, the selections for subsequent screening were 62% self-sampling, 36% gynecologist-sampling, 1% either method, and 1% other methods. The acceptability rates were higher in the district and the village than in the province. For the relationship between acceptability and pregnancy, the self-sampling selection rate was higher in the pregnancy-experienced group (75%) than in the pregnancy-inexperienced group (60%). For the relationship between selection of self-sampling and experience of screening, the self-sampling selection rate was higher in the screening-inexperienced group (62%) than in the screening-experienced group (52%). Conclusions: Our data show that this new way forward, involving a combination of self-sampling and LBC, is highly acceptable regardless of age, educational background, and residence in rural areas in a developing country.

• 대한화학회지
• /
• 제57권6호
• /
• pp.744-754
• /
• 2013

Quantitative structure-activity relationship (QSAR) analysis for recently synthesized imidazole-(benz)azole and imidazole - piperazine derivatives was studied for their anticancer activities against breast (MCF-7) cell lines. The statistically significant 2D-QSAR models ($r^2=0.8901$; $q^2=0.8130$; F test = 36.4635; $r^2$ se = 0.1696; $q^2$ se = 0.12212; pred_$r^2=0.4229$; pred_$r^2$ se = 0.4606 and $r^2=0.8763$; $q^2=0.7617$; F test = 31.8737; $r^2$ se = 0.1951; $q^2$ se = 0.2708; pred_$r^2=0.4386$; pred_$r^2$ se = 0.3950) were developed using molecular design suite (VLifeMDS 4.2). The study was performed with 18 compounds (data set) using random selection and manual selection methods used for the division of the data set into training and test set. Multiple linear regression (MLR) methodology with stepwise (SW) forward-backward variable selection method was used for building the QSAR models. The results of the 2D-QSAR models were further compared with 3D-QSAR models generated by kNN-MFA, (k-Nearest Neighbor Molecular Field Analysis) investigating the substitutional requirements for the favorable anticancer activity. The results derived may be useful in further designing novel imidazole-(benz)azole and imidazole-piperazine derivatives against breast (MCF-7) cell lines prior to synthesis.

• 한국수자원학회논문집
• /
• 제55권4호
• /
• pp.257-266
• /
• 2022

국지성 호우 및 설계빈도 이상 강우의 증가로 침수피해가 매년 증가하고 있으며 이에 따라 홍수 조절 및 방어를 위한 수공구조물의 중요성이 증가하고 있다. 수공구조물은 목적과 성능에 따른 설계가 이루어지고 있고 홍수량이 중요한 산정 요소이나 국내에서는 관측자료의 신뢰성 부족 및 데이터의 부족으로 인하여 수공구조물 설계를 위한 수문해석 입력자료로 사용되는 설계강우량은 정확한 확률강우량의 산정과 시간분포가 중요한 요소로 작용한다. 실무에서는 Huff의 4분위 방법의 누가우량백분율을 이용하여 설계강우량의 시간분포 회귀식을 산정하고 있으며 분위별 곡선에 대한 회귀식은 전반적으로 정확도가 높게 나타나는 6차 다항회귀식을 일률적으로 사용하고 있다. 본 연구에서는 실무에서 일반적으로 설계강우량의 시간분포를 위해 사용하고 있는 Huff의 4분위 방법의 누가우량백분율을 이용하여 통계 모델링에서 간결함의 원리에 따라 변수선택법을 이용하여 시간분포 회귀식을 유도하였으며, 유의성 검정을 통한 시간분포 회귀식의 검증을 실시하였다. 변수선택법과 유의성 검정을 통한 시간분포 회귀식 산정 결과 전진선택법과 후방제거법의 장점을 모두 가지고 있는 단계선택법을 이용하여 시간분포 회귀식을 유도하는 것이 가장 적합한 것으로 분석되었다.

