• Title/Summary/Keyword: formulation design

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Numerical Modeling of Soil Liquefaction at Slope Site (사면에서 발생하는 액상화 수치해석)

  • Park, Sungsik
    • Journal of the Korean GEO-environmental Society
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    • v.7 no.6
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    • pp.133-143
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    • 2006
  • A fully coupled effective stress dynamic analysis procedure for modeling seismic liquefaction on slope is presented. An elasto-plastic formulation is used for the constitutive model UBCSAND in which the yield loci are radial lines of constant stress ratio and the flow rule is non-associated. This is incorporated into the 2D version of Fast Lagrangian Analysis of Continua (FLAC) by modifying the existing Mohr-Coulomb model. This numerical procedure is used to simulate centrifuge test data from the Rensselaer Polytechnic Institute (RPI). UBCSAND is first calibrated to cyclic direct simple shear tests performed on Nevada sand. Both pre- and post-liquefaction behaviour is captured. The centrifuge test is then modeled and the predicted accelerations, excess porewater pressures, and displacements are compared with the measurements. The results are shown to be in general agreement. The procedure is currently being used in the design of liquefaction remediation measures for a number of dam, bridge, tunnel, and pipeline projects in Western Canada.

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Determination of Mequitazine in Human Plasma by Gas-Chro-matography/Mass Spectrometry with Ion-Trap Detector and Its Pharmacokinetics after Oral Administration to Volunteers

  • Kwon Oh-Seung;Kim Hye-Jung;Pyo Heesoo;Chung Suk-Jae;Chung Youn Bok
    • Archives of Pharmacal Research
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    • v.28 no.10
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    • pp.1190-1195
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    • 2005
  • The objective of this study was to develop an assay for mequitazine (MQZ) for the study of the bioavailability of the drug in human subjects. Using one mL of human plasma, the pH of the sample was adjusted and MQZ in the aqueous phase extracted with hexane; the organic layer was then evaporated to dryness, reconstituted and an aliquot introduced to a gas chromatograph/mass spectrometer (GC/MS) system with ion-trap detector. Inter- and intra-day precision of the assay were less than 15.1 and $17.7{\%}$, respectively; Inter- and intra-day accuracy were less than 8.91 and $18.6{\%}$, respectively. The limit of quantification for the current assay was set at 1 ng/mL. To determine whether the current assay is applicable in a pharmacokinetic study for MQZ in human, oral formulation containing 10 mg MQZ was administered to healthy male subjects and blood samples collected. The current assay was able to quantify MQZ levels in most of the samples. The maximum concentration ($C_{max}$ was 8.5 ng/mL, which was obtained at 10.1 h, with mean half-life of approximately 45.5 h. Under the current sampling protocol, the ratio of $AUC_{t{\rightarrow}last}$ to $AUC_{t{\rightarrow}{\infty}}$ was $934{\%}$, indicating that the blood collection time of 216 h is reasonable for MQZ. Therefore, these observations indicate that an assay for MQZ in human plasma is developed by using GC/MS with ion-trap detector and validated for the study of pharmacokinetics of single oral dose of 10 mg MQZ, and that the current study design for the bioavailability study is adequate for the drug.

Effects of Strawberry Puree and Red Pepper Powder Contents on Physicochemical Properties of Kochujang Analyzed Using Response Surface Methodology

  • Lee, Jun-Ho;Kim, Hui-Jeong
    • Preventive Nutrition and Food Science
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    • v.13 no.3
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    • pp.231-236
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    • 2008
  • Response surface methodology (RSM) was used for the analysis and optimization of the production process of strawberry Kochujang. Experiments were carried out according to a central composite design, selecting strawberry puree content and red pepper powder content as independent variables and soluble solids content, moisture content, water activity, color characteristics ($L^*-$, $a^*-$, and $b^*$-values) as response variables. The polynomial models developed by RSM were highly effective for describing the relationships between the study factors and the responses. Kochujang containing a higher amount of red pepper powder had a higher soluble solids content; on the contrary, soluble solids content decreased with the increase in the strawberry puree content in the sample. Moisture content increased with increased strawberry puree content but decreased with increased red pepper powder content. Water activity increased with the increase in strawberry puree content in the sample but was less affected by the amount of red pepper powder content. Decreases in $L^*$-values with increasing amount of red pepper powder were noted. $a^*$-values decreased with the increases in red pepper powder content but increased with the increase in strawberry puree content in the Kochujang formulation. $b^*$-values decreased with the increases in red pepper powder content but was less affected by the strawberry puree content. Overall optimization, conducted by overlaying the contour plots under investigation, was able to point out an optimal range of the independent variables within which the six responses were simultaneously optimized. The point chosen as representative of this optimal area corresponded to strawberry puree content=14.36% and red pepper powder content=11.33%, conditions under which the model predicted soluble solids content=$59.31^{\circ}Brix$, moisture content=45.30% (w.b.), water activity=0.758, $L^*$-value=24.81, $a^*$-value=7.250, and $b^*$-value=10.19.

