• Parasites, Hosts and Diseases
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• v.29 no.1
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• pp.55-66
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• 1991

A numerical taxonomy was studied on a group of heterophyid trematodes and analysis was made on the following species: Metagonimus yokogawai (3 OTU, Operational Taxonomic Unit) , Metagcnimus Miyata Type (3 OTU), Metagonimus takahashii (2 OTU), Heterophyes dispar (2 OTU), Heterephyes heterophyes (1 OTU), Heterophyes nocens (2 OTV), Heterophyopsis continua (1 OTU), Pygidiopsis summa (3 OTU), Stellantchasmus falcatus (2 OTU) and Stictodora sari (2 OTU). Twenty-six morphological characters were measured and their values were expressed as relative ratios. Similarity and correlation matrix among each individuals were calculated. Clustering analysis by Ward's method and factor analysis were performed using the SAS (Statistical Analysis System) package. As a results, the groups belonging to the genus of Metegenimus were divided into three phonons (Awetegonimus yokogawai, Metegcnimus Miyata Type, M. takahashii) , and Metagonimus Miyata Type was classified as the level of subspecies of M. takahashii. The groups belonging to the genus Heterophyes were clearly divided into three phonons (Heterophyes dispar, H. heterephyes, H. nocens), and H. nccens was classified as not a subspecies level of H. heterophyes but a distinct species. Other species were classified as distinct phonons. From these results, the appllcr lion of numerical taxonomy on trematode classification is considered to be a great aid to determine the limit of taxa.

• Journal of Preventive Medicine and Public Health
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• v.26 no.2 s.42
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• pp.192-201
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• 1993

Epidemiologic investigation was conducted on January, 1993 in Seoul to identify the cause of an infant methemoglobinemia. Field investigation of the area of outbreak, survey of household and family members, analysis of ground water, and blood tests of involved family members were performed. Following results were obtained On analyzing the quality of the ground water on patient's household high levels of nitrate was found indicating contamination of water as the cause of a methemoglobinemia outbreak. On analysing the quality of the ground waters on seven other places within the neighborhood five were contaminated by nitrate in concentration that exceeded the permissible limit implying presence nearby source of contamination. Sources of contamination were thought to be originating from human waste in conventional bathroom facilities, chicken manure used in nearby orchards and plant fields or fertilizers. But the results of water analysis with presence of bacteria or E.coli, concentration of potassium, phosphate and the past history of diarrhea among family members, chicken manure suggested the most possible source of contamination. To evaluate the health status of members in the neighborhood past history was reviewed revealing no prior existence of patient with cyanosis and 65 people in the neighborhood had normal levels of methemoglobin concentration in their blood. Conclusively, the ground water on patient's household was contaminated with nitrate and despite provision of adequate water supply, family members of the patient along with their distrust in the water supply system had used ground water as their source of drinking water resulting of methemoglobinemia. Many suburban area of Seoul and country side thought to be having similar problems concerning contaminated ground water supply and dormant outbreak of patients as a result of the drinking of the contaminated water. Epidemiologic investigation and water analysis of ground waters are advised.

• Journal of Preventive Medicine and Public Health
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• v.44 no.6
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• pp.260-266
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• 2011

Objectives: We evaluated the association between common carotid artery intima-media thickness (CCA-IMT), brachialankle pulse wave velocity (baPWV), carotid plaque, and peripheral arterial disease (PAD) as indicators of macroangiopathy and diabetic retinopathy as an indicator of microangiopathy in type 2 diabetic patients. Methods: We analyzed 605 type 2 diabetic patients registered at a public health center in Korea. Following overnight fasting, venous blood and urine samples were collected and analyzed. The CCA-IMT, levels of carotid plaque, baPWV, and ankle-brachial index (ABI) of the subjects were assessed. We used non-mydriatic fundus photography to diagnose diabetic retinopathy. Multiple logistic regression analyses were used to evaluate the association between macroangiopathy and diabetic retinopathy. CCA-IMT and baPWV were divided into tertiles: CCA-IMT, 0.39 to 0.65 mm, 0.66 to 0.78 mm, and 0.79 to 1.30 mm; baPWV, 9.9 to 15.8 m/s, 15.9 to 18.9 m/s, and 19.0 to 38.0 m/s. Results: The association between baPWV and diabetic retinopathy remained significant after adjustment, with an increasing odds ratio (OR) in the second tertile (OR, 2.41; 95% confidence interval [CI], 1.27 to 4.55) and the third tertile (OR, 4.63; 95% CI, 2.33 to 9.21). No significant differences were observed in carotid plaque, PAD, and each tertile of CCA-IMT. Conclusions: BaPWV was associated with diabetic retinopathy, while CCA-IMT, carotid plaque, and PAD were not. This study suggests that the association between macroangiopathy and microangiopathy may be attributable to functional processes rather than structural processes within the vascular system.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.5 no.1
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• pp.68-86
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• 1995

