• Yonsei Medical Journal
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• v.59 no.9
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• pp.1096-1106
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• 2018

Purpose: Alzheimer's disease (AD) is the sixth most common cause of death in the United States. MicroRNAs have been identified as vital players in neurodegenerative diseases, including AD. microRNA-128 (miR-128) has been shown to be dysregulated in AD. This study aimed to explore the roles and molecular mechanisms of miR-128 in AD progression. Materials and Methods: Expression patterns of miR-128 and peroxisome proliferator-activated receptor gamma ($PPAR-{\gamma}$) messenger RNA in clinical samples and cells were measured using RT-qPCR assay. $PPAR-{\gamma}$ protein levels were determined by Western blot assay. Cell viability was determined by MTT assay. Cell apoptotic rate was detected by flow cytometry via double-staining of Annexin V-FITC/PI. Caspase 3 and $NF-{\kappa}B$ activity was determined by a Caspase 3 Activity Assay Kit or $NF-{\kappa}B$ p65 Transcription Factor Assay Kit, respectively. Bioinformatics prediction and luciferase reporter assay were used to investigate interactions between miR-128 and $PPAR-{\gamma}$ 3'UTR. Results: MiR-128 expression was upregulated and $PPAR-{\gamma}$ expression was downregulated in plasma from AD patients and $amyloid-{\beta}$ $(A{\beta})-treated$ primary mouse cortical neurons (MCN) and Neuro2a (N2a) cells. Inhibition of miR-128 decreased $A{\beta}-mediated$ cytotoxicity through inactivation of $NF-{\kappa}B$ in MCN and N2a cells. Moreover, $PPAR-{\gamma}$ was a target of miR-128. $PPAR-{\gamma}$ upregulation attenuated $A{\beta}-mediated$ cytotoxicity by inactivating $NF-{\kappa}B$ in MCN and N2a cells. Furthermore, $PPAR-{\gamma}$ downregulation was able to abolish the effect of anti-miR-128 on cytotoxicity and $NF-{\kappa}B$ activity in MCN and N2a cells. Conclusion: MiR-128 inhibitor decreased $A{\beta}-mediated$ cytotoxicity by upregulating $PPAR-{\gamma}$ via inactivation of $NF-{\kappa}B$ in MCN and N2a cells, providing a new potential target in AD treatment.

• (The)Study of the Eastern Classic
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• no.67
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• pp.69-104
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• 2017

This paper examines the aspect of the novel which appeared in the union of the male and female relationship of "OkSuki", one of the novels of the 19th century. "Oksuki" is a work focusing on the relationship between men and women. It takes a narrative structure based on the relationship. It shows various aspects of the relationship through the structure in which the pluralities of plural persons are repeated. Other events and illustrations, except for the talk, are both an occasion of the alliance and an auxiliary role. At the beginning of the work, the main character's parents are described in detail.By arranging the prophecies related to the relationship between the protagonist and the brothers, it suggests that subsequent narratives will flow into the center of the relationship. The male characters that make up the alliance are characteristically trained and have a good taste, and the Caines are colorfully colored. It is believed that the marriage pattern faithfully follows the medieval status order. The reason why the figure of the person who becomes his wife and the person of the concubine are set differently is because the image of the wife and the concubine are different from each other ideally. The characters who are going to be hungry are emphasized on the clause, efficacy, knowledge, and inner peace, and are actively involved in. On the other hand, conciliatory characters emphasize talent and craftsmanship, and their role is reduced after marriage. The wife is a person who has both Confucian culture and knowledge and is able to care for her husband and family well. Concultation is shaped as a person who can enjoy joyful life and emphasize more affection in relation with his wife.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.33-39
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• 2021

As the interest and demand in the recycled yarn field has increased rapidly worldwide, domestic companies are also promoting research and development and business on recycled yarn. The chemical and thermal properties of four types of virgin and recycled PET samples from A and B company, which are the leading domestic companies in the recycled polyester yarn business, were confirmed through infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC). Virgin and recycled PET from two companies were compared. FT-IR spectroscopy revealed the typical spectra of PET for both companies and a different peak at 872 cm-1. DSC confirmed that the melting point and crystallization temperature of recycled PET were lower than those of virgin PET. These results indicate that small amounts of contaminants are an important parameter affecting the thermal properties of recycled PET. In the DSC results after seven repeats of the heating and cooling processes, all four samples showed that a lower melting point, crystallization temperature, and low heat flow intensity increased with increasing number of cycles. The results of melting and crystallization enthalpy also showed similar patterns.

