• Journal of Nutrition and Health
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• v.28 no.2
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• pp.115-126
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• 1995

The effects of energy-yielding substrates on coronary circulation, myocardial oxygen metabolism, and intramyocytic adenylates of perfused Wistar control rat(WC) and spontaneously hypertensive rat(SHR) hearts were examined under basal and $\beta$-adrenergic stimulation conditions. The perfusion medium (1.0mM Ca2+) contained 5mM glucose (+5U/l insulin) in combination with 5mM pyruvate, 5mM lacate, 5mM acetate, or 5mM octanoate as energy substrates. Hearts were perfused with each substrate buffer for 20min under basal conditions. Coronary functinal hyperemia was induced by infusing for 20min isoproterenol (ISO, 1uM), a $\beta$-receptor agonist. Cardiac adenylates, glycolytic intermediates, and coronary venous lactate were measured by using an enzymatic analysis technique. Under basal conditions, acetate and octanoate significantly increased coronary flow(CF) of WC in parallel with myocardial oxygen consumption. However, CF of SHR was partly attenuated by coronary vasoconstriction despite metabolic acidosis. In addition, pyruvate and lactate depressd ISO-induced coronary functional hyperemia in SHR. It should be noted that octanoate exhibited coronary dysfunction under ISO conditions. On the other hand, fat substrates depleted myocardial high energy phosphate pool and accumulated breakdown intermediates. In SHR with coronary vasoconstriction under basal conditions, and with depressed coronary functional hyperemia, high energy phosphates were greatly depleted. These results suggest that energy substrates in the myocardium and coronary smooth muscle alter remarkably coronary circulation, and that coronary circulatory function is associated with a reserve of high energy phosphates and a balance between breakdown and nono synthesis of energy phosphates. These findings could be explained by alterations in the cytosolic redox state manipulated by LDH and hence in the cytosolic phosphorylation potential, which might be involved in hypertension of SHR.

• The Korean Journal of Physiology
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• v.24 no.1
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• pp.145-159
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• 1990

Recently, it has been suggested that the endogenous adenosine may be the mediator for the intercellular communication in the regulation of tubuloglomerular feedback control and renin release. Even though two subclasses of adenosine receptors, A1 and A2, have been described, their functional roles are controversial. The present study was undertaken to clarify the role of adenosine receptors in hypertensive rabbit caused by clamping of renal artery. Experiments were done in two-kidney one clip Goldblatt hypertensive rabbits (2K1GHR) and sham-operated normotensive rabbits. Adenosine, N6-cyclohexyladenosine (CHA) and 5'-N-ethylcarboxamidoadenosine (NECA) were infused into a renal artery. The decreases in urine volume, renal blood flow, glomerular filtration rate and excreted amounts of electrolytes caused by adenosine and CHA were significantly attenuated in 2K1CHR. However, changes in renal function caused by A2 adenosine receptor agonist, NECA, tend to be accentuated in 2K1CHR. These results suggest that the attenuation of renal effect caused by adenosine and A1 adenosine receptor agonist may be due to the modification of adenosine receptor in the kidney in Goldblatt hypertensive rabbits.

• The Korean Journal of Physiology
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• v.23 no.1
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• pp.67-78
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• 1989

Since the atrial receptor was suggested to be involved in the control of extracellular fluid volume, it has been shown that the granularity of atrial cardiocytes can be changed by water and salt depletion, and that an extract of atrial tissue, when injected intravenously into anesthetized rats, causes a large and rapid increase in renal excretions of sodium and water. The immunoreactive atrial natriuretic peptide (ANP) has been found in the plasma of patients suffering from various cardiovascular diseases. A high level of ANP in the plasma has been reported in essential hypertension. Several studies on the effects of ANP on renal function and arterial blood pressure have presented contradictory results showing attenuated or accentuated responses. Thus, involvement of the ANP in the development of hypertension remains unresolved. Present study was undertaken to investigate whether the ANP is involved in the development of hypertension in two-kidney one-clip Goldblatt hypertensive rats. The plasma concentration of immunoreactive ANP appeared to be significantly elevated in hypertensive rats as compared with normotensive Goldblatt operated and sham-operated rats. Plasma renin concentration was higher in hypertensive rats than in normotensive rats, as observed in earlier experiments. Intravenous infusions of ANP resulted in increases of urine flow and urinary excretions of sodium and potassium in both hypertensive and normotensive rats. The renal response to ANP was markedly accentuated in Goldblatt hypertensive rats. The plasma concentration of ANP showed a linear relationship with the arterial blood pressure. Infusions of ANP reduced blood pressure both in hypertensive and normotensive rats. These results suggest that in Goldblatt hypertensive rats an elevation of ANP level in the plasma may not be a cause, but instead a consequence of hypertension, and that the renal responsiveness to the ANP is accentuated by some unknown mechanisms.