This study was conducted at five Ethylene Oxide(EO) sterilizing processes in hospitals located in Seoul from August 8 to August 30, 1994. The main purposes of this study were to assess the TWA(Time Weighted Average) and short term exposures to EO and to evaluate factors affecting EO concentrations in sterilizing room. Results are summarized as follows. 1. The TWA concentrations of the sterilizing operators ranged from <0.005ppm to 3.04ppm and those of two sterilizing rooms out of five exceeded 1ppm, the Korean and ACGIH standards. 2. When the door of the sterilizer is opened at the end of the sterilization cycle, the short term concentrations of operators ranged from <0.005ppm to 11.4ppm, and those of three sterilizing room out of five exceeded 5ppm, the ACGIH short term exposure limit(STEL). The short term concentrations of area samples ranged from 0.24ppm to 49.2ppm and those of four sterilizing room out of five exceeded 5ppm. 3. Factors affecting EO exposure level were aeration type, the location of storage site for sterilized item, amount of gas, use period of sterilizer(p<0.005). 4. Following recommendations are suggested to minimize exposure to EO. The use of EO gas should be reduced by using another available sterilization methods, and the sterilizers and gas tank storage site should be isolated from, other work areas. Combination of local and general ventilation system should be installed. Metal carts or baskets for sterilization load should be used, and work environment and medical monitoring should be performed regularly.

• Applied Chemistry for Engineering
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• v.3 no.3
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• pp.507-515
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• 1992

This study was carried out to investigate the heat-storage/-release characteristics of the thermochemical reaction of the calcined dolomite and steam system for the application of regenerative heat exchangers with the packed bed shape experimental apparatus. The experimental data were obtained at the following conditions ; the hydration temperature was $150-400^{\circ}C$, the dehydration temperature was $700-800^{\circ}C$ and the steam mass flow rates were 294, 430 and 567 g/hr. In the present study, it was found that MgO of the calcined dolomite was not hydrated during the hydration process under the studied experimental conditions. Therefore, MgO of the calcined dolomite can be regard as an inert material. Because the reaction was proceeded from the packed bed input to packed bed output and from wall to center, it could be thought that the rate determining step is not the reaction itself but the heat transfer.

• The Korean Journal of Health Service Management
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• v.5 no.2
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• pp.209-226
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• 2011

The purpose of this study is to analyze and find out key success factors and marketing strategies of Bumrungrad Hospital in Bangkok, Thailand. The major success factors of Bumrungrad Hospital are as follows; First, Bumrungrad Hospital had professional medical team and board of directors who had the international career. Second, Bumrungrad was supported by Thai government and they were in a cooperative relationship with each other for the development of the medical industry. Third, Bumrungrad appropriately handled the internal and external changes including Asia Financial Crises in 1997 and others. Fourth, Bumrungrad diversified and broaden its business field such as global medical investing and management, medical technology, anti-age medicine and wellness. Marketing strategies of Bumrungrad analyzed are the following four factors. First, Bumrungrad focused on the quality of services by employing professional medical staffs, who have the international certification, and by constructing IT system for hospital management. Second, Bumrungrad has maintained an equalized price policy to attract the customers bothin the domestic and foreign markets. The cost for care has appealed the foreign customers for its comparatively low price, but it focused mainly on the upper middle class in Thailand. Third, it established, managed, and consulted hospitals in the foreign countries including the Philippines and the Arab Emirates. Fourth, it adopted differentiated promotion strategies suitable for the special needs of domestic and foreign customers, and put emphasis on the buzz marketing.

• Journal of fish pathology
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• v.23 no.3
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• pp.323-334
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• 2010

Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP) are important components of the mammalian innate defence system against Gram-negative infections. The BPI/LBP cDNA was identified from the black rockfish ConA/PMA or LPS stimulated leukocyte cDNA library. The full-length BR-BPI/LBP cDNA was 2118 bp long and contained an open reading frame (ORF) of 1422 bp that encoded 473 amino-acid residues. The 5' UTR had a length of 57 bp, and the 3' UTR 639 bp. The molecular weight and theoretical isoelectric point (pI) values were calculated 51.4 kDa and 9.72, respectively. Compared with other known BPI or BPI/LBP peptide sequences, the most conserved regions of the black rockfish BPI/LBP peptide were found to be the BPI1 N-terminal, BPI2 C-terminal domains and a LPS binding domain. Phylogenetic analysis based on the deduced amino acid sequence revealed a homologous relationship between the BPI/LBP sequence of black rockfish and that of other teleosts. The black rockfish BPI/LBP gene was predominantly expressed in the PBLs, head kidney, trunk kidney and spleen. The expression of the black rockfish BPI/LBP molecule was induced in the peripheral blood leukocytes (PBLs) from 1 to 24 h following LPS stimulation, with a peak at 12 h post-stimulation.

