• Journal of computational fluids engineering
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• v.19 no.3
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• pp.24-28
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• 2014

With ever rising concerns about saving of fossil fuel resource, there have been an increasing demand for use of energy more efficiently. The electric motor driven inverters can be a great help to improve energy efficiency. They are also used to control the motor speed to the actual need. Therefore the use of them can lead to reduce energy consumption. In particular, the medium voltage(MV) drive systems used for pumps, fans, steel rolling mills and tractions have widespread applications in the industry. They cover power ratings from 0.4MW to 40MW at the MV level of 2.3kV to 13.8kV. The majority of the installed MV drive systems however, are in the 1MW to 4MW range with voltage rating from 3.3kV to 6.6kV. But they are required to reduce size and weight like other power electronic equipments. In this paper, we studied on the 3.3kV(105A) compact rack type inverter system for improving the cooling efficiency. At first, we confirmed the tendency of temperature with computational simulation using ANSYS ICEPAK and actual experimental tests. And then we researched thermal performance improvement designs in order to reduce temperature of the transformer for the safe operation. It can reduce temperature of transformer that using pipe type flow guide in the system. As a result, we found out more efficient solution by thermal-fluid analysis.

• Journal of Navigation and Port Research
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• v.38 no.4
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• pp.335-341
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• 2014

Faced with global agenda of greenhouse abatement program including regulations and $CO_2$ emission trading scheme, shipping companies are enforced to a high level of efficiency in fuel consumption. Accordingly shipbuilding companies worldwide are required to develop fuel-efficient ships which otherwise traditionally consume a great amount of fossil fuels. In this dissertation, relevant to the improvement of fuel efficiency for commercial ships, design methodology through the numerical simulations are intensively described. This work consists of derivation of effective hydrodynamic design practice based on the application of longitudinal grooves to effectively improve the pressure distribution around ship hull. The primary objective of the present study is to improve ship resistance performance using longitudinal grooves which originate from long strips on the abdomen of humpback whale. Several groove shapes have been extensively investigated and the proposed shape efficiently controlled the variation of pressure distributions acting on the hull surface.

• Parasites, Hosts and Diseases
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• v.54 no.2
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• pp.147-154
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• 2016

Toxoplasma gondii infection induces alteration of the host cell cycle and cell proliferation. These changes are not only seen in directly invaded host cells but also in neighboring cells. We tried to identify whether this alteration can be mediated by exosomes secreted by T. gondii-infected host cells. L6 cells, a rat myoblast cell line, and RH strain of T. gondii were selected for this study. L6 cells were infected with or without T. gondii to isolate exosomes. The cellular growth patterns were identified by cell counting with trypan blue under confocal microscopy, and cell cycle changes were investigated by flow cytometry. L6 cells infected with T. gondii showed decreased proliferation compared to uninfected L6 cells and revealed a tendency to stay at S or G2/M cell phase. The treatment of exosomes isolated from T. gondii-infected cells showed attenuation of cell proliferation and slight enhancement of S phase in L6 cells. The cell cycle alteration was not as obvious as reduction of the cell proliferation by the exosome treatment. These changes were transient and disappeared at 48 hr after the exosome treatment. Microarray analysis and web-based tools indicated that various exosomal miRNAs were crucial for the regulation of target genes related to cell proliferation. Collectively, our study demonstrated that the exosomes originating from T. gondii could change the host cell proliferation and alter the host cell cycle.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.1
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• pp.71-78
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• 2015

The reliable sloshing assessment methods for LNG CCS(cargo containment system) are important to satisfy the structural strength of the systems. Multiphase fluid flow of LNG and Gas Compressibility may have a large effect on excited pressures and structural response. Impinging jet model has been introduced to simulate the impact of the LNG sloshing and analyze structural response of LNG CCS as a practical FSI(fluid structure interaction) method. The practical method based on fluid structure interaction analysis is employed in order to evaluate the structural strength in actual scale for Mark III CCS. The numerical model is based on an Euler model that employs the CVFEM(control volume based finite element method). It includes the particle motion of gas to simulate not only the interphase interaction between LNG liquid and gas and the impact load on the LNG insulation box. The analysis results by proposed method are evaluated and discussed for an effectiveness of FSI analysis method.

