• BMB Reports
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• 제52권3호
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• pp.181-189
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• 2019

Cancer remains a life-threatening disease and accounts for the major mortality rates worldwide. The practice of using biomarkers for early detection, staging, and customized therapy may increase cancer patients' survival. Deubiquitinating enzymes (DUBs) are a family of proteases that remove ubiquitin tags from proteins of interest undergoing proteasomal degradation. DUBs play several functional roles other than deubiquitination. One of the important roles of DUBs is regulation of tumor progression. Several reports have suggested that the DUB family members were highly-elevated in various cancer cells and tissues in different stages of cancer. These findings suggest that the DUBs could be used as drug targets in cancer therapeutics. In this review, we recapitulate the role of the DUB family members, including ubiquitin-specific protease, otubain protease, and important candidates from other family members. Our aim was to better understand the connection between DUB expression profiles and cancers to allow researchers to design inhibitors or gene therapies to improve diagnosis and prognosis of cancers.

• 한국주거학회논문집
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• 제21권2호
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• pp.123-132
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• 2010

The housing market requires customized housing to be supplied according to the various characteristics of households. Multinominal Logistic Regression was used to analyze the effects of variables of household characteristics according to the number of family members on the choice of housing size in the scope of the whole country's housing market. Analysis showed that the number of family members has its own characteristics. When a household has a smaller number of family members, there are more variables affecting choice of housing size. Living and housing expenses variables served as significant variables that affect all household types. Results showed that households with more living and housing expenses are more likely to choose a large sized house and where households have a greater number of family members, there is more influence on that choice. The age of the householder was only found to be a meaningful variable in 1-2 person households and 3-4 person households, particularly in the choice of a small or large sized house. This shows that the age of the householder does not play an important role in choosing medium sized houses for households of under 4 people, but affects the choice of small and large sized houses. The academic ability of household members also served as a significant variable. While 1-2 person households with high academic ability tend to select a large sized house, 3-4 person households with high academic ability tend to select a small sized house. It is observed that members of both 1-2 person households and 3-4 person households tend to select their house between a large sized house and a small sized house in order to own their own houses. The result of this research suggests that there are various and detailed variables on the choice of housing size. Especially, a notable result is that household characteristics more significantly affect the housing size choice of 1-2 person households, while the trend of an aging society will more significantly affect a 3-4 person households' choice of a large sized house. Therefore, a study on the choice of housing size according to characteristics of elderly households and 1-2 person households should be continually analyzed.

• 가정과삶의질연구
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• 제14권1호
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• pp.11-20
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• 1996

When data collected from more than one family member are utilized family researchers must take the correlation of family member's perception behavior or attitude scores into account viewing the couple or family as a unit of interdependent members. This paper presents a framework for categorizing family data based on the unit of analysis and several alternatives for the statistical analysis of family variables using individual- dyadic- and family-level data.

• 대한가정학회지
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• 제38권7호
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• pp.1-12
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• 2000

Although the term 'family business' is relatively new, this style of business is universal. An Unusual feature that must be noted, is that even though it is a common style of business is not clearly defined. The purpose of this study is to identify the different family participation patterns, and the variables that effect different types of participation. '1997 Daewoo Panel Data' was used. Some descriptive statistics and a multinomial logit model were employed for the analysis. The standard type of business focused on in this study was a family owned and operated 'ma and pa' typed business and the sample was limited to households where one or both of the partners involved in a family owned and operated business. The main resets obtained from this sample were as follows: 1. Personal characteristics such as respondents' gender, age and educational level were important variables that effected the participation of family members in the business. As can be seen in the gender analysis, family businesses owned by men showed all available patterns of family operated businesses in relatively high numbers. A large percentage of businesses owned women were of self-employed pattern. According to the analysis by age and educational level, young people with a high level of education tend to managed their small businesses by employing others rather than utilising the self-employed or family operated pattern. 2. While big families showed a high percentage of a combination pattern of a family-run, and ordinary employer/employee company, relatively small families usually opted for purely family-run businesses. Whether the family have children under 6 or not, and the number of children under 6 did net significantly effect to the patterns of the family system of small family businesses. 3. The size, location and kind of family business also effected participation patterns of the family members significantly. These results suggest that further study will be required to gain more exact and meaningful information to help Korean family businesses.

