• The Korean Journal of Physiology and Pharmacology
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• 제22권5호
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• pp.481-491
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• 2018

Allergic asthma is one of the most enduring diseases of the airway. The T-helper cells and regulatory T-cells are critically involved in inflammatory responses, mucus hypersecretion, airway remodelling and in airway hyper-responsiveness. Cigarette smoke (CS) has been found to aggravate inflammatory responses in asthma. Though currently employed drugs are effective, associated side effects demand identification and development of novel drugs with negligible or no adverse effects. Rutin, plant-derived flavonoid has been found to possess antioxidant and anti-inflammatory effects. We investigated the ability of rutin to modulate T-cells and inhibit inflammation in experimentally-induced asthma in cigarette smoke exposed mice. Separate groups of neonatal mice were exposed to CS for 10 days from post-natal days 2 to 11. After 2 weeks, the mice were sensitized and challenged with ovalbumin (OVA). Treatment group were given rutin (37.5 or 75 mg/kg body weight) during OVA sensitization and challenge. Rutin treatment was found to significantly inhibit cellular infiltration in the airways and Th2 and Th17 cytokine levels as well. Flow cytometry revealed effectively raised $CD4^+CD25^+Fox3^+$ Treg cells and supressed Th17 cell population on rutin treatment. Airway hyper-responsiveness observed following CS and OVA challenge were inhibited by rutin. $NF-{\kappa}B$ and iNOS, chief regulators of inflammatory responses robustly activated by CS and OVA were down-regulated by rutin. Rutin also inhibited the expression of matrix metalloproteinase 9, thereby aiding in prevention of airway remodelling in asthma thereby revealing to be a potent candidate in asthma therapy.

• 한국물환경학회지
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• 제36권5호
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• pp.445-452
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• 2020

Tributary is a part of life space for people and a very important place that accommodates rest recreation and other daily activities. absolutely insufficient basic data about water quality and flow rate are available for basin management. Efficient water and basin management systems, which are also supported by local residents can be established by securing such basic data of major tributaries in the Nakdong river system. In this study, the fluctuation characteristics of upstream and downstream water pollution levels were compared using the measurement results of the water environment measurement network and the tributary monitoring project for the gyeseong-stream and Hwapo-stream in the Nakdong-miryang watershed. In 2017, when water pollution is the highest, it was confirmed that the annual average rainfall was the lowest. Although the upstream and downstream water quality tendencies of the Gyeseong-stream are similar, the water quality concentrations of the Gyeseong-stream are relatively different. But although the Hwapo stream has various causes of pollution, there was not much difference in the level of pollution between the upper and lower streams. In addition, both rivers need the ability to purify rivers by securing sufficient water for river maintenance, and if the correlation between water quality items can be inferred through continuous monitoring of tributaries where the aspect of water quality change is unclear, water quality management Determined to be efficient operation.

• 한국식품과학회지
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• 제40권6호
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• pp.621-625
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• 2008

오징어 간유 미세캡슐화 분말을 HPMC-FCC, zein-DP로 코팅하여 유동층 코팅 특성을 살펴본 결과, 유동층 코팅 효율은 HPMC-FCC, zein-DP 모두 90%의 효율을 나타내었다. 겉보기 밀도는 zein-DP 코팅분말이 0.6 g/mL로 높게 나타나 코팅 분말의 비중이 커져 흐름성이 개선되었음을 확인할 수 있었다. 인공위액과 인공장액에 대한 용해성을 살펴본 결과, HPMC-FCC는 각각 59.9%와 0%를 나타내었고 zein-DP는 각각 0%와 31.0%를 나타내어 코팅재료에 따라 용해성을 조절할 수 있었다. 저장 안정성은 zein-DP나 HPMC-FCC로 코팅한 분말이 미세캡슐화 분말보다 높은 PUFA/SFA 잔존율을 보여, 유동층 코팅 기술이 유지식품의 안정성을 확보할 수 있는 새로운 기술이 될 수 있음을 확인할 수 있었다.

