• IMMUNE NETWORK
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• v.21 no.5
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• pp.34.1-34.16
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• 2021

Sjögren's syndrome (SS) is an autoimmune disease characterized by dryness of the mouth and eyes. The glandular dysfunction in SS involves not only T cell-mediated destruction of the glands but also autoantibodies against the type 3 muscarinic acetylcholine receptor or aquaporin 5 (AQP5) that interfere with the secretion process. Studies on the breakage of tolerance and induction of autoantibodies to these autoantigens could benefit SS patients. To break tolerance, we utilized a PmE-L peptide derived from the AQP5-homologous aquaporin of Prevotella melaninogenica (PmAqp) that contained both a B cell "E" epitope and a T cell epitope. Repeated subcutaneous immunization of C57BL/6 mice with the PmE-L peptide efficiently induced the production of Abs against the "E" epitope of mouse/human AQP5 (AQP5E), and we aimed to characterize the antigen specificity, the sequences of AQP5E-specific B cell receptors, and salivary gland phenotypes of these mice. Sera containing anti-AQP5E IgG not only stained mouse Aqp5 expressed in the submandibular glands but also detected PmApq and PmE-L by immunoblotting, suggesting molecular mimicry. Characterization of the AQP5E-specific autoantibodies selected from the screening of phage display Ab libraries and mapping of the B cell receptor repertoires revealed that the AQP5E-specific B cells acquired the ability to bind to the Ag through cumulative somatic hypermutation. Importantly, animals with anti-AQP5E Abs had decreased salivary flow rates without immune cell infiltration into the salivary glands. This model will be useful for investigating the role of anti-AQP5 autoantibodies in glandular dysfunction in SS and testing new therapeutics targeting autoantibody production.

• Economic and Environmental Geology
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• v.45 no.1
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• pp.31-40
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• 2012

This paper examined the characteristics of ductile and brittle structural elements with detailed mapping by lithofacies classification to clarify the relationship between the geological structure and the geochemical high-grade uranium anormal zone and to provide the basic information on the flow of groundwater in the eastern area of Shinbo mine, Jinan-gun, Jeollabuk-do, Korea. It indicates that this area is mainly composed of Precambrian quartzite, metapelite, metapsammite, which show a zonal distribution of mainly ENE-WSW trend, and age unknown pegmatite and Cretaceous porphyry which intrude them. But the Cretaceous Jinan Group which unconformably covers them, contrary to assumption, could not be observed. The main ductile deformation structures of Precambrian metasedimentary rocks were formed at least through three phases of deformation [ENE striking regional foliation (D1) -> ENE or EW striking crenulation foliation (D2) -> WNW or EW trending open, tight, kink folds (D3)]. The predominant orientation of S1 regional foliation strikes ENE and dips south, being similar to the zonal distribution of Precambrian metasedimentary rocks. Most predominant orientation of high-angled brittle fracture (dip angle ${\geq}45^{\circ}$) [ENE (frequency: 24.3%) > NS (23.9%) > (N)NW (18.8%) > WNW (16.9%) > NE (16.1%) fracture sets in descending frequency order], which is closely related to the flow of groundwater, strikes ENE and dips south. It also agrees with the zonal distribution of metasedimentary rocks and the predominant orientation of S1 regional foliation. The next one strikes NS and dips east or west. Considering the controlling factor of the geochemical uranium anormal zone in the Shinbo mine and its eastern areas from the above structural data. the uranium source rock in these areas might be pegmatite and the geochemical uranium anormal zone in the Sinbo mine area could be formed by an secondary enrichment through the flow of pegmatite aquifer's groundwater into the Sinbo mine area like the previous research's result.

• The Korean Journal of Nuclear Medicine
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• v.36 no.2
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• pp.91-101
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• 2002

Purpose : The aim of this study was to identify the brain areas in which reductions of regional cerebral blood flow (rCBF) were correlated with decline of general mental function, measured by Mini-Mental State Examination (MMSE). Materials and Methods : Tc-99m HMPAO brain SPECT was peformed in 9 probable AD patients at the initial and follow-up periods of 1.8 years (average) after the first study. MMSE scores were also measured in both occasions. The mean MMSE score of the initial study 16.4 (range: 5 - 24) and the mean MMSE score of the follow-up was 8.1 (range: 0 - 17). Each SPECT image was normalized to the cerebellar activity and a correlation analysis was peformed between the level of rCBF in AD patients and the MMSE scores by voxel-based analysis using SPM99 software. Results : Significant correlation was found between the blood-flow decrease in left inferior prefrontal region (BA 47) and left middle temporal legion (BA 21) and the MMSE score changes. Additional areas such as anterior and posterior cingulate cortices, precuneus, and bilateral superior and middle prefrontal regions showed the similar trends. Conclusions : A relationship was found between reduction of regional cerebral blood flow in left prefrontal and temporal areas and decline of cognitive function in Alzheimer's disease(AD) patients. This voxel-based analysis is useful in evaluating the progress of cognitive function in Alzheimer's disease.