• Journal of Korea Entertainment Industry Association
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• v.15 no.2
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• pp.159-167
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• 2021

The main purpose of this study is to closely investigate the constructive relationship between leisure satisfaction, leisure ability, exercise satisfaction, and consistent motor behavior patterns of the elderly's participation in leisure life sports. In order to achieve this, we surveyed and utilized the sampling of conveniences that selected Yongin and Seongnam city in Gyeonggi-do sports clubs, and accumulated samples of the elderly in living sports. The sample size was 239 elderly people. Based on this, according to the purpose of the study, statistical techniques, spss 23.0, and amos programs were used for analysis. The satisfaction analysis used in the research for a data analysis includes frequency analysis, exploatory factor analysis, confirmatory facor analysis, reliability analysis, correnlation analysis and structure equation model analysis. The research has drawn the following conclusions, based on the above mentioned research method and its procedures: First, it affects the satisfaction of the leisure satisfaction movement. Second, leisure ability affects exercise satisfaction. Third, exercise satisfaction affects the consistent exercise persistence and immersion satisfaction of exercise. As a result, it can be seen that the leisure immersion according to the experience of leisure competence has an effect on the satisfaction of the exercise. As a result, and the continuation of the exercise.

• Journal of Convergence for Information Technology
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• v.11 no.5
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• pp.30-37
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• 2021

Various devices are connected to the Internet, and attacks using the Internet are occurring. Among such attacks, there are attacks that use malicious URLs to make users access to wrong phishing sites or distribute malicious viruses. Therefore, how to detect such malicious URL attacks is one of the important security issues. Among recent deep learning technologies, neural networks are showing good performance in image recognition, speech recognition, and pattern recognition. This neural network can be applied to research that analyzes and detects patterns of malicious URL characteristics. In this paper, performance analysis according to various parameters was performed on a method of detecting malicious URLs using neural networks. In this paper, malicious URL detection performance was analyzed while changing the activation function, learning rate, and neural network structure. The experimental data was crawled by Alexa top 1 million and Whois to build the data, and the machine learning library used TensorFlow. As a result of the experiment, when the number of layers is 4, the learning rate is 0.005, and the number of nodes in each layer is 100, the accuracy of 97.8% and the f1 score of 92.94% are obtained.

• Journal of Korean Society of Disaster and Security
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• v.14 no.4
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• pp.17-27
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• 2021

Streamflow prediction is a very vital disaster mitigation approach for effective flood management and water resources planning. Lately, torrential rainfall caused by climate change has been reported to have increased globally, thereby causing enormous infrastructural loss, properties and lives. This study evaluates the contribution of rainfall to streamflow prediction in normal and peak rainfall scenarios, typical of the recent flood at Piney Resort in Vernon, Hickman County, Tennessee, United States. Daily streamflow, water level, and rainfall data for 20 years (2000-2019) from two USGS gage stations (03602500 upstream and 03599500 downstream) of the Piney River watershed were obtained, preprocesssed and fitted with Long short term memory (LSTM) model. Tensorflow and Keras machine learning frameworks were used with Python to predict streamflow values with a sequence size of 14 days, to determine whether the model could have predicted the flooding event in August 21, 2021. Model skill analysis showed that LSTM model with full data (water level, streamflow and rainfall) performed better than the Naive Model except some rainfall models, indicating that only rainfall is insufficient for streamflow prediction. The final LSTM model recorded optimal NSE and RMSE values of 0.68 and 13.84 m³/s and predicted peak flow with the lowest prediction error of 11.6%, indicating that the final model could have predicted the flood on August 24, 2021 given a peak rainfall scenario. Adequate knowledge of rainfall patterns will guide hydrologists and disaster prevention managers in designing efficient early warning systems and policies aimed at mitigating flood risks.

