• 한국의학물리학회지:의학물리
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• 제16권1호
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• pp.16-23
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• 2005

본 연구에서는 자궁경부암 및 질암 치료 시 고선량률 강내 근접치료기와 병행하여 사용가능한 다채널 초음파 온열 치료 기구를 제작하였다. 텐덤형의 경우 자궁 내에 삽입이 용이하도록 외부직경 4 mm, 두께 0.7 mm, 길이 24.5 mm인 원통형 plezo-ceramic crystal transducer (PZT-5A) 물질이 초음파 발생원으로 사용되었다. 질벽 또는 질 천정치료에 이용될 치료기는 질에 삽입되어야 하므로 질의 크기와 비슷한 직경 24.5 mm, 두께 1.3 mm, 길이 15.2 mm인 원통형 PZT-8 물질이 이용되었다. 임피던스와 phase 측정결과에 따라 외부직경이 4 mm인 PZT-5A의 작동주파수는 3.2 MHz 로 결정되었고 외부직경이 24.5 mm인 PZT-8 물질의 작동 주파수는 1.7 MHz로 결정되었다. Radiation force 방법으로 측정된 초음파 발생효율은 텐덤형 초음파원은 33%이고 원통형 초음파원은 61%이다. 원통형 초음파 발생물질로부터 발생되는 초음파 분포도를 MATLAB을 이용하여 계산하였고 실제 물 팬텀 내에서 열전대를 이용하여 측정하였다. 계산을 통해 얻어진 radial 한 방향으로 방사된 초음파압은 자궁내로 삽입되는 텐덤형 트랜스듀서의 경우 표면에서 5 mm 되는 점을 기준으로 10 mm 에서는 58%이고 20 mm에서는 45%이다. 질 치료에 사용될 트랜스듀서의 세기는 표면으로부터 5 mm에서의 세기를 기준으로 15 mm 거리에서는 78%, 25 mm 거리에서는 66％로 감소하였다. 특성분석 결과 직경 4 mm인 PZT-5A 와 24.5 mm인 PZT8 물질은 온열치료의 초음파원으로 사용가능함이 입증되었다. 따라서 직경 4 mm인 PZT-5A 트랜스듀서 3개를 연결하여 치료길이가 75 mm인 텐덤형 온열치료기구를 제작하였고 직경 24.5 mm인 PZT-8 트랜스듀서 4개를 연결하여 치료길이가 61 mm인 질암 치료용 온열치료기구를 제작하였다.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 2002년도 proceedings of the second asia international conference on tribology
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• pp.115-116
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• 2002

This study was carried out as one of efforts to overcome difficulties in air bearing design due to low stiffness and low damping. Hydrodynamic effects on hydrodynamic stiffness of a fluid film in a high speed air bearing with tow-row air sources are investigated. The hydrodynamic effects by the high speed over DN 1,000,000 and eccentricity of a proceeding which are not considered in conventional design of an air bearing need to be reconsidered. The hydrodynamic effects, which dominantly influence on the load capacity of air bearing, are caused mainly by proceeding speed, eccentricity, and the source positions. The two-row source arrangement in the air bearing produces quite unique hydrodynamic effects with respect to pressure distribution of the air film. Optimal arrangement of the two-row sources improves performance of an air bearing in film reaction force and loading capacity of high speed spindles. This study compares the pressure distribution by numerical simulation as a function of eccentricity of proceeding and the source positions. The air source position 1/7L form one end of an air bearing was found to be superior to source position of 1/4L. The dynamic stiffness were obtained using a two-dimensional cutting method which can directly measure the cutting reaction forces and the displacements of the spindle in two directions using a tool dynamometer and transducer sensors. Heat generation in the air film can not be negligible over the speed of DN 2,000,000. In order to analysis effects of heat generation on the characteristics of air bearing, high cooling bearing spindle and low cooling bearing spindle were tested and compared. Characteristics of the frequency response of shaft and motion of run out errors were different for the spindle. The test results show that, in the case of low cooling bearing spindle, the stiffness became smaller due to heat generation. The results, which were obtained for high speed region, may be used as a design information for spindle which can be applied to precision devices such as ultra precision grinding and ultra high speed milling.