• The Korean Journal of Nuclear Medicine
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• v.34 no.6
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• pp.456-464
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• 2000

Purpose: To evaluate the effect of acupuncture on regional cerebral blood flow (rCBF) at acupoints suggested by oriental medicine to be related to the treatment of cerebrovascular diseases. Materials and Methods: Rest/acupuncture-stimulation Tc-99m ECD brain SPECT using a same-dose subtraction method was performed on 54 normal volunteers (34 males, 20 females, age range from 18 to 62 years) using six paradigms: acupuncture at acupoints GV. 20, GV. 26, LI. 4, ST. 36 and SP. 6. In the control study, needle location was chosen on a non-meridian focus 1 cm posterior to the right fibular head. All images were spatially normalized, and the differences between rest and acupuncture stimulation were statistically analyzed using SPM$^{(R)}$ for Windows$^{(R)}$. Results: Acupuncture applied at acupoint GV. 20 increased rCBF in both the anterior frontal lobes, the right frontotemporal lobes, and the left anterior temporal lobe and the left cerebellar hemisphere. Acupuncture at GV 26 increased rCBF in the left prefrontal cortex. Acupuncture at LI. 4 increased rCBF in the left prefrontal and both the inferior frontal lobes, and the left anterior temporal lobe and the left cerebellar hemisphere. Acupuncture at ST. 36 increased rCBF in the left anterior temporal lobe, the right inferior frontal lobes, and the left cerebellum. Acupuncture at SP. 6 increased rCBF in the left inferior frontal and anterior temporal lobes. In the control stimulation, no significant rCBF increase was observed. Conclusion: The results demonstrated a correlation between stimulation at each acupoint with increase in rCBF to the corresponding brain areas.

• Nuclear Medicine and Molecular Imaging
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• v.41 no.6
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• pp.530-537
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• 2007

Purpose: The aim of this study is to assess the specific patterns of regional cerebral blood flow (rCBF) in patients with the early stage of subcortical vascular dementia (SVaD) and Alzheimer's disease (AD) using Tc-99m HMPAO SPECT, and to compare the differences between the two conditions. Materials and Methods: Sixteen SVaD, 46 AD and 12 control subjects participated in this study. We included the patients with SVaD and AD according to NINCDS-ADRDA and NINDS-AIREN criteria. They were all matched for age, education and clinical dementia rating scores. Three groups were evaluated by Tc-99m HMPAO SPECT using statistical parametric mapping (SPM) for measuring rCBF. The SPECT data of patients with SVaD and AD were compared with those of normal control subjects and then compared with each other. Results: SPM analysis of the SPECT image showed significant perfusion deficits on the right temporal region and thalamus, left insula and superior temporal gyrus, both cingulate gyri and frontal subgyri in patients with SVaD and on the left supramarginal gyrus, superior temporal gyrus, postcentral gyrus and inferior parietal lobule, right fugiform gyrus and both cingulate gyri in AD compared with control subjects (uncorrected p<0.01). SVaD patients revealed significant hypoperfusion in the right parahippocampal gyrus with cingulated gyrus, left insula and both frontal subgyral regions compared with AD (uncorrected p<0.01). Conclusion: Our study shows characteristic and different pattern of perfusion deficits in patients with SVaD and AD, and these results may be helpful to discriminate the two conditions in the early stage of illness.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.8
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• pp.39-48
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• 2016

In this paper, we propose thermal resistance compact model of FinFET structure that has hexagon shaped source/drain. The heating effect and thermal properties were increased by reduced size of the device, and thermal resistance is an important factor to analyze the effect and the properties. The heat source and each contact that is moved heat out were set up in transistor, and domain is divided by the heat source and the four parts of contacts : source, drain, gate, substrate. Each contact thermal resistance model is subdivided as a easily interpretable structure by analyzing the temperature and heat flow of the TCAD simulation results. The domains are modeled based on an integration or conformal mapping method through the structure parameters according to its structure. First modeled by analyzing the thermal resistance to a single fin, and applying the change in the parameter of the channel increases to improve the accuracy of the thermal resistance model of the multi-fin/ finger. The proposed thermal resistance model was compared to the thermal resistance by analyzing results of the 3D Technology CAD simulations, and the proposed total thermal resistance model has an error of 3 % less in single and multi-finl. The proposed thermal resistance model can predict the thermal resistance due to the increase of the fin / finger, and the circuit characteristics can be improved by calculating the self-heating effect and thermal characterization.