• Journal of Navigation and Port Research
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• v.31 no.6
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• pp.515-521
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• 2007

To increase the stevedore efficiency and service level at container terminal, it is essential to reduce working time of container crane which has a bottle neck in the logistic flow of container. The working speed and safety are required to be improved by controlling the movement of the trolley as quick as possible without big overshoot and any residual swing motion of container in the vicinity of target position. This paper presents optimal state feedback control using RCGAs in the case of existing constrained conditions

• The Transactions of the Korea Information Processing Society
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• v.4 no.6
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• pp.1433-1442
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• 1997

Algorithm design is needed to optimized bandwidth which satisfy quality of service(QoS) requirements of vary traffic classes for Multimedia service in ATM networks. The diverse flow characteristics e.g., burstiness, bit rate and burst length, have to guarantee the different quality of service(QoS) requirements in Asynchronous Transfer Mode(ATM). The QoS parameter may be measured in terms of cell loss probability and maximum cell dely. In this paper, we consider the ATM networks which the virtual path(vip) concept is implemented by applying the Markov Modulated Deterministic Process method. We develop an efficient algorithm to computer the minimum capacity required to satisfy all the QoS requirements when multiple classes of on-off source are multiplexed on single VP. Using above the result, we propose a simple algorithm to determine the VP combination to achieve the near optimum of total capacity required for satisfying the individual QoS requirements. Numerical results are also presented to demonstrate the performance of the algorithm, when compared to the optimal total capacity required.

• Proceedings of the KIEE Conference
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• 2006.07d
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• pp.2134-2135
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• 2006

전력거래소는 발전경쟁시장(CBP; Cost-Based Pool) 장기화에 따른 운영상의 효율성을 개선하고 기 개발된 시장운영시스템(MOS; Market Operation System)을 활용하여 급전체계를 개선하기 위해 준비중이다. 현행 급전체계에서는 거래 전일에 수행한 수요예측을 바탕으로 1시간 단위운영발전계획을 전일에 수립하고 EMS(Energy Management System)를 이용하여 발전기에 대한 경제부하배분(ED; Economic Dispatch)을 시행하고 있지만, 현 EMS는 시장체제 환경 전에 도입된 설비로 시장환경에 대한 고려가 되어 있지 않고 계통운영 보조서비스의 실시간 반영이 어려운 점이 있다. 전력거래소는 실시간 급전 운영을 위해 기존 EMS에 MOS를 연계하여 MOS의 5분 단위 수요예측량을 기반으로 송전망 제약과 예비력 요구량 등을 고려한 발전기별 경제부하 배분량 및 예비력 배분량을 결정하고, 추가적으로 EMS에서 수요예측 오차 및 주파수 보정량을 실시간으로 계산하여 발전기별로 배분하도록 함으로써, 1일 전 시행하던 급전계획을 취득 자료를 기반으로 5분 단위로 실시간 계산할 수 있도록 급전 체계를 개선할 계획이다. 이를 통해 실시간으로 에너지와 예비력을 동시에 최적화함으로 전력시장 및 전력계통 운영을 한층 선진화 할 수 있는 계기를 마련하였으며 또한 저비용 발전기 사용을 극대화함으로 발전비용의 절감에도 기여하는 효과를 기대할 수 있다. MOS-EMS간 자료연계에는 ICCP(Inter-Control Communication Protocol)와 FTP 프로토콜을 사용하였고, 수차례 모의운영을 통하여 데이터베이스 및 현장 취득 자료의 정확도(accuracy)가 양 시스템 간 연계 및 전력 계통의 안정적 운영에 매우 중요한 요소로 나타났다. 전력거래소는 장기적으로 CIM(Common Information Model)기반의 표준 전력계통 데이터베이스를 구축하고 시스템 간 자료 연계를 위해 XML을 활용하여 시스템 간 상호 운영성(Interoperability)과 자료 연계의 안정성을 높일 계획이다. 본 논문은 MOS-EMS 연계에 따른 시스템 간 자료의 흐름 및 처리에 대해 주로 설명하고자 한다.