• Toxicological Research
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• 제14권2호
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• pp.183-191
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• 1998

It has been reported that 50~70% of child asthma, bronchial asthma in adult, and allergic rhinitis are caused by house dust mite. The antigen extracted from house dust mite has been used for effective treatment against allergic diseases and for clinical test. This house dust mite antigen has been entirely imported from abroad. However, the composition and content of all the antigen imported vary from a brand to other brand. Thus, we need to standardize the composition and content of the antigen by developing it domestically. We proceeded pre-clinically general pharmacological test and toxicological test that are required for the eventual human use by utilizing the house dust mite cultured in Korea. In order to obtain information on general pharmacological tests such as its toxic signs in tissues or organs which are mainly affected, we examined the effect of house dust mite on the tensions of the isolated tissues and heart rates of cardiac muscle by recording with force displacement transducer of polygragh (Glass Model 7). We determined lethality of antigen extracted from house dust mite in mice and guinea pigs. We examined acute and subacute toxicity by administrating house dust mite extract of 500, 100, 20 times of the expected clinical dose. In male and female mice and guinea pigs, given a sigle intraperitoneal dose of antigen, $LD_{50}$ values were over 5.0 $\textrm{m}{\ell}$/kg, respectively. In animals administrated with house dust mite, there were no significant change of clinical symptom, body weight, food consumption, water consumption, eye examinations, urinalysis, blood biochemistry, and histopathological examinations in any animals tested. We found no toxic effect of this house dust mite. These results show that the house dust mite cultured by us could be used in the development of medicine against allergic diseases caused by the antigen of house dust mite.

• The Korean Journal of Physiology
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• 제19권1호
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• pp.1-13
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• 1985

The influences of $Ca^{2+}-antagonists$, verapamil and $Mn^{2+}$, upon the spontaneous electrical activity and contractions were studied in guinea-pig taenia coli. Spontaneous contractions were recorded with force transducer, and spike action potentials were measured extracellularly by use of suction electrode. All experiments were performed in tris-buffered Tyrode solution Which was aerated With 100% $O_2$ and kept at $35^{\circ}C$. The results obtained were as follows : 1) Verapamil suppressed the frequency and amplitude of spontaneous contractions dose dependently, and blocked completely mechanical responses at the concentration of 1 mg/1. 2) The frequency of bursts of spike discharge(bursts frequency) and the number of spikes in a burst(spikes frequency) were reduced in a dose·dependent manner within the concentration range of $10^{-5}$ to $10^{-3}g/l$, and bursts frequency was affected more readily at a low concentration of $10^{-5}g/l$ verapamil. 3) The verapamil_induced suppression of spontaneous contractions in the Tyrode solution containing 1 mM $Ca^{2+}$ was completely antagonized by the addition of extra $Ca^{2+}$ to the Tyrode solution $(2\;m\;MCa^{2+})$. 4) $Mn^{2+}$ suppressed the amplitude of spontaneous contractions, whereas $Mn^{2+}$ accelerated the frequency dose-dependently within the range of low concentrations$(10^{-7}\;to\;10^{-4}\;M\;Mn^{2+})$. 5) The bursts frequency determining frequency of spontaneous contractions was increased in a dose-dependent manner, whereas the spikes frequency known to determine the contractions amplitude was reduced within the range of low concentrations. At a high concentration of 1 mM $Mn^{2+}$, however, all spontaneous contractile responses were blocked simultaneously with the disapperance of electrical activity. 6) The frequency and amplitude of spontaneous contractions altered by $Mn^{2+}$ in 1mM $Ca^{2+}$ Tyrode were increased by extra $Ca^{2+}(2mM)$.

• 한국정보통신학회논문지
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• 제14권10호
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• pp.2317-2323
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• 2010

근경직으로 인한 질병을 판단하기 위한 새로운 비침습적 초음파 근경직도 측정 시스템을 검증하기 위해 근경직 발생시 근전도의 변화를 분석하였다. 근경직 유발을 위해 하지 대퇴직근에서 등척성 운동을 실시하였다. 실험 프로토콜에 따라 실험을 반복 실시하였다. 이때 바이오시스템3를 이용하여 무릎관절토크의 크기 및 토크를 실시간으로 측정하였다. 또한 대퇴직근에서 근전도 측정 시스템으로 근전도를 측정하였다. 피검자는 실험 프로토콜에 따라 최초 무릎관절 토크의 최대수의적 등척성수축(MVC : maximal voluntary contraction)을 측정하고,. MVC의 50%에서 -5%로 떨어질때까지 등척성 운동을 지속하였다. 근경직 유발시 근전도 신호를 신호처리 과정을 거쳐 중앙주파수변동과 실효값 변화로 나타내었으며, 이러한 결과가 근경직도 측정 시스템의 결과와 유의함을 보였다.

