• Parasites, Hosts and Diseases
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• 제48권2호
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• pp.157-160
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• 2010

We report here a human case probably mixed-infected with Clonorchis sinensis and Fasciola sp. who was diagnosed by computed tomography (Cn scan, serological findings, and/or fecal examination. The patient was a 43-year-old Korean female and was admitted to Kyung Hee University Hospital with the complaints of fever and abdominal pain. On admission, marked eosinophilia was noted in her peripheral blood. CT scan showed specific lesions for clonorchiasis and fascioliasis in the liver, along with lesions suggestive of amebic abscess. Micro-ELISA revealed positive results for the 2 helminthic infections. Eggs of C. sinensis and trophozoites of Entamoeba histo/ytica were observed in the stool. Treatment with praziquantel followed by metronidazole and tinidazole reduced abnormalities in the liver and eosinophilia. This is the first case report of a possible co-infection with 2 kinds of liver flukes in the Republic of Korea.

• Parasites, Hosts and Diseases
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• 제22권1호
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• pp.61-65
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• 1984

1983년 12원부터 1984년 3월까지 서울에서 실시한 대편검사에서, Fibricola seculens심의 충란이 15명에게서 발견되었고, 이들을 Stoll씨 충란계산법으로 검사한 결과 EPG는 0∼500의 범위에 있었다. 이들 모두에게 Praziquantel을 20mg/kg의 용량으로 1회 투여하고, 그 중 9례를 대상으로 엄류하제를 이용하여 충체 수집을 시도하였다. 대상자 중 6례에서 F. seoulensis의 성충을 1∼78마리 수집할 수 있었다. 이들 15례에 대하여 치료 2∼6주후에 추적 검변한 결과 모두가 충란을 배출하지 않음을 확인하였다. 이들 감염자들은 임상적인 증상이 전혀 없었고, 따라서 임상검사는 시행하지 않았다. 이들은 모두가 20대 한국인 남자로, 출현의 일환으로 뱀 또는 개구리를 구워서 또는 날로 1회 이상 먹은 경험이 있었다. 이들이 마지막으로 뱀을 먹은 시기는 각각 1981년 9월에서 1983년 11일 사이에 있었다. 이들의 대변에서 발견된 충란중 100개를 계측한 결과 길이가 0.081∼0.102mm, 폭이 0.051∼0.063mrn이었다. 약절반에서 난잔(operculum)가 확인가능하였고 대부분의 경계선이 충란 장축에 비스듬하게 관찰되었다. 우리나라에서 뱀과 개구리를 먹는 민간의 습관을 고려하면 인체 fibricoliasis가 보다 널리 퍼져 있을 것으로 생각된다. 충란의 감별만으로도 진단이 가능할 것으로 판단되므로 앞으로 많은 증례의 발견이 기대된다.

• Journal of Animal Science and Technology
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• 제57권1호
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• pp.4.1-4.5
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• 2015

The study was performed to investigate the effect of dietary supplementation of a lipid-encapsulated Zinc oxide on growth parameters and intestinal mucosal morphology piglets born to Duroc-sired Landrace ${\times}$ Yorkshire dams. Twenty-four 30-day-old piglets weaned at 25 days of age were orally challenged with $5{\times}10^8$ colony forming units of enterotoxigenic Escherichia coli (ETEC) K88 and fed one of the four diets for 7 days: (i) a nursery basal diet containing 100-ppm ZnO (referred to as BASAL), (ii) BASAL supplemented with 120-ppm apramycin (referred to as ANTIBIO), (iii) BASAL with 2,400-ppm ZnO (referred to as HIGH), and BASAL containing 100-ppm lipid-encapsulated ZnO (referred to as LE). All piglets were killed at the end of the experiment for histological examination on the intestine. The results showed that the average daily gain (ADG), the villus height: crypt depth (CD) ratio in the ileum, and the goblet cell density of the villus and crypt in the duodenum, jejunum, and colon were greater in the LE-fed group that those of the BASAL (p < 0.05). Fecal consistency score (FCS) and the CD ratio in the ileum were less in the LE-fed group, compared to the BASAL-fed one (p < 0.05). The effects observed in the LE-fed group were almost equal to those of the HIGH-fed group as well as even superior to those of the ANTIBIO-fed group. Taken together, our results imply that dietary supplementation of 100-ppm lipid-encapsulated ZnO is as effective as that of 2,400-ppm ZnO for promoting growth diarrhea and intestinal morphology caused by ETEC infection.

