YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Inhibitory Effect of CW-501027 and CW-501029 on the Anti-inflammatory Action in Rats

흰쥐의 염증반응에 대한 CW-501027과 CW-501029의 억제효과

  • 정지훈 (중앙대학교 약학대학 약물학교실) ;
  • 심재호 (중앙대학교 약학대학 약물학교실) ;
  • 양성준 (중앙대학교 약학대학 약물학교실) ;
  • 민영실 (중앙대학교 약학대학 약물학교실) ;
  • 송현주 (중앙대학교 약학대학 약물학교실) ;
  • 우재광 (중앙대학교 약학대학 약물학교실) ;
  • 김용성 (중앙대학교 약학대학 약물학교실) ;
  • 조영래 (중앙대학교 약학대학 약물학교실) ;
  • 손의동 (중앙대학교 약학대학 약물학교실)
  • Published : 2004.01.01
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Abstract

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their ability to induce gastrointestinal injury. It has been shown that nitric oxide (NO), similar to pro staglandins (PGs), appears to play an important role in gastric mucosal defence. We hypothesized that NSAIDs contained NO group would be less acutely toxic to the gastric mucosa, but would not interfere with their ability to suppress inflammatory process in rats. We have compared the ulcerogenic and anti-inflammatory effect of CW-501029 (NO-NSAIDs), CW-501027 (NSAIDs) and indomethacin. Both did not change mean blood pressure and heart rates, indicating that they had no side effect on cardiovascular system. We found that CW-501029 increased nitrite/nitrate levels without changing of blood pressure and heart rates. We suggest that it may help gastric mucosal blood flow, the which helps reducing the discomfort in astrointestinal system. Carrageenan-induced PGE2 increase was reduced in a similar tendency when compared CW-501027 or CW-501027 with control in back exudate of rats, but CW-501029 less reduced PGE2 than CW-502027 or indomethacin in gastric tissues. CW-501027 or CW-501029 reduced platelet aggregation. From these results we suggest that CW-501029 may improve the side effect by reduction of short-term gastric injury and less inhibition of PGs synthesis.

Keywords

References

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