• Archives of Plastic Surgery
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• 제40권5호
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• pp.505-509
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• 2013

Background The aim of this study was to collect important data on the time of oxygen saturation change in relation to skin flap color alteration using non-invasive pulse oximetry to evaluate its ability to provide continuous monitoring of skin flap perfusion. Methods An experimental study on the monitoring of blood perfusion of 20 tube-island groin flaps of 10 male New Zealand rabbits was performed using pulse oximetry. The animals were randomly assigned to one of two groups representing a blockage of either arterial or venous blood flow. The oxygen saturation change and clinical color alteration were monitored from the beginning of vessel clamping until the saturation became undetectable. The result was analyzed by the t-test using SSPS ver. 10.0. Results The mean times from the vessel clamping until the saturation became undetectable were $20.19{\pm}2.13$ seconds and $74.91{\pm}10.57$ seconds for the artery and vein clamping groups, respectively. The mean time of the clinical alteration from the beginning of vein clamping was $34.5{\pm}11.72$ minutes, while the alteration in flaps with artery clamping could not be detected until 2.5 hours after clamping. Conclusions The use of neonate-type reusable flex sensor-pulse oximetry is objective and effective in early detection of arterial and vein blockage. It provides real-time data on vessel occlusion, which in turn will allow for early salvaging. The detection periods of both arterial occlusion and venous congestion are much earlier than the color alteration one may encounter clinically.

• 한국도로학회논문집
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• 제14권1호
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• pp.55-61
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• 2012

본 연구는 도시지역 도로측구 등에 설치할 비점오염원의 정화장치 개발을 위해 여과재의 개발에 연구의 초점을 맞추었다. 필터는 다양한 미세기공을 갖고 있어 물리적 흡착능력이 뛰어나며, 결정 구조 안에 다양한 양이온이 배위되어 있어 화학적 흡착이 탁월한, 다공성 점토광물을 직경 3mm 볼 형태로 제작하였다. 성형한 필터에 도시지역 강우 직후 발생한 오염 원수를 통과시켜 SS, COD, T-P, T-N의 제거 능력을 폐수정화에 흔히 이용되는 첨착활성탄(Impregnated Activated Carbon) 필터와 비교 분석하였다. 다공성 점토광물 필터와 첨착활성탄 필터의 T-N과 T-P 여과능력은 거의 차이가 없음을 알 수 있었다.

• 한국도로학회논문집
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• 제10권3호
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• pp.19-31
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• 2008

영상처리시스템(VIPS: Video Image Processing System)은 실시간으로 들어오는 영상정보를 분석하여 유용한 정보를 제공하며, 하나의 카메라로 여러 차로를 동시에 감시할 수 있는 알고리즘으로 교통량, 속도뿐만 아니라 밀도 및 점유율 등 다양한 정보를 제공한다. 영상검지시스템으로 상용화 제품은 Tripwire시스템으로 검지영역의 픽셀 변화량으로 차량검지를 하나, 이는 교통량, 속도 등 단편적인 정보에 국한될 수 밖에 없다. 반면, 영상검지시스템이 개별차량에 대한 추적시스템으로 개발할 경우 사고 및 차로 변경의 위험요소 감지 등 보다 다양한 정보를 제공할 수가 있다. 본 논문은 컴퓨터비전 기술을 이용하여 Tripwire에서 수집할 수 있는 교통정보와 동일한 정보를 제공하는 개별차량의 추적시스템을 개발하였으며 이 시스템을 실제 도로영상에 적용하여 상용화된 시스템과 결과를 비교함으로써 성능검증을 하였다.

• 생명과학회지
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• 제8권6호
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• pp.687-694
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• 1998

한국 남부지방의 매화노루발(Chimaphila japonica Miq.)의 유전적 다양성 및 집단구조를 조사하기 위해 전기영동을 실시하였다. 집단내 다형현상을 나타내는 대립유전자는 48.7%였다. 종 및 집단 수준에서 유전적 다양도는 각각 0.278, 0.222로 나타났고, 집단간 분화 정도는 비교적 낮았다( $G_{ST}$ =0.079). 조사한 일곱 집단내 자가 수분계수는 0.355였다. $G_{ST}$ 로부터 간접적으로 구한 세대당 집단간 이동개체수는 약간 높게 나타나므로 한반도 남부 지방의 집단간 유전자 이동이 보편적으로 이루어 지고 있음을 시사한다 (Nm=2.61). 고정지수 분석에 의하면 이형접합자의 부족이 여러 집단 및 대립유전자좌위에서 나타났다. 이 종에서 유전적 다양도가 고양된 주된 이유는 광범위한 분포, 다년생, 영양번식, 곤충에 의한 타가수분, 그리고 바람에 의한 화분분산이 빈번하게 이루어진 것으로 사료된다.

