• Korean Journal of Head & Neck Oncology
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• v.10 no.2
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• pp.200-205
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• 1994

Proliferating cell nuclear antgen(PCNA) plays an important role in DNA synthesis in nucleoli and is highly conserved non-histone nuclear protein composed of 261 amino acid. and is considered to correlated with the cells proliferative state, because it is synthesized particulary during the proliferative period of late Gland S-phase. Therefore, PCNA index meaningfully increases in the active or proliferative kinetic cells. By the use of recently developed monoclonal antibodies against PCNA, the immunohistochemical staining methods can make possible. These staining methods are the useful and productive one for ascertaining the cell's proliferating abillity. Moreover, immunohistochemical staining method with a antiPCNA antibody has particulrar advantages as follows. By means of these methods, we can stain the tissue that was already fixed in formalin or paraffin wax. We can see with naked eye that which cell is, where is differentiated through a microscope. Lastly, it maintains the whole tissue architecture and makes a search for the correlation. As we have seen above, the immunohistochemical staining methods for PCNA have been studied as an impotant factor that can find the cell proliferative kinetics in malignancy and biologic behavior of tumors. To investigate of the proliferative activity in thyroid nodule, Authors evaluated cell proliferative activity by immunostaing for PNCA in 45 pathologically confirmed solitary thyroid nodule. The results were as follows. 1) The benign nodules were 25 cases(Adenomatous Goiter: 20 cases, Follicular adenoma: 5 cases) and malignant nodules were 20 cases(Papillary Ca : 14 cases, Follicular Ca : 4 cases, Anaplastic Ca : 2 cases). 2) The Most prevalent age groups were 4th decade(11 cases), and the next group was 5th decade. 3) The average PCNA labelling indices were as follows. Adenomatous goiter(I6.9%), Follicular adenoma(37.6%), papillary Ca(26.3%), Follicular Ca(8.8%) and Anaplastic Ca(86.7%). There were no significant differences in benign(20.4) and malignant nodules (28.8%) except anaplastic Ca(p=0.3226). 4) When the average tumor size 2cm in papillary Ca, the PCNA indices were 26.0% (below 2cm) : 26.6% (above 2cm) (p=0.9642). The PCNA incidies were 23.9% (with lymphatic spread) : 28.7% (without lymphatic spread) (p=0.7056). There were no signlficant differences in the above cases. In conclusion, there were no significant differences in cell proliferative activity by staining for PCNA between benign and malignat nodules except anaplastic Ca.

• Applied Chemistry for Engineering
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• v.25 no.4
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• pp.430-436
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• 2014

Allura Red (AR) is a water-soluble harmful tar-based food colorant (FD & C Red 40). Batch adsorption studies were performed for the removal of AR using bituminous coal based granular activated carbon as adsorbent by varying the operation parameters such as adsorbent dosage, initial concentration, contact time and temperature. Experimental equilibrium adsorption data were analyzed by Langmuir, Freundlich and Temkin isotherms. The equilibrium process was described well by Freundlich isotherm. From determined separation factor ($R_L$), adsorption of AR by granular activated carbon could be employed as effective treatment method. Temkin parameter, B was determined to 1.62~3.288 J/mol indicating a physical adsorption process. By estimation of adsorption rate experimental data, the value of intraparticle diffusion rate constant ($k_m$) increased with the increasing adsorption temperature. The adsorption process were found to confirm to the pseudo second order model with good correlation. Thermodynamic parameters like change of free energy, enthalpy, and entropy were also calculated to predict the nature adsorption in the temperature range of 298~318 K. The negative Gibbs free energy change (${\Delta}G$ = -2.16~-6.55 kJ/mol) and the positive enthalpy change (${\Delta}H$ = + 23.29 kJ/mol) indicated the spontaneous and endothermic nature of the adsorption process, respectively.

• Journal of the Korean Geotechnical Society
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• v.30 no.7
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• pp.17-26
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• 2014

Tunneling-induced displacement in a jointed rock mass is an important factor to control tunnel stability and to secure a demanded space and construction quality. The magnitude of the inducible displacements is significantly affected by an elastic modulus and therefore, in a rock mass where a joint controls tunnel behavior, it is very important to estimate an elastic modulus of jointed rock mass reliably. Elastic modulus of jointed rock mass is affected by many factors such as rock type, joint condition, and loading condition. Nevertheless, most existing studies were focused on rough empirical relationships based on compressive loading conditions, which are different from tunnel excavation loading conditions, without a systematic approach of rock, joint, and loading conditions together. Therefore, this study considered rock and joint conditions systematically to estimate an elastic modulus of jointed rock mass under tunnel excavation loading. The controlled factors considered in this study are rock types and joint conditions (joint shear strength, joint inclination angle, number of joint sets, and joint spacing). Numerical parametric studies have been carried out with a consideration of different rock and joint conditions; the results have been compared with existing empirical relationships; and charts of elastic modulus change of different rock and joint conditions have been provided. The results are expected to have a great practical use for estimating the convergence induced by tunnel excavation in jointed rockmass.