• YAKHAK HOEJI
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• v.48 no.6
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• pp.317-322
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• 2004

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their ability to induce gastrointestinal injury. It has been shown that nitric oxide (NO), similar to pro staglandins (PGs), appears to play an important role in gastric mucosal defence. We hypothesized that NSAIDs contained NO group would be less acutely toxic to the gastric mucosa, but would not interfere with their ability to suppress inflammatory process in rats. We have compared the ulcerogenic and anti-inflammatory effect of CW-501029 (NO-NSAIDs), CW-501027 (NSAIDs) and indomethacin. Both did not change mean blood pressure and heart rates, indicating that they had no side effect on cardiovascular system. We found that CW-501029 increased nitrite/nitrate levels without changing of blood pressure and heart rates. We suggest that it may help gastric mucosal blood flow, the which helps reducing the discomfort in astrointestinal system. Carrageenan-induced PGE2 increase was reduced in a similar tendency when compared CW-501027 or CW-501027 with control in back exudate of rats, but CW-501029 less reduced PGE2 than CW-502027 or indomethacin in gastric tissues. CW-501027 or CW-501029 reduced platelet aggregation. From these results we suggest that CW-501029 may improve the side effect by reduction of short-term gastric injury and less inhibition of PGs synthesis.

• Journal of the Korean Society of Groundwater Environment
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• v.1 no.1
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• pp.1-5
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• 1994

The contaminant migration through the subsurface of Nanjido landfill is studied using a 2-D finite element model of contaminant transport. The leachate mounding caused by the installation of partial slurry wall around the pheriperal area of the Landfill is analysed using the finite difference model of groundwater flow. Model parameters were validated using in-situ concentration data and the behavior of the transport next 30 years is predicted. The sensitivities of chloride concentration by the change of model parameters, e.g. leachate mounding in the Landfill and the dispersivity are analysed. The results of the analyses show that the maximum chloride concentration level near Han River caused by the leachate of Nanjido Landfill would be 1488mg/1 and comes 17 years after the landfill closure. Increase of the leachate concentration is caused by the increase of both the leachate mounding and the dispersivity. However, the rate of concentration increase becomes higher with the rise of leachate mounding level, while it tends to converge a certain concentration with the increase of the dispersivity.

• Proceedings of the KWS Conference
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• 2002.10a
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• pp.757-762
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• 2002

Many reports have been shown that the buoyancy, electromagnetic force, surface tension, and gas shear stress are the driving forces of weld pool circulation in arc welding. Among them, the surface tension of molten metal plays an important role in the flow in weld pool, which are clarified by the specially designed experiments with small particles as well as the numerical simulations. The surface tension is also related to the penetration in arc welding. Therefore, a quantitative evaluation of surface tension is demanded for the development of materials and arc process control. However, there are few available data published on the surface tension of molten metals, since it depends on the temperature and the composition of materials. In this study, a new method was proposed for the evaluation of surface tension and its temperature dependence, in which it is evaluated by the equilibrium condition of acting forces under a given surface geometry, especially back surface. When this method was applied to the water pool and to the back surface of molten pool in the stationary gas tungsten arc welding of thin plate, following results were obtained. In the evaluation of surface tension of water, it was shown that the back surface geometry was very sensitive to the evaluation of surface tension and the evaluated value coincided with the surface tension of water. In the measurement of molten pool in the stationary gas tungsten arc welding, it was also shown that the comparison between the surface tension and temperature distribution across the back surface gave the temperature dependent surface tension. Applying this method to the mild steel and stainless steel plates, the surface tension with negative gradient for temperature is obtained. The evaluated values are well matched with ones in the published papers.

• Journal of Korean Society on Water Environment
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• v.26 no.3
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• pp.518-524
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• 2010

Continuous removal of organic matters (CROM) using freshwater bivalve Anodonta woodiana was operated to evaluate the effect of water current on the water quality improvement (clearance) of eutrophic lake. The CROM system comprised three treatment steps such as flow control, treatment and analysis, and operated at the two different currents ($24L\;h^{-1}$ and $48L\;h^{-1}$) with mussels at density of $312.5indiv.\;m^{-2}$ for 12 consecutive days. Water quality including suspended solids (SS) and chlorophyll-a (Chl-a) was daily measured at the same time. Results indicate that although both the system strongly decreased the concentration of SS and chl-a, a slow CROM system was more effective to diminish the SS contents than a fast CROM system; 82% and 66%, respectively (ANOVA, P<0.0001). Clearance rates, based on chl-a, were also significantly higher in a slow system than a fast system (ANOVA, P<0.0001), although the mussel mortality was conversely. In both systems, there showed a remarkable excretion of dissolved inorganic nutrients (i.e. $NH_3-N$ and $PO_4-P$), while a slow CROM system was higher than a fast system, significantly (ANOVA, P<0.0001). Therefore, it may suggest that a slow current CROM system is more suitable to maximize the efficacy of water quality improvement, but further study is needed to diminish the mortality of mussel and to reuse the nutrient released during the operation.