• Diabetes and Metabolism Journal
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• v.42 no.6
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• pp.451-464
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• 2018

Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by a less intensive autoimmune process and a broad clinical phenotype compared to classical type 1 diabetes mellitus (T1DM), sharing features with both type 2 diabetes mellitus (T2DM) and T1DM. Since patients affected by LADA are initially insulin independent and recognizable only by testing for islet-cell autoantibodies, it could be difficult to identify LADA in clinical setting and a high misdiagnosis rate still remains among patients with T2DM. Ideally, islet-cell autoantibodies screening should be performed in subjects with newly diagnosed T2DM, ensuring a closer monitoring of those resulted positive and avoiding treatment of hyperglycaemia which might increase the rate of ${\beta}-cells$ loss. Thus, since the autoimmune process in LADA seems to be slower than in classical T1DM, there is a wider window for new therapeutic interventions that may slow down ${\beta}-cell$ failure. This review summarizes the current understanding of LADA, by evaluating data from most recent studies, the actual gaps in diagnosis and management. Finally, we critically highlight and discuss novel findings and future perspectives on the therapeutic approach in LADA.

• Structural Engineering and Mechanics
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• v.71 no.6
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• pp.739-749
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• 2019

This article deals with the application of reliability analysis for determining the safety of simply supported beam under the uniformly distributed load. The uncertainties of the existing methods were taken into account and hence reliability analysis has been adopted. To accomplish this aim, Generalized Regression Neural Network (GRNN), Extreme Learning Machine (ELM) and Gaussian Process Regression (GPR) models are developed. Reliability analysis is the probabilistic style to determine the possibility of failure free operation of a structure. The application of probabilistic mathematics into the quantitative aspects of a structure and improve the qualitative aspects of a structure. In order to construct the GRNN, ELM and GPR models, the dataset contains Modulus of Elasticity (E), Load intensity (w) and performance function (${\delta}$) in which E and w are inputs and ${\delta}$ is the output. The achievement of the developed models was weighed by various statistical parameters; one among the most primitive parameter is Coefficient of Determination ($R^2$) which has 0.998 for training and 0.989 for testing. The GRNN outperforms the other ELM and GPR models. Other different statistical computations have been carried out, which speaks out the errors and prediction performance in order to justify the capability of the developed models.

• International Journal of High-Rise Buildings
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• v.7 no.4
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• pp.299-311
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• 2018

As engineered timber such as Glulam is seeing increasing use in tall timber buildings, building codes are adapting to allow for this. In order for this material to be used confidently and safely in one of these applications, there is a need to understand the effects that fire can have on an engineered timber structural member. The post-fire resilience aspect of glulam is studied herein. Two sets of experiments are performed to consider the validity of zero strength guidance with respect to short duration fire exposure on thin glulam members. Small scale samples were heated in a cone calorimeter to different fire severities. These samples illustrated significant strength loss but high variability despite controlled quantification of char layers. Large scale samples were heated locally using a controlled fuel fire in shear and moment locations along the length of the beam respectively. Additionally, reduced cross section samples were created by mechanically carving a way an area of cross section equal to the area lost to char on the heated beams. All of the samples were then loaded to failure in four-point (laterally restrained) bending tests. The beams that have been burnt in the shear region were observed as having a reduction in strength of up to 34.5% from the control beams. These test samples displayed relatively little variability, apart from beams that displayed material defects. The suite of testing indicated that zero strength guidance may be under conservative and may require increasing from 7 mm up to as much as 23 mm.

• Journal of the Architectural Institute of Korea Structure & Construction
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• v.34 no.12
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• pp.35-40
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• 2018

In this study, experimental research was carried out to evaluate the seismic performance of reinforced concrete exterior beam-column joint regions using hybrid retrofitting with AFRP sheets and embedded CFRP reinforcements in existing reinforced concrete building. Therefore it was constructed and tested three specimens retrofitting the beam-column joint regions using such retrofitting materials. Specimens, designed by retrofitting the beam-column joint regions of existing reinforced concrete structure, were showed the stable failure mode and increase of load-carrying capacity due to the effect of crack control at the times of initial loading and confinement of retrofitting materials during testing. Specimens RBCJ-SRA3 designed by the retrofitting of AFRP sheets and embedded CFRP reinforcements in reinforced exterior beam-column joint regions were increased its maximum load carrying capacity by 1.86 times and its energy dissipation capacity by 1.65 times in comparison with standard specimen RBCJ for a displacement ductility of 5.

• Quality Improvement in Health Care
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• v.27 no.1
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• pp.2-9
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• 2021

Patient safety remains one of the most important health care issues in Korea. To improve patient safety, we have introduced concepts from the field of safety science such as the Swiss cheese model, and adopted several methodologies previously used in other industries, including incident reporting systems, root cause analysis, and failure mode and effects analysis. This approach has enabled substantial progress in patient safety to be made through undertaking patient safety improvement activities in hospitals that are systems-based, rather than individual-based. However, these methods have the shared limitation of focusing on negative consequences of patient safety. Therefore, the paradigm shift from Safety I to Safety-II in safety science becomes the focus of our discussion. We believe that Safety-II will complement, rather than replace, Safety-I in the discipline of patient safety. In order to continuously advance patient safety practices in Korea, it is necessary that Korea keeps abreast of the recent global trends and development in safety science. In addition, more focus should be placed on testing the feasibility of new patient safety approaches in real-world situations.

