• Journal of Nutrition and Health
• /
• 제29권7호
• /
• pp.806-820
• /
• 1996

The relationship between exercise and hone mineral density (BMD) was investigated in 153 healthy women. The BMD of lumbar spine, femur(neck, ward's triangle, trochanter) and total body was determined by dual energy X-ray absorptiometry in a group subjects(65) aged 19-59 years who had been exercising(swimming or aerobic dancing) regularly for at least 2 years as well as in a similar group of nonexercising control subjects(88). Weight, height, total lean body mass(=weight-total fat body mass-bone mineral content), animal and meat Ca, Ca index, energy expenditure, BMD, PYD/Cr were significantly higher in the exercisers than the controls. There were significantly negative correlations between age, ALP and osteocalcin and BMD, but significantly positive correlations between weight, BMI, total fat body mass and total lean body mass and BMD. Stepwise multiple regression analysis revealed that total lean body mass may be a better independent predictor to BMD than total fat body mass. The nutrient intakes were more closely related to BMD in the exercisers than the controls, but energy expenditure was more closely related to BMD in the controls than the exercisers Stepwise multiple regression analysis revealed that BMD was closely related to menopause, osteocalcin, age, weight in both groups but energy intake in the exercisers alone, energy expenditure in control alone. In premenopausal women, the exercisers had significantly greater BMD than the controls. But, in postmenopausal women, no significant difference between two groups was detected. When compared to BMD of the subjects with same age range to minimize the effect of age, aerobic dancing appears to be capable of exerting a positive effect on BMD in a group of subjects aged 19-44. However, no relationship of the swimming to BMD could be identified in a group of subjects aged 37-59. The results of this study suggest that the usefulness of exercisng appears to be significantly greater in preemenopausal women than postmenoparusal women and weight bearing activity, aerobic dancing is associated with increasing BMD at the weight bearing sites and could be beneficial in the prevention of bone loss. But the usefulness of swimming on bone should be further investgated.

• 동아시아식생활학회지
• /
• 제4권3호
• /
• pp.21-30
• /
• 1994

The relationship between bone mineral density and the environmental factors were investigated from the view point of preventing osteoporosis in Korean pubescent girls. The effects of calcium, nutrient intake, physical activity on total bone mineral density, lumbar spine and femoral bone mineral density and total bone mineral content were evaluated 33 healthy pubescent girls aged 14∼16y. A convenient method was used to assess nutritional and energy intake and calcium index was used together. Calcium intake in childhood was estimated by asking whether subjects usually drank milk as children. Eating habits data and history of menstruation were obtained by questionnaire and interview. Average energy expenditure was calculated. Bone mineral density and content were measured by dual energy x-ray absorptiometry using a Lunar DPX＋Scanner (Lunar, Madison, WI). The lumbar spine(L2∼L4) and three sites in the proximal femur (femoral neck, trochanteric region, and Ward's triangle)were measured. Height and weight were measured, and the body mass index(BMI) was derived from the formula : BMI=kg/㎡ Statistical analysis was performed by simple correlation using the SAS package. The mean calcium intake (736mg) was below the RDA of 800mg/d. Twelve percent of the total subjects did not drink milk at all because they did not like the taste. Skipping meals, low calcium intake and low energy intake were significantly correlated with the low BMD. Also the data indicate that girls who reported drinking milk with every meal during childhood had significantly higher bone densities than girls who reported drinking milk less frequently. The results suggest that milk consumption in childhood appears to be needed not only for growth and development, but possibly also to assure an optimal peak of bone mass and thus greater latitude for the maintenance or skeletal integrity in the face of bone losses. There was a highly significant correlation between the total BMD and overall level of physical activity. Body weight was a better predictor of total BMD than was and other factor. Simple mechanical loading may explain why body weight, but total BMC was positively relatd to height. Conclusively, increasing calcium intake and physical activity in the pubescent girls could influence BMD.

• Advances in Traditional Medicine
• /
• 제1권1호
• /
• pp.97-106
• /
• 2000

The preventive effect of herbal formulation, ‘Dae-Bo-Won-Chun’(DBWC), on the progress of bone loss induced by ovariectomy (OVX) was studied in rats. From light microseopic analyses, a porous or erosive appearances were observed on the surface of trabecular bone of tibia in ovariectomized rats. Whereas those of the same bone in sham rats were composed of fine particles. The trabecular bone area and trabecular thickness in ovariectomized rats decreased by 50% from those in sham-operated rats, these decreases were completely inhibited by administration of DBWC at concentration of 10mg/kg per day for 7 weeks. The mechanical strength in femur neck was decreased by ovariectomy, and this was significantly suppressed by the administration of DBWC. Serum phosphorus, alkaline phosphatase, and thyroxine levels in ovariectomized rats were increased compared to those in sham-operated rats, and increases were completely inhibited by the administration of DBWC. These results strongly suggest that DBWC is effective in preventing the development of bone loss induced by ovariectomy in rats.