• The Korean Journal of Physiology
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• 제17권2호
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• pp.103-107
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• 1983

This experiment was undertaken to see whether dopamine has any effect on a uterine function and whether the uterus has a dopamine receptor. We used 14 female rats in the diestrus state which was identified by a vaginal smear. Under ether anesthesia, 3 pieces(1 cm length) from each side of the uterus were dissected out and mounted in 3 tissue chambers (4 cm diameter, 10 cm height) that contained Krebs-Ringer solution. The solution was continuously aerated with 95% $O_2$ containing 5% $CO_2$ and kept $37^{\circ}C$ consistantly during the whole experimental period. The spontaneous contractile activity of the isolated uterus was recorded using a force transducer. After a recovery period of 15 min in the chamber, the following experiments were carried out. In 7 rats, each piece of the uterus was received dopamine at concentrations of $10^{-4}$, $10^{-5}$ or $10^{-6}\;M$ for 10 min and then followed by domperidone at a concentration of $10^{-5}\;M$. In another 7 rats, each piece was received domperidone, a specific peripheral dopamine receptor antagonist, was administered at a concentration of $10^{-5}\;M$ for 5 min prior to dopamine at concentrations of $10^{-4}$, $10^{-5}$, or $10^{-6}\;M$. Dopamine inhibited the spontaneous uterine contraction dose-dependently (r=0.99, p<.01). The inhibited contractility by dopomine was significantly (P<.05) resumed by post-treatment of domperidone. Pre-treatment of domperidone also blocked significantly(p<.05) the inhibitory effect of dopamine. It is concluded from these results that dopamine has inhibitory role upon the spontaneous uterine contraction of the rat in the diestrus state and domperidone antagonized the inhibitory effect of dopamine. These results suggest strongly that dopamine may exert the inhibitory effect via the dopamine receptor in the rat uterus.

• Structural Engineering and Mechanics
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• 제64권6권
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• pp.703-721
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• 2017

The experimental study of the behavior of dry medium and loose sandy soil under the action of a single impulsive load is carried out. Different falling masses from different heights were conducted using the falling weight deflectometer (FWD) to provide the single pulse energy. The responses of soils were evaluated at different locations (vertically below the impact plate and horizontally away from it). These responses include; displacements, velocities, and accelerations that are developed due to the impact acting at top and different depth ratios within the soil using the falling weight deflectometer (FWD) and accelerometers (ARH-500A Waterproof, and Low capacity Acceleration Transducer) that are embedded in the soil and then recorded using the multi-recorder TMR-200. The behavior of medium and loose sandy soil was evaluated with different parameters, these are; footing embedment, depth ratios (D/B), diameter of the impact plate (B), and the applied energy. It was found that increasing footing embedment depth results in: amplitude of the force-time history increases by about 10-30%. due to increase in the degree of confinement with the increasing in the embedment, the displacement response of the soil will decrease by about 25-35% for loose sand, 35-40% for medium sand due to increase in the overburden pressure when the embedment depth increased. For surface foundation, the foundation is free to oscillate in vertical, horizontal and rocking modes. But, when embedding a footing, the surrounding soil restricts oscillation due to confinement which leads to increasing the natural frequency, moreover, soil density increases with depth because of compaction, that is, tendency to behave as a solid medium.

• The Korean Journal of Physiology and Pharmacology
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• 제1권5호
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• pp.581-589
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• 1997

This study was undertaken to examine the effects of ultraviolet light (UVL) and rebamipide on the cutaneous blood flow and tissue survival on rabbit skin flap. In a random bipedicle flap, Laser Doppler Flowmetry (LDF) was employed to measure the blood flow of flap (BFF). Wound Margin Strength (WMS) measured by force transducer and Light microscophy were used for evaluation of tissue viability. Single exposure to UVL increased the BFF gradually for more than 15 hours, and decreased the vasoconstrictor effect of intravenous phenylephrine. The UVL-induced increase in BFF regressed after 18 hours of irradiation, and this regression was tended to be enhanced by intradermal injection of L-NAME, a nitric oxide synthase (NOS) inhibitor, but the regression was significantly reversed by acetylcholine, an endothelial constitutive NOS (cNOS) activator and L-arginine, an NO precusor. Rebamipide, a novel antiulcer agent known to scavenge the hydroxyl radical, abruptly reversed the spontaneous regression of the UVL- induced increase in BFF by the same manner as L-arginine. In ischemic skin flap, rebamipide increased the BFF abruptly by the same manner as sodium nitroprusside (SNP), an NO doner, while N-acetylcystein (NAC), a free radical scavenger, gradually increase the BFF. The rebamipide-induced increase in BFF was sustained at the level of the SNP-induced increase in BFF during the late period of experiment. Rebamipide increased the WMS of skin flaps and prevented the tissue necrosis in comparison with L-NAME. Based on these results, it is concluded that in rabbit skin, UVL irradiation increases the BFF by NO release, and rebamipide exerts a protective effect on the viability of ischemic skin flaps by either or both the increase in BFF by NO release and free radical scavenger effect.