• Journal of the Korean Geotechnical Society
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• v.34 no.7
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• pp.5-15
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• 2018

The unconfined compressive strength (UCS) test through coring is widely used to determine the reinforcement effect of the ground with grouting. However, the UCS test through coring can disturb the ground, is expensive and takes a lot of time to prepare the specimen. In this study, the factors affecting UCS of microfine cement grouted sand are evaluated and an empirical equation of UCS of microfine grouted sand is suggested. It is observed that UCS increases linearly until 28 days, however, the increasing rate of strength decreases sharply after that 28 days. The W/C ratio is dominant factor influencing UCS and UCS increases exponentially with the decrease of water/cement (W/C) ratio. Also, UCS increases linearly with increasing the relative density ranging from 30% to 70% and with decreasing median particle size. However, in case of W/C ratio=1 and K6 ($D_{50}=0.47mm$), UCS is lower than that of K4 ($D_{50}=1.08mm$) and K5 ($D_{50}=0.80mm$) due to filtration effect. Based on the experimental results, the empirical equation of UCS of microfine cement grouted sand can be expressed as the function of median particle size ($D_{50}$), porosity (n) and W/C ratio.

• Korean Journal of Health Education and Promotion
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• v.8 no.2
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• pp.34-51
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• 1991

In the research and analysis for survey practice on stability on the nutrition intake relities to an affect influence factor for variable reason to discovers dweller in cities area which is in order to prevent an unfortunately influence that thus obviously restricted by nutrition intake would be restoration. And then attempted to avhivement of stability fulfil to correct nutrition intake needed under the establish for effectiveness measured to provide the primary required resources be considerations must accomplish certain survey of goals. Therefore subject of criticism for survey was conducted during January 4 1990 to January 24 1990 through 20 days adapted place were Seoul, Taegu and Pohang cities dweller 1206 person be conducted under the expert survey personnel by directly the survey was conducted with the questional form has atapted for its survey conclusion of result be summarixed as bellow. 1) The subject of criticism for survey was ferformed to personnel adapted age group 40 to 49 were 24.9%, Age group 50 to 59 were 18.4% shows most adult group has significant higher value rate appearenced. In consideration the education level were evaluated the college grauated ; 48.8% and High School graduated: 30.1% shows that more educated level has significant higher rate value were appearenced. 2) On the subject of criticism to evaluation for adapted personnel by native place such as larger citypeople ; 29.6%, Farming and fishing village people were 28.4%, although the classfication of job analysis for estimation appearence rate were ; students 27.4%, Sales and service field personnel rate ; 15.1% and expert technique field personnel were ; 90% comprehensively appearenced. Although consideration for ecnomics situation review to the middle level shows of rate ; 61.7% and lower level was appearenced rate ; 23.9% of each others. 3) The people of resident in cities were appearenced nutrition intake has more than 2 weeks continuousely practiced by experiance rate shows ; 72% thus intake has experianced rate were 74.6% and female was 68.5% affact is comprehensively male has more many higher rate valued. In the classfication by age group 60 year old has 100% they have experiaced of nutrition intake and age group 50 to be appearenced its rate ; 76.4 % and age group 40 were 75.5% Thus result of survey for comparative rate shows in generally say more aged group has intake significant higher than younger age of group. Nevertheless, age group 10 years old be experienced of nutrition of intake rate ; 63.2% and age group 20 shows 73.9% was comparative more significant higher than age group 30 years old level adolescents.

• Journal of Digital Contents Society
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• v.16 no.1
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• pp.63-70
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• 2015

In this paper, we estimate the life cycle from acceleration life test about the hard disk of disk array of image storage of PACS. Webuil distribution was selected by the Anderson-Darling goodness-of-fit test with data of down time at $50^{\circ}C$ and $60^{\circ}C$. The equality test of shape parameter and scale parameter was conducted, so that the probability distribution estimated from data of down time at $50^{\circ}C$ and $60^{\circ}C$ was not statistically significant. The shape parameter was 1.0409, The characteristic life was 24603.5 hours at normal user condition($30^{\circ}C$) by the analysis of weibull-arrhenius modeling which included the acceleration factor of temperature, and The activation energy was 0.5011 eV through arrhenius modeling. The failure analysis of the failure samples of acceleration test and the samples of market return was conducted, so that the share percentage of failure mode was detail difference but the rank of share percentage was almost same. This study suggest the test procedure of acceleration test of hard disk drive in PACS using environment, and help the life estimation at manufacture and use.

