• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.11
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• pp.5284-5291
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• 2012

This research is to develop the Web-Based Ventilator Management Education Program that reflects the needs of nursing site nursing which is intended to help nursing duties. ISD model-building process has been developed for the analysis, design, development, operation, and evaluation of methods. The education program was developed from April to July 2011, and SPSS 18.0 was used for data analysis. The analysis stage, document review and requirement analysis, content analysis, learner analysis, technology and environment analysis have been executed. Through the processes, higher education requirements for the practical ventilator, a large number of subjects under the age of 30, and the career of less than 3 years of ICU were searched. At the design stage, the education content that was presented by the content expert group was executed in information design, mutual interaction design, synchronization design through discussion with program experts. At the development stage, author made the story flow and gathered data and integrated it through the review of related document and data. At the operation and evaluation stage, author executed the developed program and revised and supplemented it on the basis of the evaluation results through the experts and subjects evaluation. The Web-Based Ventilator Management Education Program could contribute to the improvement of nursing because the program has been developed to reflect the diverse needs of nursing practice in the process of building program.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.473-477
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• 2012

Introduction: The esophagus squamous cell carcinoma (ESCC) is one of the most deadly malignances, and a current challenge is the development of effective therapeutic agents. Our present work addressed the effect of HIF-$1{\alpha}$ siRNA alone or in combination with cisplatin on the growth of ESCC in nude mice. Materials and Methods: Xenografts were established by inoculating ESCC TE-1 cells in nude mice, and transplanted tumors were treated with HIF-$1{\alpha}$ siRNA, cisplatin alone or together. Growth was assessed by measuring tumor volume. HIF-$1{\alpha}$ mRNA and protein expression were detected using RT-PCR and immunohistochemistry, respectively. Apoptosis of ESCC TE-1 cells was analyzed by flow cytometry. Results: In our nude mice model, HIF-$1{\alpha}$ siRNA effectively inhibited the growth of transplanted ESCC, downregulating HIF-$1{\alpha}$ mRNA and protein expression, and inducing ESCC TE-1 cell apoptosis. Notably when combinated with cisplatin, HIF-$1{\alpha}$ siRNA showed synergistic interaction in suppressing tumor growth. Furthermore, the proportion of apoptotic cells in HIF-$1{\alpha}$ siRNA plus cisplatin group was significantly higher than that in cisplatin or HIF-$1{\alpha}$ siRNA-treated groups (P<0.05). Conclusions: Down-regulated HIF-$1{\alpha}$ expression induced by siRNA could effectively suppress the growth of transplanted ESCC $in$ $vivo$. HIF-$1{\alpha}$ siRNA could enhance the cytotoxicity of cisplatin, which suggests that a combination of these two agents may have potential for therapy of advanced ESCC.

• Journal of the Korean Geotechnical Society
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• v.31 no.1
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• pp.5-14
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• 2015

Seabed may undergo large excess pore water pressure in the case of long duration of high wave loading. This excess pore water pressure may reduce effective stress and, consequently, the seabed may liquefy. Thus, it is necessary to develop a numerical technique which can precisely evaluate the dynamic response of seabed due to wave action. In this study, a new numerical technique named mixed model (2D NIT & FLIP models) was proposed. The dynamic wave pressure and water flow velocity acting on the boundary between seabed and the wave field was estimated using 2D-NIT model. This result was used as input data in FLIP program for investigation of dynamic response of seabed. To secure the reliability of the mixed model, the numerical analysis results of the mixed model were compared with Yamamoto's solution and Chang's experiment results. The comparison results indicated that there were some differences between them, but the general trend of the effective stress increment and the excess pore water pressure along the depth of seabed was similar to each other. Thus, this study clearly supports the plausibility of the numerical analysis of the mixed model.

• Journal of the Korean Society for Marine Environment & Energy
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• v.20 no.1
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• pp.37-44
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• 2017

Complexity of multiphase flows due to existence of more than two interface including free-surface in one system, cannot be simulated easily. Since more than two fluids affect to flows and disturb interface, non-linearities such as instabilities can be appeared. Among several instabilities on multiphase flows, one of representative is Rayleigh-taylor instability. In order to examine in importance of density disparity, several cases with numerous Atwood number are set. Moreover, investigation of influence on initial disturbance were also considered. Moving particle simulation (MPS) method, which was employed in this paper, was not widely used for multiphase problem. In this study, by adding new particle interaction models such as self-buoyance correction, surface tension, and boundary condition at interface models, MPS were developed having more strength of physics and robust. By applying newly developed multiphase MPS, considered cases are performed and compared each other. Additionally, though existence of disagreement of magnitude of rising velocity between theoretical values from linear potential theory and that of numerical simulation, agreement of tendency can be proved of similarity of result. the discordance of magnitude can be explained due to non-linear effects on numerical simulation which was not considered in theoretical result.

