• Journal of Physiology & Pathology in Korean Medicine
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• v.38 no.1
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• pp.16-21
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• 2024

Haepyoijin-tang and its main components have been used for phlegm, cough and dyspnea. Using a respiratory inflammation model, we intend to reveal the anti-inflammatory effect and pharmacological mechanism of Haepyoijin-tang. We induced the respiratory inflammation model by Aspergillus oryzae protease and ovalbumin administration. Female Balb/c mice (8 weeks old) were classified into four groups as follows: saline control group, aspergillus oryzae protease and ovalbumin induced respiratory inflammation group (vehicle), inflammation with Haepyoijin-tang (200 mg/kg) administration group, inflammation with dexamethasone (5 mg/kg) administration group (n=7). To identify the anti-inflammatory effects of Haepyoijin-tang water extracts, we measured the inflammatory cell number in bronchoalveolar lavage fluid (BALF) and total live lung cell number. In addition, we checked eosinophil ratio and number in BALF. And Interleukin (IL)-5 level was also measured in lung cell culture supernatant. To confirm the mechanism of anti-inflammatory effects, we analyzed the activated helper T cell (CD4⁺CD25⁺ cell) and Th2 cell (CD4⁺GATA3⁺ cell) ratio and number in lung by using flow cytometry. Finally, we attempted to confirm the immune mechanism by measuring the ratio and number of regulatory T cells (CD4⁺Foxp3⁺ cell). Haepyoijin-tang extracts treatment diminished inflammatory cell, especially, eosinophil number in BALF and total live lung cell number. Moreover, IL-5 level was reduced in Haepyoijin-tang treated group. Surprisingly, Haepyoijin-tang extracts administration not only decreased the activated helper T cell but also Th2 cell population in lung. Additionally, regulatory T cell population was increased in Haepyoijin-tang administration group. Our findings proved that Haepyoijin-tang extract have anti-inflammatory efficacy by suppressing Th2 cell activation and promoting regulatory T cell population.

• Journal of Drive and Control
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• v.13 no.2
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• pp.10-18
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• 2016

A front-end loader (FEL) mounted on an agricultural tractor is one of the most commonly used implements to mechanize routine agricultural tasks. When the FEL is used with a loaded bucket, careful operation is required to maintain safety and avoid spillage when the tractor passes a bump because a change in the gravity center of the tractor due to varied loadings can affect the stability of the tractor. Use of a boom suspension system consisting of accumulators and orifice dampers can be instrumental in reducing pitching vibrations while increasing the handling performance of the FEL-mounted tractor. The objective of this research was to reduce bump shocks by adding an orifice and a flow control valve to the original hydraulic circuit composed solely of accumulators. A simulation study was performed using the SimulationX program to investigate the effects of an accumulator and an orifice-throttle damper on bump shocks. Results showed that the peak pressure on a boom cylinder and the vertical acceleration of a bucket were significantly affected by use of both an accumulator and an orifice damper. In a field test conducted with a 75-kW tractor, the peak pressure of the boom cylinder, and the root mean square (RMS) vertical acceleration of the bucket and seat were reduced by on average, 23.0, 42.2, and 44.9% respectively, as compared to those measured with the original accumulator system, showing that an improved design for the accumulator hydraulic circuit can reduce bump shocks. Further studies are needed to design a tractor suspension system that includes the effects of cabin suspension and tires as well as dynamic analysis.

• Wind and Structures
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• v.13 no.1
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• pp.21-36
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• 2010

A new full scale testing apparatus generically named the Wall of Wind (WoW) has been built by the researchers at the International Hurricane Research Center (IHRC) at Florida International University (FIU). WoW is capable of testing single story building models subjected up to category 3 hurricane wind speeds. Depending on the relative model and WoW wind field sizes, testing may entail blockage issues. In addition, the proximity of the test building to the wind simulator may also affect the aerodynamic data. This study focuses on the Computational Fluid Dynamics (CFD) assessment of the effects on the quality of the aerodynamic data of (i) blockage due to model buildings of various sizes and (ii) wind simulator proximity for various distances between the wind simulator and the test building. The test buildings were assumed to have simple parallelepiped shapes. The computer simulations were performed under both finite WoW wind-field conditions and in an extended Atmospheric Boundary Layer (ABL) wind flow. Mean pressure coefficients for the roof and the windward and leeward walls served as measures of the blockage and wind simulator proximity effects. The study uses the commercial software FLUENT with Reynolds Averaged Navier Stokes equations and a Renormalization Group (RNG) k-${\varepsilon}$ turbulence model. The results indicated that for larger size test specimens (i.e. for cases where the height of test specimen is larger than one third of the wind field height) blockage correction may become necessary. The test specimen should also be placed at a distance greater than twice the height of the test specimen from the fans to reduce proximity effect.

