• Journal of Integrative Natural Science
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• v.10 no.2
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• pp.85-94
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• 2017

Fibroblast growth factor receptor (FGFR) belongs to the family of receptor tyrosine kinase. They play important roles in cell proliferation, differentiation, development, migration, survival, wound healing, haematopoiesis and tumorigenesis. FGFRs are reported to cause several types of cancers in humans which make it an important drug target. In the current study, HQSAR analysis was performed on a series of recently reported 1H-Pyrazolo [3,4-b]pyridine derivatives as FGFR antagonists. The model was developed with Atom (A) and bond (B) connection (C), chirality (Ch), hydrogen (H) and donor/acceptor (DA) parameters and with different set of atom counts to improve the model. A reasonable HQSAR model ($q^2=0.701$, SDEP=0.654, NOC=5, $r^2=0.926$, SEE=0.325, BHL=71) was generated which showed good predictive ability. The contribution map depicted the atom contribution in inhibitory effect. A contribution map for the most active compound (compound 24) indicated that hydrogen and nitrogen atoms in the side chains of ring B as well as hydrogen atoms in the side chain of ring C and the nitrogen atom in the ring D contributed positively to the activity in inhibitory effect whereas, the lowest active compound (compound 04) showed negative contribution to inhibitory effect. Thus results of our study can provide insights in the designing potent and selective FGFR kinase inhibitors.

• The Journal of Internal Korean Medicine
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• v.33 no.1
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• pp.26-38
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• 2012

Objectives : The aim of this study was to investigate the effect of partial pyloric obstruction on body weight, gastric juice, gastric surface area and gastric edema in normal intact and/or vagotomized rats. Methods : Partial pyloric obstruction was performed by wrapping a non-absorbable rubber ring (D:6 mm, W:4 mm, T:1 mm) around the 1st portion of the duodenum. Vagotomy was performed by resecting the branches around the esophagogastric junction. Pre-post body weight differential, fasting gastric juice volume, gastric surface area and gastric edema were measured at 8 weeks and 20 weeks. For the effect of pyloric reperfusion the rubber ring was removed after 8 weeks and then an additional 12 weeks of observation was performed to the end of the 20-week experimental period. Results : In the initial 8 weeks observation, the effect of pylorus obstruction and/or vagotomy was significantly remarkable in the pylorus obstructed and vagotomized group; slowdown of weight gain, increase of fasting gastric juice volume, dilatation of gastric surface area and severe gastric edema were shown. In the remaining 12 weeks observation, the effect of reperfusion was significantly remarkable in the ring-removed antral dilated group; recovery of weight gain, decrease of gastric surface area and decrease of gastric edema were shown. However, gastric juice volume was not significantly different from the other group. Conclusions : Partial pyloric obstruction plays a aggravating role and the vagus nerve plays a protective role in body weight, gastric juice, gastric surface area, and gastric edema. Furthermore, pyloric valve dysfunction as an aggravating factor strengthened in defect of the vagus nerve. These results suggest that patients with both functional pyloric outlet obstruction and hypofunction of vagus nerve need to be diagnosed in good time and treated properly.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.11
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• pp.1055-1064
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• 2017

Since a device such as a rocket motor requires very high reliability, a reasonable reliability design process is essential. However, Korea has implemented a design method for applying a safety factor to each component. In classic reliability analysis, input variables such as mean and standard deviation, used in the limit state function, are treated as deterministic values. Because the mean and standard deviation are determined by a small amount of data, this approach could lead to inaccurate results. In this study, reliability analysis is performed for bolted joints and o-ring seals, and the Bayesian approach is used to statistically estimate the input variables. The estimated variables and failure probability, calculated by the reliability analysis, are derived in the form of probability distributions.

• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.860-866
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• 2022

An accurate prediction of the pressure drop along the flow paths is crucial in the design of advanced passive systems cooled by heavy liquid metal coolants. To date, a generic pressure drop correlation over spacer grids by Rehme has been applied extensively, which was obtained from substantial experimental data with multiple types of components. However, a few experimental studies have reported that the correlation may give large discrepancies. To provide a more reliable correlation for ring-type spacer grids, the current numerical study aims at figuring out the most critical factor among four hypothetical parameters, namely the flow area blockage ratio, number of fuel rods, type of fluid, and thickness of the spacer grid in the flow direction. Through a set of computational fluid dynamics simulations, we observed that the flow area blockage ratio dominantly influences the pressure loss characteristics, and thus its dependence should be more emphasized, whereas the other parameters have little impact. Hence, we suggest a new correlation for the drag coefficient as C_B = C_ν,m/ε^2.7, where C_ν,m is formulated by a nonlinear fit of simulation data such that C_ν,m = -11.33 ln(0.02 ln(Re_b)).