• Economic and Environmental Geology
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• v.46 no.3
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• pp.267-278
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• 2013

The East African Rift System(EARS) is known to be hosted epithermal Au-Ag deposits, and the best-known example is Main Ethiopian Rift Valley(MER) related to Quaternary bimodal volcanism. Large horst-graben system during rifting provides open space for emplacement of bimodal magmas and flow channel of geothermal fluids. In recent, large hydrothermally altered zones(Shala, Langano, and Allalobeda) and hot spring related to deeply circulating geothermal water have been increasing their importance due to new discoveries in MER and Danakil depression. The hot springs in Shala and Allalobeda occur as boiling pool and geyser on the surface, whereas some areas didn't observe them due to decreasing ground water table. The host rocks are altered to quartz, kaolinite, illite, smectite, and chlorite due to interaction with rising geothermal water. The hot springs in MER are neutral to slightly alkaline pH(7.88~8.83) and mostly classified into $HCO_3{^-}$ type geothermal water. They are strongly depleted in Au, and Ag, but show a higher Se concentration of up to 26.7 ppm. In contrast, siliceous altered rocks around hot springs are strongly enriched in Pb(up to 33 ppm, Shala), Zn(up to 313 ppm, Shala), Cu(up to 53.1 ppm, Demaegona), and Mn(up to 0.18 wt%t, Shala). In conclusion, anomalous Se in hot spring water, Pb, Zn, Cu, and Mn in siliceous altered rocks, and new discoveries in MER have been increasing potential for epithermal gold mineralization.

• Journal of Distribution Research
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• v.10 no.1
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• pp.33-57
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• 2005

After 1990's, many multi-level marketing companies lave been introduced in Korea. These MLM companies operate their stores as same way as general retailing stores. The major characteristics of these MLM companys' store is that their main customers are distributors who sell the purchased merchandise to another customers. Many studies about merchandise display in general retailing stores were reported. But, there was less research about merchandise display in these special type stores such as MLM companys' stores. This paper investigates the effects of merchandise display on distributor's merchandise selection in channel flow of multi-level marketing company. For this purpose, we formulated four hypotheses about display variance in quantity, height, location, and related merchandise to analyze the effect of merchandise display methods in MLM companys' stores. The experiment had been proceeded in three stores in a MLM company for 6 weeks and the sales data were collected by POS. The methods to analyze the data were used ANOVA and T-test. Findings of this study are as follows; First, there was no effect to store sale by the interaction effect between merchandise display method and scale of store. Second, scale of store affected considerably the volume of sales of each store according to main effect analysis. Third, display variance in quantity, height, and location did not affect store sale. In the related merchandise display, however, sale in all store was increased. Fourth, in additional analysis considering merchandise display only, display variance in both height and location affected their sale in large scale store. Based on the above results, we may predict merchandise display can affect sale in MLM companys' store as well as general retailing stores. Therefore if MLM company has large scale store, it should consider merchandise display methods in its stores.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.9
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• pp.597-604
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• 2016

A parallel algorithm of bi-conjugate gradient method was developed based on CUDA for parallel computation of the incompressible Navier-Stokes equations. The governing equations were discretized using splitting P2P1 finite element method. Asymmetric stenotic flow problem was solved to validate the proposed algorithm, and then the parallel performance of the GPU was examined by measuring the elapsed times. Further, the GPU performance for sparse matrix-vector multiplication was also investigated with a matrix of fluid-structure interaction problem. A kernel was generated to simultaneously compute the inner product of each row of sparse matrix and a vector. In addition, the kernel was optimized to improve the performance by using both parallel reduction and memory coalescing. In the kernel construction, the effect of warp on the parallel performance of the present CUDA was also examined. The present GPU computation was more than 7 times faster than the single CPU by double precision.