• 분석과학
• /
• 제24권6호
• /
• pp.533-543
• /
• 2011

hERG (human ether-a-go-go related gene) 이온채널은 심장 재분극의 중요 요소이며 이 채널의 저해제는 부정맥과 돌연사를 유발할 수 있다. 따라서, 신약개발과정에서 후보물질이 hERG 이온채널의 잠재적인 저해제일 경우에는 심장독성 부작용을 유발하므로, 이를 최소화하고자 많은 노력이 집중되고 있다. 본 연구는 HEK(인간 배아 신장)세포에서 얻은 202개 유기화합물의 $IC_{50}$ 데이터를 이용하여 2차원 구조-활성의 정량적 관계(2D-QSAR)방법으로 예측하는 모델을 개발하였다. hERG이온채널 저해제의 기계 학습방법으로는 다중선형회귀(Multiple Linear Regression), 서포트 벡터 머신(Support Vector Machine: SVM)방법과 인공신경망(Artificial Neural Network)방법이며, 교차검증을 적용한 모집단 기반 전진선택(forward selection)방법과 결합하여 각 학습모델에 적합한 최적의 표현자들을 결정하였다. 가장 우수한 방법은 14종의 표현자를 사용한 인공신경망방법($R^2_{CV}$=0.617, RMSECV=0.762, MAECV=0.583)이었고, 다중선형회귀방법을 통해서 hERG이온채널 저해물질의 구조적 특징과 수용체와의 상호작용을 설명할 수 있다. QSAR모델의 검증은 교차검증과 Y-scrambling test방법으로 수행하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제10권12호
• /
• pp.5231-5248
• /
• 2016

As a service-oriented paradigm, web service composition has obtained great attention from both academia and industry, especially in the area of cloud service. Nowadays more and more web services providing the same function but different in QoS are available in cloud, so an important mission of service composition strategy is to select the optimal composition solution according to QoS. Furthermore, the selected composition solution should satisfy the service level agreement (SLA) which defines users' request for the performance of composite service, such as price and response time. A composite service is feasible only if its QoS satisfies user's request. In order to obtain composite service with the optimal QoS and avoid SLA violations simultaneously, in this paper we first propose a QoS evaluation method which takes the SLA satisfaction into account. Then we design a service selection algorithm based on our QoS evaluation method. At last, we put forward a parallel running strategy for the proposed selection algorithm. The simulation results show that our approach outperforms existing approaches in terms of solutions' optimality and feasibility. Through our running strategy, the computation time can be reduced to a large extent.

• 한국인터넷방송통신학회논문지
• /
• 제14권4호
• /
• pp.45-50
• /
• 2014

본 논문에서는 사용자 모바일 장치를 중계기로 사용할 경우 발생할 수 있는 간섭 제약에 대해 정의하였다. 또한, 사용자 모바일 장치에서 발생하는 간섭을 완화하기위해 장치 선택 및 전력 할당 기법을 적용하였다. 제안된 전송 알고리즘을 적용할 경우 간섭을 완화시킬 수 있다. 또한, 간섭이 약한 채널에 적용할 경우 통신망 과부하 문제를 해결 할 수 있다. 따라서 추가적인 중계기 설치 없이 사용자 모바일 장치만으로 네트워크 용량을 증가시킬 수 있다. 마지막 으로, 제안한 프로토콜을 레일리 페이딩 환경에서 비트오류율(Bit Error Rate)과 아웃티지 확률(Outage Probability)을 통해 시스템의 성능을 평가한다.

• 한국철도학회:학술대회논문집
• /
• 한국철도학회 2008년도 춘계학술대회 논문집
• /
• pp.1308-1314
• /
• 2008

In this paper, Seoulmetro that is the first operation organization which operates a city railroad rolling-stock maintenance RIMS(rolling stock information maintenance system) collected and analyzed a light maintenance data and introduced time a series analysis technique to find the way how to contribute to a use efficiency improvement of a city railroad. The purpose of time a series analysis is to remove a seasonal change including data and to check an irregular fluctuation. First of all, a collection range of the data comes under a light maintenance, however it needs a data of more than 3 years to check the seasonal change. We put a study for an accumulated scope that the data satisfy a period like this and are able to extend a range of the study when time flys forward. The data used for study is filtered using a movement average method after passing proper selection working and is solved with a method which looks for season index. Using the season index that was getten in here, we predict a light working frequency, if it has an irregular change, we will contribute it to a city railroad a use efficiency improvement and establish the cause by carrying out prevent maintenance in advance.