• 한국임상수의학회지
• /
• 제30권5호
• /
• pp.366-370
• /
• 2013

7개월령 암컷 포메라니안견이 오른쪽 후지 파행 증상으로 내원하였다. 내원시 신체 검사에서 오른쪽 대퇴 관절을 신장하였을 때 통증을 호소하였고 일반 방사선 사진에서 오른쪽 대퇴골두에 미약한 방사선 투과성 병변과 오른쪽 대퇴관절 공간의 확장을 확인하였다. 14일 후 일반 방사선 사진에서 오른쪽 대퇴골두 골단의 변위를 확인하였고 컴퓨터단층촬영에서 오른쪽 대퇴골두에 저음영의 병변과 골절선을 확인하였다. 오른쪽 대퇴골두 절제술을 실시하였고 조직학적 검사에서 골두 골간단과 골단의 괴사를 확인하였다. 본 증례는 초기 허혈성 대퇴골두 괴사증이 있는 개의 방사선학적, 컴퓨터단층촬영, 수술적, 조직학적 소견을 기술하였다.

• Journal of Trauma and Injury
• /
• 제26권3호
• /
• pp.125-130
• /
• 2013

Purpose: This study was undertaken in order to identify the characteristics of patients diagnosed with occult an hip fracture after hip trauma. Methods: We retrospectively reviewed the medical records and radiology reports of all patients who underwent hip skeletal computed tomography (CT) for suspected hip fractures but had normal initial X-rays after hip trauma between August 2006 and January 2012. The variables evaluated included age, gender, body mass index (BMI), accident mechanism, previous fracture, independence, late presentation, ability to bear weight, pain on passive rotation, tenderness of the groin area, diagnosis and treatment. Patients were divided into two groups, with hip fracture (occult hip fracture group) and without hip fracture (no fracture group) to evaluate the characteristics associated with an occult hip fracture. Results: The patients, a total of 139, had a mean age of 58.3 years and included 72 male patients(51.8%). The occult hip fracture group included 43 patients(30.9%). Of those 43, 21 patients(48.8%) had intertrochanteric or trochanteric fractures, 8 patients(18.6%) had femur neck fractures and 14 patients(32.6%) had acetabular fractures. Of the 43, 15 patients(34.9%) needed operative treatment. Age was higher in the occult hip fracture group than it was in the no fracture group($64.4{\pm}19.1$ years vs. $55.5{\pm}23.6$ years, p=0.021). A previous fracture was associated with the presence of a new fracture (p=0.014; OR=3.971, 95% CI=1.314-11.997). Conclusion: Further evaluation of patients who are older or have history of fractures is prudent, even though the initial X-rays are normal.

• 대한지역사회영양학회지
• /
• 제22권2호
• /
• pp.136-144
• /
• 2017

Objectives: The purpose of this study was to determine which factors influence the bone mineral density (BMD) of total femur (TF), femoral neck (FN) and lumbar spine (LS) of the adult men by analyzing nationally representative Korean survey data. Methods: This study was conducted based on the data of 1,770 men aged 19-64 years from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V), 2010~2011. The BMD was analyzed by various factors (general characteristics, anthropometric data, health habits, chronic diseases, nutrient intake status). SPSS statistics for complex samples was used to analyze the data. Results: We observed that the BMD decreased significantly with aging. The BMD in each of the second lowest quartile of waist circumference (in TF & FN) and body mass index (in TF & LS) was lower than the respective BMD in the highest quartile group. The BMD in FN was higher in the group who reported the weight training. The BMD in LS was lower in hypercholesterolemia group than in the normal group. The BMD in TF, FN and LS was lower in hypertriglyceridemia group and in diabetes group than in the normal group. The BMD in TF, FN and LS was higher in the group with < Estimated Average Requirement iron intake. But there was no evidence to suggest that the BMD was related with educational level, income level, smoking, alcohol intake, anemia and nutrient intake status (except for iron). Conclusions: This study suggested that aging, waist circumference, body mass index, weight training, hypercholesterolemia, hypertriglycemia, diabetes were site-specifically associated with the BMD in TF, FN and LS in the adult men. These bone site-specific factors need to be considered for the prevention of osteoporosis.

• 한국동물위생학회지
• /
• 제46권4호
• /
• pp.339-348
• /
• 2023

The outbreak of lumpy skin disease (LSD), caused by LSD virus (LSDV), in Jeollabuk-do was first confirmed at a Korean cattle farm in Buan-gun on October 24, 2023. Afterwards, thirteen cases (twelve cases in Gochang-gun and a case in Imsil-gun) were further confirmed, resulting in a total of fourteen cases over 25 days until November 17, 2023. Clinical examination were conducted on infected and co-habitting cattle from the LSD-affected farms with particular focus on the presence of nodules throughout the body such as head, neck, chest, femur, head, and perineum. As a results, abnormal clinical signs were observed in fifteen cows: loss of appetite in six cows, high fever in three cows, eye mucosal nodules in a cow, nasal mucosal nodules in six cows, nodules on perineum in five cows, scrotum nodules in two cows, papillary nodules in a cow, and/or skin nodules in eleven cows. By the PCR methods, the common gene of capripox virus and/or the specific gene of LSDV were detected in 35 of the 69 cows tested this study. In the Farm1, capripox virus-specific gene, LSDV wild strain-specific gene, and LSDV vaccine strain-spcific gene were simultaneously detected in affected cows, indicating the cattle farm was affected by various strain of LSDV. As a result of combining clincal examination and PCR test, it was found that clinically and subclinically infeted cows coexist in the LSDV-infected farms. These finding in this study will be a great help in diagnosis and prevention of the LSD in Korean cattle farms.

