• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.1
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• pp.61-66
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• 2006

The simple Langmuir isotherm is frequently employed to describe the equilibrium behavior of protein adsorption on a wide variety of adsorbents. The two adjustable parameters of the Langmuir isotherm - the saturation capacity, or $q_m$, and the dissociation constant, $K_d$ - are usually estimated by fitting the isotherm equation to the equilibrium data acquired from batch equilibration experiments. In this study, we have evaluated the possibility of estimating $q_m$ and $K_d$ for the adsorption of bovine serum albumin to a cation exchanger using batch kinetic data. A rate model predicated on the kinetic form of the Langmuir isotherm, with three adjustable parameters ($q_m,\;K_d$, and a rate constant), was fitted to a single kinetic profile. The value of $q_m$ determined as the result of this approach was quantitatively consistent with the $q_m$ value derived from the traditional batch equilibrium data. However, the $K_d$ value could not be retrieved from the kinetic profile, as the model fit proved insensitive to this parameter. Sensitivity analysis provided significant insight into the identifiability of the three model parameters.

• The Journal of the Korean dental association
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• v.51 no.11
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• pp.595-603
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• 2013

The requirements for the successful treatment of all-ceramic restorations are not so different from the ones of conventional restorations. "The provisional restoration followed by an adequate tooth reduction and the accurately fitting prostheses with corresponding to final impression" can be the examples of them. Nevertheless, the one which all-ceramic restorations are distinguished from conventional restorations is the additional procedure of so called "bonding". In addition to the application of resin cement between "inner surface of restoration and outer surface of abutment", bonding technology can be also applied to the treatment process of "Post and Core" in particular if the abutments are non-vital teeth. Core build-up for all-ceramic crown is conducted with fiber post and tooth colored composite by considering the properties of the restorations transmitting light. We know well that a vital abutment is easier than a non-vital one to get the targeted goals for clinical success in connection with esthetics and structure. The creation of "Post and Core" with bonding technique is a decisive factor for a long-term success if the abutment is non-vital tooth with dentinal collapse. I would like to share my clinical experience about "post & core build-up and all-ceramic restoration bonding" out of several success strategies of all-ceramic crown with this presentation.

• Structural Engineering and Mechanics
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• v.66 no.2
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• pp.173-183
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• 2018

This paper proposes a developed optimization model for steel frames with semi-rigid beam-to-column connections and fixed bases using teaching-learning-based optimization (TLBO) and genetic algorithm (GA) techniques. This method uses rotational deformations of frame members ends as an optimization variable to simultaneously obtain the optimum cross-sections and the most suitable beam-to-column connection type. The total cost of members plus connections cost of the frame are minimized. Frye and Morris (1975) polynomial model is used for modeling nonlinearity of semi-rigid connections, and the $P-{\Delta}$ effect and geometric nonlinearity are considered through a stepped analysis process. The stress and displacement constraints of AISC-LRFD (2016) specifications, along with size fitting constraints, are considered in the design procedure. The developed model is applied to three benchmark steel frames, and the results are compared with previous literature results. The comparisons show that developed model using both LTBO and GA achieves better results than previous approaches in the literature.

• Nuclear Engineering and Technology
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• v.30 no.3
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• pp.262-272
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• 1998

The experiences and causes of pressure tube cracking accidents in the CANDU reactors and the development of the fuel channel at AECL(Atomic Energy Canada Limited) have been described. Most of the accidents were caused by Delayed Hydride Cracking(DHC). In the cases of the Pickering units 3&4 and the Bruce unit 2, excessive residual stresses induced by an improper rolled joint process played a role in DHC. In the Pickering unit 2, cracks formed by contact between the pressure and calandria tubes due to the movement of the garter spring were the direct cause of the failure. To extend the life of a fuel channel, several R&D programs examining each component of the fuel channel have been carried out in Canada. For a pressure tube, the main concern is focused on changing the fabrication processes, e.g., increasing cold working rate, conducting intermediate annealing and adding a third element like Fe, V, and Cr to the tube material. In addition to them, chromium plating on the end fitting and increasing wall thickness at both ends of the calandria tube are considered. There has also been much interest in the improvement of fuel channel performance in our country and several development programs are currently under way.

• Geophysics and Geophysical Exploration
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• v.7 no.1
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• pp.51-55
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• 2004

This paper presents a fast and stable imaging scheme using the localized nonlinear (LN) approximation of integral equation (IE) solutions for inverting electromagnetic data obtained in a crosswell survey. The medium is assumed to be cylindrically symmetric about a source borehole, and to maintain the symmetry a vertical magnetic dipole is used as a source. To find an optimum balance between data fitting and smoothness constraint, we introduce an automatic selection scheme for a Lagrange multiplier, which is sought at each iteration with a least misfit criterion. In this selection scheme, the IE algorithm is quite attractive for saving computing time because Green's functions, whose calculation is a most time-consuming part in IE methods, are repeatedly re-usable throughout the inversion process. The inversion scheme using the LN approximation has been tested to show its stability and efficiency, using both synthetic and field data. The inverted image derived from the field data, collected in a pilot experiment of water-flood monitoring in an oil field, is successfully compared with that derived by a 2.5-dimensional inversion scheme.