• Fashion & Textile Research Journal
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• v.16 no.6
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• pp.979-986
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• 2014

This study establishes basic data for operations management by organizing processes and measuring time in the mini line for female jackets to improve productivity, ensure competitiveness, and maintain operator competency and the line process flow balance between apparel manufacturing companies. The results of this study are as follows. Sewing operations are divided into preparation functions, arrangement, partial tasks, and assembly that consist of 84 processes. The results from time measurement indicate that 3238.41seconds (sec) were required to produce a single jacket and that the average time required for operators was 231.32 sec. A control limit was established to increase the reliability of the measured value for net time. After outside values were removed, the operation time was measured to be 3176.35 sec. This accounted for 98.08% of the total operation time, with net time decreasing by 62.06. Skill and effort level coefficients were applied to measure the operator performance, the total real time was calculated to be 3415. The requirement for preparation and arrangement operations were 1233.35 sec, and 2182.22 sec for partial tasks and assembly operations. Process separation and organization were performed after the bottleneck operation was selected to identify the maximum line balance. Consequently, process efficiency of preparation and arrangement operations increased from 79.19% to 93.00%, and the partial tasks and assembly operations increased from 62.36% to 90.93%.

• Biomedical Science Letters
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• v.19 no.2
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• pp.158-163
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• 2013

Cholestatic liver is associated with hepatic inflammation and elevated proinflammatory cytokines. Recent studies indicate that certain cytokines can modulate bile secretion. In the present study, we have examined the role of interleukin (IL-2) on the bile secretion by a combination of study models. To examine the relevance of IL-2 on bile secretion, the expression of IL-2 and IL-2 receptor (IL-2R) of isolated normal and bile duct ligated (BDL) rats cholangiocytes was first measured by RT-PCR. In BDL rats, the expression of IL-2 and IL-2R was significantly increased compared with normal rats. To study the effect of IL-2 on bile secretion, bile flow was measured in normal and BDL rats. At the level of cholangiocytes, secretory responses of isolated bile duct unit (IBDU)s were quantified by videomicroscopy. The administrations of IL-2 had no significant effect on basal bile secretion in normal and BDL rats. There was no significant effect of IL-2 on basal bile ductular secretion as evidenced by no significant difference in luminal area of the IBDUs perfusedwith 100 pM of IL-2 from those of albumin carrier control. However, the secretin-stimulated bile ductular secretion was significantly (P < 0.01) inhibited by $34{\pm}4%$ (normal, n = 12), $21{\pm}5.3%$ (BDL 2 wk, n = 12) and $15{\pm}5.2%$ (BDL 4 wk, n = 12) with the co-administration of IL-2. As with other cytokines, physiologically relevant concentration of IL-2 can significantly inhibit secretin-stimulated bile ductular secretion. These findings support the important roles of cytokines in modulating bile secretion and may contribute to the cholestasis seen in cholestatic liver diseases.

• Journal of Society of Preventive Korean Medicine
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• v.17 no.3
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• pp.165-176
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• 2013

Objective : The purpose of this study was to establish the simultaneous analysis for six compounds in Gumiganghwal-tang (GMGHT, Jiuweiqianghuo-tang) and to investigate the anti-atherosclerotic effects of GMGHT in vitro. Methods : The column for separation of six compounds was used Luna $C_{18}$ column and maintained at $40^{\circ}C$. The mobile phase for gradient elution consisted of two solvent systems, 1.0% acetic acid in water and 1.0% acetic acid in acetonitrile. The analysis was carried out at a flow rate of 1.0 mL/min with pothodiode array (PDA) detection at 254, 280, and 320 nm. The injection volume was 10 ${\mu}L$. The antioxidant activities of GMGHT were evaluated by measuring free radical scavenging activities on 2,2'-Azinobis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) and 1-1-diphenyl-2-picrylhydrazyl (DPPH). The inhibitory effects on low-density lipoprotein (LDL) oxidation were evaluated by the formation of thiobarbituric acid relative substances (TBARS), relative electrophoretic mobility (REM), and fragmentation of apolipoprotein B (ApoB)-100. Results : Calibration curves were acquired with $r^2{\geq}0.9998$. The contents of liquiritin, ferulic acid, baicalin, baicalein, glycyrrhizin, and wogonin in GMGHT were 1.784, 1.693, 37.899, 0.258, 1.869, and 0.034 mg/g, respectively. The GMGHT showed the radical scavenging activity in a dose-dependent manner. The concentration required for 50% reduction ($RC_{50}$) against ABTS and DPPH radicals were 72.51 ${\mu}g/mL$ and 128.49 ${\mu}g/mL$. Furthermore, GMGHT reduced the oxidation properties of LDL induced by $CuSO_4$. Conclusion : HPLC-PDA is considered as an available and convenient method for quality control and standardization of GMGH and GMGHT has potentials on anti-atherosclerosis by anti-oxidative effect and suppressive effect on LDL oxidation.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.11
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• pp.1091-1097
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• 2013

