• Current Optics and Photonics
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• 제3권3호
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• pp.256-262
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• 2019

Extensive tumor resection accompanied by radiotherapy and chemotherapy is the standard of care for malignant gliomas. However, there is a significant obstacle to the complete resection of the tumor due to the difficulty of distinguishing tumor and normal brain tissue with a conventional surgical microscope. Recently, multiple studies have shown the possibility of fluorescence-guided surgery in malignant gliomas. The most used fluorescence dyes for brain tumor surgery are 5-aminolevulinic acid (5-ALA) and indocyanine green (ICG). In this paper, a new fluorescence guided operation system, which can detect both 5-ALA and ICG fluorescent images simultaneously, is presented. This operation system consists of light emitting diodes (LEDs) which emits 410 nm and 740 nm wavelengths. We have performed experiments on rats in order to verify the operation of the newly developed operation system. Oral administration and imaging were performed to observe the fluorescence of 5-ALA and ICG fluorescence in rats. When LEDs at wavelengths of 410 nm and 740 nm were irradiated on rats, 628 nm wavelength with a violet fluorescence color and 825 nm wavelength with a red fluorescence color were expressed in 5-ALA and ICG fluorescent material, respectively, thus we were able to distinguish the tumor tissues easily. Previously, due to the poor resolution of the conventional surgical microscope and the fact that the color of the vein is similar to that of the tumor, the tumor resection margin was not easy to observe, thus increasing the likelihood for cancer recurrence. However, when the tumor is observed through the fluorescence guided operation system, it is possible to easily distinguish the color with the naked eye and it can be completely removed. Therefore, it is expected that surgical removal of cancerous tumors will be possible and surgical applications and surgical microscopes for cancer tumor removal surgery will be promising in the future.

• 한국조명전기설비학회:학술대회논문집
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• 한국조명전기설비학회 1990년도 추계학술발표회논문집
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• pp.17-22
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• 1990

A computer program to calculate the color temperature (To) and color rendering index (Ra) of the light source was developed. Using this program and a measuring system with a monochromator and a integrating sphere, To and Ra of incandescent lamp and fluorescent lamp was calculated. As a result, it is known that To of the I/L and the F/L with a reactor ballast is changing about 40˚K with varying source voltage of 5 V. Ra variations of these lamps have a trend but can be disregarded.

• 한국세라믹학회지
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• 제45권11호
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• pp.658-661
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• 2008

Deep red color emitting $YVO_4:Eu^{3+}$ phosphors were investigated in an attempt to achieve promising performances in cold cathode fluorescent lamp (CCFL) applications. For this purpose, several additives such as LiF, $Li_2CO_3$ and $HBO_3$ were introduced in the processing. While two of the additives were ineffective, the inclusion of $LiCO_3$ during the solid state synthesis of $YVO_4:Eu^{3+}$ phosphors was proven to enhance photoluminescent intensity and the color chromaticity. Unlike the commercially available $YVO_4:Eu^{3+}$ red phosphor for use in PDP applications, pure $YVO_4:Eu^{3+}$ excluding phosphorous was shown to be favorable for CCFL applications, improving color chromaticity at 254nm excitations.

• Macromolecular Research
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• 제16권7호
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• pp.604-608
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• 2008

Color dye-doped silk fibroin nanoparticles were successfully fabricated using a microemulsion method. An aqueous silk fibroin solution was prepared by dissolving cocoons (Bombyx mori) in a concentrated lithium bromide solution followed by dialysis. A color dye solution was also mixed with the aqueous silk fibroin solution. The surfactants used for the microemulsion were then removed by methanol and ethanol, yielding color dye-doped silk fibroin nanoparticles, approximately 167 nm in diameter. The secondary structure of the nanoparticles showed a $\beta$-sheet conformation, as characterized by Fourier transform infrared spectroscopy. The morphology of the nanoparticles was determined by field emission scanning electron microscopy, transmission electron microscopy and atomic force microscopy, and their size and size distribution were measured by dynamic light scattering. The color dye-doped silk fibroin nanoparticles were examined by confocal laser scanning microscopy.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2009년도 9th International Meeting on Information Display
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• pp.489-492
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• 2009

We report white OLED with high color temperature based on simple stacked structure for medical display applications. White OLED was fabricated with two emitting materials of fluorescent blue dopant and phosphorescent yellow dopant. We achieved luminance efficiency of 16.2cd/A and CIE color coordinates of (0.305, 0.317) at 10mA/$cm^2$. In particular, the correlated color temperature was higher than 7,000K, enough for display applications.

• 분석과학
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• 제18권1호
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• pp.89-95
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• 2005

Studies on the electrochemical reduction of 7-acetoxy-4-bromomethyl-coumarin (ABMC), 7-acetoxymethyl coumarin (AMC), and coumarin in 0.1 M tetraethyl ammonium perchlorate acetonitrile solution were carried out with direct current, differential pulse polarography, cyclic voltammetry, and controlled potential coulometry. The electrochemical reduction of ABMC was proceeded through three irreversible steps coupled with the chemical reactions. The solution color was changed to yellow when the carbonyl group was reduced during second step and the color change was independent with bromo group of ABMC. Fluorescent intensity was highest when the electrochemical reduction was controlled at near the overpotential of supporting electrolyte (-2.3 volts).