• Journal of the Korean Society for Geothermal and Hydrothermal Energy
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• v.5 no.1
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• pp.1-6
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• 2009

In this study, an ORC (Organic Rankine Cycle) is investigated for a low-temperature geothermal power generation by a simulation method. A steady-state simulation model is developed to analyze cycle's performance. The model contains a turbine, a pump, an expansion valve and heat exchangers. The turbine and pump are modelled by an isentropic efficiency. Simulations were carried out for the given heat source and sink inlet temperatures, and given flow rate that is based on the typical power plant thermal-capacitance-rate ratio. HFC-245fa is considered as a working fluid of the cycle. Simulation results, at the given secondary working fluids conditions, show that even though the power can be presented by both the evaporating temperature and the turbine inlet superheat, it depends on the evaporating temperature primarily.

• Journal of Sensor Science and Technology
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• v.18 no.1
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• pp.86-94
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• 2009

Temperature measurement capability was inter-compared using the transfer standard platinum resistance thermometers(SPRT) among four laboratories of KRISS. The transfer SPRTs were primarily calibrated at the triple point of water and Ga melting point, then used at inter-comparison experiment. Temperature difference of calibration value between temperature laboratory and length laboratory at $20^{\circ}C$ was -0.7 mK and +2.4 mK at density laboratory. Temperature measured near $20^{\circ}C$, $25^{\circ}C$ and $30^{\circ}C$ at fluid flow laboratory was deviated by $34.2{\sim}80.4\;mK$ from the calibration values of the transfer SPRT. Ga melting points was inter-compared among three laboratories, and the difference of Ga melting points against the standard Ga melting point of temperature laboratory were $0.03{\sim}0.54\;mK$ at length laboratory and 0.02 mK at density laboratory.

• KIEAE Journal
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• v.13 no.5
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• pp.43-50
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• 2013

Recent researches on plant factory system deal with the convergence of lighting technology, agricultural technology inclusive to the high-tech industries worldwide in order to respond to the decreasing crop harvest due to global warming and abnormal weather phenomena. However, the fundamental performance standard is not currently being introduced in the case of plants factory and its commercialization is not activated because of high initial investment and operating cost. Large portion of the initial investment and operating cost of a plant factory is ascribed to artificial light sources and thermal control facilities, therefore, innovation should be provided in order to improve the economics of the plant factory. As an alternative, new plant factory could harness solar thermal and geothermal systems for heating, cooling and ventilation. In this study, a natural light dependent multi-layer plant factory's thermal environment was analyzed with two-dimensional numerical methods to elicit efficient operation conditions for optimized internal physical environment. Depending on the supply air temperature and airflow rate introduced in the facility, the temperature changes around the crops was interpreted. Since the air supplied into the plant factory does not stay long enough, the ambient temperature predicted around the plating trays was not significantly different from that of the supplied air. However, the changes of airflow rate and air flow pattern could cause difference to the temperature around the planting trays. Increasing the amount of time of air staying around the planting trays could improve energy performance in case the thermal environment of a natural light based multi-layer plant factory is considered.

• Journal of Korean Critical Care Nursing
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• v.9 no.1
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• pp.40-50
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• 2016

Purpose: Continuous renal replacement therapy (CRRT) has become the preferred dialysis method to support critically ill children and neonates with acute kidney injury. Using CRRT on neonates has increased, but reports about experience are limited. The aim of this study is to describe the clinical application, outcomes, and complications of CRRT in children and neonates. Methods: A retrospective review was performed in 135 children and 36 neonates who underwent CRRT at a tertiary hospital from 2008 to 2015. Results: At the initiation of CRRT, the median age of children was 72 months and the corrected age of neonates was 37.1 weeks. Median body weight of neonates was 3.2 kg. In neonates, initial degree of fluid overload [FO%], blood flow rate [BFR] and ultrafiltration rate [UFR] rate during CRRT were higher than in children. Median real time of CRRT was 90.5 and 53.5 hours in children and neonates, respectively. Downtime of CRRT was 0.7 and 1.3 hours/day. Median mortality rates (44.4% vs.47.2%) and complication rates were similar between the groups. Conclusion: CRRT can be used for a wide range of critically ill children and neonates. Different application methods of CRRT can contribute to increased survival of neonates.

