• Journal of Veterinary Clinics
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• v.21 no.2
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• pp.172-176
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• 2004

We described the clinical signs, gross lesions, histopathological lesions, and electronmicroscopy of pig Foot-and-Mouth Disease cases which had occurred in 2002, Korea. Grossly affected pigs showed vesicles on snout, tongue, coronary band, and udder. Histoapthologically, severe intercellular edema and necrosis of prickle cells, and separation between epidermis and dermis were found on the mucosa of tongue and coronary band. And myocardial necrosis and mononuclear cells infiltration in myocardium were found. Electronmicroscopically numerous picornavirus particles(18∼22 nm in diameter) were found in the cytoplasm of prickle cells. By those results, we confirm that those cases were typical FMD cases.

• Journal of Korean Foot and Ankle Society
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• v.24 no.4
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• pp.156-160
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• 2020

Malignant peripheral nerve sheath tumors (MPNSTs) usually arise in soft tissues; they are rarely found in the bone. This paper reports a case of MPNST in the foot and ankle joint involving the distal tibia, talus, calcaneus, navicular, medial intermediate, and lateral cuneiform, cuboid, and 2nd to 4th metatarsal bone. Palliative treatment was performed. The authors encountered a patient with intraosseous MPNST of the midfoot who presented with nonspecific clinical and radiologic findings. This case shows that a high index of suspicion and a histopathology examination, including immunohistochemistry, will be necessary for an accurate diagnosis.

• The Korean Journal of Malacology
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• v.29 no.1
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• pp.7-13
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• 2013

This study was conducted to find out biological response of Manila clam, Ruditapes philippinarum exposed to lead (Pb). Experimental period was four weeks. Experimental groups were composed of one control condition and three lead exposure conditions (0.25, 0.50 and 1.00 mg/l). The results of the study confirmed that lead induces reduction of survival rate and oxygen consumption rate and histopathology of organ structure of the bivalve. Oxygen consumption rate was observed exposure groups lower than control decline by 25%-72%. Histological analysis of organ system illustrated expansion of hemolymph sinus, disappearance of epidermal layer and degeneration of connective tissue layer of the mantle. Also, histological degenerations as epithelial necrosis and hyperplasia of mucous cells are recognized in the gill and it was observed expansion of hemolymph sinus, disruption of epithelial layer, decrease of mucous cell and degeneration of connective tissue layer in the foot. In the digestive diverticulum, it was showed atrophy of basophilic cell and degeneration of epithelial cell in the digestive tubules, and as the concentration of lead increased the accumulation of lipofuscin increased.

• The Korean Journal of Malacology
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• v.31 no.2
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• pp.151-158
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• 2015

This study was conducted to find out the changes of survival, respiration and organ structure of Tegillarca granosa exposed to copper (Cu). Experimental period was four weeks. Experimental groups were composed of one control condition and three copper exposure conditions (0.125, 0.250 and 0.500 mg/L). The results of the study confirmed that copper induces reduction of survival rate and respiration rate and histopathology of organ structure of the bivalve. In the copper concentration of 0.500 mg/L, mortality was 66.7% after Cu exposure of 4 weeks. Respiration rate was observed exposure groups lower than control decline by 18%. Histological analysis of organ system illustrated degeneration of epithelial layer and connective tissue layer of the mantle. Also, histological degenerations as epithelial atrophy and disappearance of lateral cilia are recognized in the gill and it was observed expansion of hemolymph sinus, disruption of epithelial layer, acidification of mucous and degeneration of muscle fiber bundles in the foot. In the digestive diverticulum, it was showed atrophy and destruction of basophilic cell and epithelial cell in the digestive tubules.

• The Korean Journal of Malacology
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• v.29 no.4
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• pp.303-311
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• 2013

This study investigated survival, falling and structural changes of foot in Haliotis discus hannai with various water temperature and salinity. Experimental conditions were composed of control with $20^{\circ}C/33.5$ psu, higher temperature group with 23, 26, 29 and $32^{\circ}C$, lower temperature group with 3, 6, 9 and $12^{\circ}C$, and different salinities group with 33.5, 26.8, 20.1, 13.4, 6.7 and 3.3 psu. Experimental period was 7 days. Survival and falling rate of the abalone exposed to 7 days at control and experimental condition of $12^{\circ}C$ and $23^{\circ}C/33.5$ psu were 100% and 0%, respectively. Mortality and falling rate of the abalone exposed to the different temperature and salinity were dose dependent by experimental condition. Histopathological changes in epithelial and muscular layer of foot showed more obvious with experimental condition of salinity decrease than different temperature condition.