• Journal of Nutrition and Health
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• 제30권2호
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• pp.187-194
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• 1997

The effects of diet induced hyperlipidemia on kidney function were studied in Sprague-Dawley rats fed high fat diet containing 20% beef tallow and high cholesterol diet containing 5% cholesterol for 8, 12, 16 weeks, respectively. The concentrations of serum total lipid, total cholesterol and LDL-cholesterol were significantly high cholesterol diet groups during all experimental periods (p<0.05). HDL-cholesterol concentration was the lowest value in high cholesterol diet group of 16 weeks(p<0.05). Triglyceride concentration was not affected by experimental diets. Serum total protein, albumin and creatinine concentration tended to higher in high cholesterol diet groups than those in high fat diet groups. And serum urea-N concentration was higher in high fat diet group of 16 weeks than that in other diet groups. Urinary total protein and urea-N were higher in high cholesterol diet groups than those in other diet groups regardless of experimental period period. There was no significant difference in urinary creatinine concentratin among diet groups(p<0.05). GFR was lower in high cholesterol diet groups than that in high fat diet groups at 8, 16 weeks, respectively. Wet weight per body weight, total lipid, triglyceride, total cholesterol concentations of liver tissue were apparently high in high cholesterol diet groups(p<0.05). Kidney wet weight per body weight wer not affected by experimently diets, total lipid concentration of kidney tissue was significantly high in high fat diet groups of 12 weeks(p<0.05), kidney tissue triglyceride concentrations of high cholesterol diet groups of 12, 16 weeks apparently low, and total cholesterol concentration of kidney tissue was higher in experimental diet groups than that of control groups at 12, 16 weeks(p<0.05). Fecal excretion, total lipid, triglyceride and cholesterol concentrations of feces were markedly high in all high cholesterol diet groups except high fat diet group of 16 weeks. The results of light microscopic examination indicated that glomerulosclerosis was not obsrved in rats fed experimental diets.

• Parasites, Hosts and Diseases
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• 제51권2호
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• pp.207-212
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• 2013

Chronic diarrhea with a 35 kg weight loss (75 kg to 40 kg) occurred during 2 years in an alcoholic patient was diagnosed with Isospora belli infection in the Republic of Korea. The patient, a 70-year old Korean male, had been a heavy drinker for more than 30 years. He was admitted to the Seoul National University Hospital because of long-standing diarrhea and severe weight loss. He had an increased white blood cell (WBC) count with high peripheral blood eosinophilia (36.8-39.9%) and lowered protein and albumin levels but without any evidence of immunosuppression. A parasitic infection was suspected and fecal examination was repeated 3 times with negative results. Peroral endoscopy with mural biopsy was performed in the upper jejunum. The biopsy specimens revealed villous atrophy with loss of villi together with various life cycle stages of I. belli, including trophozoites, schizonts, merozoites, macrogamonts, and microgamonts. The patient was treated successfully with oral doses of trimethoprim 160-320 mg and sulfamethoxazole 800-1,600 mg daily for 4 weeks. A follow-up evaluation at 2.5 years later revealed marked improvement of body weight (68 kg), increased protein and albumin levels, and normal WBC count with low eosinophils (3.1%). This is the first clinical case of isoporiasis with demonstration of various parasitic stages in the Republic of Korea.

• Parasites, Hosts and Diseases
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• 제55권5호
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• pp.579-582
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• 2017

To investigate the prevalence of intestinal parasite infections in Yanbian Prefecture, Jilin Province, China, epidemiological surveys were conducted on a collaboration basis between the Korean Centers for Disease Control and Prevention and the Yanbian Center for Disease Control and Prevention. A total of 8,396 (males 3,737 and females 4,659) stool samples were collected from 8 localities and examined with the formalin-ether sedimentation technique, and additionally examined with the cellotape anal swab to detect Enterobius vermicularis eggs. The overall rate of intestinal parasites was 1.57%. The prevalence of Ascaris lumbricoides was the highest (0.80%), followed by Entamoeba spp. (0.23%), heterophyid flukes (0.15%), Clonorchis sinensis (0.08%), Enterobius vermicularis (0.07%), hookworms (0.06%), Trichostrongylus spp. (0.06%), Giardia lamblia (0.04%), Paragonimus spp. (0.02%), Diphyllobothrium spp. (0.02%), Trichuris trichiura (0.02%). The prevalence by sex was similar, 1.58% (n=59) in males and 1.57% (n=73) in females. By the present study, it is partly revealed that the prevalences of intestinal parasite infections are relatively low among the inhabitants of Yanbian Prefecture, Jilin Province, China.