On the Accuracy of Calculation in the Analysis of Natural Transverse Vibrations of a Ship's Hull (선체고유횡진동해석(船體固有橫振動解析)에 있어서의 계산정도(計算精度))

  • K.C.,Kim;H.S.,Lee
    • Bulletin of the Society of Naval Architects of Korea
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    • v.13 no.1
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    • pp.1-9
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    • 1976
  • Using the computer programs for calculation of natural vibrations of ship's hull developed by the authors et al., an investigation into influences of various parameters on the accuracy of calculation was done through example calculations of a 30,000 DWT petroleum products carrier M/S Sweet Brier built by Korea Shipbuilding and Engineering Corporation. The methodical principles employed for the computer program development are as follows; (a) the ship system is reduced to an equivalent discrete elements system conforming to Myklestad-Prohl model, (b) the problem formulation is of transfer matrix method, and (c) to obtain solutions an extended $G\ddot{u}mbel's$ initial value method is introduced. The scope of the investigation is influences of number of discrete elements, choice of significant system parameters such as rotary inertia, bending stiffness and shear stiffness, and simplification of distributions of added mass and stiffness as trapezoidal ones referred to those of midship section on the calculation accuracy. From the investigation the followings are found out; (1) To obtain good results for the modes up to the seven-noded thirty or more divisions of the hull is desirable. For fundamental mode fifteen divisions may give fairly good results. (2) The influence of rotary inertia is negligibly small at least for the modes up to the 5- or 6- noded. (3) In the case of assuming either bending modes or shear modes the calculation results in considerably higher frequencies as compared with those based on Timoshenko beam theory. However, the calculation base on the slender beam theory surprisingly gives frequencies within 10% error for fundamental modes. (4) It is proved that to simplify distributions of added mass and stiffness as trapezoidal ones referred to those of midship section is a promising approach for the prediction of natural frequencies at preliminary design stage; provided good accumulation of data from similar type ships, we may expect to obtain natural frequencies within 5% error.

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End-to-End Congestion Control of High-Speed Gigabit-Ethernet Networks based on Smith's Principle

  • Lee, Seung-Hyub;Cho, Kwang-Hyun
    • Proceedings of the IEEK Conference
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    • 2000.07a
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    • pp.101-104
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    • 2000
  • Nowadays, the issue of congestion control in high-speed communication networks becomes critical in view of the bandwidth-delay products for efficient data flow. In particular, the fact that the congestion is often accompanied by the data flow from the high-speed link to low-speed link is important with respect to the stability of closed-loop congestion control. The Virtual-Connection Network (VCN) in Gigabit Ethernet networks is a packet-switching based network capable of implementing cell- based connection, link-by-link flow-controlled connection, and single- or multi-destination virtual connections. VCN described herein differ from the virtual channel in ATM literature in that VCN have link-by-link flow control and can be of multi-destination. VCNs support both connection-oriented and connectionless data link layer traffic. Therefore, the worst collision scenario in Ethernet CSMA/CD with virtual collision brings about end-to-end delay. Gigabit Ethernet networks based on CSMA/CD results in non-deterministic behavior because its media access rules are based on random probability. Hence, it is difficult to obtain any sound mathematical formulation for congestion control without employing random processes or fluid-flow models. In this paper, an analytical method for the design of a congestion control scheme is proposed based on Smith's principle to overcome instability accompanied with the increase of end-to-end delays as well as to avoid cell losses. To this end, mathematical analysis is provided such that the proposed control scheme guarantees the performance improvement with respect to bandwidth and latency for selected network links with different propagation delays. In addition, guaranteed bandwidth is to be implemented by allowing individual stations to burst several frames at a time without intervening round-trip idle time.

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A Study on the Control System of Dynamic Vibration Absorber for Ship Superstructure (선박용 동흡진기 시스템에 관한 연구 - 중력진자식 및 원심진자식 동흡진기에 대한 -)

  • S.S. Kim;S.Y. Han;J.K. Eom;M.H. Hyun;J.H. Kim;M.H. Kim;D.K. Lee
    • Journal of the Society of Naval Architects of Korea
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    • v.32 no.3
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    • pp.1-18
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    • 1995
  • This paper deals with the vibration absorbers of gravitational and centrifugal pendulum types for vibration controls of ship's substructures such as radarmasts, bridgewings and funnels. The mathematical model of such a vibrating system with an absorber is described as a 2 degree of freedom system and an efficient formulation for optimum design of the absorber is presented. For investigation applicability of the two types of the absorbers to a structure system, numerical calculations and experiments hove been performed with variation of mass ratios for each type. According to the results of investigations, the vibration absorber of gravitational type proved to be more useful and efficient than one of centrifugal pendulum type in a view point of mass ratio.

