• Korean Journal of Clinical Pharmacy
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• v.30 no.1
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• pp.31-35
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• 2020

Objective: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are frequently prescribed medications worldwide for the treatment of hypercholesterolemia. Statins are considered to be well tolerated; however, they have a potential for myotoxicity. Concomitant drugs that inhibit cytochrome P450 3A4 can increase the concentration of statins and thus the risk of developing myotoxicity. The purpose of this study was to evaluate risk factors associated with potential drug-drug interactions in patients receiving statins. Methods: The subjects of this study were patients aged more than 18 years who received at least one prescription of statins in a general hospital located in Chuncheon-si, Korea, between January 1, 2018, and March 31, 2018. Data regarding statin use and baseline characteristics was collected from the computerized hospital database. Logistic regression analysis was used to identify risk factors associated with potential drug-drug interactions. Results: A total of 1061 patients were finally included in the study. The incidence of potential drug-drug interactions was 45% in all subjects. According to the results of the multivariate logistic regression analysis, myocardial infarction as the indication of statin, arrhythmia or heart failure as a comorbidity, and aspartate aminotransferase levels higher than 40 IU/L were significant risk factors for potential drug-drug interactions in study subjects. Diltiazem was the most commonly co-prescribed drug that caused potential drug-drug interactions with statins. Conclusion: There was a considerable rate of potential drug-drug interactions in patients receiving statins. Health care professionals should attempt to reduce potential drug-drug interactions during statin administration.

• Journal of the Korea Convergence Society
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• v.8 no.1
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• pp.131-138
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• 2017

The purpose of research and bamboo for failure, Damyang-county, Jeollanam-do at 2015 Damyang bamboo the world fairs held according to the attachment to local factors impact of regional development and hosting support. To identify the impact on the property held. Fair after setting up a hypothesis to carry out research in the visitors through after sample surveys and survey and Empirical Analysis. Show areas are improving in the future, due to host tourists want to come up with the purpose of research to become a popular tourist attraction again. Attachment or environmental factors and social factors showed that, and affect the region. The host of social factors turned out to be the biggest influence, and economic factors, environmental factors shown to affect, and to a venue in order.Attachment is a factor appears to be affecting the region was the venue. The property is shown to environmental factors is not statistically significant, and host local affection, support appears to be factors affecting the holding. As a result, Fair, held regional attachment to the Influence Factors of regional development support, and according to the next fair in the Region and through the impact on the property held.Evaluation strategy could contribute to explore the festival.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.2
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• pp.130-137
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• 2017

Due to the economic growth and development of construction technology, a role of foundation to resist heavy loads has been increased. In this present study to improve the structural performance of reinforced concrete pile, the precast HPC pile reinforced with rebar and filling concrete was developed and the strength of pile was predicted based on the limit state design method. The safety of HPC pile strength was evaluated by comparing with the design values. The geometry of HPC pile is a decagon cross section with a maximum width of 500 mm and a minimum width of 475 mm, and the hollow head of pile thickness is 70 mm. The inner area of the hollow head part was made as the square ribbed shape presented in the limit state design code in order to achieve horizontal shear strength between pile concrete and filling concrete. From the shear test results, it was found that the stable shear strength were secured without abrupt failure until maximum load stage despite the shear cracks was found. Shear strength is 135% and 119% higher than that of design value calculated from limit state design code. The driving test results of HPC pile according to the presence of additional reinforcement showed the outstanding crack resistance against impact loads condition. From the bending test results the flexural load between PHC pile and HPC pile was 1.51 times and 1.48 times higher than that of the design flexural load of conventional PHC pile.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.6
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• pp.65-72
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• 2016