• 대한약리학회지
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• 제19권2호
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• pp.1-8
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• 1983

Prostaglandin(PG) is ubiquitously distributed in most mammalian tissue and their actions are complicated. Especially in autonomic nervous system, there are evidences indicating that PGs act as neuromodulators i.e., PGs, which are released in the vicinity of autonomic neuroeffector junctions, influence the release and the response of the neurotransmitter. Present study was undertaken to elucidate the interrelationship between $PGF_{2\alpha}$ and adrenergic ${\alpha}_2-receptor$ function in electrical field stimulation induced contractile response of vas deferens in rat. Male rat, weighing 150{\sim}200\;g, was sacrificed and vas deferens was obtained. The isolated vas deferens strip was placed between two platinum electrodes in temperature controlled $(37^{\circ}C)$ muscle chamber containing Tyrode's solution and the electrical field stimulation(EFS) induced contraction was recorded with Grass Polygraph(Model 7) via force displacement transducer (FT .03, Grass). The results are summarized as follows: 1) Electrical field stimulation for 1sec( 1 msec, 40 cps) induced contraction of vas deferens was completely blocked by tetrodotoxin. 2) Bretylium caused marked inhibition of the EFS-induced contraction, hut tyramine and cocaine augmented the contraction. 3) EFS-induced contraction was inhibited or little affected in distal portion of vas deferens by norepinephrine or methoxamine, but the contraction was rather augmented by the ${\alpha}-agonists$ in proximal portion. 4) Clonidine inhibited the EFS-induced contraction proportionally to the concentration in distal portion, which was blocked by yohimbine pretreatment, but in the presence of $PGF_{2\alpha}$ the blockade by yohimbine was reversed. 5) Indomethacin pretreatment reduced the effect of clonidine, but addition of $PGF_{2\alpha}$ after washing-out the indomethacin caused the contraction to the control level. From these results it is suggested that PG synthesis is a necessary step and the PG itself has a permissive role in ${\alpha}_2-adrenoceptor$ action in rat vas deferens.

• 대한한방내과학회지
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• 제12권2호
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• pp.74-88
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• 1991

In order to study the effects of Goosunsan known clinically for their effects of treatment for cough and asthmas the study was carried out to investigate the effect of Goosunsan extract on the contractile force of the isolated guinea pig's vaviovs kinds smooth muscles and elucidate its mechanism The result were obtained as follows: 1. The isolated trachea & ileum smooth muscles of guinea pig was suspended in the organ bath with oxygenated kreb's Henselsite bicarbonate buffer solution at $37^{\circ}C$, and the developed tension by the drug was recorded with Isometric transducer (nacro F-60). The resting tension was approximately 0.5g. 2. The isolated trachea & ileum smooth muscles of guinea pig was remakably relaxed by the administration of Goosunsan. 3. The contractile response of the trachea smooth muscle of the isolated guinea pig to histamine 10-4 M was remakably by Goosunsan extract. 4. The contractile response of the ileum smooth muscle of the isolated guinea pig to histamine 10-4 M was remakably by Goosunsan extract. 5. The contractile response of the trachea smooth muscle of the isolated guinea pig to acetylcholine 10-4 M was remakably by Goosunsan extract. 6. The contractile response of the ileum smooth muscle of the isolated guinea pig to acetylcholine 10-4 M was remakably by Goosunsan. 7. The contractile response of the trachea smooth muscle of the isolated guinea pig to 5-hydroxytryptamine 10-4 M was remakably by Goosunsan. 8. The contractile response of the ileum smooth muscle of the isolated guinea pig to 5-hydroxytryptamine 10-4 M was remakably by Goosunsan.