• Bulletin of the Korean Chemical Society
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• 제33권7호
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• pp.2287-2294
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• 2012

Deep blue fluorescent host materials based on a novel spiro[benzo[c]fluorene-7,9'-fluorene] core structure with side aromatic wings in the 5- and 9-positions, namely, 5,9-di(naphthalen-2-yl)spiro[benzo[c]fluorene-7,9'-fluorene] (DN-SBFF), 5,9-bis(4-t-butylphenyl)spiro[benzo[c]fluorene-7,9'-fluorene] (BP-SBFF), and 5,9-bis(4-fluorophenyl)spiro[benzo[c]fluorene-7,9'-fluorene] (FP-SBFF), were designed and successfully prepared using the Suzuki reaction. The physical properties of these materials and their EL characteristics as blue host materials doped with N,N,N',N'-tetraphenylspiro[benzo[c]fluorene-7,9'-fluorene]-5,9-diamine (TPA-SBFF) were investigated. The device used comprised ITO/N,N'-diphenyl-N,N'-bis[4-(phenyl-m-tolyl-amino)phenyl]-biphenyl-4,4'-diamine (DNTPD)/N,N'-di(1-naphthyl)-N,N'-diphenylbenzidine (NPB)/(FP-SBFF):dopant x%/tris(8-hydroxyquinoline)aluminum ($Alq_3$)/LiF. The device obtained using FP-SBFF doped with TPA-SBFF showed high color purity (0.13, 0.18) and an efficiency of 6.61 cd/A at 7 V.

• 한국전기전자재료학회논문지
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• 제28권11호
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• pp.704-710
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• 2015

We studied white organic light-emitting diodes using blue fluorescent and red phosphorescent materials. White single OLEDs were fabricated using SH-1 : BD-2 (3 vol.%) and CBP : $Ir(mphmq)_2(acac)$ (2 vol.%) as emitting layer (EML). The white single OLED using SH-1 : BD-2 (3 vol.% 8 nm) / CBP : $Ir(mphmq)_2(acac)$ (2 vol.% 22 nm) as emitting layer showed maximum current efficiency of 8.8 cd/A, Commission Internationale de l'Eclairage (CIE) coordinates of (0.403, 0.351) at $1,000cd/m^2$, and variation of CIE coordinates with ($0.402{\pm}0.012$, $0.35{\pm}0.002$) from 500 to $3,000cd/m^2$. The white tandem OLED using SH-1 : BD-2 (3 vol.% 12 nm) / CBP : $Ir(mphmq)_2(acac)$ (2 vol.% 18 nm) showed maximum efficiency of 19.6 cd/A, CIE coordinates of (0.354, 0.365) at $1,000cd/m^2$, and variation of CIE coordinates with ($0.356{\pm}0.016$, $0.364{\pm}0.002$) from 500 to $3,000cd/m^2$. Maximum current efficiency of the white tandem OLED was more twice as high as the single OLED. Our findings suggest that tandem OLED was possible to produce improved efficiency and excellent color stability.

• 대한방사성의약품학회지
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• 제1권1호
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• pp.62-73
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• 2015

We developed an evans blue-indocyanine green-$^{99m}Tc$-human serum albumin conjugate for sentinel lymph node mapping and we describe its unique potential usage for clinical implications. This conjugate has combined the strengths of visible blue dye, near-infrared fluorescence and radioisotope into one single conjugate without any additional weakness/disadvantage. All the components of evans blue-indocyanine green-$^{99m}Tc$-human serum albumin are safe and of low cost, and they have already been clinically used. This conjugate was stable in the serum, it showed a long retention time in the lymphatic system and the lymph nodes showed a much higher signal-to-noise ratio after the conjugate was injected intradermally into the paw of mice. Both the single-photon emission computed tomography and near-infrared fluorescent images of the mice were successfully obtained at the same time as the excised sentinel lymph nodes showed blue color. The visual color, near-infrared fluorescence and gamma ray from this agent could be complementary for each other in all the steps of sentinel lymph node sampling: exploring and planning sentinel lymph node before excision with visualization of the exact sentinel lymph node location during an operation. Therefore, the triple modal agent will possibly be very ideal for sentinel lymph node mapping because of the high signal-to-noise ratio for non-invasive imaging and its complementary multimodal nature, easy preparation and safety. It is promising for clinical applications and it may have great advantages over the traditional single modal methods.

• 한국버섯학회지
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• 제15권4호
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• pp.259-263
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• 2017

표고 '농진고'를 LED 혼합광에 따른 갓의 색차 및 경도차를 확인한 결과 갓의 명도값은 형광등 처리구 대비 LED혼합광 처리구 모두 낮아지는 결과를 나타내었다. 적색도는 형광등 처리구에 비해 처리구 모두 높아졌고, 황색도는 낮아지는 결과를 보였다. 광원별 자실체의 생육특성을 조사한 결과 형광등 대조구 대비 처리구 모두에서 갓직경이 컸으며, 자실체들에 대한 균일도는 형광등 처리구 대비 LED를 사용하였을 경우 낮은 값을 나타내어 형광등을 처리하는 것보다 균일도가 있는 것으로 나타났다. 대직경은 처리구간 큰 차이를 보이지는 않았으나 White Green LED에서 다른 처리구보다 높은 것으로 조사되었고, 대길이는 형광등 처리구보다 LED처리구 모두에서 다소 높게 조사되었다. 갓직경과 대길이의 비를 조사한 결과 White Green LED을 제외한 White LED와 White Blue LED에서 형광등 처리구 대비 높은 값을 나타내어 대길이에 비해 갓의 직경이 길어지는 것을 확인할 수 있었다. 자실체 물추출물의 항산화능을 확인한 결과 형광등 처리구에서 가장 높은 항산화능을 확인할 수 있었고 LED 처리는 White LED처리에서 가장 큰 항산화능을 확인하였고 White Green LED, White Blue LED간에는 유의한 차이를 보이지 않았으나 LED처리는 Vitamin C 보다 높은 항산화능을 나타내었다. 위의 결과를 통해 White LED와 White Blue 처리가 표고버섯 자실체의 생육 및 항산화능에 영향을 미치는 광원임을 확인할 수 있었다.