Service life evaluation for RC Structures exposed to chloride attack is very important, however the previous two methods(deterministic and probabilistic method) show a big difference. The paper presents a service life simulation using deterministic and probabilistic method with time-dependent diffusion coefficient. Three different cases are considered for diffusion coefficient, concrete cover depth, and surface chloride content respectively, and then the PDF(probability of durability failure) and the related service life are obtained. Through adopting time-dependent diffusion, the discrepancy between the two methods can be reduced, which yields reasonable service life. When diffusion coefficient increases from $2.5{\times}10^{-12}m^2/sec$ to $7.5{\times}10^{-12}m^2/sec$, the service life decreases to 25.5~35.6% level, and cover depth does from 75 mm to 125 mm, it increases to 267~311% level as well. In the case of surface chloride content from $5.0kg/m^3$ to $15.0kg/m^3$, it changes to 40.9~54.5%. The effect of cover depth is higher than the others by 8~10 times and also implies it is a key parameter to service life extension.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.2
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• pp.151-159
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• 2015

In this study, experimental research was carried out to evaluate and improve the seismic performance of reinforced concrete beam-column joint regions using strengthening materials (CFRP sheet, AFRP sheet, embedded CFRP rod) in existing reinforced concrete structure. Therefore it was constructed and tested seven specimens retrofitting the beam-column joint regions using such retrofitting materials. Specimens, designed by retrofitting the beam-column joint regions of existing reinforced concrete structure, were showed the stable failure mode and increase of load-carrying capacity due to the effect of crack control at the times of initial loading and confinement of retrofitting materials during testing. Specimens LBCJ-CRUS, designed by the retrofitting of CFRP Rod and CFRP Sheet in reinforecd beam-column joint regions were increased its maximum load carrying capacity by 1.54 times and its energy dissipation capacity by 2.36 times in comparison with standard specimen LBCJ for a displacement ductility of 4 and 7. And Specimens LBCJ-CS, LBCJ-AF series were increased its energy dissipation capacity each by 2.04~2.34, 1.63~3.02 times in comparison with standard specimen LBCJ for a displacement ductility of 7.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.2
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• pp.160-169
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• 2015

In this study, experimental research was carried out to improve the seismic performance of reinforced concrete exterior beam-column joint regions using replacing recycled coarse aggregate with hybrid fiber (steel fiber+PVA fiber) in existing reinforced concrete building. Therefore it was constructed and tested seven specimens retrofitting the beam-column joint regions using such retrofitting materials. Specimens, designed by retrofitting the beam-column joint regions of reinforced concrete building, were showed the stable failure mode and increase of load-carrying capacity due to the effect of crack control at the times of initial loading and bridge of retrofitting hybrid fiber during testing. Specimens BCJGPSR series, designed by the retrofitting of replacing recycled coarse aggregate with hybrid fiber in reinforecd beam-column joint regions were increased its maximum load carrying capacity by 1.01~1.04 times and its energy dissipation capacity by 1.06~1.29 times in comparison with standard specimen BCJS. Also, specimen $BCJGPSR_1$ were increased its energy dissipation capacity by 1.33~1.65 times in comparison with specimens BCJS, BCJP and BCJGPR series for a displacement ductility of 9.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.2
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• pp.170-178
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• 2015

In this study, it was developed eco-friendly alkali-activated slag fiber reinforced concrete using ground granulated blast furnace slag, alkali activator (water glass, sodium hydroxides), and steel fiber. Eight reinforced concrete beam using alkali-activated slag concrete were constructed and tested under monotonic loading. The major variables were mixture ratio of alkali activator, mixed/without of steel fiber. Experimental programs were carried out to improve and evaluate the flexural performance of such test specimens, such as the load-displacement, the failure mode, the maximum load carrying capacity, and ductility capacity. All the specimens were modeled in scale-down size. The reinforced concrete beams using the eco-friendly alkali-activated slag fiber reinforced concrete was failed by the flexure or flexure-shear in general. In addition, the maximum strength increased with the adding the mol of sodium hydroxide, and the specimen reinforced the steel fiber showed the value of maximum strength which is increased by 15.8% through 25.9%. It is thought that eco-friendly alkali-activated slag fiber reinforced concrete can be used with construction material and product to replace normal concrete. If there is applied to structures such as precast concrete member and production of 2nd concrete product, it could be improved the productivity and reduction of construction duration etc.