• 대한간호학회지
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• 제29권3호
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• pp.467-484
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• 1999

The main objectives of this study were to investigate the concept of family function from the perspective of the contemporary Korean family, and to construct model of change of family function with chronic illness. The hybrid model approach was applied in which three phases(theoretical phase, empirical phase, and analytic phase) of concept development were explored for family functioning. The study was conducted from 1997 to 1998. In empirical phase, two groups of purposive samples were drawn : normal family group composed of six families without ill family member, and ill family group composed of seven families of which wives have rheumatoid arthritis. Only families with child(or children) in primary or secondary schools were included in the study. The results were as follows : In theoretical phase, six dimensions of family concept were emerged : affective, structural, control, cognitive, financial, and reproductive dimension. In order to analyse the Korean normal family function in middle class with middle-aged women, financial and reproductive dimension were not included. In empirical phase, five dimensions(affective, structural, control, cognitive, and external relationship) were found from the normal family data. External relationship dimension is very important factor as a resource of the support, especially when their parents or siblings had no help or support to them. In the affective dimension, Korean family emphasized harmony and balance rather than affective expression between couples and between parents and children. They also showed common goals of the families to solve their problems to control the family members. The priority of the goals was getting into the higher education of their children or helping their unhealthy parents or family members. Six dimensions (affective, structural, control, cognitive, external relationship, and financial) of family functions were emerged from the ill family data. From the analysis of ill family data, types of restructuring house chore after wives illness were developed : (a) negociated, (b) accomodated, and (c) isolated, enduring types. Although the dimensions of family functioning identified in this study are similar to the conceptualizations that exist in the western literature, there were distinct differences in the nature of major themes and subconcepts under these family function dimensions.

• 대한간호학회지
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• 제29권6호
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• pp.1324-1335
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• 1999

The purpose of this study was to explore the educational needs of patients with, kidney transplants and their family members to develop a rehabilitational and educational program. Data were collected from January 29, 1999 to April 20, 1999 with interviews using a structured questionnaire. There were 184 subjects in this study. of them, 107 were patients who had kidney transplants and had visited at the out-patient department of three general hospitals located in Seoul and 77 were family members. The questionnaire used for this study was developed by the investigator through a literature review and from data collected from 11 professional personnel and three kidney transplant patients and their families. The data were analyzed using the SAS program with t-test, ANOVA, Scheff test, Pearson correlation coefficient. The results are as follows; 1) In the patient group, total mean score for educational needs was 154.61 and the item mean score was 3.96. For the family group, total mean score for educational needs was 168.84 and the item mean score was 4.15. So in the family group, educational needs were scored higher than by the patient group. With regard to domains, both patient and family groups had as the highest educational needs, the domain of physical health and the top ten items in the educational needs were also in the domain of physical health. 2) In the patient group, women and the divorce/ bereavement group had higher educational needs in the domain of nutritional management, those who had been admitted longer than four weeks from their kidney transplant had higher educational needs in the domain of physical health and those who were less than 4 years from their transplant had higher educational needs in the domain of follow-up care. In the family group, those who were Catholics and had high school education had higher educational needs in the domain of nutritional management. 3) In the patient group, academic background was positively correlated(r=.208, p=.031) to educational needs.

• 한국사회복지학
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• 제42권
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• pp.397-422
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• 2000

Since 1998 when economic assistance from IMF started, the empirical research on the effects of unemployment and drastic income loss on psychological functioning among the unemployed as well as their family members has increased. These studies have found that unemployment and drastic income loss following unemployment have significant negative influence on the psychological outcomes such as anxiety and depression of the unemployed and their family members. Studies have also focused on the role of social support in this process, and reported that depending on the levels of received social support, unemployment and income loss have differential effects on the psychological aspects of the unemployed. However, these studies have several weaknesses. First, most of the related studies employed the data which were collected from limited regions of the country, which imposes limitations on the scope of the generalizability of research findings. Second, the main independent variables used in these studies were mainly unemployment or income loss, which ignore the psychological evaluation by the employed of their family financial situations. Third, in analyzing the moderating effects of social support, most studies have focused mainly on showing the existence of moderating effects by social support. Consequently, the nature and role of social support remained unanalyzed and left to speculations. The purpose, of this study is to examine the effects of economic pressure experienced by family heads who were unemployed and to analyze the moderating role of social support based on a nationally representative sample. The findings showed that economic pressure has negative influence on anxiety and depressive feelings among the unemployed, and that the effect of economic pressure on depressive feelings were substantially higher among those who have received lower levels of social support from family members than that among those with higher levels of family support.