• Bulletin of the Korean Chemical Society
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• v.34 no.9
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• pp.2629-2634
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• 2013

Fisetin is a naturally occurring flavonoid with some anti-cancer and anti-inflammation capabilities. In this study, we perform docking studies between human c-Jun N-terminal kinase 1 (JNK 1) and fisetin and proposed a binding model of fisetin and JNK 1, in which the hydroxyl groups of the B ring and oxygen at the 4-position of the C ring play key roles in binding interactions with JNK. Fluorescence quenching and saturation-transfer difference (STD) NMR experiments showed that fisetin exhibits good binding affinity to JNK, $1.32{\times}10^8M^{-1}$. The anti-inflammatory activity of fisetin was also investigated. Fisetin significantly suppressed tumor necrosis factor, the NO production, and macrophage inflammatory cytokine release in LPS-stimulated RAW264.7 mouse macrophages. We found that the anti-inflammatory cascade of fisetin was mediated through the JNK, and cyclooxygenase (COX)-2 pathways. Our findings suggest the potential of fisetin as an anti-inflammatory agent.

• Corrosion Science and Technology
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• v.3 no.1
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• pp.6-13
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• 2004

The effect of inhibitors on the electrochemical behavior and the stress corrosion cracking resistance of Alloy 600(UNS N06600) was evaluated in 10% sodium hydroxide solution at $315^{\circ}C$. The specimens of a C-ring type for stress corrosion cracking test were polarized at 150 mV above the corrosion potential for 120 hours with and without inhibitors such as titanium oxide, titanium boride and cerium boride. The chemical compositions of the films formed on the crack tip in the C-ring specimens were analyzed using a scanning Auger electron spectroscopy. The cerium boride, the most effective, was observed to decrease the crack propagation rate more than a factor of three compared with that obtained in no inhibitor solution. It was found that the changes of the active-passive transition potentials and the film compositions were related to the resistance to stress corrosion cracking in high temperature caustic solution.

• Journal of electromagnetic engineering and science
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• v.10 no.3
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• pp.86-91
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• 2010

In this paper, a double-layered frequency selective surface(FSS) superstrate was built and tested. The unit cell of the proposed FSS consists of a ring slot and a dipole-shaped structure and shows a complementary frequency response. Each unit cell is printed on two sides of a substrate. By using these double-layered structures, the first resonant frequency of the pass-band can be lowered. As a result, the size of the unit cell is minimized and the spacing between the other cells is reduced. The proposed FSS-dipole composite antenna is designed for the gain enhancement of wide-band code division multiple access(WCDMA) frequency bands(1.92~2.17 GHz) with a low quality factor(Q=0.17). To verify the gain enhancement performance of the FSS, an FSS-dipole composite antenna was created. Although the FSS layer enhances the gain of the primary radiation source of the dipole antenna, the FSS-dipole complex antenna cannot show a uniform gain over the entire desired frequency band. The experimental results show a gain enhancement of 3 dBi with an FSS superstrate in the WCDMA frequency band.

• Molecules and Cells
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• v.27 no.6
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• pp.667-671
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• 2009

Visfatin (Nampt/PBEF) plays a pivotal role in the salvage pathway for $NAD^+$ biosynthesis. Its potent inhibitor, FK866, causes cellular $NAD^+$ levels to decline, thereby inducing apoptosis in tumor cells. In an effort to improve the solubility and binding interactions of FK866, we designed and synthesized IS001, in which a ribose group is attached to the FK866 pyridyl ring. Here, we report the crystal structure of rat visfatin in complex with IS001. Like FK866, IS001 is positioned at the dimer interface, and all of the residues that interact with IS001 are involved in hydrophobic or ${\pi}-{\pi}$-stacking interactions. However, we were unable to detect any strong interactions between the added ribose ring of IS001 and visfatin, which implies that a bulkier modifying group is necessary for a tight interaction. This study provides additional structure-based information needed to optimize the design of visfatin inhibitors.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.25 no.5
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• pp.361-365
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• 2012

A bolt-clamped ultrasonic viscometer was designed and fabricated using a pair of ring-shaped piezoelectric ceramic resonators. For its compactness and low operation frequencies, simulation of piezoelectric resonators was carried out using an ATILA program. Ring-shaped resonators using $0.05Pb(Mn_{1/3}Sb_{2/3})O_3-0.95Pb(Zr_{0.475}Ti_{0.525})O_3$ ceramics were prepared by a conventional ceramic processing, which were then clamped with a pair of metal caps. The fabricated sensor module with a small volume of less than 1 $cm^3$ and an operation frequency as low as 26.5 kHz showed a good relationship between its quality factor and the viscosity of oil.

• Applied Chemistry for Engineering
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• v.9 no.7
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• pp.1018-1022
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• 1998

Characteristics and catalytic activities of 12-molybdophosphoricacid catalysts modified by ring opening polymerization of tetrahydrofuran (THF) were studied in this work. 12-Molybdophosphoricacid catalysts modified by THF showed higher conversions and product yields than the mother acid in the vapor-phase ethanol conversion. It was believed that the enhanced catalytic activities of modified 12-molybdophosphoricacids were due to structural flexibility of heteropolyanions and weakened hydrogen bond around heteropolyanions. THF interacted with protons and crystalline water molecules of heteropolyacids. The interaction between THF and heteropolyanoins, which crystalline water molecules act as intermediary, was the dominant factor deciding the catalytic activities of modified 12-molybophosphoricacids.