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Behaviour of Leaking Tunnels under Unconfined Flow Condition (비구속 흐름조건하에 있는 배수형 터널의 거동)

  • Shin Jong-Ho
    • Journal of the Korean Geotechnical Society
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    • v.21 no.7
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    • pp.43-54
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    • 2005
  • Tunnelling in a water bearing soil may cause draw-down of ground water table. Modelling of this problem requires considering the change of phreatic surface including the stress constitutive relationship for an unsaturated soil. However, it is normally assumed that ground water is confined. Numerical formulation of coupled behavior considering phreatic surface is described and implemented into computer program. Influence of unconfined flow on tunnel and ground is thoroughly investigated and compared with that of confined flow condition. It is identified that ground and lining behaviour below phreatic surface is almost the same as that under confined flow conditions, however, there is considerable difference in ground behaviour above phreatic surface. It is generally concluded that the assumption of confined flow is acceptable in terms of lining design.

Color Fastness of Digital Textile Printing on Silk Fabrics - The effect of the mixed pre-treatment agent (디지털 프린팅 견직물의 색상 변화 및 견뢰도 - 혼합 전처리제의 영향)

  • Jeong, Dong-Seok;Chun, Tae-Il
    • Fashion & Textile Research Journal
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    • v.15 no.5
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    • pp.808-814
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    • 2013
  • In this study, The mixture of three kinds of pre-treatment agents, Carboxymethyl cellulose sodium salt(CMC), Sodium alginate and Dextrin, have been prepared for the better coloration of digital textile printing. To get sharpness of outline during digital printing process, the optimal formulation is the CMC and Sodium alginate mixture 1:1 ratio by volume. Cyan, Yellow, and Black colours are excellent on the Sodium alginate mixtures. But, Magenta is excellent in the CMC and Dextrin mixture. Sharpness and printability are closely related to viscosity of the mixture. The most optimal sharpness of outline achieved with a consideration of coloring, and field operations account for production when the viscosity of the mixed pre-treatment agent approximately is 10~13 cSt. Change in shade and staining of wash fastness for all the treated samples with the mixtures rated 4-5 grade. Both dry rubbing fastness to shade change and staining are good in the treated samples, whereas wet rubbing fastness rated 2-3 grade. To improve wet rubbing fastness, the Sodium alginate and Dextrine mixture, which rated 3-4 grade for Black color, is applicable. With exception of 3 rating to black color, Light fastness is 4 rating for the remaining three colors in the regardless of treatment condition and mixing of the pre-treatment agent. Dry cleaning fastness of all samples are also 4-5 rating.

High-precision modeling of uplift capacity of suction caissons using a hybrid computational method

  • Alavi, Amir Hossein;Gandomi, Amir Hossein;Mousavi, Mehdi;Mollahasani, Ali
    • Geomechanics and Engineering
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    • v.2 no.4
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    • pp.253-280
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    • 2010
  • A new prediction model is derived for the uplift capacity of suction caissons using a hybrid method coupling genetic programming (GP) and simulated annealing (SA), called GP/SA. The predictor variables included in the analysis are the aspect ratio of caisson, shear strength of clayey soil, load point of application, load inclination angle, soil permeability, and loading rate. The proposed model is developed based on well established and widely dispersed experimental results gathered from the literature. To verify the applicability of the proposed model, it is employed to estimate the uplift capacity of parts of the test results that are not included in the modeling process. Traditional GP and multiple regression analyses are performed to benchmark the derived model. The external validation of the GP/SA and GP models was further verified using several statistical criteria recommended by researchers. Contributions of the parameters affecting the uplift capacity are evaluated through a sensitivity analysis. A subsequent parametric analysis is carried out and the obtained trends are confirmed with some previous studies. Based on the results, the GP/SA-based solution is effectively capable of estimating the horizontal, vertical and inclined uplift capacity of suction caissons. Furthermore, the GP/SA model provides a better prediction performance than the GP, regression and different models found in the literature. The proposed simplified formulation can reliably be employed for the pre-design of suction caissons. It may be also used as a quick check on solutions developed by more time consuming and in-depth deterministic analyses.

Load-carrying capacity degradation of reinforced concrete piers due to corrosion of wrapped steel plates

  • Gao, Shengbin;Ikai, Toyoki;Ni, Jie;Ge, Hanbin
    • Steel and Composite Structures
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    • v.20 no.1
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    • pp.91-106
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    • 2016
  • Two-dimensional elastoplastic finite element formulation is employed to investigate the load- carrying capacity degradation of reinforced concrete piers wrapped with steel plates due to occurrence of corrosion at the pier base. By comparing with experimental results, the employed finite element analysis method is verified to be accurate. After that, a series of parametric studies are conducted to investigate the effect of corrosion ratio and corrosion mode of steel plates located near the base of in-service pier P2 on load-carrying capacity of the piers. It is observed that the load-carrying capacity of the piers decreases with the increase in corrosion ratio of steel plates. There exists an obvious linear relationship between the load-carrying capacity and the corrosion ratio in the case of even corrosion mode. The degradation of load-carrying capacity resulted from the web's uneven corrosion mode is more serious than that under even corrosion mode, and the former case is more liable to occur than the latter case in actual engineering application. Finally, the failure modes of the piers under different corrosion state are discussed. It is found that the principal tensile strain of concrete and yield range of steel plates are distributed within a wide range in the case of slight corrosion, and they are concentrated on the column base when complete corrosion occurs. The findings obtained from the present study can provide a useful reference for the maintenance and strengthening of the in-service piers.