• Journal of the Korean Society of Marine Environment & Safety
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• v.24 no.2
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• pp.246-252
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• 2018

In this paper, the friction drag force of 3D submerged body is investigated by considering the surface roughness, the first grid height, and the Reynolds number using open CFD source code, OpenFOAM 4.0. A procedure for estimating drag components by CFD code is set up and suggested in this study. In the 3D submerged body, because of the form factor in the 3D computations, the friction resistance with the small roughness of $12{\mu}m$ obtains different result with the smooth wall. As the Reynolds number increased, the boundary layer becomes thinner and the fiction resistance tends to decrease. In the computations for the effect of y+, the friction resistance and wall shear stress are excessively predicted when the y+ value deviates from the log layer. This is presumably because the boundary layer becomes thicker and the turbulence energy is excessively predicted in the nose due to the increase in y+ value. As the roughness increases, the boundary layer becomes thicker and the turbulence kinetic energy on the surface increases. From this study, the drag estimation method, considering the roughness by numerical analysis for ships or offshore structures, can be provided by using the suggested the y+ value and surface roughness with wall function.

• Clean Technology
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• v.24 no.2
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• pp.146-153
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• 2018

The water footprint is an important component of the Single Market for Green Product initiative based on the EU's Roadmap to a Resource Efficient Europe. In July 2014, the EU has established the International Standard for Water Footprint (ISO 14046) and Korea has complied with the Korean Industrial Standard (KS I ISO 14046) in April 2015. If a certification system based on the international standard (ISO 14046) is introduced, developing countries such as India and Vietnam, which are not equipped with bases, can become a trade barriers in exporting, so Korea should establish a strategy to reverse them. On the other hand, water footprints are designed to take into account local environmental impacts when compared to similar footprints (eg, carbon footprint) using LCA, so that products manufactured and manufactured in Korea will have an impact on domestic waters Should be considered. Therefore, the method of the water footprint should conform to the standard for compatibility with other countries. In order to consider the domestic water condition, it is necessary to identify suitable indicator or factor for estimating water footprint on Korea. For this purpose, this study analyzed the water footprint estimation study conducted at domestic and foreign based on international standards and through the analysis of statistical data related to domestic water resources, we confirmed the applicability of the water footprint methodology in Korea.

• Korean Journal of Agricultural Science
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• v.25 no.2
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• pp.260-270
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• 1998

The field tests were performed to suggest the rational method for stability evaluation of soft clay. The behavior of settlement-displacement obtained by field monitoring system was to compare and analyze the results of the observationed method, and to investigate the complex behavior of soft clay with filling height. The results of this study are summarized as follows. 1. The horizontal displacement was suddenly increased when physical properties of soft clay showed maximum values and the part of the turning point. The values of these properties were available to the fundamental data for stability evaluation. The shear deformation appeared that difference of the horizontal displacement was maximum values. 2. Although the stability of embankment by step filling showed the unstable part over the failure standard line, the embankment was confirmed stable. So the evaluation of the stability of embankment is reasonable to use the inclination of curve than failure standard line. 3. The horizontal displacement and relative settlement were increased as same ratio at improvement ground. Estimation of shear deformation using Terzaghi's modified bearing capacity should consider the relations of embankment load and undrained shear strength at nonimprovement ground, and minimum safety factor is recommended to use larger than 1.2. 4. Excess pore water pressure was increased with increasing of filling height and decreased with maintain the filling height. The embankment was unstable when filling height was exceed the evaluation standard line, and the behavior of excess pore water pressure and horizontal displacement could use as a standard of judgement of the filling velocity control because their behavior were agree with each other.

• Journal of Korean Society on Water Environment
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• v.30 no.4
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• pp.418-428
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• 2014

The purpose of this study is to predict the spatio-temporal changes in land uses and to evaluate land-based pollutant loads in the future under Total Water Pollution Load Management System using CLUE-S model. For these ends, sensitive parameters of conversion elasticities in CLUE-S model were calibrated and these calibrated parameters of conversion elasticities, level II land cover map of year 2009, and 7 driving factors of land use changes were used in predicting future land uses in 2002 with two scenarios(Scenario 1: non area restriction, Scenario 2: area restriction). This projected land use map of 2020 was used to estimate land-based pollutant loads. It was expected that urban areas will increase in 2020 from both scenarios 1 and 2. In Scenario 1, urban areas are expected to increase within greenbelt areas and deforest would be expected. Under Scenario 2, these phenomena were not expected. Also the results of estimation of BOD and TP pollutant loads, the BOD difference between scenarios 1 and 2 was 719 kg/day in urban areas and TP difference was 17.60 kg/day in urban areas. As shown in this study, it was found that the CLUE-S model can be useful in future pollutant load estimations because of its capability of projecting future land uses considering various socio-economic driving factors and area-restriction factors, compared with conventionally used land use prediction model.