• Nuclear Engineering and Technology
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• v.54 no.1
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• pp.186-192
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• 2022

Flow accelerated corrosion (FAC) is a type of pipe corrosion in which the pipe thickness decreases depending on the fluid flow conditions. In nuclear power plants, FAC mainly occurs in the carbon steel pipes of a secondary system. However, because the temperature of a secondary system pipe is over 150 ℃, in situ monitoring using a conventional ultrasonic non-destructive testing method is difficult. In our previous study, we developed a waveguide ultrasonic thickness measurement system. In this study, we applied a waveguide ultrasonic thickness measurement system to monitor the thinning of the pipe according to the change in pH. The Korea Atomic Energy Research Institute installed FAC-proof facilities, enabling the monitoring of internal fluid flow conditions, which were fixed for ~1000 h to analyze the effect of the pH. The measurement system operated without failure for ~3000 h and the pipe thickness was found to be reduced by ~10% at pH 9 compared to that at pH 7. The thickness of the pipe was measured using a microscope after the experiment, and the reliability of the system was confirmed with less than 1% error. This technology is expected to also be applicable to the thickness-reduction monitoring of other high-temperature materials.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.21 no.6
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• pp.8-14
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• 2022

In this study reports experiments were conducted to determine the quality of weld beads of different materials, Al and Cu. Among the lasers used to make battery cells for electric vehicles, non-destructive testing was performed using deep learning to determine the quality of beads welded with the ARM laser. Deep learning was performed using AlexNet algorithm with a convolutional neural network structure. The results of quality identification were divided into good and bad, and the result value was derived that all the results were in agreement with 94% or more. Overall, the best welding quality was obtained in the experiment for the fixed ring beam output/variable center beam output, in the case of the fixed beam (ring beam) 500W and variable beam (center beam) 1,050W; weld bead failure was seldom observed. The tensile force test to confirm the reliability of welding reported an average tensile force of 2.5kgf/mm or more in all sections.

• Earthquakes and Structures
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• v.21 no.6
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• pp.641-652
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• 2021

Digging well foundation has been widely used in railway bridges due to its good economy and reliability. In other instances, bridges with digging well foundation still have damage risks during earthquakes. In this study, a new type of digging well foundation with prefabricated roots was proposed to reduce earthquake damage of these bridges. Quasi-static tests were conducted to investigate the failure mechanism of the root digging well foundation, and then to analyze seismic behaviors of the new type well foundation. The testing results indicated that these prefabricated roots could effectively limit the rotation and uplift of the digging well foundation and increase the lateral bearing capacity of the digging well foundation. The elastic critical load and ultimate load can be increased by 69% and 36% if prefabricated roots were added in the digging well foundation. The prefabricated roots drived more soil around the foundation to participate in working, the stiffness of the bridge pier with root digging well foundation was improved. Moreover, the root participation could improve the energy dissipation capacity of soil-foundation-pier interaction system. The conclusions obtained in this paper had important guiding significance for the popularization and application of the digging well foundation with prefabricated roots in earthquake-prone zones.

• Steel and Composite Structures
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• v.43 no.4
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• pp.511-522
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• 2022

An experimental investigation to study the behaviour of connections between cold-formed steel (CFS) joist and plywood structural panel is presented in this paper. Material testing on CFS and plywood was carried out to assess their mechanical properties and behaviour. Push-out tests were conducted to determine the slip modulus and failure modes of three different shear connection types. The employed shear connectors in the study were; size 14 (6mm diameter) self-drilling screw, M12 coach screw, and M12 nut and bolt. The effective bending stiffness of composite cold-formed steel and plywood T-beam assembly is calculated based on the slip modulus values computed from push-out tests. The effective bending stiffness was increased by 25.5%, 18% and 30.2% for self-drilling screw, coach screw, nut and bolt, respectively, over the stiffness of cold-formed steel joist alone. This finding suggests the potential to enhance the structural performance of composite cold-formed steel and timber flooring system by mobilisation of composite action present between timber sheathing and CFS joist.

• Nuclear Engineering and Technology
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• v.54 no.5
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• pp.1652-1656
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• 2022

Fire tests were conducted on cables using fire-retardant paint employed in nuclear power plants that transmit electrical power, control and instrument signals. The failure criteria of various power and control cables coated with fire retardant coating at three different coating thicknesses (~0.5 mm, 1.0 mm & 1.5 mm) were studied under direct flame test using Container Fire Test Facility (CFTF) based on standard tests for bare cables. A direct flame fire test was conducted for 10 min with an LPG ribbon burner rated at ten by fixing the cable samples in a vertical cable track. Inner sheath temperature was measured until ambient conditions were achieved by natural convection. The cables are visually evaluated for damage and the mass loss percentage. Cable functionality is ascertained by checking for electrical continuity for each sample. The thickness of cable coating on fire exposure is also studied by comparing the transient variation of inner sheath temperature along the Cable length. This study also evaluated the adequacy of fire-retardant coating on cables used for safety-critical equipment in nuclear power plants.