• 생명과학회지
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• 제14권2호
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• pp.345-350
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• 2004

한국내 물오리나무(Ainus hirsuta) 집단의 미소지리적 변이를 공간적 상관관계에 적용하였다. 분리된 등급간 대립유전자의 각 형태의 산출을 정규분포 편차 통계에서 임의분포를 하고 있는지를 검정하였다. 모든 경우에서 예상 값이 유의성을 가지는지 Moran의 I값으로 추정한 결과 120 경우 준 24 경우(20.0%)에서 유의성을 나타내었다. 이들 값 중에서 17 경우는 음의 값을 나타내었는데 이는 한국의 물오리집단이 10등급 간격에서 유사하지 않다는 점을 시사하였다. 그 한 원인으로는 화목(火木)을 위한 인간의 간섭을 추정할 수 있다. 열매를 맺는 가지나 줄기의 간헐적인 벌목에 의해 유전자 유동이 조장되었기 때문일 것이다. 한편, 그루터기나 밑둥으로부터 영양번식을 할 수 있는 능력 또한 유전적 구조를 어지럽히는 한 요인으로 작용한 것으로 사료된다.

• 사상체질의학회지
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• 제19권2호
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• pp.11-21
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• 2007

1. Objectives The object of this thesis is to find the basis on why Jejo was assigned as a Taeumin medicine, and to understand Taeumin edema. 2. Methods ${\ulcorner}$Dongyisusebowon${\lrcorner}$ 'Shinchukbon', 'Gabobon', 'Chobonkwun', other related Sasang Constitutional Medicine(SCM) books, herbal medicine books such as ${\ulcorner}$Bonchokangmok${\lrcorner}$, and etc. were compared and researched. 3. Results & Conclusions (1) In Sasang Constitutional Medicine, edema is seen as a critical condition. The first cause of edema in Taeumin is fatigue, a condition where the flow of Qi and Fluid Qi is stagnated. Secondly, edema is caused as Taeeumin is mentally stressed(勞心焦思) and he/she is unable to accomplish his/her plans over many trials or as when they find pleasure in striving for greed. When Lungs which is Incline & Small Viscera(偏小之臟) in Taeumin decreases, it diminishes Real Count of Longevity(命脈實數) which leads to edema formation. (2) Perspective of Human Nature & Character(心性學) and Regimen(養生法) became included gradually in the treatment methods and prescription of edema in Taeumin as ${\ulcorner}$Dongyisusebowon${\lrcorner}$ was revised over time. The revisions also lead to more diversity in prescriptions. (3) Jejo didn't appear In ${\ulcorner}$Dongyisusebowon${\lrcorner}$ 'Chobonkwun' and 'Gabobon'. It was first presented in 'Shinchukbon' as a medicine to treat edema in Taeumin. (4) Jejo have effects of easing clumps. Also it has a strong radiating ability(發散力) which induces perspiration to treat diseases. Finally Jejo is used to remove Takki(濁氣) by utilizing powerful Exhale Gathering Qi contained in it.

• 지구물리와물리탐사
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• 제7권1호
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• pp.14-18
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• 2004

High levels of ambient noise and safety factors often limit the use of 'active-source' seismic methods for geotechnical investigations in urban environments. As an alternative, shear-wave velocity-depth profiles can be obtained by treating the background microtremor wave field as a stochastic process, rather than adopting the traditional approach of calculating velocity based on ray path geometry from a known source. A recent field test in Melbourne demonstrates the ability of the microtremor method, using only Rayleigh waves, to resolve a velocity inversion resulting from the presence of a hard, 12 m thick basalt flow overlying 25 m of softer alluvial sediments and weathered mudstone. Normally the presence of the weaker underlying sediments would lead to an ambiguous or incorrect interpretation with conventional seismic refraction methods. However, this layer of sediments is resolved by the microtremor method, and its inclusion is required in one-dimensional layered-earth modelling in order to reproduce the Rayleigh-wave coherency spectra computed from observed seismic noise records. Nearby borehole data provided both a guide for interpretation and a confirmation of the usefulness of the passive Rayleigh-wave microtremor method. Sensitivity analyses of resolvable modelling parameters demonstrate that estimates of shear velocities and layer thicknesses are accurate to within approximately $10\%\;to\;20\%$ using the spatial autocorrelation (SPAC) technique. Improved accuracy can be obtained by constraining shear velocities and/or layer thicknesses using independent site knowledge. Although there exists potential for ambiguity due to velocity-thickness equivalence, the microtremor method has significant potential as a site investigation tool in situations where the use of traditional seismic methods is limited.