• Archives of Plastic Surgery
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• v.33 no.1
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• pp.116-119
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• 2006

Management of chronic wound has been a great problem to many surgeons because the wound is usually associated with an underlying disease of the patient. Without accurate diagnosis and treatment of the disease, the wound can not be healed. Systemic vasculitis is a rare systemic disease which causes inflammation and obstruction of the vessels. This autoimmune disease involves multiple organs and may inflict skin wound spontaneously without traumas. It would improve or aggravate the wound in proportion to the activities of the disease. Our experience is a case of 28-year-old female who has had chronic ulcers on her right foot, especially on the great toe for 1 year. Although she had several operations of sympathectomy, debridement and artificial dermal graft, her wound was not improved. She has been diagnosed as systemic vasculitis during the evaluation for histopathology and cause of fever and pancytopenia. After medical treatments, she had the operation of adipofascial turnover flap coverage and skin graft, and the wound was improved without any complication or relapse. The diagnosis and treatment of the underlying disease should be ahead of the management of chronic wound.

• The Korean Journal of Malacology
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• v.29 no.2
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• pp.129-137
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• 2013

This study was conducted to find out the changes of survivorship, respiration and organ structure of Mactra veneriformis exposed to copper (Cu). Experimental period was four weeks. Experimental groups were composed of one control condition and three copper exposure conditions (0.025, 0.050 and 0.100 mg/L). The results of the study confirmed that copper induces reduction of survival rate and respiration rate and histopathology of organ structure of the bivalve. In the copper concentration of 0.100 mg/L, mortality was 100% after Cu exposure of 3 weeks. Respiration rate was observed exposure groups lower than control decline by 75%. Histological analysis of organ system illustrated expansion of hemolymph sinus, disappearance of epidermal layer and degeneration of connective tissue layer of the mantle. Also, histological degenerations as epithelial necrosis and hyperplasia of mucous cells are recognized in the gill and it was observed expansion of hemolymph sinus, disruption of epithelial layer, decrease of mucous cell and degeneration of connective tissue layer in the foot. In the digestive diverticulum, it was showed atrophy of basophilic cell and degeneration of epithelial cell in the digestive tubules, and as the concentration of copper increased the accumulation of lipofuscin increased.

• Childhood Kidney Diseases
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• v.16 no.1
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• pp.21-31
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• 2012

Focal segmental glomerulosclerosis (FSGS) is the name of the primary glomerular disease as well as the terminology to describe the secondary phenomena of any other glomerular diseases. It is characterized by sclerosis, hyalinosis, foam cell infiltration, vacuolar change of podocytes, and halo formation in the glomerulus. Throughout the interstitium, lymphocytes infiltration, tubular atrophy and vascular changes are accompanied. Occasionally, IgM and/or C3 depositions are noted in the sclerotic areas. Electron microscopically, diffuse effacement of foot processes are seen in non-sclerotic area like minimal change disease. Podocyte injury patterns including vacuolar changes are frequently examined. Recently, Columbia group has suggested morphologic classification of FSGS and they demonstrated very good prognosis of tip lesion and poor prognosis of both collapsing and cellular types. However, the pathogenetic classification has been suggested by others; hyperfilteration, podocyte injury, genetic lesions etc. Further studies are necessary to understand and treat this disease.

• The Korean Journal of Malacology
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• v.32 no.2
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• pp.111-118
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• 2016

This study was conducted to find out concentration of trace metal, survival rate, falling rate and structural changes of the abalone Haliotis discus hannai exposed to nickel chloride. Experimental groups were composed of one control condition and four nickel chloride exposure conditions (7.0, 12.0, 17.0 and $22.0\;NiCl_2\;mg/L$). The concentration of nickel in abalone was significantly increased all exposure groups. Though the exposure groups had lower survival rate than the control group, falling rate higher than the control group. Histopathological changes in the foot, gill and hepatopancreas of abalone was revealed prominently with exposure group than control group.

• The Korean Journal of Malacology
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• v.31 no.3
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• pp.195-201
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• 2015

This study was conducted to find out concentration of trace metal, survival rate, falling rate and structural changes of abalone, Haliotis discus hannai exposed to zinc chloride. Experimental groups were composed of one control condition and four exposure conditions (0.3, 0.8, 1.3, $1.8\;ZnCl_2\;mg/L$). The accumulation of trace metal (zinc) in abalone was significantly increased all exposure group. Though the exposure groups had lower survival rate than the control group, higher falling rate than the control group. Histopathological changes in the foot, gill and hepatopancreas of abalone revealed obvious with exposure group than control group.