• Ocean and Polar Research
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• v.44 no.4
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• pp.269-285
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• 2022

The interaction between ocean and ice shelf is a critical physical process in relation to water mass transformations and ice shelf melting/freezing at the ocean-ice interface. However, it remains challenging to thoroughly understand the process due to a lack of observational data with respect to ice shelf cavities. This is the first study to simulate the variability and circulation of water mass both overlying the continental shelf and underneath an ice shelf and an ice tongue in the Terra Nova Bay (TNB), East Antarctica. To explore the properties of water mass and circulation patterns in the TNB and the corresponding effects on sub ice shelf basal melting, we explicitly incorporate the dynamic-thermodynamic processes acting on the ice shelf in the Regional Ocean Modeling System. The simulated water mass formation and circulation in the TNB region agree well with previous studies. The model results show that the TNB circulation is dominated by the geostrophic currents driven by lateral density gradients induced by the releasing of brine or freshwater at the polynya of the TNB. Meanwhile, the circulation dynamics in the cavity under the Nansen Ice shelf (NIS) are different from those in the TNB. The gravity-driven bottom current induced by High Salinity Shelf Water (HSSW) formed at the TNB polynya flows towards the grounding line, and the buoyance-driven flow associated with glacial meltwater generated by the HSSW emerges from the cavity along the ice base. Both current systems compose the thermohaline overturning circulation in the NIS cavity. This study estimates the NIS basal melting rate to be 0.98 m/a, which is comparable to the previously observed melt rate. However, the melting rate shows a significant variation in space and time.

• Journal of Software Assessment and Valuation
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• v.16 no.1
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• pp.65-79
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• 2020

As Programmable Logic Controllers (PLCs), popular components in industrial control systems (ICS), are incorporated with the technologies such as micro-controllers, real-time operating systems, and communication capabilities. As the latest PLCs have been connected to the Internet, they are becoming a main target of cyber threats. This paper proposes two sanitizers that improve the security of uC/OS-II based firmware for a PLC. That is, we devise BU sanitizer for detecting out-of-bounds accesses to buffers and UaF sanitizer for fixing use-after-free bugs in the firmware. They can sanitize the binary firmware image generated in a desktop PC before downloading it to the PLC. The BU sanitizer can also detect the violation of control flow integrity using both call graph and symbols of functions in the firmware image. We have implemented the proposed two sanitizers as a prototype system on a PLC running uC/OS-II and demonstrated the effectiveness of them by performing experiments as well as comparing them with the existing sanitizers. These findings can be used to detect and mitigate unintended vulnerabilities during the firmware development phase.

• Korean Journal of Ecology and Environment
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• v.55 no.4
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• pp.294-304
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• 2022

This study carried out from March 2021 to October 2021 in the upper part (St. 1) and middle part (St. 2) section of Yongsu stream, a branch of the Geum river, using PIT telemetry to understand the movement patterns and habitat characteristics of Odontobutis interrupta, a Korean endemic species. O. interrupta collection was used kick net (5×5 mm) and fish trap (5×5 mm). After collecting fish, PIT tag insertion was performed immediately in the site. Reader (HPR Plus Reader, biomark, USA) and portable Antenna (BP Plus Portable Antenna, biomark, USA) were used for detection of fish to monitoring the tagged O. interrupta. As a result of PIT telemetry applied to 70 individuals, mean movement distance was 36.5 (SE, ±6.6) m. There was a significant difference between total length and movement distance (P≤0.05). O. interrupta was mainly identified in average water depth, 36.2±1.9 cm, average water velocity, 0.03±0.07 m s^-1 and average distance from watershed, 4.4±0.3 m. Extent of rock used for habitat was varied from 32 to 4,000 cm². There was no statistical difference between the area of the first selected rock and the area of the after selected rock (P>0.05). but there was significant difference between total length and the area of the rock except for detection before 24 hours (P<0.01). Therefore, to restore the habitat, it is considered necessary to create various substrate structures by providing various habitat environments (water depth, flow rate, stone, etc.) for each individual size.

• Land and Housing Review
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• v.14 no.3
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• pp.93-106
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• 2023

This study attempted to simulate changes in the thermal environment according to the type of apartment complex in Korea using CFD techniques and evaluate the thermal environment by type of apartment. First, apartment complex types in the 2000s and 2010s were referred from previous studies and four types of apartment complex were extracted from. Second, the layout of the apartment complex and temperature changes were analyzed by the direction of wind inflow. Third, a standardized model was created from each type using tower type, plate type, and mixed driving. Last, CFD simulations were performed by setting up the inflow of wind from a total of eight directions. The temperature was relatively low in the type consisting of only the tower type and the type of placing the tower type in the center of the complex, regardless of the direction of the wind. It was due to the good inflow of wind from these types to the inside of the complex. It can be interpreted because wind flows easily into the complex in these types. The findings showed that wind flow and resulting temperature distribution patterns differed depending on the building type and complex layout type, confirming the need for careful consideration of the complex layout in the early design stage. The results are expected to be used as basic data for creating a sustainable residential environment in the early design stage of apartment complexes in the future.