This paper presents a rectifier with comparator using unbalanced body biasing in $0.11{\mu}m$ RF CMOS process. It is composed of MOSFETs and two comparators. The comparator is used to reduce reverse leakage current which occurs when the load voltage is higher than input voltage. For the comparator, unbalanced body biasing is devised. By using unbalanced body biasing, reference voltage for comparator changing from high state to low state is increased, and it reduces time interval for leakage current to flow. 13.56 MHz 2 Vpp signal is used for input and $1k{\Omega}$ resistor and 1 nF capacitor are used for output load for simulation and experimental environment. In simulation environment, voltage conversion efficiency(VCE) is 87.5 % and Power conversion efficiency(PCE) is 50 %. When the rectifier is measured, VCE shows 90.203 % and PCE shows 45 %.

• Research in Plant Disease
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• v.20 no.1
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• pp.15-20
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• 2014

A rapid, user-friendly and simple immune-chromatographic dipstick kit named 'rapid immune-gold strip' (RIGS) kit was developed in a novel single strip format to detect on-site detection of Tomato spotted wilt virus (TSWV). Immunoglobulin G (IgG) from polyclonal antisera raised in rabbits against TSWV was purified through protein-A affinity chromatography and then the purified TSWV-IgG was conjugated to colloidal gold nano-particles which served as a test line on nitrocellulose membrane. Protein A that non-specifically binds to TSWV antibody was used as a control line on the same strip. The diagnosis process with the TSWV-RIGS involves simply grinding the suspect plant sample in a bag that contains the extraction buffer and inserting the strip the bag. Results can be seen in 2-5 minutes. The flow of the complexes of gold particles coated with TSWV-IgG and a crude sap from TSWV-infected pepper, tobacco and tomato plants resulted in intensive color formed on the test lines proportional to the concentrations of TSWV. The RIGS-TSWV kit did not show any cross-reactions against other tomato-infecting viruses unrelated to TSWV. These results indicate that the TSWV-RIGS kit is highly sensitive and is not required for laboratory training and experience prior to testing. The TSWV-RIGS kit is suitable for on-site detection of suspect TSWV-infected plants as well as for laboratory diagnosis.

• International Journal of Oral Biology
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• v.37 no.3
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• pp.115-120
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• 2012

Retinoic acid plays an important role in the regulation of cell growth and differentiation. In our present study, we evaluated the effects of all-trans retinoic acid (RA) on cell proliferation and on the cell cycle regulation of human gingival fibroblasts (HGFs). Cell proliferation was assessed using the MTT assay. Cell cycle analysis was performed by flow cytometry, and cell cycle regulatory proteins were determined by western blot. Cell proliferation was increased in the presence of a 0.1 nM to 1 ${\mu}M$ RA dose range, and maximal growth stimulation was observed in cells exposed to 1 nM of RA. Exposure of HGFs to 1 nM of RA resulted in an augmented cell cycle progression. To elucidate the molecular mechanisms underlying cell cycle regulation by RA, we measured the intracellular levels of major cell cycle regulatory proteins. The levels of cyclin E and cyclin-dependent kinase (CDK) 2 were found to be increased in HGFs following 1 nM of RA treatment. However, the levels of cyclin D, CDK 4, and CDK 6 were unchanged under these conditions. Also after exposure to 1 nM of RA, the protein levels of $p21^{WAF1/CIP1}$ and $p16^{INK4A}$ were decreased in HGFs compared with the control group, but the levels of p53 and pRb were similar between treated and untreated cells. These results suggest that RA increases cell proliferation and cell cycle progression in HGFs via increased cellular levels of cyclin E and CDK 2, and decreased cellular levels of $p21^{WAF1/CIP1}$ and $p16^{INK4A}$.