• 한국임상수의학회지
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• 제30권5호
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• pp.371-375
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• 2013

체중 3.5 kg 11년령 요크셔 테리어가 대변실금, 뒤무직(이급후증), 회음부의 종괴를 동반하는 증상으로 내원하였다. 신체 검사상 비대 유선, 질 분비물과 정복이 가능한 회음부의 종괴가 발견되었다. 임상증상과 방사선검사를 바탕으로 배쪽 양측 회음 허니아와 자궁축농증으로 진단하였다. 자궁난소 적출술 후 양측 회음 허니아는 결장 고정술과 방광 고정술 후 반힘즐 근육 전위술을 이용하여 정복하였다. 수술 후 방사선과 컴퓨터 단층 촬영 검사상에 배쪽 양측 회음 허니아의 정복을 확인할 수 있었다. 술 후 10일째 정상적인 활동을 보였고 1년 동안에 검사상 수술과 관련된 부작용은 관찰되지 않았다. 배쪽 양측 회음 허니아는 결장 고정술과 방광 고정술 후 반힘즐 근육 전위술을 이용하여 성공적으로 치료 되었다.

• 미생물학회지
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• 제38권4호
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• pp.276-280
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• 2002

본 연구는 수환경이나 먹는샘물 생산 공장 등에서 녹농균이 검출되었을 경우 오염원추적의 1차 조사수단으로 세포막 지방산의 유사도 분석 활용 가능성을 평가함을 목적으로 하였다. 이를 위하여 54개 수환경 분리 균주, 3개 표준 균주, 토양과 분변 분리 균주 4종 등 총 61 개 녹농균의 세포 지방산을 분석하였고, 유사도를 산정하여 가계도식 도표(dendrogram)로 나타내었다. 그 결과 61개 균주 모두가 ED (Euclidian Distance) 8.4에서 단일한 cluster로 grouping되었고 ED 6.9에서 4개의 subgroups들로 분류되었다. 그 subgroups들은 현장 분리, 외국의 표준 균주 등 기원에 따라 각각의 subgroup으로 분류되어 미생물 동정에 사용되는 세포 지방산 분석의 유사도 산출이 먹는샘물 공장 등 수환경에서 경제적이고 간단한 오염원 조사의 1차 수단으로서 활용 될 가능성을 보여주었다.

• Parasites, Hosts and Diseases
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• 제43권1호
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• pp.1-5
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• 2005

The prevalence of parasitic infections was investigated in human immunodeficiency virus (HIV)-infected patients (n = 105) who visited Seoul National University Hospital, Seoul, Korea, during the period from 1995 to 2003. Fecal samples were collected from 67 patients for intestinal parasite examinations, and sputum or bronchoalveolar lavage samples from 60 patients for examination of Pneumocystis carinii. Both samples were obtained from 22 patients. Thirty-three ($31.4\%$) of the 105 were found to have parasitic infections; Cryptosporidium parvum ($10.5\%$; 7/67), Isospora belli ($7.5\%$; 5/67), Clonorchis sinensis ($3.0\%$; 2/67), Giardia lamblia ($1.5\%$; 1/67), Gymnophalloides seoi ($1.5\%$; 1/67), and Pneumocystis carinii ($28.3\%$; 17/60). The hospital records of the 11 intestinal parasite-infected patients showed that all suffered from diarrhea. This study shows that parasitic infections are important clinical complications in HIV-infected patients in the Republic of Korea.

• Parasites, Hosts and Diseases
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• 제26권3호
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• pp.221-226
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• 1988

면역기능이 저하된 한국인 73세 남자가 요통을 주소로 입원하였다. 환자는 prednisolone 을 장기간 투여하였다고 하며 입원시 전신성 pitting edema와 기침, 객담, 구토, 설사를 하였고 빈 사상태였다. 백혈구는 증가하였으나 초산구중가증은 없었으며 저 단백혈증, hypoalbuminemia, 패혈증, 빈혈이 있었다. 뇨는 한색이었다. 대변검사에서 rhabditiform 유충이 관찰되었으며 대변 배양 검사로 분선충의 filariform유충이 확인되어 분선충에 의한 hyperinfection으로 진단되었다. 치료목적으로 입원 제3일부터 albendazole을 4일간 투여하였다. 입원 제7일에 객담검사에서 filariform유충이 관찰되었으며 설사변에서 분선충의 기생세대 자충 619마리를 수집하였다. 그러나 환자는 희망없이 빈사상태로 퇴원하였으며 얼마 후 자택에서 사망하였다.