• Korean Journal of Animal Reproduction
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• v.18 no.2
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• pp.141-150
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• 1994

Morphological features of the interaction between the hatching blastocyst and implantation in pig were studied by electron microscopy. The observations extended from late blastocyst stage to the completion of trophoblastic erosion of the epithelium and early decidual transformation of the epithelium and early decidual transformation of the stromal cells. Between day 7 and 17 of pregnancy, blastocysts from 0.3 to 12 mm in diameter were flushed from the uterine horns of Dutch Landrace pigs. On the 7th of development in the pig blastocyst, the blastocyst shedded of the zona pellucida established the tips of microvilli and with bleb-like cytoplasmic protrusions of the epithelial cells. From day 11 on in pig embryo, the bilayered trophoblast undergoes a dramatic phase of elongation so that the initially spherical expanded blastocyst becomes tubular. In pig, close apposition to the uterine wall beg-ins at about 12 $^1$/$_2$ days and then attachment occurred during the afternoon of the 16th or 18th day post coitum. At this stage, embryonic loss compared with corpus luteum number is up to 40% of ovulated oocytes. Therefore, the implantation failture of these embryos may be mainly caused by morphological abnormality and failture of zona shedding.

• Journal of Energy Engineering
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• v.20 no.3
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• pp.242-251
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• 2011

The effects of top and bottom lids on the natural convection heat transfer phenomena inside vertical cylinders were investigated experimentally for $Ra_{Lw}$ from $9.26{\times}10^9$ to $7.74{\times}10^{12}$. Using the concept of analogy between heat and mass transfer, a cupric acid-copper sulfate electroplating system was employed as mass transfer experiments replacing heat transfer experiments. The natural convection heat transfer of both-open cylinders in laminar and turbulent flows was in good agreement with the existing heat transfer correlations developed for vertical plates. The effects of top and bottom lids on the heat transfer rates were very similar to the studies of Krysa et al. and Sedahmed et al. and Chung et al. With the copper lids, the bottom-closed cavity showed the highest heat transfer rates and then followed both-closed, top-closed, both-open ones in both laminar and turbulent flows. However with the acryl lids, the similar trends were observed except that the heat transfer rates for both-open were higher than top-closed one. The use of the copper lids increased the heat transfer rates compared to the acryl lids due to the hydrodynamic interaction of the flows developed for the different heated faces. This study extended the ranges of flow conditions of the existing literatures and proposed the empirical correlations.

• Journal of Astronomy and Space Sciences
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• v.28 no.3
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• pp.163-172
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• 2011

An intensive analysis of 185 timings of WZ Cep, including our new three timings, was made to understand the dynamical picture of this active W UMa-type binary. It was found that the orbital period of the system has complexly varied in two cyclical components superposed on a secularly downward parabola over about 80y. The downward parabola, corresponding to a secular period decrease of $-9.{^d}97{\times}10^{-8}y^{-1}$, is most probably produced by the action of both angular momentum loss (AML) due to magnetic braking and mass-transfer from the massive primary component to the secondary. The period decrease rate of $-6.^{d}72{\times}10^{-8}y^{-1}$ due to AML contributes about 67% to the observed period decrease. The mass flow of about $5.16{\times}10^{-8}M_{\odot}y^{-1}$ from the primary to the secondary results the remaining 33% period decrease. Two cyclical components have an $11.^{y}8$ period with amplitude of $0.^{d}0054$ and a $41.^{y}3$ period with amplitude of $0.^{d}0178$. It is very interesting that there seems to be exactly in a commensurable 7:2 relation between their mean motions. As the possible causes, two rival interpretations (i.e., light-time effects (LTE) by additional bodies and the Applegate model) were considered. In the LTE interpretation, the minimum masses of $0.30M_{\odot}$ for the shorter period and $0.49M_{\odot}$ for the longer one were calculated. Their contributions to the total light were at most within 2%, if they were assumed to be main-sequence stars. If the LTE explanation is true for the WZ Cep system, the 7:2 relation found between their mean motions would be interpreted as a stable 7:2 orbit resonance produced by a long-term gravitational interaction between two tertiary bodies. In the Applegate model interpretation, the deduced model parameters indicate that the mechanism could work only in the primary star for both of the two period modulations, but could not in the secondary. However, we couldn't find any meaningful relation between the light variation and the period variability from the historical light curve data. At present, we prefer the interpretation of the mechanical perturbation from the third and fourth stars as the possible cause of two cycling period changes.