• Economic and Environmental Geology
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• v.39 no.3 s.178
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• pp.301-328
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• 2006

The geology of the Tumbang Mirih area in the Middle Kalimantan, Indonesia comprises Permian to Carboniferous Pinoh Metamorphic Rocks and Cretaceous Sepauk Plutonics of the Sunda Shield, late Eocene Tanjung Formation, Oligocene Malasan Volcanics, Oligocene to early Miocene Sintang Intrusives and Quaternary alluvium. Results of geochemical exploration and geological mapping exposed obviously that large amounts of gold-bearing quartz veins were found in the whole Tumbang Mirih areas. In many places, gold grains were megascopically detectable from panning products of stream sediments and conglomerate as Quaternary sediments. Even though no remnants of quartz veins are revealed in the most of survey area except Taran region, association of fold grains with layers of quartz pebbles and clays which correspond to the horizon of unconformity or previous river bottom indicates that the gold grains were separated from quartz veins. Along rivers often pebbles and clay layers just over or 10 to 20cm above the current waterlevel are recognized. The occurrence of gold in the conglomeratic layer was frequently confirmed during geochemical exploration. Since the conglomeratic layer was old stream sediments of Quaternary, it can be assumed that deposition of golds was controlled by shape of river floor, speed and shape of river flow, and distance from the source rock. Taran area and northern Takaoi area based on the all data are recommended as the promising areas.

• The Korean Journal of Nuclear Medicine
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• v.35 no.3
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• pp.142-151
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• 2001

Purpose: This study was performed to search the relatively specific brain regions related to the semantic processing of Korean and English words on the one hand and the regions common to both on the other. Materials and Methods: Regional cerebral blood flow associated with different semantic tasks was examined using $[^{15}O]H_2O$ positron omission tomography in 13 healthy volunteers. The tasks consisted of semantic tasks for Korean words, semantic tasks for English words and control tasks using simple pictures. The regions specific and common to each language were identified by the relevant subtraction analysis using statistical parametric mapping. Results: Common to the semantic processing of both words, the activation site was observed in the fusiform gyrus, particularly the left side. In addition, activation of the left inferior temporal gyrus was found only in the semantic processing of English words. The regions specific to Korean words were observed in multiple areas, including the right primary auditory cortex; whereas the regions specific to English words were limited to the right posterior visual area. Conclusion: Internal phonological process is engaged in performing the visual semantic task for Korean words of the high proficiency, whereas visual scanning plays an important role in performing the task for English words of the low proficiency.

• Journal of the Korean association of regional geographers
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• v.17 no.1
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• pp.40-57
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• 2011

A feng-shui map is a kind of map that features such propitious positions as fortune-bringing spots or ideal grave sites. The map is a representation of the most ideal natural terrains in terms of feng-shui perspectives. This study did research on two feng-shui maps registered on some genealogical tables in order to see how the map was drawn up. In addition, the detailed characteristics of landform expressions like the frame of the map, viewpoints, center-oriented mapping, water flow, mountain theories were delved into. The results of the research are as follows: the feng-shui maps for this research used the techniques of double scale and aerial view, described terrains with grave sites in their centers, and enlarged important terrains compared with surroundings for exaggeration purposes. In addition, other vital landforms not observed from grave sites were depicted with viewpoints moved and were represented in fine details. The part of mountain theories had the following points as their main subject matter: geographical locations, overall orientations of mountain ranges, topographical traits, grave seat directions and surrounding terrains.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.33 no.5
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• pp.335-342
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• 2015

In this study, data linking module called GeoSWMM was developed using a typical secondary flooding model SWMM in order to improve the accuracy of the input data of SWMM and to map hourly inundation estimation areas that were not represented in the conventional inundation map. GeoSWMM is a data linking module of GIS and SWMM, which can generate a SWMM project file directly from sewer network GIS data. Utilizing the GeoSWMM the project file of SWMM model was constructed in the study area, Seocho 2-dong, Seoul. The actual flooding has occurred September 21, 2010 and the actual rainfall data were used for flood simulation. As a result, the outflow started from 2 PM due to the lack of water flow capacity of the sewage system. Based on the results, hourly inundation estimation maps were produced and compared with flood train map in 2010. The comparison showed about 66% matching in the overlap of inundation areas. By utilizing GeoSWMM that was developed in this study, it is easy to build the sewer network data for SWMM. In addition, the creation of hourly inundation estimation map using SWMM will be much help to flood disaster prevention plan.