• Geomechanics and Engineering
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• v.15 no.3
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• pp.851-859
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• 2018

There are two primary causes of the ground movement due to tunnelling in urban areas; firstly the lost ground and secondly the groundwater depression during construction. The groundwater depression was usually not considered as a cause of settlement in previous research works. The main purpose of this study is to analyze the combined effect of these two phenomena on the transverse settlement trough. Centrifuge model tests and numerical analysis were primarily selected as the methodology. The characteristics of settlement trough were analyzed by performing centrifuge model tests where acceleration reached up to 80g condition. Two different types of tunnel models of 180 mm diameter were prepared in order to match the prototype of a large tunnel of 14.4 m diameter. A volume loss model was made to simulate the excavation procedure at different volume loss and a drainage tunnel model was made to simulate the reduction in pore pressure distribution. Numerical analysis was performed using FLAC 2D program in order to analyze the effects of various groundwater depression values on the settlement trough. Unconfined fluid flow condition was selected to develop the phreatic surface and groundwater level on the surface. The settlement troughs obtained in the results were investigated according to the combined effect of excavation and groundwater depression. Subsequently, a new curve is suggested to consider elastic settlement in the modified Gaussian curve. The results show that the effects of groundwater depression are considerable as the settlement trough gets deeper and wider compared to the trough obtained only due to excavation. The relationships of maximum settlement and infection point with the reduced pore pressure at tunnel centerline are also suggested.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.2
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• pp.1-9
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• 2023

Objectives : This study used a network pharmacology approach to analyze the treatment mechanisms of Yijin-tang on Meniere's disease, and comparative analysis the treatment mechanisms of drugs recommended in the Meniere's disease treatment guidelines. Methods : We collected information on the recommended drugs from the Meniere's disease treatment guidelines and their target proteins were screened via the STITCH database. The intersection targets were obtained through Venny 2.1.0. Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis were performed using ClueGO. Results : The 7 proteins(TNF, CASP9, PARP1, CCL2, CFTR, NOS2, NOS1) were associated with both Yijin-tang and Meniere's disease related genes. The 10 proteins(AQP2, KCNE1, AQP1, AVP, ACE, HRH1, HRH3, NOS1, CA1, CFTR) were associated with both the recommended drugs in the guidelines and Meniere's disease related genes. The 2 proteins(CFTR, NOS1) were common across all three groups. Further, GO/KEGG pathway analysis of the collected proteins revealed that the common mechanisms of action between Yijin-tang and the recommended drugs in the guidelines were related to pathways involving immune dysfunction and disturbances in lymphatic fluid homeostasis. In addition, the recommended drugs in the guidelines appeared to act through mechanisms that improve blood flow through vasodilation. Conclusions : Pharmacological network analysis can help to explain the treatment mechanisms of Yijin-tang on Meniere's disease.

• IMMUNE NETWORK
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• v.21 no.1
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• pp.11.1-11.10
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• 2021

Coronavirus causes an infectious disease in various species and crosses the species barriers leading to the outbreak of zoonotic diseases. Due to the respiratory diseases are mainly caused in humans and viruses are replicated and excreted through the respiratory tract, the nasal fluid and sputum are mainly used for diagnosis. Early diagnosis of coronavirus plays an important role in preventing its spread and is essential for quarantine policies. For rapid decision and prompt triage of infected host, the immunochromatographic assay (ICA) has been widely used for point of care testing. However, when the ICA is applied to an expectorated sputum in which antigens are present, the viscosity of sputum interferes with the migration of the antigens on the test strip. To overcome this limitation, it is necessary to use a mucolytic agent without affecting the antigens. In this study, we combined known mucolytic agents to lower the viscosity of sputum and applied that to alpha and beta coronavirus, porcine epidemic diarrhea virus (PEDV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively, spiked in sputum to find optimal pretreatment conditions. The pretreatment method using tris(2-carboxyethyl)phosphine (TCEP) and BSA was suitable for ICA diagnosis of sputum samples spiked with PEDV and MERS-CoV. This sensitive assay for the detection of coronavirus in sputum provides an useful information for the diagnosis of pathogen in low respiratory tract.