• Clinical and Experimental Pediatrics
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• v.61 no.11
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• pp.366-370
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• 2018

Purpose: Tuberculosis (TB) is one of the most important diseases that cause significant mortality and morbidity in young children. Data on TB transmission from an infected child are limited. Herein, we report a case of disseminated TB in a child and conducted a contact investigation among exposed individuals. Methods: A 4-year-old child without Bacille Calmette-$Gu{\acute{e}}rin$ vaccination was diagnosed as having culture-proven disseminated TB. The child initially presented with symptoms of inflammatory bowel disease, and nosocomial and kindergarten exposures were reported. The exposed individuals to the index case were divided into 3 groups, namely household, nosocomial, or kindergarten contacts. Evaluation was performed following the Korean guidelines for TB. Kindergarten contacts were further divided into close or casual contacts. Chest radiography and tuberculin skin test or interferon-gamma-releasing assay were performed for the contacts. Results: We examined 327 individuals (3 household, 10 nosocomial, and 314 kindergarten contacts), of whom 18 (5.5%), the brother of the index patient, and 17 kindergarten children were diagnosed as having latent TB infection (LTBI). LTBI diagnosis was more frequent in the children who had close kindergarten contact with the index case (17.1% vs. 4.4%, P=0.007). None of the cases had active TB. Conclusion: This is the first reported case of TB transmission among young children from a pediatric patient with disseminated TB in Korea. TB should be emphasized as a possible cause of chronic diarrhea and failure to thrive in children. A national TB control policy has been actively applied to identify Korean children with LTBI.

• Radiation Oncology Journal
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• v.33 no.3
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• pp.179-187
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• 2015

Purpose: The purpose of this study was to investigate the predictable value of pretreatment $^{18}F$-fluorodeoxyglucose positron emission tomography-computed tomography ($^{18}F$-FDG PET-CT) in radiotherapy (RT) for patients with hepatocellular carcinoma (HCC) or portal vein tumor thrombosis (PVTT). Materials and Methods: We conducted a retrospective analysis of 36 stage I-IV HCC patients treated with RT. $^{18}F$-FDG PET-CT was performed before RT. Treatment target was determined HCC or PVTT lesions by treatment aim. They were irradiated at a median prescription dose of 50 Gy. The response was evaluated within 3 months after completion of RT using the Response Evaluation Criteria in Solid Tumors (RECIST). Response rate, overall survival (OS), and the pattern of failure (POF) were analyzed. Results: The response rate was 61.1%. The statistically significant prognostic factor affecting response in RT field was maximal standardized uptake value (maxSUV) only. The high SUV group (maxSUV ${\geq}5.1$) showed the better radiologic response than the low SUV group (maxSUV < 5.1). The median OS were 996.0 days in definitive group and 144.0 days in palliative group. Factors affecting OS were the %reduction of alpha-fetoprotein (AFP) level in the definitive group and Child-Pugh class in the palliative group. To predict the POF, maxSUV based on the cutoff value of 5.1 was the only significant factor in distant metastasis group. Conclusion: The results of this study suggest that the maxSUV of $^{18}F$-FDG PET-CT may be a prognostic factor for treatment outcome and the POF after RT. A %reduction of AFP level and Child-Pugh class could be used to predict OS in HCC.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.3
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• pp.169-176
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• 2016

Our Korean cuisine, due to growing interests in Korean culture along with outstanding performance of K-pop stars, is attracting worldly attention. As the worldly food pursuit tendency is changing from"fast food" to "slow food", preference for our Korean cuisine, which is well-known for its healthiness, is growing. However, our Korean cuisine, in terms of the world citizen's preference, as receiving evaluation for being lacking behind of Sushi of Japan, Dimsum of China, pizza and pasta of Italy, rice noodle of Vietnam, even to Indonesian and Middle-East foods, has not been achieving drastic advancements despite the cosmopolitan's attention. The previous studies were suggesting that, failure of a localization strategy that changes our traditional taste and aroma adaptive to foreigners' preference, is a cause for this. This study, through case studies of Korean food businesses in the US which have achieved a success through localization strategy, attempts to propose the following global entrepreneurial strategy of Koran food at the US dining out market. As a global entrepreneurial strategy for success, we propose, first a sales strategy not for Koreans but for local people as main customers, second a customization strategy which is not our traditional way but that meets local standard, and finally a committed entrepreneurship.