• 대한간호학회지
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• 제25권1호
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• pp.45-60
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• 1995

This study investigated the effects of education program conducted through individual home visit by CHPs, which was developed ,by the operational re-search technique for families of dementia patients. (Yeo Shin Hong et at,1994) The study was conducted in the form of a primary experimental design with 43 people as subjects, including dementia patients and family member in several Myon areas of Chungcheong Namdo between June 10 and August 20, 1994. The data was collected by questionnaires through the home visit by the CHPs. The results of study are as follows. 1. There is no difference in the quality of life between before and after the education program. 2. Role stress 'before the education program' was significantly different than 'after the education program'. 3. There was no difference in the feeling of burden between before and after the education program. 4. There was a significant difference in the abnormal behaviors of patients between before and after the education program. 5. The knowledge of dementia by the patient's family increased significantly after the education program, compared to that of 'before the education program'. 6. There was a significant difference in the attitude of family members toward the education program on dementia between before and after the education program. 7. The results of analysis on the coefficient relationship of various variables showed that the age of patients and family members have a significant correlation with role stress(p=.01). 8. In the subjective evaluation of family members on changes in actual nursing actions and the improvement of knowledge and technique in terms of daily living, (including abnormal behavior of patients, adjustment of environment for patients, activity programs for patients, communication technique with patients, ensuring the safety of patients, clothing, meals and elimination, 60-65% of family members responded that their knowledge had increased. As for improvement in techniques for each item, the technique for communication with patients showed the greatest improvement while the action program method for patients showed the least change. As for the nursing service provided to patients, most respondents showed a positive change. The specific items for which more than 80% respondents answered positively were as follows : recognizing the demand of patients, getting patients to do simple house works, talking softly and gently, removing dangerous things, preparing comfortable clothes that are easy to put on and take off, and limiting water consumption at night. As a result of study, the following suggestions can be made. The purpose of the study was to examine the effect of an education program developed and applied for dementia patients and family members in the community. This needs to be compared with a similar study conducted in the urban setting. In addition, a community service program (ex : nursing hem and shelter) including the application of the education program should be developed and the study done to investigate its effect.

• 한국산학기술학회논문지
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• 제20권11호
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• pp.446-457
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• 2019

본 연구의 목적은 청소년 남학생 흡연과 가족구성원의 흡연의 관련성을 분석하기 위함이다. '제14차(2018년) 청소년건강행태조사'에 응답한 27,276명을 이용하여 빈도분석, 교차분석, 다중 로지스틱 회귀분석을 실시하였다. 남학생 중 비흡연율은 91.5%, 흡연율은 8.5%(가끔 흡연함 2.5%, 자주 흡연함 6.0%)이다. 연구결과, 가족구성원의 흡연자 수에 따른 남학생의 흡연 상태는 유의한 차이가 있다(p<0.001). 인구사회학적 특성에 따른 흡연은 학년, 학업성적, 경제상태, 아버지 학력, 어머니 학력에서 유의한 차이가 있고(p<0.001), 건강행태관련 특성에 따른 흡연은 음주 정도, 자살 생각률, 우울감 경험률, 스트레스 정도, 아침식사 빈도, 수면 후 피로회복 정도, 주관적 건강 인지 정도에서 유의한 차이가 있다(p<0.001). 남학생의 흡연가능성은 가족구성원 흡연자가 1명일 때보다 가족구성원 흡연자가 2명이상일 때 더 높다(p<0.001). 본 연구의 의의는 남학생 흡연이 가족구성원 흡연상태에 따라 영향을 받는다는 것을 확인하였으며 이러한 연구결과는 청소년 흡연의 예방 및 금연사업을 구성할 때 가족 흡연자의 금연 사업을 병행하여 설계한다면 좋은 효과를 거둘 수 있음을 시사한다.

• 디지털정책학회지
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• 제2권3호
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• pp.17-24
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• 2023

본 연구는 응급구조학과 학생들의 자기가치감과 대학생활적응의 정도를 파악하고, 종교의 유무와 가족구성원의 친밀도에 따라 차이가 있는지를 분석하였다. 대학교에 재학 중인 응급구조학과 학생들을 183명을 대상으로 온라인 설문을 실시하였으며, 대상자의 성별, 종교의 유무, 가족구성원과의 친밀도는 빈도와 백분율로 분석하였다. 종교의 유무 및 가족구성원과의 친밀도에 따른 자기가치감과 대학생활적응은 평균, 표준편차와 t-test와 ANOVA로 분석하였다. 연구 결과, 종교의 유무 및 가족구성원과의 친밀도에 따라 자기가치감에 차이가 있었으며, 가족구성원과의 친밀도에 따라 대학생활적응의 하위요인 중 학업적응에 유의한 차이가 있는 것으로 나타났다. 본 연구의 결과를 통해 개인의 자기가치감 향상과 대학생활적응 요인에 맞도록 상담전략을 세우는 데에 있어 종교의 유무와 가족구성원과의 친밀도를 고려할 필요가 있으며, 자기가치감 향상을 위한 다양한 대학생활적응 증진 프로그램을 개발해 응급구조학과 학생들에게 적용하고 그 효과를 검증할 것을 제언한다.