• Archives of Pharmacal Research
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• v.28 no.5
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• pp.598-603
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• 2005

The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appen dicitis patients. Gentamicin was administered intravenously over 0.5 h every 8 h. Three specimens were collected at 48 h after the first dose from all patients at the following times, just before regularly scheduled infusion, at 0.5 h and 2 h after the end of 0.5 h infusion. Serum gentamicin levels were analyzed by fluorescence polarization immunoassay technique with TDxFLx. The standard deviation (SD) of the assay over its working range had been determined at the serum gentamicin concentrations of 0, 2, 4, 8, 12, and 16 ${\mu}g$/mL in quadruplicate. The polynominal equation of gentamicin assay error was found to be SD (${\mu}g$/mL) = 0.0246-(0.0495C)+ (0.00203C$^2$). There were differences in the influence of weight with gentamicin assay error on pharmacokinetic parameters of gentamicin using the nonlinear least squares regression analysis but there were no differences on the Bayesian analysis. This polynominal equation can be used to improve the precision of fitting of pharmacokinetic models to optimize the process of model simulation both for population and for individualized pharmacokinetic models. The result would be improved dosage regimens and better, safer care of patients receiving gentamicin.

• Journal of Magnetics
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• v.16 no.2
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• pp.169-172
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• 2011

This study reports an alternative method for measuring the magnetoresistance of unpatterned magnetic tunnel junctions similar to the current-in-plane tunneling (CIPT) method. Instead of using microprobes, a series of point contacts with different spacings are coated on the top surface of the junctions and R-H loops at various spacings are then measured by the usual four-point probe method. The values of magnetoresistance and resistance-area products can be obtained by fitting the measured data to the CIPT theoretical model. The test results of two types of junctions were highly similar to those obtained from standard CIPT tools. The proposed method may help to accelerate the process for evaluating the quality of magnetic tunnel junctions when commercial CIPT tools are not accessible.

• Journal of the Korean Society of Costume
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• v.67 no.2
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• pp.36-51
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• 2017

Taekwondo has been known as one of the most symbolic korean sports to publicize Taekwondo various groups have performed exhibitions. These exhibition performances have gained popularity domestically and globally due to the exhibitions' display of artistry and technical mastery. Performance wear has also received wide exposure and thus needs artistic symbolism and functional considerations. This study was done to develop Taekwondo exhibition performance wear for K-Tigers, one of the most active Taekwondo exhibition performing groups. Investigation of current Taekwondo exhibition performance wear and interviewing with K-Tigers members and staff were conducted before designing the uniforms. Interviews demonstrated 3 guidelines: First, the uniforms should not be too different from the traditional wear, but still look unique. Second, it should symbolize the Korean spirit and culture. Third, it should be casual and trendy enough to appeal to young people. Based on these guidelines, 3 styles were made: Dobok style, Hanbok style and Casual style. 5 final designs were selected among 75 sketches with the consensus of the K-Tigers members. This was followed by the 3-step correction process: wearing, check fitting, and correcting design and pattern to provide satisfaction to wearers, and give more detailed information to Taekwondo performance wear design.

• Current Optics and Photonics
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• v.1 no.5
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• pp.505-513
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• 2017

Measuring the thickness of thin films is strongly required in the display industry. In recent years, as the size of a pattern has become smaller, the substrate has become larger. Consequently, measuring the thickness of the thin film over a wide area with low spatial sampling size has become a key technique of manufacturing-yield management. Interferometry is a well-known metrology technique that offers low spatial sampling size and the ability to measure a wide area; however, there are some limitations in measuring the thickness of the thin film. This paper proposes a method to calculate the thickness of the thin film in the following two steps: first, pre-estimation of the thickness with the phase at the peak position of the interferogram at the bottom surface of the thin film, using white-light phase-shift interferometry; second, accurate correction of the measurement by fitting the interferogram with the theoretical pattern through the estimated thickness. Feasibility and accuracy of the method has been verified by comparing measured values of photoresist pattern samples, manufactured with the halftone display process, to those measured by AFM. As a result, an area of $880{\times}640$ pixels could be measured in 3 seconds, with a measurement error of less than 12%.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.26 no.1
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• pp.24-38
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• 2017

Prosthetics procedures in dental clinics 1) Tooth preparation 2) Temporary restoration 3) Post and core 4) Impression 5) Cementation of final prosthesis The final step in the prosthodontic procedure is the fitting of the final prosthesis to the patient's abutment with an exact fit and occlusal relationship. By the way, this final prosthesis is not made in the clinic but is made in the dental lab and comes to the clinic with some time difference. In the clinic, the only medium to deliver the patient's oral information to the dental laboratory is the impression. However, many errors occur in this process. Dentists and dental technicians should try to identify the cause and make an accurate prosthesis to reduce this error.