• 한국방재학회:학술대회논문집
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• 2008.02a
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• pp.799-802
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• 2008

General behaviors based on hydraulic characteristics of natural streams and channels have been recently analyzed and developed via various numerical models. However in the states of natural hydraulics, an experimental research must be performed simultaneously with the mathematical analysis due to effects of hydraulic properties such as meander, sediment, and so on. In this study based on 2-D advection-dispersion equation, flow and tracer experiments were performed in the S-curved meandering laboratory channel with a rectangular cross-section. The channel was equipped with instrument carriages which was equipped with an auto-traversing system to be used with velocity measuring sensors throughout the depth and breadth of the flow field. To measure concentration distribution of the salt solution was adjusted to that of the flume water by adding methanol and a red dye (KMnO4) was added to aid the visualization of the tracer cloud, the tracer was instantaneously injected into the flow as a full-depth vertical line source by the instantaneous injector and the initial concentration of the tracer was 100,000 mg/l. The secondary current as well as the primary flow pattern was analyzed to investigate the flow distribution in the meandering channels. The velocity distribution of the primary flow for all cases skewed toward the inner bank at the first bend, and was almost symmetric at the crossovers, and then shifted toward the inner bank again at the next alternating bend. Thus, one can clearly notice that the maximum velocity occurs taking the shortest course along the channel, irrespective of the flow conditions. The result of the tracer tests shows that pollutant clouds are spreading following the maximum velocity lines in each cases with various mixing patterns like superposition, separation, and stagnation of pollutant clouds. Flow characteristics in each cases performed in this study can be compared with tracer dispersion characteristics with using evaluation of longitudinal and transverse dispersion coefficients(LDC, TDC). As expected, LDC and TDC in meandering parts have been evaluated with increasing distribution and straight parts have effected to evaluate minimum of LDC and TDC due to symmetric flow patterns and attenuations of secondary flow.

• Journal of Korean Medical classics
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• v.21 no.1
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• pp.13-26
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• 2008

Pediatrics in Geumwon(金元) age had fanned peculiar children's etiology, Byeonggihak(病機學) and Byeonjeungnon(辦證論) curative system grounded on medical theory in Geumwonsadaega(金元四大家). Yuwanso(劉完素), who was front-running man in that age, used so many times 'Yanggyeoksan(凉隔散)' or 'Bangpungtongseongsan(防風通聖散)' which have Hanryang(寒凉) disposition for curing children's disease in view of pathology in Yeoldahanso(熱多寒少), which is his special academic thought, after then Judangye(朱丹溪) succeed Yuwanso(劉完素)'s this view of pathology, Yang-eumjahyeol(養陰滋血) developed the one and made it a standing rule to cure children. Also Idongwon(李東垣) grasped that the main cause of disease is starvation because of war. As a result of it, he insisted on theory, internal cause's outbreak of person's illness, Naesangbiwi(內傷脾胃), Baekbyeong-yusaeng(百病由牛). In this view of this principle, he assorted and used following medicine 'Seungma(升麻), Siho(柴胡), Hwanggi' as 'Seungbalyanggi(升發陽氣)' method to cure children, and concentrated on children's spleen and stomach cure with this way. Jangjongjeong(張從政) applied 'Purgation therapy[攻下法]', Hantoha(汗吐下) centered on the theory of exogenous factors[外因說] , which explains that children's disease is Sagichimseup(邪氣侵襲), too. Like this, in Geumwon(金元) age, they had studied very seriously about main cause of children' s disease in two part, an internal cause and an external cause. Also, in pathological part they had approached academically 'Hwayeolchibyeong(火熱致病)' and 'Gigiseunggangsiljo(氣機乘降失調)' from diverse angles.

• Nutritional Sciences
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• v.9 no.1
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• pp.14-19
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• 2006

Breast cancer may be the consequence of free radical damage, which is partially caused by the excessive intake of dietary fat and imbalances in antioxidant scavenger system;. In this experiment, we examined! the effects of dietary peroxidizability index (PI) values on hepatic thiobmbituric acid reaction substances (TBARS) and antioxidant enzyme activities in rats treated with 7,12-dimethylbenz[$\alpha$]anthracene (DMBA). Female Sprague-Dawley rats were used and 7,12-DMBA (20 mg/kg body weight) was gastrically intubated at seven weeks of age in order to induce mammary tumors (MT). The levels of dietary PI were 36, 81, 126 and 217 (LPI, MLPI, MHPI and HPI), while dietary polyunsaturated/saturated fatty acids ratio was maintained at the same level (1.0). Fat used in the experiment was mixed with soybean oil, com oil, palm oil, perilla oil, sesame oil, fish oil, and beef tallow. Experimental diets were given for the following 20 weeks. We measured tumor numbers and weights, and then assayed the hepatic TBARS levels and antioxidant enzyme activities such as superoxide dismutase (SOD), catalase, glutathione peroxidase, glutathione-S-transferase (GST) and glutathione reductase (GR). The incidence of Mr was the lowest in the MHPI group. The hepatic TBARS level was significantly raised with increasing dietary PI value. The hepatic SOD and GR activities were differed significantly by dietary PI value. The hepatic SOD activity was negatively correlated with dietary PI value and GR activity was the highest in the rats fed the MHPI diet. When the dietary P/S ratio is kept at 1.0, adequate dietary PI value (PI value of 126) may reduce the incidence and growth of Mr, but this benefit may be lost with higher dietary PI value. These results suggest that the awareness of dietary PI values may help to decrease breast cancer incidence and growth.