• The Korean journal of internal medicine
• /
• 제39권1호
• /
• pp.148-159
• /
• 2024

Background/Aims: We evaluated the efficacy and safety of denosumab treatment in severe chronic kidney disease (CKD) patients with osteoporosis. We also investigated whether the treatment affects the coronary artery calcifications. Methods: Twenty-seven postmenopausal women with Stage 3b-4 CKD and osteoporosis were enrolled. Twenty patients received denosumab plus calcium carbonate and vitamin D, and seven controls received calcium carbonate and vitamin D for 1 year. Dual-energy X-ray absorptiometry and coronary artery calcium (CAC) scoring computed tomography were performed before and after treatment. Hypocalcemic symptoms and serum calcium levels were evaluated. Results: After 1 year of treatment, the percent changes of femur neck (3.6 ± 3.2% vs. -0.7 ± 4.4%, p = 0.033) and total hip (3.4 ± 3.8% vs. -1.9 ± 2.1%, p = 0.001) bone mineral density (BMD) were significantly increased in the denosumab treated group compared to the control group. However, the percent change of lumbar spine BMD did not differ between two groups (5.6 ± 5.9% vs. 2.7 ± 3.9%, p = 0.273). The percent change of bone alkaline phosphatase was significantly different in the denosumab-treated group and control group (-31.1 ± 30.0% vs. 0.5 ± 32.0%, p = 0.027). CAC scores did not differ between groups. No hypocalcemic events occurred in both groups. Conclusions: If carefully monitored and supplemented with calcium and vitamin D, denosumab treatment for 1 year provides significant benefits in patients with Stage 3b-4 CKD and osteoporosis. However, denosumab treatment did not affect coronary artery calcifications in these patients.

• 한국산학기술학회논문지
• /
• 제13권10호
• /
• pp.4711-4716
• /
• 2012

본 연구는 2008-2009년 국민건강영양조사 자료에서 자궁절제술을 하지 않은 폐경 후 12년 미만의 폐경기 여성 686명을 대상으로 콩 단백질 섭취량과 요추 및 대퇴골 골밀도의 연관성을 알아보고자 하였다. 연구대상을 골 소실이 상대적으로 빠른 폐경 후 4년 미만 기간에 있는 여성군과 폐경후 4년 이상인 여성군으로 층화하여 각각 콩 단백질 섭취량과 골밀도의 관계를 분석하였다. 연령, 체중, 신장, 칼슘 섭취량 등을 보정하였을 때 폐경 후 4년 미만인 여성군에서는 콩 단백질 섭취량과 요추 및 대퇴골 골밀도 사이에 유의한 연관성이 없었다. 반면 동일한 보정을 하였을 때 폐경 후 4년 이상인 여성에서는 콩 단백질 섭취와 대퇴골(femoral neck, total hip 부위) 골밀도 사이에는 역방향의 유의한 연관성이 있었으나, 총단백질 섭취량, Na섭취량, 에너지섭취량을 추가 보정한 결과 그 연관성이 사라졌다. 결론적으로 한국인 폐경기 여성에서 콩 단백질 섭취와 골밀도는 연관성이 없는 것으로 사료된다.

• 정보처리학회논문지B
• /
• 제19B권2호
• /
• pp.99-106
• /
• 2012

본 연구에서는 각기 다른 측정 부위에서 도출된 골밀도와 골소주 패턴 간의 상관관계를 복합적으로 분석하여 측정부위에 따른 평가변수의 골다공증 예측 가능성을 평가하고자 하였다. 실험대상은 40대 이상의 폐경기 이후 여성 40명을 선정하였고, T-Score 분류법에 따라 각각 20명의 정상군 및 골다공증군으로 분류하였다. 실험대상의 골밀도는 이중 에너지 X선 흡수 계측법을 통해 대퇴경부(Femoral Neck), 전자부(Trochanter) 및 워드 삼각부(Ward's Triangle)에서 측정하였다. 또한 각 측정부위에 $50{\times}50$ 픽셀 크기의 관심영역을 지정하고, 기존 연구에서 제안된 영상처리기법을 적용하여 각 영역의 골소주 패턴을 추출하였다. 골다공증을 예측하기 위한 평가변수는 구조적 변수(평균 회색조, 골면적, 골둘레, 골두께, 말단거리), 골격화 변수(골개수, 골길이) 및 프랙탈 차원(fractal dimension)으로 구분되는 총 8가지를 선정하였다. 실험결과, 골면적, 골둘레, 골두께, 말단거리, 골개수, 골길이 및 프랙탈 차원이 골밀도를 유의하게 반영하였고(p<0.003), 평가변수의 분석을 통한 골다공증의 높은 예측 가능성을 확인하였다.