• 산업경영시스템학회지
• /
• 제11권18호
• /
• pp.7-15
• /
• 1988

This study is concerned with selecting mutually dependent quality improvement alternatives with resource constraints. These qualify improvement alternatives art different fro the tradition at alternatives which are independent from each other. In other words, selection of any improvement alternative requires other related specific improvement. Also the overall product quality in a multi stage manufacturing process is characterized by a complex multiplication method rather than a simple addition method which dose not allow to solve a linear knapsack problem despite its popularity in the traditional study. This study suggests a non-linear integer programming model for selecting mutually dependent quality improvement alternatives in multi-stage manufacturing process. In order to apply the model to selecting alternatives. This study also suggests a heuristic mode1 based on a dynamic programming model which is more practical than the non-linear integer programming model. The logic of the heuristic model enables 1) to estimate improvement effectiveness values on all improvement alternatives specifically defined for this study. 2) to arrange the effectiveness values in a descending order, and 3) to select the best one among the alternatives based on their forward and backward linkage relationships. This process repeats to selects other best alternatives within the resource constraints. This process is presented in a Computer programming in Appendix A. Alsc a numerical example of model application is presented in Chapter 4.

• 한국지능시스템학회논문지
• /
• 제22권6호
• /
• pp.793-798
• /
• 2012

In this paper, we explored the new method for extracting feature from the electroencephalography (EEG) signal based on linear regression technique with the orthonormal polynomial bases. At first, EEG signals from electrodes around motor cortex were selected and were filtered in both spatial and temporal filter using band pass filter for alpha and beta rhymic band which considered related to the synchronization and desynchonization of firing neurons population during motor imagery task. Signal from epoch length 1s were fitted into linear regression with Legendre polynomials bases and extract the linear regression weight as final features. We compared our feature to the state of art feature, power band feature in binary classification using support vector machine (SVM) with 5-fold cross validations for comparing the classification accuracy. The result showed that our proposed method improved the classification accuracy 5.44% in average of all subject over power band features in individual subject study and 84.5% of classification accuracy with forward feature selection improvement.

• 국제학술발표논문집
• /
• The 4th International Conference on Construction Engineering and Project Management Organized by the University of New South Wales
• /
• pp.432-438
• /
• 2011

The purpose of the present thesis is to develop bankruptcy prediction models capable of being applied to the Korean construction industry and to deduce an optimal model through comparative evaluation of final developed models. A study population was selected as general contractors in the Korean construction industry. In order to ease the sample securing and reliability of data, it was limited to general contractors receiving external audit from the government. The study samples are divided into a bankrupt company group and a non-bankrupt company group. The bankruptcy, insolvency, declaration of insolvency, workout and corporate reorganization were used as selection criteria of a bankrupt company. A company that is not included in the selection criteria of the bankrupt company group was selected as a non-bankrupt company. Accordingly, the study sample is composed of a total of 112 samples and is composed of 48 bankrupt companies and 64 non-bankrupt companies. A financial ratio was used as early predictors for development of an estimation model. A total of 90 financial ratios were used and were divided into growth, profitability, productivity and added value. The MDA (Multivariate Discriminant Analysis) model and BLRA (Binary Logistic Regression Analysis) model were used for development of bankruptcy prediction models. The MDA model is an analysis method often used in the past bankruptcy prediction literature, and the BLRA is an analysis method capable of avoiding equal variance assumption. The stepwise (MDA) and forward stepwise method (BLRA) were used for selection of predictor variables in case of model construction. Twenty two variables were finally used in MDA and BLRA models according to timing of bankruptcy. The ROC-Curve Analysis and Classification Analysis were used for analysis of prediction performance of estimation models. The correct classification rate of an individual bankruptcy prediction model is as follows: 1) one year ago before the event of bankruptcy (MDA: 83.04%, BLRA: 93.75%); 2) two years ago before the event of bankruptcy (MDA: 77.68%, BLRA: 78.57%); 3) 3 years ago before the event of bankruptcy (MDA: 84.82%, BLRA: 91.96%). The AUC (Area Under Curve) of an individual bankruptcy prediction model is as follows. : 1) one year ago before the event of bankruptcy (MDA: 0.933, BLRA: 0.978); 2) two years ago before the event of bankruptcy (MDA: 0.852, BLRA: 0.875); 3) 3 years ago before the event of bankruptcy (MDA: 0.938, BLRA: 0.975). As a result of the present research, accuracy of the BLRA model is higher than the MDA model and its prediction performance is improved.